Artesunate nanosuspension and preparation method thereof

By preparing artesunate nanosuspension, the problem of poor water solubility of artesunate is solved, efficient drug dissolution and absorption are achieved, bioavailability is improved, toxic side effects are reduced, and it is suitable for industrial production.

CN120732782AInactive Publication Date: 2025-10-03ZHAOQING TIANYING BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511084037.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-04
Publication Date
2025-10-03
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Artesunate has poor water solubility, resulting in low bioavailability, slow dissolution and absorption, requiring larger doses and increasing toxic side effects. Existing nanoemulsion and liposome preparations also have problems such as complex preparation, high cost, and limited drug loading capacity.

Method used

Artesunate nanosuspension is used to prepare artesunate into nano-scale particles through high-pressure homogenization technology. Dispersants, suspending agents and antioxidants are used in combination with nano-processing to form a stable nanosuspension with particle size controlled at the nanoscale. Artesunate nanosuspension is obtained after filtration and sterilization.

Benefits of technology

Significantly improve the water solubility and dissolution rate of artesunate, increase bioavailability by 30%-50%, reduce dosage, reduce toxic side effects, have excellent stability, are suitable for industrial production, reduce costs, and improve drug safety.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an artesunate nanosuspension and a preparation method thereof, artesunate is used as an active pharmaceutical ingredient, and the content of artesunate is 0.1-10% (w / v); the dispersing agent is selected from one or more of polyvinyl alcohol, povidone, lauryl sodium sulfate, poloxamer and the like, and the content of the dispersing agent is 0.5-5% (w / v. By means of the method, the medicine performance is greatly improved, the specific surface area of artesunate is remarkably increased through the nanoscale particles, the water solubility and the dissolution rate of artesunate are greatly improved, the bioavailability is improved by 30%-50%, and the bioavailability of artesunate is improved by 30%-50%. The drug administration dosage is reduced while the curative effect is enhanced, the toxic and side effects are reduced, and the stability is excellent. The dispersing agent and the suspending aid have a synergistic effect and are combined with a nanocrystallization process, so that particles are effectively prevented from gathering and settling; the antioxidant is accurately proportioned, oxidative degradation of the medicine is inhibited, the medicine content is kept at 95% or above after the medicine is stored at normal temperature for 6 months, and the particle size change does not exceed 10%.
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