Medical silicone gel for scar repair and preparation method and application thereof

Abstract

The invention discloses medical silicone gel for scar repair and a preparation method and application thereof, and relates to the technical field of medical gel. The aloe polysaccharide silicone gel mask comprises the following raw materials in percentage by mass: 25-45% of aloe polysaccharide silicone gel, 1-2% of sodium hyaluronate, 0.2-0.8% of poly-L-lactic acid, 2-4% of vitamin E, 5-8% of asiaticoside, 1-3% of resveratrol, 1-2% of curcumin, 1-2% of hydroquinone, 2-4% of arbutin, 2-4% of a vitamin C derivative, 3-5% of a traditional Chinese medicine composition, 0.5-1.5% of an odor regulator, 0.1-0.3% of a preservative and the balance of water. And the balance of purified water. The smell regulator is a pH response release type adsorbent. The medical silicone gel not only can effectively repair scars, but also is good in skin feeling and not prone to sensitivity.

Description

Technical Field

[0001] The present application relates to the field of medical gel technology, and in particular to a medical silicone gel for scar repair, and a preparation method and use thereof. Background Art

[0002] Skin wounds, whether caused by external force or surgery, may cause scar formation. Scars are a general term for a series of changes in the appearance, morphology and tissue pathology of the skin after trauma. Usually, scars appear as tissue proliferation that is higher than the surrounding normal skin. The surface color may appear red or purple, the texture is locally thickened and hardened, and it is often accompanied by itching and pain. In many cases, scars not only lead to decreased tactile sensation, reduced skin elasticity and limited range of motion, but also cause significant aesthetic problems when scars appear on exposed skin areas such as the face. Therefore, the development of treatment methods and means that can minimize or even eliminate scars has important clinical significance and market demand.

[0003] Silicone gel is a commonly used product for scar repair. Its main ingredient is dimethyl silicone oil (silicone). Silicone gel can create a closed and moist microenvironment for scar tissue, including increasing hydration, controlling pH, regulating temperature, and controlling oxygen tension, which partially improves the fibroblasts and collagen cells in scar tissue.

[0004] During the scar healing process, bacteria will break down proteins and fats in the tissue to produce volatile organic compounds. These volatile organic compounds include cadaverine, putrescine, sulfides and short-chain fatty acids, which usually have an unpleasant odor. In order to enhance the user experience of the product, many silicone gels will add ingredients such as fragrances to cover up possible chemical odors and make the product have a more pleasant smell. However, fragrances contain a variety of chemical ingredients, which may cause allergic symptoms after contact with the skin, including skin redness, itching, tingling, rash, etc. In severe cases, blisters, exudate and other manifestations of contact dermatitis may also appear. Summary of the Invention

[0005] In order to solve the problems existing in the prior art, the present application provides a medical silicone gel for scar repair, a preparation method and use thereof.

[0006] The present application provides a medical silicone gel for scar repair, which adopts the following technical solution:

[0007] A medical silicone gel for scar repair, comprising, by mass percentage, 25-45% aloe polysaccharide silicone gel, 1-2% sodium hyaluronate, 0.2-0.8% poly-L-lactic acid, 2-4% vitamin E, 5-8% asiaticoside, 1-3% resveratrol, 1-2% curcumin, 1-2% hydroquinone, 2-4% arbutin, 2-4% vitamin C derivative, 3-5% traditional Chinese medicine composition, 0.5-1.5% odor regulator, 0.1-0.3% preservative, and the balance being purified water;

[0008] The odor modifier is a pH-responsive release adsorbent;

[0009] The pH-responsive release adsorbent is prepared from the following raw materials in parts by weight: 1-3 parts of methacrylic acid-methyl methacrylate copolymer, 0.1-0.3 parts of carboxyl modified activated carbon, 0.005-0.015 parts of N,N'-methylenebisacrylamide, 14-20 parts of dichloromethane, 3-5 parts of anhydrous ethanol, 0.001-0.003 parts of potassium persulfate, 1.2-2 parts of emulsifier, and 50-80 parts of deionized water.

[0010] Preferably, the traditional Chinese medicine composition comprises lithospermum erythrorhizon extract and safflower extract; the mass ratio of the lithospermum erythrorhizon extract to the safflower extract is (1-2):(2-3).

[0011] Preferably, the preservative comprises p-hydroxyacetophenone and octanoylhydroxamic acid, and the mass ratio of p-hydroxyacetophenone to octanoylhydroxamic acid is 1:0.3-0.7.

[0012] Preferably, the aloe polysaccharide silicone gel is prepared from the following raw materials in parts by weight: 3-7 parts of modified aloe polysaccharide powder, 100-140 parts of deionized water, 8-14 parts of double-terminal hydrogen silicone oil, 20-25 parts of double-terminal vinyl silicone oil, and 1-2 parts of Custer catalyst.

[0013] Preferably, the modified aloe polysaccharide powder is prepared from the following raw materials in parts by weight: 100-175 parts of deionized water, 5-10 parts of aloe polysaccharide, and 15-25 parts of vinyltriethoxysilane.

[0014] Preferably, the preparation method of the modified aloe polysaccharide powder comprises the following steps:

[0015] After heating deionized water to 50-60°C, add aloe polysaccharide and stir until completely dissolved; then add vinyl triethoxysilane, heat to 80-90°C, and react for 22-26 hours; after the reaction is completed, centrifuge, wash, and vacuum dry to obtain modified aloe polysaccharide powder.

[0016] Preferably, the preparation method of the aloe polysaccharide silicone gel comprises the following steps:

[0017] The modified aloe polysaccharide powder is added to deionized water and ultrasonically dispersed evenly. Then, double-terminal hydrogen silicone oil and Custer catalyst are added to the evenly dispersed modified aloe polysaccharide solution, and the mixture is heated to 80-90°C while stirring and reacted for 1-2 hours. After the reaction is completed, double-terminal vinyl silicone oil is added and stirred evenly to obtain aloe polysaccharide silicone gel.

[0018] Preferably, the preparation method of the pH-responsive release adsorbent comprises the following steps:

[0019] Methacrylic acid-methyl methacrylate copolymer is added to a mixed solution of dichloromethane and anhydrous ethanol and stirred to dissolve; carboxyl modified activated carbon and emulsifier are then added and stirred evenly, followed by ultrasonic emulsification for 15-20 minutes; N,N'-methylenebisacrylamide and potassium persulfate are then added and ultrasonic emulsification is continued for 2-4 minutes; the obtained emulsion is added to deionized water and stirred for 6-8 hours, the microspheres are separated after centrifugation, and the pH-responsive release adsorbent is obtained after freeze-drying.

[0020] The present application provides a method for preparing a medical silicone gel for scar repair, which adopts the following technical solution:

[0021] A method for preparing medical silicone gel for scar repair comprises the following steps:

[0022] S1. Mix aloe polysaccharide silicone gel and sodium hyaluronate and heat in a 40-50°C water bath until homogeneous to form a base gel matrix;

[0023] S2. Poly-L-lactic acid, vitamin E, asiatica glycoside, resveratrol, curcumin, hydroquinone, arbutin, vitamin C derivatives and traditional Chinese medicine compositions were added to purified water and ultrasonically dispersed for 10-20 min to form a uniform dispersion;

[0024] S3. Add the dispersion obtained in S2 to the basic gel matrix obtained in S1, stir in a water bath at 40-50°C for 30-50 minutes, add an odor regulator and stir evenly, perform vacuum degassing, then add a preservative and stir evenly to obtain a medical silicone gel for scar repair.

[0025] The present application provides a use of a medical silicone gel for scar repair, which adopts the following technical solution:

[0026] Disclosed is a use of a medical silicone gel for scar repair, and application of the medical silicone gel in scar repair.

[0027] In summary, this application includes at least one of the following beneficial technical effects:

[0028] 1. By adopting the above technical scheme, the combination of Centella asiatica, resveratrol and curcumin can effectively inhibit the excessive proliferation of fibroblasts, reduce collagen deposition and relieve scar congestion; the combination of hydroquinone, arbutin and vitamin C derivatives can effectively inhibit tyrosinase activity, block melanin synthesis and lighten pigment deposition; the combination of sodium hyaluronate, poly-L-lactic acid and vitamin E can promote collagen synthesis, increase skin elasticity and fill depressed scars; by adopting the combination of lithospermum extract and safflower extract as a traditional Chinese medicine composition, it can promote blood circulation and remove blood stasis, promote microcirculation and effectively accelerate scar metabolism; by adopting the combination of p-hydroxyacetophenone and caprylhydroxamic acid as preservatives, the natural preservative system can reduce the risk of sensitization; the medical silicone gel provided in this application is suitable for various hyperplastic, depressed and pigmented scars, has good scar removal effect and is less irritating to the skin.

[0029] 2. By adopting the above technical solution, the ester exchange method is adopted to modify aloe polysaccharide using vinyl triethoxysilane, and then using Custer catalyst to catalyze the modified aloe polysaccharide and the vinyl group of the double-terminal vinyl silicone oil with the silicon hydrogen group of the double-terminal hydrogen silicone oil to undergo a silylation addition reaction to prepare aloe polysaccharide silicone gel; the aloe polysaccharide silicone gel has good hygroscopicity and moisturizing properties, can provide sufficient moisture to the scar area, prevent the scar from drying and cracking, and soften the scar tissue to make it softer and more elastic; it also has a significant anti-inflammatory effect, can reduce the inflammatory response in the scar area, relieve discomfort symptoms such as redness, swelling, and pain, and create a good environment for scar repair.

[0030] 3. By adopting the above technical solution, the pH-responsive release-type adsorbent provided by the present application undergoes protonation of the methacrylic acid-methyl methacrylate copolymer on the surface in the slightly acidic environment of the scar (pH <6.0), triggering the release of the adsorbent, thereby enhancing the adsorption capacity for odor molecules (such as sulfides and short-chain fatty acids), reducing the odor concentration of scar metabolites, and avoiding stinging or allergic reactions caused by direct contact with the skin. DETAILED DESCRIPTION

[0031] The present application is further described in detail below with reference to the embodiments.

[0032] The chemical reagents used in the preparation examples, embodiments and comparative examples provided by the present invention are all commercially available products, and their brands and manufacturers are as follows:

[0033] Vitamin C derivatives, Jiangsu Haolong Chemical Co., Ltd.;

[0034] Lithospermum officinale extract, Fujian Shengshi Jiatai Biotechnology Co., Ltd.;

[0035] Safflower extract, Xinxiang Bokai Biotechnology Co., Ltd.;

[0036] Aloe polysaccharide, Shanghai Chengshao Biotechnology Co., Ltd.;

[0037] Sodium hyaluronate, Changzhou Wobang Biotechnology Co., Ltd., P238001;

[0038] Poly-L-lactic acid, Shanghai Yuanye Biotechnology Co., Ltd.;

[0039] Centella asiatica (Centella asiatica), Shanghai MacLean Biochemical Technology Co., Ltd., A964372;

[0040] Resveratrol, Nanjing Longze Pharmaceutical Chemical Co., Ltd.;

[0041] Curcumin, Xi'an Jiuqi Biotechnology Co., Ltd.;

[0042] Hydroquinone, Panhua Chemical (Shanghai) Co., Ltd.;

[0043] Arbutin, Wuhan Dongkangyuan Technology Co., Ltd.;

[0044] Vitamin E, Wuhan Belka Pharmaceutical Co., Ltd.

[0045] Preparation Example 1 Preparation of Aloe Polysaccharide Silicone Gel

[0046] Preparation Example 1.1

[0047] S1. After heating 100g of deionized water to 50°C, 5g of aloe polysaccharide was added and stirred until completely dissolved; 15g of vinyltriethoxysilane was then added, and the mixture was heated to 80°C and reacted for 22h; after the reaction, the mixture was centrifuged, washed, and vacuum-dried to obtain a modified aloe polysaccharide powder;

[0048] S2. Add 3g of modified aloe polysaccharide powder to 100g of deionized water and disperse it evenly by ultrasonication. Then, add 8g of double-ended hydrogen silicone oil and 1g of Custer catalyst to the evenly dispersed modified aloe polysaccharide solution, heat to 80°C while stirring, and react for 1h. After the reaction, add 20g of double-ended vinyl silicone oil and stir evenly to obtain aloe polysaccharide silicone gel.

[0049] Preparation Example 1.2

[0050] S1. After heating 135g of deionized water to 55°C, 7.5g of aloe polysaccharide was added and stirred until completely dissolved; 20g of vinyltriethoxysilane was then added, and the mixture was heated to 85°C and reacted for 24h; after the reaction, the modified aloe polysaccharide powder was obtained by centrifugation, washing, and vacuum drying;

[0051] S2. Add 5g of modified aloe polysaccharide powder to 120g of deionized water and disperse it evenly by ultrasonication. Then, add 11g of double-ended hydrogen silicone oil and 1.5g of Custer catalyst to the evenly dispersed modified aloe polysaccharide solution, heat to 85°C while stirring, and react for 1.5h. After the reaction, add 22.5g of double-ended vinyl silicone oil and stir evenly to obtain aloe polysaccharide silicone gel.

[0052] Preparation Example 1.3

[0053] S1. After heating 175g of deionized water to 60°C, 10g of aloe polysaccharide was added and stirred until completely dissolved; 25g of vinyltriethoxysilane was then added, and the mixture was heated to 90°C and reacted for 26h; after the reaction, the modified aloe polysaccharide powder was obtained by centrifugation, washing, and vacuum drying;

[0054] S2. Add 7g of modified aloe polysaccharide powder to 140g of deionized water and disperse it evenly by ultrasonication. Then, add 14g of double-ended hydrogen silicone oil and 2g of Custer catalyst to the evenly dispersed modified aloe polysaccharide solution, heat to 90°C while stirring, and react for 2h. After the reaction, add 25g of double-ended vinyl silicone oil and stir evenly to obtain aloe polysaccharide silicone gel.

[0055] Preparation Example 2 Preparation of pH-responsive release adsorbent

[0056] Preparation Example 2.1

[0057] S1. 1 g of activated carbon was repeatedly rinsed with deionized water and dried in vacuum at 60°C for 8 h. The dried activated carbon was then immersed in a 10 mol / L nitric acid solution and reacted in a 40°C water bath for 6 h. After the reaction, the mixture was filtered, washed with deionized water, and then dried at 105°C for 12 h to obtain carboxylated activated carbon.

[0058] S2. Add 1 g of methacrylic acid-methyl methacrylate copolymer to a mixed solution of 14 g of dichloromethane and 3 g of anhydrous ethanol, and stir to dissolve; then add 0.1 g of carboxylated modified activated carbon and 1.2 g of emulsifier Tween 80, stir evenly, and then ultrasonically emulsify at 21 kHz for 15 minutes; then add 0.005 g of N,N'-methylenebisacrylamide and 0.001 g of potassium persulfate and continue ultrasonicating at 21 kHz for 2 minutes; add the obtained emulsion to 50 g of deionized water and stir at 500 rpm for 6 hours. After centrifugation, separate the microspheres, and freeze-dry to obtain a pH-responsive release adsorbent.

[0059] Preparation Example 2.2

[0060] S1. 1 g of activated carbon was repeatedly rinsed with deionized water and dried in vacuum at 65°C for 6 h. The dried activated carbon was then immersed in 8 mol / L nitric acid solution and reacted in a 45°C water bath for 7 h. After the reaction, the mixture was filtered, washed with deionized water, and then dried at 110°C for 13 h to obtain carboxylated activated carbon.

[0061] S2. Add 2 g of methacrylic acid-methyl methacrylate copolymer to a mixed solution of 17 g of dichloromethane and 4 g of anhydrous ethanol, and stir to dissolve; then add 0.2 g of carboxylated modified activated carbon and 1.6 g of emulsifier Tween 80, stir evenly, and then ultrasonically emulsify at 21.5 kHz for 18 minutes; then add 0.01 g of N,N'-methylenebisacrylamide and 0.002 g of potassium persulfate, and continue ultrasonicating at 21.5 kHz for 3 minutes; add the obtained emulsion to 50 g of deionized water and stir at 500 rpm for 6 hours. After centrifugation, separate the microspheres, and freeze-dry to obtain a pH-responsive release adsorbent.

[0062] Preparation Example 2.3

[0063] S1. 1 g of activated carbon was repeatedly rinsed with deionized water and vacuum-dried at 70°C for 4 h. The dried activated carbon was then immersed in a 5 mol / L nitric acid solution and reacted in a 50°C water bath for 8 h. After the reaction, the mixture was filtered, washed with deionized water, and then dried at 115°C for 14 h to obtain carboxylated activated carbon.

[0064] S2. Add 3 g of methacrylic acid-methyl methacrylate copolymer to a mixed solution of 20 g of dichloromethane and 5 g of anhydrous ethanol, and stir to dissolve; then add 0.3 g of carboxylated modified activated carbon and 2 g of emulsifier Tween 80, stir evenly, and then ultrasonically emulsify at 22 kHz for 20 minutes; then add 0.015 g of N,N'-methylenebisacrylamide and 0.003 g of potassium persulfate, and continue ultrasonicating at 22 kHz for 4 minutes; add the obtained emulsion to 50 g of deionized water and stir at 500 rpm for 6 hours. After centrifugation, separate the microspheres, and freeze-dry to obtain a pH-responsive release adsorbent.

[0065] Example 1

[0066] S1. 25 g of the aloe polysaccharide silicone gel prepared in Preparation Example 1.1 was mixed with 1 g of sodium hyaluronate and heated in a 40 ° C water bath until uniform to form a base gel matrix;

[0067] S2. 0.2 g of poly-L-lactic acid, 4 g of vitamin E, 5 g of asiaticoside, 1 g of resveratrol, 2 g of curcumin, 1 g of hydroquinone, 2 g of arbutin, 4 g of vitamin C derivatives and 3 g of the Chinese medicine composition were added to 51.2 g of purified water and ultrasonically dispersed for 10 min to form a uniform dispersion;

[0068] S3. The dispersion obtained in S2 was added to the base gel matrix obtained in S1, and stirred in a 40°C water bath for 30 min. 0.5 g of the pH-responsive release adsorbent prepared in Preparation Example 2.1 was added and stirred evenly. The mixture was vacuum degassed, and 0.1 g of a preservative was added and stirred evenly to obtain a medical silicone gel for scar repair.

[0069] The Chinese medicine composition used in this embodiment includes Lithospermum officinale extract and Carthamus tinctorius extract in a mass ratio of 1:2;

[0070] The preservatives used include p-hydroxyacetophenone and octanoylhydroxamic acid in a mass ratio of 1:0.3.

[0071] Example 2

[0072] S1. 35 g of the aloe polysaccharide silicone gel prepared in Preparation Example 1.1 was mixed with 1.5 g of sodium hyaluronate and heated in a 40 ° C water bath until uniform to form a base gel matrix;

[0073] S2. 0.5 g of poly-L-lactic acid, 3 g of vitamin E, 6.5 g of asiaticoside, 2 g of resveratrol, 1.5 g of curcumin, 1.5 g of hydroquinone, 2.5 g of arbutin, 3 g of vitamin C derivatives and 4 g of the Chinese medicine composition were added to 37.8 g of purified water and ultrasonically dispersed for 10 min to form a uniform dispersion;

[0074] S3. The dispersion obtained in S2 was added to the base gel matrix obtained in S1. After stirring in a 40°C water bath for 30 min, 1 g of the pH-responsive release adsorbent prepared in Preparation Example 2.1 was added and stirred evenly. The mixture was vacuum degassed and 0.2 g of a preservative was added and stirred evenly to obtain a medical silicone gel for scar repair.

[0075] The Chinese medicine composition used in this embodiment includes Lithospermum officinale extract and Carthamus tinctorius extract in a mass ratio of 1:2;

[0076] The preservatives used include p-hydroxyacetophenone and octanoylhydroxamic acid in a mass ratio of 1:0.3.

[0077] Example 3

[0078] S1. 45 g of the aloe polysaccharide silicone gel prepared in Preparation Example 1.1 was mixed with 2 g of sodium hyaluronate and heated in a 40 ° C water bath until uniform to form a base gel matrix;

[0079] S2. 0.8 g of poly-L-lactic acid, 2 g of vitamin E, 8 g of asiaticoside, 3 g of resveratrol, 1 g of curcumin, 2 g of hydroquinone, 4 g of arbutin, 2 g of vitamin C derivatives and 5 g of the Chinese medicine composition were added to 23.4 g of purified water and ultrasonically dispersed for 10 min to form a uniform dispersion;

[0080] S3. The dispersion obtained in S2 was added to the base gel matrix obtained in S1, and stirred in a 40°C water bath for 30 min. 1.5 g of the pH-responsive release adsorbent prepared in Preparation Example 2.1 was added and stirred evenly. The mixture was vacuum degassed, and 0.3 g of a preservative was then added and stirred evenly to obtain a medical silicone gel for scar repair.

[0081] The Chinese medicine composition used in this embodiment includes Lithospermum officinale extract and Carthamus tinctorius extract in a mass ratio of 1:2;

[0082] The preservatives used include p-hydroxyacetophenone and octanoylhydroxamic acid in a mass ratio of 1:0.3.

[0083] Example 4

[0084] S1. 25 g of the aloe polysaccharide silicone gel prepared in Preparation Example 1.2 was mixed with 1 g of sodium hyaluronate and heated in a 45 ° C water bath until uniform to form a base gel matrix;

[0085] S2. 0.2 g of poly-L-lactic acid, 4 g of vitamin E, 5 g of asiaticoside, 1 g of resveratrol, 3 g of curcumin, 1 g of hydroquinone, 2 g of arbutin, 4 g of vitamin C derivatives and 2 g of the Chinese medicine composition were added to 51.2 g of purified water and ultrasonically dispersed for 15 min to form a uniform dispersion;

[0086] S3. The dispersion obtained in S2 was added to the base gel matrix obtained in S1, and stirred in a 45°C water bath for 40 min. 0.5 g of the pH-responsive release adsorbent prepared in Preparation Example 2.2 was added and stirred evenly. The mixture was vacuum degassed, and 0.1 g of a preservative was added and stirred evenly to obtain a medical silicone gel for scar repair.

[0087] The Chinese medicine composition used in this embodiment includes Lithospermum officinale extract and Carthamus tinctorius extract in a mass ratio of 1.5:2.5;

[0088] The preservatives used include p-hydroxyacetophenone and octanoylhydroxamic acid in a mass ratio of 1:0.5.

[0089] Example 5

[0090] S1. 25 g of the aloe polysaccharide silicone gel prepared in Preparation Example 1.3 was mixed with 1 g of sodium hyaluronate and heated in a 50 ° C water bath until uniform to form a base gel matrix;

[0091] S2. 0.2 g of poly-L-lactic acid, 4 g of vitamin E, 5 g of asiaticoside, 1 g of resveratrol, 3 g of curcumin, 1 g of hydroquinone, 2 g of arbutin, 4 g of vitamin C derivatives and 2 g of the Chinese medicine composition were added to 51.2 g of purified water and ultrasonically dispersed for 20 min to form a uniform dispersion;

[0092] S3. The dispersion obtained in S2 was added to the base gel matrix obtained in S1, and stirred in a 50°C water bath for 50 min. 0.5 g of the pH-responsive release adsorbent prepared in Preparation Example 2.3 was added and stirred evenly. The mixture was vacuum degassed, and 0.1 g of a preservative was then added and stirred evenly to obtain a medical silicone gel for scar repair.

[0093] The Chinese medicine composition used in this embodiment includes Lithospermum officinale extract and Carthamus tinctorius extract in a mass ratio of 2:3;

[0094] The preservatives used include p-hydroxyacetophenone and octanoylhydroxamic acid in a mass ratio of 1:0.7.

[0095] Comparative Example 1

[0096] The difference between Comparative Example 1 and Example 1 is that in Comparative Example 1, an equal amount of ordinary silicone is used instead of aloe polysaccharide silicone gel.

[0097] Comparative Example 2

[0098] The difference between Comparative Example 2 and Example 1 is that in Comparative Example 2, no pH-responsive release adsorbent is added, and an equal amount of purified water is used instead.

[0099] Performance testing

[0100] 160 volunteers with burn scars within 6 months were recruited and randomly divided into 8 groups, with 20 cases in each group.

[0101] Among them, groups 1-7 used the medical silicone gel prepared in Examples 1-5 and Comparative Examples 1-2, respectively; Group 8 was the control group, using a medical silicone gel dressing (Henan Huibo Medical Co., Ltd., Yuxie No. 20182140641, 15 g).

[0102] Each group was treated with local saline rinse every day, and then appropriate amount of test product was applied to the scar surface, evenly spread, and gently massaged for 3-5 minutes, twice a day for 14 consecutive days, and the clinical efficacy was compared.

[0103] Markedly effective: The burn scar area is reduced by >90%, and there is no itching or pain on the wound surface; Effective: The burn scar area is reduced by 50-90%, and the itching and pain on the wound surface are mild; Ineffective: The burn scar area is reduced by <50%, and the itching and pain on the wound surface are severe.

[0104] Total effective rate = (number of markedly effective + effective) cases / total number of cases × 100%.

[0105] The results are shown in Table 1.

[0106] The specific test results are as follows:

[0107] Table 1 Clinical efficacy

[0108]

[0109]

[0110] (P<0.05)

[0111] It can be seen from the test results in Table 1 that the medical silicone gel for scar repair provided by the present application has a significantly higher total effective rate, indicating that the medical silicone gel provided by the present application has an excellent repair effect.

[0112] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A medical silicone gel for scar repair, characterized by: The raw materials include, by mass percentage, 25-45% of aloe polysaccharide silicone gel, 1-2% of sodium hyaluronate, 0.2-0.8% of poly-L-lactic acid, 2-4% of vitamin E, 5-8% of asiaticoside, 1-3% of resveratrol, 1-2% of curcumin, 1-2% of hydroquinone, 2-4% of arbutin, 2-4% of vitamin C derivative, 3-5% of traditional Chinese medicine composition, 0.5-1.5% of odor regulator, 0.1-0.3% of preservative, and the balance is purified water; The odor modifier is a pH-responsive release adsorbent; The pH-responsive release adsorbent is prepared from the following raw materials in parts by weight: 1-3 parts of methacrylic acid-methyl methacrylate copolymer, 0.1-0.3 parts of carboxyl modified activated carbon, 0.005-0.015 parts of N,N'-methylenebisacrylamide, 14-20 parts of dichloromethane, 3-5 parts of anhydrous ethanol, 0.001-0.003 parts of potassium persulfate, 1.2-2 parts of emulsifier, and 50-80 parts of deionized water.

2. The medical silicone gel for scar repair according to claim 1, characterized in that: The traditional Chinese medicine composition comprises lithospermum officinale extract and safflower extract; the mass ratio of the lithospermum officinale extract to the safflower extract is (1-2):(2-3).

3. The medical silicone gel for scar repair according to claim 1, characterized in that: The preservative comprises p-hydroxyacetophenone and octanoylhydroxamic acid, and the mass ratio of the p-hydroxyacetophenone to octanoylhydroxamic acid is 1:0.3-0.

7.

4. The medical silicone gel for scar repair according to claim 1, characterized in that: The aloe polysaccharide silicone gel is prepared from the following raw materials in parts by weight: 3-7 parts of modified aloe polysaccharide powder, 100-140 parts of deionized water, 8-14 parts of double-terminal hydrogen-containing silicone oil, 20-25 parts of double-terminal vinyl silicone oil, and 1-2 parts of Custer catalyst.

5. The medical silicone gel for scar repair according to claim 4, characterized in that: The modified aloe polysaccharide powder is prepared from the following raw materials in parts by weight: 100-175 parts of deionized water, 5-10 parts of aloe polysaccharide, and 15-25 parts of vinyltriethoxysilane.

6. The medical silicone gel for scar repair according to claim 5, characterized in that: The preparation method of the modified aloe polysaccharide powder comprises the following steps: After heating deionized water to 50-60°C, add aloe polysaccharide and stir until completely dissolved; then add vinyl triethoxysilane, heat to 80-90°C, and react for 22-26 hours; after the reaction is completed, centrifuge, wash, and vacuum dry to obtain modified aloe polysaccharide powder.

7. The medical silicone gel for scar repair according to claim 4, characterized in that: The preparation method of the aloe polysaccharide silicone gel comprises the following steps: The modified aloe polysaccharide powder is added to deionized water and ultrasonically dispersed evenly. Then, double-terminal hydrogen silicone oil and Custer catalyst are added to the evenly dispersed modified aloe polysaccharide solution, and the mixture is heated to 80-90°C while stirring and reacted for 1-2 hours. After the reaction is completed, double-terminal vinyl silicone oil is added and stirred evenly to obtain aloe polysaccharide silicone gel.

8. The medical silicone gel for scar repair according to claim 1, characterized in that: The preparation method of the pH-responsive release adsorbent comprises the following steps: Methacrylic acid-methyl methacrylate copolymer is added to a mixed solution of dichloromethane and anhydrous ethanol and stirred to dissolve; carboxyl modified activated carbon and emulsifier are then added and stirred evenly, followed by ultrasonic emulsification for 15-20 minutes; N,N'-methylenebisacrylamide and potassium persulfate are then added and ultrasonic emulsification is continued for 2-4 minutes; the obtained emulsion is added to deionized water and stirred for 6-8 hours, the microspheres are separated after centrifugation, and the pH-responsive release adsorbent is obtained after freeze-drying.

9. The method for preparing a medical silicone gel for scar repair according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1. Mix aloe polysaccharide silicone gel and sodium hyaluronate and heat in a 40-50°C water bath until homogeneous to form a base gel matrix; S2. Poly-L-lactic acid, vitamin E, asiatica glycoside, resveratrol, curcumin, hydroquinone, arbutin, vitamin C derivatives and traditional Chinese medicine compositions were added to purified water and ultrasonically dispersed for 10-20 min to form a uniform dispersion; S3. Add the dispersion obtained in S2 to the basic gel matrix obtained in S1, stir in a water bath at 40-50°C for 30-50 minutes, add an odor regulator and stir evenly, perform vacuum degassing, then add a preservative and stir evenly to obtain a medical silicone gel for scar repair.

10. The use of a medical silicone gel for scar repair according to any one of claims 1 to 8, characterized in that: Application of the medical silicone gel in scar repair.

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