Reagent loading method and sample analysis system

Abstract

The invention discloses a reagent loading method and a sample analysis system. The reagent loading method comprises the following steps: loading and caching a kit through a reagent loading disc; acquiring reagent information of a reagent in a reagent loading disc; acquiring distribution information of the kits in the reagent plate; according to the reagent information, the distribution information and the running state of the sample analysis system, the loading operation of the reagent box in the reagent tray is completed. The reagent loading disc is used for loading and caching the reagent, loading operation of the reagent in the reagent disc is completed through the reagent information and the distribution information, the situation that the reagent is manually placed at the corresponding reagent disc position and detection information such as the item type and the reagent amount is manually input is avoided, the possibility of errors in the loading process is reduced, and the loading efficiency is improved. The accuracy of the task result is improved, and the operability is high.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnosis, and in particular to a reagent loading method and a sample analysis system. Background Art

[0002] In the field of sample analysis, a large number of reagents are often used for testing, and the reagent loading process consumes a lot of time and manpower. However, with the continuous development of sample analyzers, the requirements for measurement speed and automation level are constantly increasing. Traditional reagent loading requires manual placement of reagents on the corresponding reagent tray position, and then manual input of reagent information such as project type and reagent volume. Due to the excessive number of reagent types and quantities loaded into the reagent tray, errors are prone to occur during the loading process, resulting in deviations in task results and poor operability. Summary of the Invention

[0003] The invention discloses a reagent loading method and a sample analysis system, which are intended to solve the problems in the prior art of requiring manual loading and prone to errors in the loading process.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions: A reagent loading method comprises the following steps: Load and cache the reagent kit via the reagent loading tray; Get the reagent information of the reagent in the reagent loading tray; Obtain distribution information of the reagent kit in the reagent tray; The reagent kit is loaded into the reagent tray according to the reagent information, distribution information and the operating status of the sample analysis system.

[0005] Furthermore, the loading operation of the reagent kit into the reagent tray is completed according to the reagent information, the distribution information and the operating status of the sample analysis system, including: In the standby state, the reagent tray is loaded with reagent kits according to the reagent information and distribution information; In the detection state, after the empty reagent kit is taken out from the reagent tray, the reagent kit in the reagent tray is loaded according to the reagent information and distribution information.

[0006] Furthermore, the empty reagent box in the reagent tray is removed, comprising the following steps: Obtain the remaining amount of reagents in the reagent box on the reagent tray; It is determined whether there is an empty reagent kit based on the remaining amount information. If so, the empty reagent kit is removed after the reagent dispensing operations of all reagent samples are completed.

[0007] Furthermore, the reagent information includes project information and packaging information.

[0008] Furthermore, in the detection state, when reagents are placed into the reagent loading tray, a space is left in the reagent tray for taking out the empty reagent cartridge.

[0009] A sample analysis system, comprising: Reagent loading tray, used for loading cache of reagent kit; Reagent tray, used for loading the reagent kit; Reaction disk, used to receive samples and reagents and perform processing and analysis; The robot is used to load the reagent kit from the reagent loading tray to the reagent tray.

[0010] Furthermore, two reagent loading trays are provided, and the two reagent loading trays are connected to each other to form an inner and outer tray structure.

[0011] Furthermore, it also includes a barcode scanner for scanning the reagent kit on the reagent loading tray to obtain reagent information of the reagent in the reagent kit.

[0012] The present invention adopts the above technical solution and has the following advantages: The present invention loads and caches reagents through a reagent loading tray, and completes the loading operation of reagents in the reagent tray under different operating states through reagent information and distribution information, avoiding manual placement of reagents in corresponding reagent tray positions and manual input of reagent information such as project type and reagent amount, reducing the possibility of errors in the loading process, improving the accuracy of task results, and having high operability. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 is a schematic diagram of a sample analysis system of the present invention; Figure 2 The figure is a flow chart of the detection reagent loading method of the present invention.

[0014] Figure numerals: 1 - reagent loading tray; 2 - reagent tray; 3 - reaction tray; 4 - robot arm. DETAILED DESCRIPTION

[0015] The following is a clear and complete description of the technical solutions in the embodiments of the present application. Obviously, the embodiments described are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0016] like Figure 1 As shown, a sample analysis system includes: a reagent loading tray 1 for loading and caching the reagent kit; a reagent tray 2 for loading the reagent kit; a reaction tray 3 for receiving samples and reagents and performing processing and analysis; and a manipulator 4 for loading the reagent kit from the reagent loading tray 1 to the reagent tray.

[0017] The present invention provides a reagent loading tray, so that the operator can directly place the reagent kit into the reagent loading tray for loading and caching, and then the robot grabs the reagent kit from the reagent loading tray to the reagent tray for loading, avoiding the manual placement of the reagent kit directly to the corresponding position of the reagent tray, reducing the possibility of errors in the manual loading process, improving the accuracy of the task results, and having high operability; at the same time, it avoids the situation where it is difficult for the operator to reach all reagent positions at the same position when manually placing the reagent kit on the reagent tray due to the large instrument.

[0018] It is understandable that the present invention has no special requirements for the specific structure and number of reagent loading trays, as long as the loading and caching function of the test kit can be realized. In order to facilitate the understanding of the present invention, in one embodiment of the present invention, two reagent loading trays are set, and the two reagent loading trays are independent of each other, forming an inner and outer tray structure relative to the inner and outer spaces of the sample analysis system; the two reagent loading trays have two independent drive systems, so that the two reagent loading trays can move synchronously or independently; when the reagent loading tray facing the operator rotates into the interior of the sample analysis system to perform the test kit loading operation, the reagent loading tray inside the sample analysis system simultaneously rotates to the outside of the sample analysis system, so that the operator can place the test kit into the outer reagent loading tray to perform the test kit loading and caching operation while the inner reagent loading tray is performing the test kit loading operation.

[0019] The present invention provides two reagent loading trays. While one reagent loading tray is performing the reagent kit loading operation, the other reagent loading tray can be used for reagent kit loading and caching operations. This satisfies the requirement of simultaneous reagent kit loading and loading operations, and also realizes continuous reagent kit loading operations, reduces the operator's waiting time during the reagent kit loading operation, and improves the working efficiency of the sample analysis system.

[0020] The system also includes a barcode scanner for scanning the reagent kit on the reagent loading tray to obtain reagent information of the reagent in the reagent kit.

[0021] After the operator places the reagent kit onto the reagent loading tray, the tray first carries the reagent kit to the barcode scanner, which scans the reagent kit placed on the tray and obtains the reagent information for subsequent reagent loading operations. This system uses a barcode scanner to scan and identify the reagent kit and obtain the reagent information, which not only avoids the error-prone manual entry of reagent information but also improves the efficiency of the sample analysis system.

[0022] like Figure 2As shown, in order to enhance the intelligent control effect of the above sample analysis system, the present invention further discloses a reagent loading method, comprising the following steps: Load and cache the reagent kit via the reagent loading tray; Get the reagent information of the reagent in the reagent loading tray; Obtain distribution information of the reagent kit in the reagent tray; The reagent kit is loaded into the reagent tray according to the reagent information, distribution information and the operating status of the sample analysis system.

[0023] The present invention loads and caches the reagent kit through the reagent loading tray, and completes the loading operation of the reagent kit in the reagent tray under different operating states of the sample analysis system according to the reagent information and distribution information, thereby avoiding manual placement of the reagent kit to the corresponding position on the reagent tray, reducing the possibility of errors in the manual loading process, improving the accuracy of the task results, and having high operability; at the same time, the present invention can perform the loading operation of the reagent kit under different operating states of the sample analysis system, and can realize the reagent tray to complete the replacement and loading operation of the reagent kit without stopping the machine, avoiding the operator having to stop the machine before replacing and loading the reagent kit, and reducing the waiting time for the operator to replace and load the reagent kit.

[0024] It can be understood that the distribution information of the reagent kits in the reagent tray of the present invention refers to the specific position information of the existing reagent kits in the reagent tray and the vacancy information of the reagent tray. When the reagent tray is designed, the positions where the reagent kits are stored in the reagent tray will be numbered. After the reagent kits are placed in the numbered reagent tray, the specific position information of the existing reagent kits and the vacancy information of the reagent tray are obtained to form the distribution information of the reagent kits.

[0025] The reagent information of the present invention includes project information and packaging information; the project information of the present invention includes the specific application of the reagent in the kit, the production batch number, the number of times it can be used, etc.; the use of the reagent of the present invention refers to the use of the reagent in the kit, such as a dilution reagent for diluting high-concentration samples, an enhanced cleaning reagent for cleaning needles, and a detection reagent for disease diagnosis; the project information is explained using the detection reagent as an example, for example, a certain batch number of alanine aminotransferase detection kit for liver function testing projects has a usable number of 100 times; the packaging information refers to whether the kit is in a closed state. After the reagent loading operation is completed, all loaded reagents are uniformly uncapped according to the packaging information.

[0026] Furthermore, the loading operation of the reagent kit into the reagent tray is completed according to the reagent information, the distribution information and the operating status of the sample analysis system, including: In the standby state, the reagent tray is loaded with reagent kits according to the reagent information and distribution information; In the detection state, after the empty reagent kit is taken out from the reagent tray, the reagent kit in the reagent tray is loaded according to the reagent information and distribution information.

[0027] Furthermore, the empty reagent kit is taken out from the reagent tray, which includes the following steps: Obtain the remaining amount of reagents in the reagent box on the reagent tray; It is determined whether there is an empty reagent kit based on the remaining amount information. If so, the empty reagent kit is removed after the reagent dispensing operations of all reagent samples are completed.

[0028] The present invention monitors the remaining amount of reagents in the reagent box on the reagent tray. When an empty reagent box exists, the empty reagent box can be taken out and the reagent box can be loaded in the detection state. The reagent tray can complete the replacement and loading operations of the reagent box without stopping the machine, avoiding the waiting time for the operator to replace the reagent box after stopping the machine; and the sample analysis system can continue to work for a long time.

[0029] It can be understood that when the sample analysis system is in standby mode, the manipulator can continuously load reagents according to the distribution of existing reagents and reagent information in the reagent tray; in the detection state, if the reagents in a reagent kit in the reagent tray are used up, the reagent tray will stop working after the reagent dispensing operations of all the samples with reagents are completed, and the manipulator will take out the empty reagent kit and put it into the reagent loading tray, and then load the same reagent kit in the reagent loading tray to the vacant position in the reagent tray; for example, in the reaction tray, a batch of samples first undergoes the dispensing operation of the first reagent R1, and after the dispensing operation, the first reagent R1 is used up. At this time, the reagent used for the second dispensing operation of some samples in the batch of samples is the second reagent R2, and the reagent used for the second dispensing operation of other samples is the second reagent R3. Then the reagent tray will stop working after the dispensing operations of the second reagent R2 and the second reagent R3 of the batch of samples are completed, and then the empty reagent kit replacement and loading operations are performed.

[0030] It is understood that in order to avoid the impact of reagent cartridge loading on the reaction detection during the detection process, each reagent cartridge replacement and loading is only performed after an empty reagent cartridge is present. In addition, since the empty reagent cartridge must be removed from the reagent tray before reagent replacement and loading, when the operator in the detection state places a reagent cartridge on the reagent loading tray, a position is left empty on the reagent loading tray each time for the empty reagent cartridge to be removed from the reagent tray.

[0031] The reagent cartridge is loaded and cached via the reagent loading tray, including: Put the reagent kit to be loaded into the reagent loading tray. Specifically, in the standby state, when the reagent tray needs to be loaded with the reagent kit, the operator will take the empty reagent kit on his or her reagent loading tray, and then put the reagent kit to be loaded into the reagent loading tray in sequence. After the placement is completed, the two reagent loading trays run clockwise at the same speed, and the external reagent loading tray carrying the reagent kit runs to the barcode scanner position. The barcode scanner starts scanning, scans the reagent kit on the reagent loading tray, and obtains the reagent information of the reagent in the reagent loading tray. After the scanning is completed, it runs to the loading position, and the reagent is loaded according to the reagent information and the distribution information of the reagent in the reagent tray. Specifically, the reagent loading tray and the corresponding reagent tray are rotated in sequence. Then the robot starts to run, grabs the reagent kit in the reagent loading tray and loads it onto the reagent tray; after the reagent loading tray carrying the reagent kit runs to the loading position, the other reagent loading tray rotates to a position facing the operator, so that the reagent kit loading and caching operation on the external reagent loading tray can be performed while the reagent tray is loading; in the detection state, when the reagent loading operation is required, after an empty reagent kit appears on the reagent tray, the reagent replacement operation is first performed, and the robot takes out the empty reagent kit on the reagent tray, and then loads the same reagent kit from the reagent loading tray into the vacant position on the reagent tray; similarly, while the reagent tray is performing the reagent kit replacement and loading operation, the operator can continue to perform the loading and caching operation on the external reagent loading tray.

[0032] It is understandable that when the reagent loading tray moves to the scanner position and scans the reagent, if no reagent or invalid reagent is found at a certain position on the reagent loading tray, the scanning of the reagent at the next position is skipped.

[0033] The present invention reduces excessive manual intervention and operation in traditional reagent loading, automatically loads reagents according to reagent information, distribution information and the operating status of the sample analysis system, and forms a more accurate, rapid and stable reagent loading and distribution method.

[0034] The present invention only requires placing the reagents into the reagent loading tray to perform continuous loading and unloading operations, which greatly improves operational safety; reagent information can be quickly obtained without the need for complicated manual information input; the operator's operating intensity and operating time are reduced, the detection process is accelerated, and the efficiency and accuracy of the detection are improved.

[0035] The above are merely embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention are included in the scope of the claims of the present invention to be approved.

Claims

1. A reagent loading method, characterized in that: The following steps are involved: Load and cache the reagent kit via the reagent loading tray; Get the reagent information of the reagent in the reagent loading tray; Obtain distribution information of the reagent kit in the reagent tray; The reagent kit is loaded into the reagent tray according to the reagent information, distribution information and the operating status of the sample analysis system.

2. A reagent loading method according to claim 1, characterized in that, Complete the loading operation of the reagent kit into the reagent tray according to the reagent information, distribution information and the operating status of the sample analysis system, including: In the standby state, the reagent tray is loaded with reagent kits according to the reagent information and distribution information; In the detection state, the empty reagent kit in the reagent tray is taken out and the reagent kit in the reagent tray is loaded according to the reagent information and distribution information.

3. A reagent loading method according to claim 2, characterized in that, The empty reagent box in the reagent tray is removed, comprising the following steps: Obtain the remaining amount of reagents in the reagent box on the reagent tray; It is determined whether there is an empty reagent kit based on the remaining amount information. If so, the empty reagent kit is removed after the reagent dispensing operations of all reagent samples are completed.

4. A reagent loading method according to claim 1, characterized in that, The reagent information includes project information and packaging information.

5. A reagent loading method according to claim 2, characterized in that, In the detection state, when the reagent is placed into the reagent loading tray, a space is left in the reagent tray for taking out the empty reagent cartridge.

6. A sample analysis system, characterized in that: include: Reagent loading tray, used for loading cache of reagent kit; Reagent tray, used for loading the reagent kit; Reaction disk, used to receive samples and reagents and perform processing and analysis; The robot is used to load the reagent kit from the reagent loading tray to the reagent tray.

7. A sample analysis system according to claim 6, characterized in that: There are two reagent loading trays, and the two reagent loading trays are connected to each other to form an inner and outer tray structure.

8. The sample analysis system according to claim 6, characterized in that: The system also includes a barcode scanner for scanning the reagent kit on the reagent loading tray to obtain reagent information of the reagent in the reagent kit.

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