Red fading and repairing composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and discloses a red fading and repairing composition as well as a preparation method and application thereof. The preparation method of the red fading and repairing composition comprises the following steps: (1) crushing and sieving oat kernels, and extracting with pure water to obtain an oat kernel extract; (2) adding fresh mung beans into a glycerol / water mixed solution containing glycolic acid, crushing, dispersing and homogenizing by adopting a high-speed homogenizer until no particles exist, and stirring and extracting at a low temperature of 4-10 DEG C to obtain a mung bean seed extract; and (3) uniformly mixing the glycerophosphoinositide choline salt with the oat kernel extract and the mung bean seed extract according to a mass ratio of (0.1-2): (10-40): (50-80) to obtain the red fading and repairing composition. The red fading and repairing composition disclosed by the invention adopts the mung bean seed extract prepared by a specific process as a main raw material, and through the synergistic effect of the oat kernel extract and GPI, the red fading and repairing effects can be remarkably improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a redness-removing and repairing composition, a preparation method and an application thereof. Background Art

[0002] With the improvement of modern living standards, the application and promotion of minimally invasive and non-invasive medical aesthetic technologies, as well as the excessive use of fast-acting cosmetics, often cause a certain degree of damage to the skin's stratum corneum. This leads to a weakening of the skin's barrier function, making it more susceptible to external stimuli from environmental factors (such as wind, cold air, and sunlight) and cosmetic ingredients, resulting in skin problems such as redness, itching, or burning. A care solution that can be applied to these multiple scenarios is extremely urgent.

[0003] Patent document publication number CN112603867A describes a skin membrane repair essence solution. Through the interaction of glycerophosphoinositol choline salt, ectoine, and Stephania tetrandra extract, it has excellent anti-allergic, anti-inflammatory, and antipruritic effects, allowing damaged skin to regenerate and effectively repair the skin barrier. It also regulates skin oil secretion and controls oil. Patent document publication number CN119454555A describes a composition with after-sun repair and whitening effects. By combining glycerophosphoinositol choline salt, citrus peel extract, and a skin-lightening agent, the composition can simultaneously enhance the after-sun repair and whitening effects.

[0004] Patent document CN112842985A describes a moisturizing and repairing composition that combines glucan with oat (AVENA SATIVA) kernel extract to soothe and care for the skin, helping it repair itself while retaining moisture. Patent document CN119112748A describes a soothing and repairing composition comprising a 45% to 55% raspberry fruit extract solution, a 40% to 50% acerola cherry extract solution, and a 5% to 15% oat kernel extract powder. The combination of these three ingredients enhances the soothing and repairing effects of raspberry fruit.

[0005] The patent document with publication number CN107961199A records a skin repair cream for removing acne and reducing inflammation. It uses traditional Chinese medicine ingredients including mung beans and natural plant active ingredients to cooperate with each other and work synergistically. It not only has no side effects on the skin, but also has good acne and anti-inflammatory effects.

[0006] The currently disclosed existing technologies mainly focus on the synergistic effects of glycerophosphoinositol choline salt, oat kernel extract, and mung bean ingredients with different functional components to achieve corresponding soothing, repairing, acne-removing and anti-inflammatory effects. However, no relevant research has been conducted on the synergistic effects among glycerophosphoinositol choline salt, oat kernel extract, and mung bean seed extract, as well as the influence of the preparation process conditions of mung bean seed extract on the efficacy of the composition. Summary of the Invention

[0007] In view of the shortcomings and deficiencies of the above-mentioned prior art, the primary purpose of the present invention is to provide a method for preparing a redness-removing and repairing composition.

[0008] Another object of the present invention is to provide a redness-removing and repairing composition prepared by the above method.

[0009] Another object of the present invention is to provide use of the above-mentioned redness-removing and repairing composition in cosmetics.

[0010] The purpose of the present invention is achieved through the following technical solutions:

[0011] A method for preparing a redness-removing and repairing composition comprises the following steps:

[0012] (1) Preparation of oat kernel extract: Oat kernel (unripened) was crushed and sieved, and then extracted with pure water to obtain oat kernel extract;

[0013] (2) Preparation of mung bean seed extract: fresh mung beans were added to a glycerol / water mixed solution containing glycolic acid, crushed and dispersed using a high-speed homogenizer until there were no particles, and stirred and extracted at a low temperature of 4-10°C to obtain the mung bean seed extract;

[0014] (3) Glycerol phosphoinositol choline (GPI) is mixed evenly with oat kernel extract and mung bean seed extract in a mass ratio of 0.1-2:10-40:50-80 to obtain a redness-removing and repairing composition.

[0015] Furthermore, the crushing and screening in step (1) refers to passing through a 60-mesh sieve.

[0016] Furthermore, the material-liquid mass ratio of the pure water extraction in step (1) is 1:20-40, the extraction temperature is 85-95° C., and the extraction time is 1-3 h.

[0017] Furthermore, the mixed solution after the pure water extraction in step (1) is naturally cooled and refrigerated at 0-4° C. for 12-36 hours, and centrifuged at 5000-10000 rpm for 10-30 minutes to obtain the supernatant to obtain the oat kernel extract.

[0018] Oat kernels primarily contain β-glucans, flavonoids, phenolic acids and their derivatives, vitamin E, phytic acid compounds, and unsaturated oils. They offer moisturizing, barrier repair, anti-wrinkle, antioxidant, and whitening benefits. This invention utilizes oat kernel extract to further enhance the redness-reducing and repairing properties of mung bean seed extract.

[0019] Furthermore, the mass percentage of glycerol in the glycerol / water mixed solution containing glycolic acid in step (2) is 20-40%, and the content of glycolic acid makes the pH value of the mixed solution 4.5-6. The extraction process of the mung bean seed extract of the present invention has a significant effect on the redness-repairing effect of the obtained composition. By using a mixed solvent of glycerol and water for extraction, the affinity and compatibility of glycerol with polyhydroxy active ingredients such as chlorogenic acid can be used to obtain an extract rich in chlorogenic acid, and by extracting under the acidic conditions of glycolic acid and low temperature conditions of 4-10°C, the activity of ingredients such as chlorogenic acid is effectively guaranteed, thereby significantly improving the redness-repairing effect of the composition.

[0020] Furthermore, in step (2), the fresh mung beans are added to the glycerol / water mixed solution containing glycolic acid in a material-liquid mass ratio of 1:5-15.

[0021] Furthermore, the stirring extraction time in step (2) is 2-4 hours, and the extracted mixed solution is centrifuged at 5000-10000 rpm for 10-30 minutes to obtain the supernatant to obtain the mung bean seed extract.

[0022] Mung bean seed extract has moisturizing, anti-inflammatory, and anti-allergic properties. It can inhibit the release of inflammatory mediators, reduce skin allergic reactions, soothe irritated skin, and rebuild a healthy sebum membrane for lasting skin relief. This composition, using mung bean seed extract as its primary ingredient, enhances its redness-reducing and repairing properties through the synergistic effects of multiple components and a specialized preparation process.

[0023] Glycerolphosphoinositol choline (GPI), used in this invention, is a semisynthetic derivative of glycerolphosphoinositol and a natural cellular component produced by lipid metabolism. It can prevent the glycation of proteins such as the transcription factor NF-κB, collagen, and enzymes, leading to the production of advanced glycation end products (AGEs) that cause inflammation. By inhibiting the translocation of NF-κB to the nucleus, it reduces the transcription of inflammatory and aging factors that contribute to inflammation. As a natural phospholipid derivative, it can promote normal keratinocyte differentiation, enhance epidermal barrier function, and reduce water loss.

[0024] The molecular structure of GPI is shown below:

[0025]

[0026] The present invention adopts GPI to further synergistically enhance the redness-removing and repairing effect of mung bean seed extract.

[0027] Furthermore, in step (3), the mass ratio of the glycerophosphoinositol choline salt to the oat kernel extract and the mung bean seed extract is 1-2:20-40:59-79.

[0028] A redness-removing and repairing composition is prepared by the above method.

[0029] Application of the above redness-removing and repairing composition in cosmetics.

[0030] Furthermore, the cosmetic is a redness-removing and repairing essence, and its formula weight percentage composition is as follows:

[0031] Redness-removing repair composition 10-40%, 1,3-butylene glycol 3-8%, D-panthenol 1-3%, glyceryl stearate and / or PEG-100 stearate 1-2%, allantoin 0.5-2%, 1,2-hexanediol 0.5-1%, parahydroxyacetophenone 0.2-1%, jojoba oil 0.2-1%, ammonium acryloyldimethyltaurate / VP copolymer 0.1-0.3%, hyaluronic acid 0.1-0.2%, vitamin E (VE) 0.05-0.2%, and the balance is water.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] (1) The redness-removing and repairing composition of the present invention uses mung bean seed extract, which has a wide range of raw material sources and low cost, as the main raw material. Through the synergistic effect of oat kernel extract and GPI, it can achieve significantly improved redness-removing and repairing effects.

[0034] (2) The present invention further adopts a specific process to prepare mung bean seed extract, which can further improve the redness-removing and repairing effect of the obtained composition. DETAILED DESCRIPTION

[0035] The present invention will be further described in detail below with reference to examples, but the embodiments of the present invention are not limited thereto.

[0036] Example 1

[0037] A method for preparing a redness-removing and repairing composition comprises the following steps:

[0038] (1) Preparation of oat kernel extract: Oat kernel (unripened) was crushed and passed through a 60-mesh sieve, and then extracted with pure water at a mass ratio of 1:30. The extract was performed at 85-95°C for 2 h, and then naturally cooled and refrigerated at 4°C for 24 h. The supernatant was collected by centrifugation at 8000 rpm*15 min to obtain oat kernel extract (hereinafter referred to as AS).

[0039] (2) Preparation of mung bean seed extract: Fresh mung beans were added to a 30% (W / W) glycerol / water mixed solution with a material-liquid mass ratio of 1:10. Hydroxyacetic acid was added to adjust the pH value to 5.0. Then, a high-speed homogenizer was used to crush and disperse the slurry until there were no particles. The temperature was controlled at 4-10°C and stirred for 3 hours. The supernatant was collected by centrifugation at 8000 rpm*15 minutes to obtain mung bean seed extract (hereinafter referred to as VR).

[0040] (3) Glycerol phosphoinositol choline (GPI) was mixed with oat kernel extract (AS) and mung bean seed extract (VR) in a mass ratio of 1:20:79 to obtain a redness-removing and repairing composition.

[0041] Examples 2 to 6 and Comparative Examples 1 to 5

[0042] The preparation methods of the redness-repairing compositions of Examples 2 to 6 and Comparative Examples 1 to 5 are the same as those of Example 1, except that the raw material ratios in step (3) are adjusted according to Table 1.

[0043] Table 1 Raw material ratios of Examples 1 to 6 and Comparative Examples 1 to 5

[0044] Examples / Comparative Examples raw material Ratio % (w / w) Example 1 GPI:AS:VR 1:20:79 Example 2 GPI:AS:VR 0.1:20:79.9 Example 3 GPI:AS:VR 2:20:78 Example 4 GPI:AS:VR 1:40:59 Example 5 GPI:AS:VR:Water 1:10:79:10 Example 6 GPI:AS:VR:Water 1:20:50:29 Comparative Example 1 GPI: Water 2:98 Comparative Example 2 AS: Water 40:60 Comparative Example 3 VR 100 Comparative Example 4 GPI:VR 1:99 Comparative Example 5 AS:VR 20:80

[0045] Comparative Example 6

[0046] A method for preparing a redness-removing and repairing composition comprises the following steps:

[0047] (1) The preparation of oat kernel extract was the same as in Example 1.

[0048] (2) Preparation of mung bean seed extract: Fresh mung beans were added to pure water with a mass ratio of 1:10, and then a high-speed homogenizer was used to crush and disperse the slurry until there were no particles. The temperature was controlled at 4-10°C and stirred for 3 hours. The supernatant was collected by centrifugation at 8000 rpm*15 minutes to obtain mung bean seed extract (VR).

[0049] (3) The preparation method of the redness-removing and repairing composition is the same as that in Example 1.

[0050] Performance test 1: redness removal test

[0051] The products prepared in the examples and comparative examples were tested on 8 subjects for each product. The subjects were healthy females (ie, non-allergic) aged between 20 and 53.

[0052] Usage: After cleansing your face every day, apply an appropriate amount of product on your face, once in the morning and once in the evening, for 7 consecutive days.

[0053] The skin image analysis system Visia 7 is used to detect, analyze and observe all facial aging and lesions from the epidermis to the dermis through photography. The red area mainly analyzes the red area of ​​the facial skin dermis, characterizing the location, number, shape, size and clinical severity of red blood vessels. The higher the measurement value, the more severe the inflammation.

[0054] The improvement rate in the red zone was calculated by comparing the test results on the 7th day after using the product, 3 days after stopping the product (10th day), and the initial value before using the product.

[0055] The calculation formula of the red zone improvement rate is: {(the red discrimination value of the subject before use-the red discrimination value of the same subject after 7 days / 10 days of use) / the red discrimination value of the subject before use}×100%.

[0056] The test results are shown in Table 2 below:

[0057] Table 2 Redness removal test results of Examples 1 to 6 and Comparative Examples 1 to 6

[0058]

[0059]

[0060] It can be seen from the test results that the effects of Examples 1 and 3 are very significant. Due to factors such as the limited use of GPI and cost, GPI:AS:VR=1:20:79 is the optimal solution overall. At the same time, by comparing the results of Comparative Examples 1 to 5 with the examples, it can be seen that the GPI, AS and VR in the composition of the present invention have a significant synergistic effect in removing redness. The lack of any one of the components or the reduction of the content will lead to a significant reduction in the redness-removing effect. In addition, by comparing the results of Comparative Example 6 with Example 1, it can be seen that the composition prepared by extracting with a mixed solvent of glycerol and water of the present invention and by extracting VR obtained under acidic conditions of glycolic acid has a significantly improved redness-removing effect.

[0061] The results also showed that after 3 days of discontinuation (compared to 7 days of use), there was no significant fluctuation in the data, which further demonstrates the effectiveness of redness reduction and the absence of recurrence.

[0062] Performance test 2: Repair effect test

[0063] The test objects and test methods of Performance Test 2 are the same as those of Performance Test 1. The difference lies in the detection method. The detection method of the repair effect is as follows:

[0064] The TEWL rate (TEWL) of the subjects' cheeks was measured using a Tewameter™ Hex probe. Lower values ​​indicate less TEWL per unit time and cross-sectional area, indicating a better skin barrier. TEWL data were analyzed on the seventh day of use, three days after discontinuation (day 10), and before product use. The TEWL improvement rate was calculated as: {(TEWL before use - TEWL at the same site on the same subject after 7 days (10 days) of use) / TEWL before use} × 100%.

[0065] The test results are shown in Table 3 below:

[0066] Table 3 Repair effect test results of Examples 1 to 6 and Comparative Examples 1 to 6

[0067]

[0068] The above results demonstrate that GPI, AS, and VR in the composition of the present invention exhibit a significant synergistic effect on skin repair efficacy; the absence of any of these components significantly reduces skin repair efficacy. Furthermore, a comparison of the results of Comparative Example 6 with Example 1 demonstrates that compositions prepared using VR extracted using the present invention's mixed solvent of glycerol and water, as well as VR extracted under acidic conditions in glycolic acid, exhibit significantly enhanced skin repair efficacy.

[0069] The transepidermal water loss value did not increase significantly after 3 days of discontinuation, indicating that the skin barrier was improved.

[0070] Performance Test 3: Formula Application and Redness Removal and Allergy Relief Effect

[0071] The test objects and test methods of performance test 3 are the same as those of test example 1. The difference lies in the detection method. The detection method of the redness-removing and allergy-relief effect is as follows:

[0072] A facial image analyzer was used to analyze the a-value of the cheek red area using IPP. The larger the measured value, the more severe the skin redness.

[0073] The improvement rate of the a value was calculated as follows: {(the red zone a value of the subject before use - the red zone a value of the same subject 7 days later) / the red zone a value of the subject before use}×100%.

[0074] The test formula is shown in Table 4 below:

[0075] Table 4 Application formula

[0076]

[0077]

[0078] The corresponding test results are shown in Table 5 below:

[0079] Table 5 Application effect test results of Examples 1 to 6 and Comparative Examples 1 to 6

[0080]

[0081]

[0082] The data in Table 5 demonstrate that Examples 1 and 3 exhibit optimal application performance, positively correlating with the results of Performance Test 1. Furthermore, the compositions of the present invention exhibit significant synergistic effects in terms of their redness-removing and allergy-relief properties. Furthermore, compositions prepared using the VR extracted with the present invention's mixed solvent of glycerin and water, as well as extraction under acidic conditions with glycolic acid, exhibit significantly enhanced redness-removing efficacy, consistent with the results of Performance Test 1. This is likely due to the formulation, even though the dosage of the composition used in the application formula (30%) is far less than that used in Performance Test 1.

[0083] The above embodiments are preferred implementations of the present invention, but the implementations of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. A method for preparing a redness-repairing composition, characterized in that: The method comprises the following preparation steps: (1) Preparation of oat kernel extract: Oat kernels are crushed and sieved, and then extracted with pure water to obtain oat kernel extract; (2) Preparation of mung bean seed extract: fresh mung beans were added to a glycerol / water mixed solution containing glycolic acid, crushed and dispersed using a high-speed homogenizer until there were no particles, and stirred and extracted at a low temperature of 4-10°C to obtain the mung bean seed extract; (3) Mixing glycerophosphoinositol choline salt, oat kernel extract and mung bean seed extract in a mass ratio of 0.1-2:10-40:50-80 to obtain a redness-repairing composition.

2. The method for preparing a redness-removing and repairing composition according to claim 1, wherein: The crushing and screening in step (1) refers to passing through a 60-mesh sieve.

3. The method for preparing a redness-removing and repairing composition according to claim 1, wherein: The material-liquid mass ratio of the pure water extraction in step (1) is 1:20-40, the extraction temperature is 85-95° C., and the extraction time is 1-3 h.

4. The method for preparing a redness-removing and repairing composition according to claim 3, wherein: The mixed solution after the pure water extraction is naturally cooled and then refrigerated at 0-4° C. for 12-36 hours, and centrifuged at 5000-10000 rpm for 10-30 minutes to obtain the supernatant to obtain the oat kernel extract.

5. The method for preparing a redness-removing and repairing composition according to claim 1, wherein: The mass percentage of glycerol in the glycerol / water mixed solution containing glycolic acid in step (2) is 20-40%, and the content of glycolic acid makes the pH value of the mixed solution 4.5-6.

6. The method for preparing a redness-removing and repairing composition according to claim 1, wherein: In step (2), the fresh mung beans are added to the glycerol / water mixed solution containing glycolic acid in a material-liquid ratio of 1:5-15; the stirring extraction time is 2-4 hours, and the extracted mixed solution is centrifuged at 5000-10000 rpm for 10-30 minutes to obtain the supernatant to obtain the mung bean seed extract.

7. The method for preparing a redness-removing and repairing composition according to claim 1, wherein: The mass ratio of the glycerophosphoinositol choline salt to the oat kernel extract and the mung bean seed extract in step (3) is 1-2:20-40:59-79.

8. A redness-removing and repairing composition, characterized in that: It is prepared by the method according to any one of claims 1 to 7.

9. Use of the redness-removing and repairing composition according to claim 8 in cosmetics.

10. Use of the redness-removing and repairing composition according to claim 9 in cosmetics, characterized in that: The cosmetic is a redness-removing and repairing essence, and its formula weight percentage composition is as follows: The redness-removing and repairing composition of claim 9 comprises 10-40%, 1,3-butylene glycol 3-8%, D-panthenol 1-3%, glyceryl stearate and / or PEG-100 stearate 1-2%, allantoin 0.5-2%, 1,2-hexanediol 0.5-1%, parahydroxyacetophenone 0.2-1%, jojoba oil 0.2-1%, ammonium acryloyldimethyltaurate / VP copolymer 0.1-0.3%, hyaluronic acid 0.1-0.2%, vitamin E 0.05-0.2%, and the balance is water.

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