Pharmaceutic adjuvant rectification equipment

Abstract

The invention provides pharmaceutical adjuvant rectification equipment, and belongs to the technical field of rectification towers. Comprising a rectifying tower body, a lower-layer discharging area, a rectifying area and an upper-layer discharging area are sequentially arranged in the rectifying tower body from bottom to top, the side wall of the rectifying tower body is connected with a feeding pipe, the top of the rectifying tower body is connected with an exhaust pipe, and the bottom of the rectifying tower body is connected with a liquid discharging pipe. The upper-layer gas phase is condensed and then flows back into the rectification equipment, the rectification area is divided into a primary distillation section and a rectification section through a cylindrical separation barrel, a cleaning assembly is arranged on the separation barrel and used for cleaning tower plates on the inner side and the outer side, and a filtering assembly is arranged between a liquid discharging pipe and the heat pump heating system. The crystals in the tower plate and the through holes of the tower plate can be regularly cleaned, and are filtered and collected in the filtering assembly, so that the effect of preventing the structural pipeline in the rectification equipment from being blocked is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of distillation towers, in particular to a pharmaceutical excipient distillation device. Background Art

[0002] In the production of pharmaceutical excipients, distillation technology is mainly used to extract and purify volatile liquids, organic substances with good thermal stability, or solvent excipients that require high-purity separation.

[0003] Patent publication number CN102872609B discloses a distillation tower with a dividing wall. A dividing plate is installed along the longitudinal direction of the tower, dividing the interior of the tower into a top junction area, a feed side of the dividing wall area, a discharge side of the dividing wall area, and a bottom junction area. The distillation tower also includes a mid-section liquid reflux distribution system and a bottom-tower ascending gas distribution control system.

[0004] However, during the process of separating and purifying substances in the distillation tower, due to the crystallization of the medium or the formation of polymers, these substances will accumulate in the tower plates and pipes, causing blockage of necessary structural equipment in the distillation equipment and affecting the normal operation of the distillation equipment. Summary of the Invention

[0005] In view of the above problems, the present invention provides a pharmaceutical excipient distillation device.

[0006] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is as follows: Provided is a pharmaceutical excipient distillation device, comprising a distillation tower body, wherein a lower discharge area, a distillation area, and an upper discharge area are sequentially arranged in the distillation tower body from bottom to top; a feed pipe connected to the distillation area is connected to the side wall of the distillation tower body; an exhaust pipe is connected to the top of the distillation tower body; a drain pipe is connected to the bottom of the distillation tower body; a filter assembly is connected to the drain pipe; a heat pump heating system is connected to the drain pipe on a side of the filter assembly away from the distillation tower body; the drain pipe is connected to an air inlet pipe communicating with the lower discharge area of ​​the distillation tower body after passing through the heat pump heating system; the drain pipe is connected to a first discharge pipe; the exhaust pipe is connected to a condensation system after passing through the heat pump heating system; the condensation system is connected to a condensation reflux pipe communicating with the upper discharge area of ​​the distillation tower body; and the condensation reflux pipe is connected to a second discharge pipe; A dividing cylinder is coaxially arranged in the distillation zone of the distillation tower body, and the distillation zone of the distillation tower body is divided into an inner primary distillation section and an outer distillation section by the dividing cylinder. Multiple layers of tower plates are arranged from bottom to top in the primary distillation section and the distillation section, and each layer of tower plates is penetrated by a number of through holes. A third discharge pipe connected to the distillation section is connected to the outer wall of the distillation tower body.

[0007] Furthermore, a cleaning assembly for cleaning the trays and through-holes is provided in the distillation tower body, the cleaning assembly comprising a cleaning rod and a cleaning cylinder, the separation cylinder being coaxially rotatably arranged in the distillation tower body, a mounting rod being coaxially fixedly provided in the distillation tower body, the trays in the primary distillation section being fixedly provided on the mounting rod, the trays in the distillation section being fixedly provided on the inner side wall of the distillation tower body, and a first driving assembly for driving the separation cylinder to rotate is provided on the distillation tower body; The cleaning rods are fixed on the inner and outer walls of the separation cylinder. The cleaning rods correspond to each tower plate and are located above the corresponding tower plate. The cleaning rods are provided with bristles that contact the surface of the tower plate below. A plurality of cleaning cylinders are arranged at intervals along the length direction of the cleaning rod. The diameter of the cleaning cylinder is not larger than the diameter of the through hole. The cleaning cylinder is located on one side of the bristles. The cleaning cylinder is slidably arranged on the cleaning rod in the vertical direction. A second driving component is provided on the distillation tower body and the cleaning rod to drive the cleaning cylinder to rise and fall to clean the through hole.

[0008] Furthermore, the first drive assembly includes a first drive motor, which is arranged on the outer wall of the distillation tower body, and the output shaft of the first drive motor extends into the distillation tower body and is in driving connection with the top of the separation cylinder; The second driving assembly includes a guide ring and a spring. The guide ring is coaxially arranged above the tower plate. A number of downward guide protrusions are provided on the guide ring. The guide protrusions correspond one-to-one to the through holes on the tower plate. A roller is rotatably provided on the top of the cleaning cylinder. The spring is used to drive the cleaning cylinder to move upward so that the roller maintains rolling contact with the bottom wall of the guide ring. When the roller is aligned with the guide protrusion, the bottom end of the cleaning cylinder passes through the through hole.

[0009] Furthermore, the tower plates are staggered in the primary distillation section and the rectifying section, a baffle is provided on one edge of the tower plate and an overflow plate is provided on the other edge, a first discharge outlet for material to flow downward is provided on both the baffle and the overflow plate, the bottom wall of the first discharge outlet is flush with the top wall of the tower plate, a first gate for opening and closing the first discharge outlet is provided on both the overflow plate and the baffle plate, and a third driving member for driving the first gate to rise and fall vertically is provided on the rectifying tower body; The third driving member includes a first connecting frame, a second connecting frame, a first driving push rod and a second driving push rod. The first connecting frame is fixedly connected to each first gate in the primary distillation section. The first driving push rod is fixedly provided on the distillation tower body and is used to drive the first connecting frame to move vertically. The second connecting frame is fixedly connected to each first gate in the distillation section. The second driving push rod is fixedly provided on the distillation tower body and is used to drive the second connecting frame to move vertically.

[0010] Furthermore, the distillation tower body is provided with a liquid diverter trough in the upper discharge area, the condensation reflux pipe is connected to the liquid diverter trough, two second discharge outlets facing the primary distillation section and the distillation section are respectively opened on both sides of the liquid diverter trough, a second gate for opening and closing the two second discharge outlets is vertically lifted on the liquid diverter trough, and a fourth driving member for independently driving the two second gates to vertically lift and lower is provided on the distillation tower body; The fourth driving member includes a third driving push rod and a fourth driving push rod. The third driving push rod and the fourth driving push rod are both fixedly arranged on the distillation tower body. The third driving push rod and the fourth driving push rod respectively drive the second gate on the liquid diversion trough close to the primary distillation section and close to the distillation section to rise and fall.

[0011] Furthermore, a support plate is provided in the distillation tower body between the lower discharge area and the distillation area, the bottom end of the dividing cylinder is rotatably connected to the support plate, a plurality of guide grooves are provided on the support plate, a clearance hole is provided through the bottom of the guide groove, a plurality of liquid holes are provided through the inner wall of the guide groove, a shielding cylinder with an inner diameter consistent with the clearance hole is coaxially fixed inside the guide groove, a first mounting plate corresponding to the primary distillation area and a second mounting plate corresponding to the distillation area are vertically lifted below the support plate, and the A ventilation cylinder that matches the size of the shielding cylinder is fixedly provided on the first mounting plate and the second mounting plate. A strip-shaped ventilation hole is vertically opened on the outer wall of the ventilation cylinder. The ventilation hole extending from the top of the shielding cylinder connects the upper and lower parts of the support plate. A gas distributor is provided in the lower discharge area. The air inlet pipe is connected to the gas distributor. A plurality of branch pipes are connected to the gas distributor. The top ends of the branch pipes are open and vertically slide through the ventilation cylinder. A fifth driving member for independently driving the first mounting plate and the second mounting plate to rise and fall is provided on the distillation tower body. The fifth driving member includes a fifth driving push rod and a sixth driving push rod. The fifth driving push rod is fixed on the distillation tower body and is used to drive the first mounting plate to move vertically. The sixth driving push rod is fixed on the distillation tower body and is used to drive the second mounting plate to move vertically.

[0012] Furthermore, the heat pump heating system includes a compressor and a reboiler, the reboiler has a first heat exchange channel and a second heat exchange channel spaced apart from each other, the inlet of the compressor is connected to the exhaust pipe at the top of the distillation tower body, and the outlet is connected to the inlet of the first heat exchange channel, the outlet of the first heat exchange channel is connected to the condensation system, and one end of the second heat exchange channel of the reboiler is connected to the drain pipe and the other end is connected to the air inlet pipe.

[0013] Furthermore, the condensation system includes a pressure reducing valve and a cooler, the inlet of the cooler is connected to the pressure reducing valve, the outlet of the first heat exchange channel is connected to the pressure reducing valve and the cooler in sequence, and the outlet of the cooler is connected to the condensation reflux pipe.

[0014] Furthermore, the filter assembly includes a filter tank, which has an inlet and a slag discharge port at the top and bottom respectively, and an outlet connected to the side wall of the filter tank. The inlet and outlet of the filter tank are both connected to the drain pipe. A layer of filter cartridge is coaxially arranged in the filter tank, and the outlet of the filter tank is separated from the inlet and the slag discharge port by the filter cartridge. A valve is provided at the slag discharge port and can be detachably connected to the slag collecting tank.

[0015] Furthermore, a third connecting frame is coaxially rotatable inside the filter tank, the third connecting frame is annular, a cleaning roller is rotatably arranged on the third connecting frame, the outer wall of the cleaning roller is provided with bristles that contact the outer wall of the filter cartridge, a second drive motor is provided on the outer wall of the filter tank, the output shaft of the second drive motor extends into the filter tank and engages with the third connecting frame for transmission.

[0016] The beneficial effects of the present invention are as follows: 1. A rotating partition cylinder is used as a partition component of a partition wall distillation device, and the partition cylinder is used as an installation base for a cleaning assembly on a tower plate, so that the tower plates inside and outside the partition cylinder and the through-holes on the tower plates can be effectively cleaned, and the cleaned crystals on the tower plates can be conveniently and effectively discharged. The liquid phase in the distillation tower is then filtered through the filtering assembly to collect the impurities of the crystals in the liquid phase, effectively avoiding blockage of necessary structural equipment in the distillation device; 2. A liquid diversion trough combined with a second gate with adjustable opening is used to control the liquid flow ratio in the primary distillation section and the rectifying section. A gas distributor combined with a height-adjustable breather cylinder extending into the rectifying section can control the gas flow ratio in the primary distillation section and the rectifying section to meet the separation and purification process requirements of different components. 3. Compared with the traditional dividing wall distillation tower, the cylindrical primary distillation section and the rectifying section extend the flow length of the liquid phase on each tray in the rectifying section, making the liquid phase temperature on each tray in the rectifying section obvious, thereby improving the separation accuracy of the intermediate components; 4. A heat pump heating system is used to heat the liquid phase in the lower discharge area. Compared with the traditional steam heating method, it has low energy consumption, energy saving and environmental protection. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall structure of the pharmaceutical excipient distillation equipment according to an embodiment of the present application.

[0018] Figure 2 This is a schematic diagram of the internal structure of the distillation tower body of an embodiment of the present application.

[0019] Figure 3 This is a schematic diagram of the internal structure of the primary distillation section of an embodiment of the present application.

[0020] Figure 4 Schematic diagram of the internal structure of the distillation section of an embodiment of the present application.

[0021] Figure 5for Figure 2 Schematic diagram of the partial structure of the cleaning component in part A.

[0022] Figure 6 for Figure 2 Schematic diagram of the partial cross-sectional structure of the guide groove, shielding tube, ventilation tube and air distribution tube on the support plate of part B in the middle.

[0023] Figure 7 This is a schematic structural diagram of the filter assembly according to an embodiment of the present application.

[0024] Among them, 1. distillation tower body; 11. lower discharge area; 121. primary distillation section; 122. distillation section; 13. upper discharge area; 14. feed pipe; 15. exhaust pipe; 151. condensation reflux pipe; 152. second discharge pipe; 16. drain pipe; 161. first discharge pipe; 162. air inlet pipe; 17. third discharge pipe; 18. mounting rod; 2. filter assembly; 21. filter tank; 22. filter cartridge; 23. slag collecting tank; 24. third connecting frame; 241. cleaning roller; 242. second drive motor; 31. compressor; 32. reboiler; 41. pressure reducing valve; 42. cooler; 5. separator; 6. tray; 61. through hole; 62. baffle; 63. overflow plate; 64. first discharge port; 65. first Gate; 651, first connecting frame; 652, second connecting frame; 653, first driving push rod; 654, second driving push rod; 71, cleaning rod; 72, cleaning cylinder; 721, roller; 73, first driving motor; 74, guide ring; 741, guide protrusion; 75, spring; 8, liquid diversion groove; 81, second discharge port; 82, second gate; 83, third driving push rod; 84, fourth driving push rod; 9, support plate; 91, guide groove; 92, clearance hole; 921, liquid passing hole; 93, shielding cylinder; 94, first mounting plate; 941, fifth driving push rod; 95, second mounting plate; 951, sixth driving push rod; 96, vent cylinder; 961, vent hole; 97, air distribution cylinder; 971, branch pipe. DETAILED DESCRIPTION

[0025] In order to better understand the above technical solution, the above technical solution will be described in detail below with reference to the accompanying drawings and specific implementation methods.

[0026] The present application discloses a pharmaceutical excipient distillation device, referring to Figure 1 、 Figure 2 、 Figure 3 and Figure 4The distillation tower body 1 includes a lower discharge area 11, a distillation area, and an upper discharge area 13 arranged in order from bottom to top. A feed pipe 14 connected to the distillation area is connected to the side wall of the distillation tower body 1. An exhaust pipe 15 is connected to the top of the distillation tower body 1. A drain pipe 16 is connected to the bottom of the distillation tower body 1. The drain pipe 16 is connected to the filter assembly 2. The drain pipe 16 is connected to a heat pump heating system on the side of the filter assembly 2 away from the distillation tower body. After passing through the heat pump heating system, the drain pipe 16 is connected to an air inlet pipe 162 connected to the lower discharge area 11 of the distillation tower body 1. A first discharge pipe 161 is connected to the drain pipe 16. The exhaust pipe 15 is connected to a condensation system after passing through the heat pump heating system. The condensation system is connected to a condensation reflux pipe 151 connected to the upper discharge area 13 of the distillation tower body 1. The condensation reflux pipe 151 is connected to a second discharge pipe 152. Multiple layers of trays 6 are arranged from bottom to top in the distillation zone, and each tray 6 is penetrated by a plurality of through holes 61 .

[0027] During operation of the distillation equipment, the material enters the distillation zone from the feed pipe 14, enters the condensation system through the exhaust pipe 15, and condenses and refluxes into the distillation tower body 1. After flowing through each tray 6 in sequence, it is collected in the lower discharge zone 11. The heat pump heating system is then activated, and the liquid phase collected in the lower discharge zone 11 enters the heat pump heating system through the discharge pipe 16. The gas discharged from the exhaust pipe 15 is pressurized and heated again by the heat pump heating system, and then undergoes heat exchange with the liquid phase in the discharge pipe 16, heating the liquid phase to gas, and then discharged into the lower discharge zone 11. The gas passes through the through-holes 61 on each tray 6 in sequence, achieving distillation of the material. Part of the liquid phase obtained by condensation in the condensation reflux pipe 151 is discharged through the second discharge pipe 152 to obtain the separated and purified first component. Of the liquid phase discharged from the discharge pipe 16 to the heat pump heating system, part of the liquid phase is discharged through the first discharge pipe 161 to obtain the separated and purified second component.

[0028] In the embodiment of the present application, a separator barrel 5 is coaxially disposed within the distillation zone within the distillation tower body 1. The separator barrel 5 divides the distillation zone of the distillation tower body 1 into an inner primary distillation section 121 and an outer distillation section 122. Multiple layers of trays 6 are arranged from bottom to top in both the primary distillation section 121 and the distillation section 122. The trays 6 in the primary distillation section 121 and the distillation section 122 are arranged along the circumference of the distillation tower body 1. A feed pipe 14 connects to the primary distillation section 121. A third discharge pipe 17, connected to the outer wall of the distillation tower body 1 and connected to the distillation section 122, is connected. A partitioned wall structure is formed within the distillation tower body 1 by the separator barrel 5, and the third component is separated and purified using the third discharge pipe 17. The area ratio of trays 6 in the primary distillation section 121 and the rectifying section 122 can be customized according to process requirements. The liquid phase flows in a circumferential direction on the trays 6. In the primary distillation section 121, the liquid phase has a short flow path on the trays 6, allowing the condensed reflux liquid phase to flow quickly into the lower discharge area 11. The liquid phase has a long flow path on the trays 6 in the rectifying section 122, allowing the reboiled steam to fully contact the liquid phase. The temperature on each tray 6 in the rectifying section 122 varies significantly, improving the purification effect and accurately controlling the output of the third component. A heat pump heating system reduces energy consumption during the distillation and purification process, and the use of a partitioned wall structure with a separator barrel 5 enables the simultaneous production of three high-purity products within a single tower.

[0029] Reference Figure 5 In order to keep the surfaces of the trays 6 and the inner walls of the through-holes 61 in the distillation tower body 1 clean and prevent crystals in the liquid phase from depositing on the surfaces of the trays 6 and clogging the through-holes 61, thereby affecting the normal operation of the distillation equipment, in the embodiment of the present application, a cleaning assembly for cleaning the trays 6 and through-holes 61 is provided in the distillation tower body 1. In the embodiment of the present application, a mounting rod 18 is coaxially fixedly provided in the distillation tower body 1. The trays 6 in the initial distillation section 121 of the distillation tower body 1 are fixedly mounted on the mounting rod 18, and the trays 6 in the distillation section 122 are fixedly mounted on the inner side wall of the distillation tower body 1. The dividing barrel 5 is coaxially rotatably mounted in the distillation tower body 1. The distillation tower body 1 is provided with a first drive assembly for driving the dividing barrel 5 to reciprocate. The first drive assembly can be a first drive motor 73, which is fixedly mounted to the outer wall of the distillation tower body 1 by bolts. The output shaft of the first drive motor 73 extends into the distillation tower body 1 and is transmission-connected to the top of the dividing barrel 5. Specifically, a bevel gear is coaxially fixedly connected to the output shaft of the first drive motor 73, and a bevel gear ring is coaxially fixed to the top of the separation cylinder 5. The bevel gear and the bevel gear ring are engaged, so that the first drive motor 73 drives the separation cylinder 5 to rotate reciprocatingly.

[0030] The cleaning assembly can be a cleaning rod 71 and a cleaning cylinder 72. The cleaning rod 71 is fixedly mounted on the inner and outer walls of the separation cylinder 5. The cleaning rod 71 corresponds to each tower plate 6 one by one and is located above the corresponding tower plate 6. The cleaning rod 71 is provided with bristles that contact the surface of the lower tower plate 6. A plurality of cleaning cylinders 72 are arranged at intervals along the length direction of the cleaning rod 71. The cleaning cylinder 72 is located on one side of the bristles. The cleaning cylinder 72 is vertically slidably mounted on the cleaning cylinder 72 with the cleaning rod 71 as the installation base. The diameter of the cleaning cylinder 72 is not greater than the diameter of the through hole 61. The distillation tower body 1 and the cleaning rod 71 are provided with a second drive assembly that drives the cleaning cylinder 72 to rise and fall to clean the through hole 61. The second driving assembly can be a movable part including a guide ring 74 and a spring 75. The guide ring 74 is coaxially arranged above the tower plate 6. Specifically, the guide ring 74 can be fixed to the bottom of the other tower plate 6 above the corresponding tower plate 6 or fixed to the mounting rod 18 or the inner wall of the distillation tower body 1. The guide ring 74 is provided with a plurality of downward guide protrusions 741, and the guide protrusions 741 correspond one-to-one with the through holes 61 on the tower plate 6. A roller 721 is rotatably provided on the top of the cleaning cylinder 72. A spring 75 is sleeved on the cleaning cylinder 72. One end of the spring 75 is fixedly connected to the cleaning rod 71 and the other end is fixedly connected to the cleaning cylinder 72. The spring 75 is used to drive the cleaning cylinder 72 to move upward so that the roller 721 maintains rolling contact with the bottom wall of the guide ring 74. When the roller 721 aligns with the guide protrusion 741, the bottom end of the cleaning cylinder 72 passes through the through hole 61.

[0031] When the first drive motor 73 drives the separation cylinder 5 to rotate, the cleaning rods 71 ​​inside and outside the separation cylinder 5 move on the tower plate 6 to clean the crystals on the surface of the tower plate 6. By rearranging the position of each cleaning rod 71 on the separation cylinder 5, the cleaning rod 71 can simultaneously approach the edge of one side of the corresponding tower plate 6. During the rotation of the separation cylinder 5, each cleaning rod 71 can move from one end of the corresponding tower plate 6 to the other end, thereby synchronously cleaning each tower plate 6. During the movement of the cleaning rod 71, the roller 721 on the cleaning cylinder 72 maintains rolling contact with the bottom wall of the guide ring 74. When the roller 721 moves to the guide protrusion 741, the cleaning cylinder 72 is guided and pushed by the guide protrusion 741 to drive the cleaning cylinder 72 into the through hole 61. The cleaning cylinder 72 cooperates with the through hole 61 to clear the inner wall of the through hole 61, thereby keeping the through hole 61 on the tower plate 6 working smoothly.

[0032] In the embodiment of the present application, the tower plates 6 are staggered in the primary distillation section 121 and the rectifying section 122. An edge plate is fixed to the edge of the tower plate 6 near the dividing barrel 5. A baffle 62 is provided on one edge of the tower plate 6, and an overflow plate 63 is provided on the other edge. The baffle 62 is higher than the overflow plate 63. The liquid phase on the tower plate 6 flows through the overflow plate 63 to the tower plate 6 on the lower layer. A first discharge port 64 for downward flow of material is provided on both the baffle 62 and the overflow plate 63. The bottom wall of the first discharge port 64 is flush with the top wall of the tower plate 6. A first gate 65 for opening and closing the first discharge port 64 is vertically raised and lowered on both the overflow plate 63 and the baffle 62. A third driving member for driving the first gate 65 to rise and fall vertically is provided on the rectifying tower body 1. By periodically driving the first gate 65 to rise and opening the first discharge port 64, the cleaning rod 71 can clean the crystals on the tower plate 6 to the edges on both sides of the tower plate 6, and the crystals are discharged from the first discharge port 64 to the bottom along with the liquid phase, thereby preventing the crystals from accumulating in the edge corners of the tower plate 6 and improving the cleaning effect of the tower plate 6.

[0033] The third driving member includes a first connecting frame 651, a second connecting frame 652, a first driving push rod 653, and a second driving push rod 654. The first connecting frame 651 is fixedly connected to each first gate 65 in the primary distillation section 121. The first driving push rod 653 is fixedly arranged on the distillation tower body 1 and is used to drive the first connecting frame 651 to move vertically. The second connecting frame 652 is fixedly connected to each first gate 65 in the distillation section 122. The second driving push rod 654 is fixedly arranged on the distillation tower body 1 and is used to drive the second connecting frame 652 to move vertically. In other embodiments, the first connecting frame 651 and the second connecting frame 652 can be connected as a whole in the upper discharge area 13 and driven to rise and fall by a single driving push rod, thereby realizing synchronous control of the rise and fall of the first gates 65 in the primary distillation section 121 and the distillation section 122.

[0034] In the embodiment of the present application, a liquid diverter trough 8 is provided in the upper discharge area 13 of the distillation tower body 1. The liquid diverter trough 8 is located above the dividing barrel 5, and the condensation reflux pipe 151 is connected to the liquid diverter trough 8. Two second discharge ports 81 are respectively provided on either side of the liquid diverter trough 8, facing the primary distillation section 121 and the distillation section 122. A second gate 82 for opening and closing the two second discharge ports 81 is provided on the vertically movable liquid diverter. The distillation tower body 1 is provided with a fourth drive member for independently driving the two second gates 82 to vertically raise and lower. The fourth driving member may be a third driving push rod 83 and a fourth driving push rod 84. Both the third driving push rod 83 and the fourth driving push rod 84 are fixedly mounted on the distillation column body 1 by bolts. The output sections of the third driving push rod 83 and the fourth driving push rod 84 extend into the distillation column body 1 and are fixedly connected to the two second gates 82 on the liquid diverter trough 8 near the primary distillation section 121 and the rectifying section 122, respectively. The third driving push rod 83 and the fourth driving push rod 84 independently drive the two second gates 82 on the liquid diverter trough 8 to rise and fall. The extension and retraction of the output ends of the third driving push rod 83 and the fourth driving push rod 84 are precisely controlled by a computer. By controlling the opening of the two second discharge ports 81, the flow distribution ratio of the condensed reflux liquid phase entering the primary distillation section 121 and the rectifying section 122 is controlled and adjusted.

[0035] Reference Figure 6 Furthermore, a support plate 9 is provided within the distillation tower body 1, between the lower discharge zone 11 and the distillation zone. The bottom end of the dividing cylinder 5 is rotatably connected to the support plate 9. The support plate 9 is provided with a plurality of guide grooves 91. A clearance hole 92 is provided through the bottom of the guide groove 91. A plurality of liquid passage holes 921 are provided through the inner wall of the guide groove 91. A shielding cylinder 93 is coaxially fixed to the inner bottom wall of the guide groove 91. The inner diameter of the shielding cylinder 93 is consistent with the inner diameter of the liquid passage hole 921. Several guide grooves 91 are provided within the projection range of the support plate 9 in both the primary distillation section 121 and the distillation section 122. These guide grooves 91 can receive the liquid phase flowing down from the upper tray 6 and allow the liquid phase to enter the lower discharge zone 11 from the distillation zone. A first mounting plate 94 corresponding to the primary distillation section 121 and a second mounting plate 95 corresponding to the distillation section 122 are vertically lifted below the support plate. A ventilation tube 96 adapted to the size of the shielding tube 93 is fixedly provided on the first mounting plate 94 and the second mounting plate 95. A strip-shaped ventilation hole 961 is vertically opened on the outer wall of the ventilation tube 96. The ventilation tube 96 slides and is correspondingly slid into the shielding tube 93. The ventilation hole 961 on the ventilation tube 96 is blocked by the shielding tube 93. A fifth driving member for independently driving the first mounting plate 94 and the second mounting plate 95 to rise and fall is provided on the distillation tower body 1. The first mounting plate 94 and / or the second mounting plate 95 are independently driven to rise by the fifth driving member, so that the ventilation hole 961 extends from the top of the shielding tube 93, so that the distillation area can be connected with the lower discharge area 11.

[0036] The fifth driving member can be a fifth driving push rod 941 and a sixth driving push rod 951. The fifth driving push rod 941 is fixedly provided on the distillation tower body 1 and is used to drive the first mounting plate 94 to move vertically. The sixth driving push rod 951 is fixedly provided on the distillation tower body 1 and is used to drive the second mounting plate 95 to move vertically. A gas separation cylinder 97 is provided in the lower discharge area 11. The air inlet pipe 162 is connected to the gas separation cylinder 97. A plurality of branch pipes 971 are connected to the gas separation cylinder 97. The top end of the branch pipe 971 is open and vertically slides through the air vent cylinder 96. By adjusting the length of the air vent 961 extending out of the shielding cylinder 93, the gas phase entering from the air inlet pipe 162 can be distributed in the primary distillation section 121 and the distillation section 122 to meet the purification and separation needs of different components. The first driving push rod 653 , the second driving push rod 654 , the third driving push rod 83 , the fourth driving push rod 84 , the fifth driving push rod 941 and the sixth driving push rod 951 may all be electric push rods, so that the extension length of the output rod can be precisely adjusted.

[0037] In the embodiment of the present application, the heat pump heating system includes a compressor 31 and a reboiler 32. The reboiler 32 has a first heat exchange channel and a second heat exchange channel spaced apart from each other. The inlet of the compressor 31 is connected to the exhaust pipe 15 at the top of the distillation tower body 1, and the outlet is connected to the inlet of the first heat exchange channel. The outlet of the first heat exchange channel is connected to the condensation system. One end of the second heat exchange channel of the reboiler 32 is connected to the drain pipe 16, and the other end is connected to the air inlet pipe 162. The compressor 31 is used to pressurize and increase the temperature of the gas phase discharged from the exhaust pipe 15. When the gas enters the reboiler 32, the high-temperature gas in the reboiler 32 exchanges heat with the liquid phase discharged from the drain tank, causing the liquid phase to heat up and enter the lower discharge area 11 through the air inlet pipe 162 in the vapor phase, effectively reducing the energy consumption of the distillation equipment during operation.

[0038] The condensation system includes a pressure reducing valve 41 and a cooler 42. The inlet of the cooler 42 is connected to the pressure reducing valve 41. The outlet of the first heat exchange channel is sequentially connected to the pressure reducing valve 41 and the cooler 42. The outlet of the cooler 42 is connected to the condensation reflux pipe 151. After the high-temperature gas in the exhaust pipe 15 undergoes heat exchange in the reboiler 32, the gas enters the pressure reducing valve 41 to reduce the pressure in the pipeline, and then enters the cooler 42. The cooler 42 can be a water-cooled heat exchanger, which condenses the gas phase into a liquid phase. The liquid phase enters the condensation reflux pipe 151 and returns to the upper discharge area 13 or is discharged through the second discharge pipe 152.

[0039] Reference Figure 7The filter assembly 2 is used to filter and collect crystals and impurities in the liquid phase entering the reboiler 32 from the lower discharge area 11, so as to maintain smooth flow of the liquid phase in the distillation equipment. The filter assembly 2 includes a filter tank 21, the top and bottom of which are respectively provided with an inlet and a slag discharge port, and the side wall of the filter tank 21 is connected to an outlet, and the inlet and outlet of the filter tank 21 are both connected to the drain pipe 16. A filter cartridge 22 is coaxially arranged in the filter tank 21, and the outlet of the filter tank 21 is separated from the inlet and the slag discharge port by the filter cartridge 22. The slag discharge port is detachably connected to a slag collecting tank 23, and the slag collecting tank 23 can be detachably connected to the bottom of the filter barrel by a flange and bolts.

[0040] Furthermore, a third connecting frame 24 is coaxially rotatably disposed within the filter tank 21. The third connecting frame 24 is annular and rotatably disposed on the third connecting frame 24. A cleaning roller 241 is rotatably disposed on the third connecting frame 24. The outer wall of the cleaning roller 241 is provided with bristles that contact the outer wall of the filter cartridge 22. A second drive motor 242 is disposed on the outer wall of the filter tank 21. The output shaft of the second drive motor 242 extends into the filter tank 21 and meshes with the third connecting frame 24 for transmission. Specifically, a gear ring is coaxially disposed on the third connecting frame 24. The output shaft of the second drive motor 242 extends into the filter tank 21 and is coaxially connected to a gear, which meshes with the gear ring for transmission.

[0041] When the third connecting frame 24 rotates, the cleaning roller 241 moves in a circular motion on the outer side of the filter cartridge 22. The bristles of the cleaning roller 241 embed into the filter holes on the outer wall of the filter cartridge 22, pushing the crystals blocked in the filter holes into the filter tank 21, so that the crystals can sink to the bottom and be collected in the slag collecting tank 23. The bristles on the cleaning roller 241 continuously embed into the outer wall of the filter cartridge 22, so that the cleaning roller 241 rolls on the outer wall of the filter cartridge 22 during the rotation of the third connecting frame 24, thereby maintaining the filtering function of the filter cartridge 22 for a long time. In other embodiments, a valve can be provided at the slag discharge port of the filter cartridge 22, separating the slag collecting tank 23 from the filter cartridge 22 through the valve. After the valve is closed regularly, the slag collecting tank 23 can be removed without stopping the distillation equipment, thereby achieving online cleaning of impurities.

[0042] Those skilled in the art will appreciate that while preferred embodiments of the present invention have been described, further variations and modifications may be made to these embodiments once those skilled in the art are aware of the underlying inventive concepts. Therefore, the appended claims are intended to be interpreted as encompassing the preferred embodiments and all variations and modifications that fall within the scope of the present invention. Clearly, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, the present invention is intended to encompass such modifications and variations as fall within the scope of the claims and their equivalents.

Claims

1. A pharmaceutical excipient distillation device, characterized by: The invention comprises a distillation tower body (1), wherein the distillation tower body (1) is provided with a lower discharge area (11), a distillation area and an upper discharge area (13) in order from bottom to top, a feed pipe (14) connected to the distillation area is connected to the side wall of the distillation tower body (1), an exhaust pipe (15) is connected to the top of the distillation tower body (1), and a drain pipe (16) is connected to the bottom of the distillation tower body (1), and a filter assembly (2) is connected to the drain pipe (16), and the drain pipe (16) is located at a position away from the filter assembly (2) and away from the distillation tower body (1). ) is connected to a heat pump heating system on one side, the liquid discharge pipe (16) is connected to an air inlet pipe (162) in communication with the lower discharge area (11) of the distillation tower body (1) after passing through the heat pump heating system, the liquid discharge pipe (16) is connected to a first discharge pipe (161), the exhaust pipe (15) is connected to a condensation system after passing through the heat pump heating system, the condensation system is connected to a condensation reflux pipe (151) in communication with the upper discharge area (13) of the distillation tower body (1), and the condensation reflux pipe (151) is connected to a second discharge pipe (152); A dividing cylinder (5) is coaxially arranged in the distillation zone of the distillation tower body (1), and the dividing cylinder (5) divides the distillation zone of the distillation tower body (1) into an inner primary distillation section (121) and an outer distillation section (122). Multiple layers of tower plates (6) are arranged from bottom to top in the primary distillation section (121) and the distillation section (122), and each layer of tower plates (6) is penetrated by a plurality of through holes (61). A third discharge pipe (17) communicating with the distillation section (122) is connected to the outer wall of the distillation tower body (1).

2. A pharmaceutical excipient distillation device according to claim 1, characterized in that: A cleaning assembly for cleaning the trays (6) and the through holes (61) is provided in the distillation tower body (1), the cleaning assembly comprising a cleaning rod (71) and a cleaning cylinder (72); the separating cylinder (5) is coaxially rotatably provided in the distillation tower body (1); a mounting rod (18) is coaxially fixedly provided in the distillation tower body (1); the trays (6) in the primary distillation section (121) are fixedly provided on the mounting rod (18); the trays (6) in the distillation section (122) are fixedly provided on the inner side wall of the distillation tower body (1); and a first driving assembly for driving the separating cylinder (5) to rotate is provided on the distillation tower body (1); The cleaning rod (71) is fixedly arranged on the inner and outer walls of the separation cylinder (5), the cleaning rod (71) corresponds to each tower plate (6) one by one and is located above the corresponding tower plate (6), and the cleaning rod (71) is provided with bristles that contact the surface of the tower plate (6) below; The cleaning rod (71) is provided with a plurality of cleaning cylinders (72) spaced apart along its length direction. The diameter of the cleaning cylinder (72) is not greater than the diameter of the through hole (61). The cleaning cylinder (72) is located on one side of the bristles. The cleaning cylinder (72) is slidably arranged on the cleaning rod (71) in a vertical direction. A second driving component is provided on the distillation tower body (1) and the cleaning rod (71) for driving the cleaning cylinder (72) to rise and fall to clean the through hole (61).

3. A pharmaceutical excipient distillation device according to claim 2, characterized in that: The first drive assembly comprises a first drive motor (73), the first drive motor (73) being arranged on the outer wall of the distillation tower body (1), the output shaft of the first drive motor (73) extending into the distillation tower body (1) and being in driving connection with the top of the separation cylinder (5); The second driving assembly includes a guide ring (74) and a spring (75). The guide ring (74) is coaxially arranged above the tower plate (6). The guide ring (74) is provided with a plurality of downward guide protrusions (741). The guide protrusions (741) correspond one-to-one to the through holes (61) on the tower plate (6). A roller (721) is rotatably provided on the top of the cleaning cylinder (72). The spring (75) is used to drive the cleaning cylinder (72) to move upward so that the roller (721) maintains rolling contact with the bottom wall of the guide ring (74). When the roller (721) is aligned with the guide protrusions (741), the bottom end of the cleaning cylinder (72) penetrates the through hole (61).

4. A pharmaceutical excipient distillation device according to claim 2, characterized in that: The tower plates (6) are staggeredly arranged in the primary distillation section (121) and the rectifying section (122); a baffle (62) is provided on one side edge of the tower plate (6) and an overflow plate (63) is provided on the other side edge; a first discharge port (64) for material to flow downward is provided on the baffle (62) and the overflow plate (63); the bottom wall of the first discharge port (64) is flush with the top wall of the tower plate (6); a first gate (65) for opening and closing the first discharge port (64) is provided on the overflow plate (63) and the baffle (62) so as to be vertically raised and lowered; and a third driving member for driving the first gate (65) to be vertically raised and lowered is provided on the rectifying tower body (1); The third driving member includes a first connecting frame (651), a second connecting frame (652), a first driving push rod (653) and a second driving push rod (654), wherein the first connecting frame (651) is fixedly connected to each first gate (65) in the primary distillation section (121), the first driving push rod (653) is fixedly arranged on the distillation tower body (1) and is used to drive the first connecting frame (651) to move vertically, the second connecting frame (652) is fixedly connected to each first gate (65) in the distillation section (122), and the second driving push rod (654) is fixedly arranged on the distillation tower body (1) and is used to drive the second connecting frame (652) to move vertically.

5. The pharmaceutical excipient distillation equipment according to claim 4, characterized in that: The distillation tower body (1) is provided with a liquid diversion trough (8) in the upper material discharge area (13), the condensation reflux pipe (151) is connected to the liquid diversion trough (8), two second discharge outlets (81) facing the primary distillation section (121) and the distillation section (122) are respectively provided on both sides of the liquid diversion trough (8), a second gate (82) for opening and closing the two second discharge outlets (81) is provided on the liquid diversion trough (8) for vertically lifting, and a fourth driving member for independently driving the two second gates (82) to vertically lift; The fourth driving member includes a third driving push rod (83) and a fourth driving push rod (84). The third driving push rod (83) and the fourth driving push rod (84) are both fixedly arranged on the distillation tower body (1). The third driving push rod (83) and the fourth driving push rod (84) respectively drive the second gate (82) on the liquid diversion trough (8) close to the primary distillation section (121) and close to the distillation section (122) to rise and fall.

6. The pharmaceutical excipient distillation equipment according to claim 1, characterized in that: A support plate (9) is provided in the distillation tower body (1) between the lower discharge area (11) and the distillation area. The bottom end of the separation cylinder (5) is rotatably connected to the support plate (9). A plurality of guide grooves (91) are provided on the support plate (9). A clearance hole (92) is provided through the bottom of the guide groove (91). A plurality of liquid holes (921) are provided through the inner wall of the guide groove (91). A shielding cylinder (93) having an inner diameter consistent with the clearance hole (92) is coaxially fixedly provided inside the guide groove (91). A first mounting plate (94) corresponding to the primary distillation area and a second mounting plate (95) corresponding to the distillation area are vertically lifted below the support plate (9). The first mounting plate (94) and the second mounting plate (95) are vertically lifted. A breathable cylinder (96) having a size adapted to that of the shielding cylinder (93) is fixedly provided on each of the two mounting plates (95), a strip-shaped breathable hole (961) is vertically provided on the outer wall of the breathable cylinder (96), and the breathable hole (961) extending from the top of the shielding cylinder (93) connects the upper and lower parts of the support plate (9), a gas distribution cylinder (97) is provided in the lower discharge area (11), the air inlet pipe (162) is connected to the gas distribution cylinder (97), and a plurality of branch pipes (971) are connected to the gas distribution cylinder (97), the top ends of the branch pipes (971) are opened and vertically slide through the breathable cylinder (96), and a fifth driving member for independently driving the first mounting plate (94) and the second mounting plate (95) to rise and fall is provided on the distillation tower body (1); The fifth driving member includes a fifth driving push rod (941) and a sixth driving push rod (951). The fifth driving push rod (941) is fixedly arranged on the distillation tower body (1) and is used to drive the first mounting plate (94) to move vertically. The sixth driving push rod (951) is fixedly arranged on the distillation tower body (1) and is used to drive the second mounting plate (95) to move vertically.

7. The pharmaceutical excipient distillation equipment according to claim 1, characterized in that: The heat pump heating system comprises a compressor (31) and a reboiler (32), wherein the reboiler (32) has a first heat exchange channel and a second heat exchange channel spaced apart from each other, wherein the inlet of the compressor (31) is connected to the exhaust pipe (15) at the top of the distillation tower body (1), and the outlet is connected to the inlet of the first heat exchange channel, the outlet of the first heat exchange channel is connected to the condensation system, and one end of the second heat exchange channel of the reboiler (32) is connected to the drain pipe (16), and the other end is connected to the air inlet pipe (162).

8. The pharmaceutical excipient distillation equipment according to claim 7, characterized in that: The condensation system includes a pressure reducing valve (41) and a cooler (42), the inlet of the cooler (42) is connected to the pressure reducing valve (41), the outlet of the first heat exchange channel is sequentially connected to the pressure reducing valve (41) and the cooler (42), and the outlet of the cooler (42) is connected to the condensation reflux pipe (151).

9. The pharmaceutical excipient distillation equipment according to claim 1, characterized in that: The filter assembly (2) comprises a filter tank (21), wherein the top and bottom of the filter tank (21) are respectively provided with an inlet and a slag discharge port, and the side wall of the filter tank (21) is connected to an outlet, and the inlet and outlet of the filter tank (21) are both connected to a liquid discharge pipe (16). A filter cartridge (22) is coaxially arranged in the filter tank (21), and the outlet of the filter tank (21) is separated from the inlet and the slag discharge port by the filter cartridge (22). A valve is provided at the slag discharge port and is detachably connected to a slag collecting tank (23).

10. The pharmaceutical excipient distillation equipment according to claim 9, characterized in that: A third connecting frame (24) is coaxially rotatably provided in the filter tank (21), the third connecting frame (24) being annular, a cleaning roller (241) is rotatably provided on the third connecting frame (24), bristles of which are in contact with the outer wall of the filter cartridge (22) are provided on the outer wall of the cleaning roller (241), a second drive motor (242) is provided on the outer wall of the filter tank (21), an output shaft of the second drive motor (242) extends into the filter tank (21) and is meshed with the third connecting frame (24) for transmission.

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