Dental composition and method for producing dental composition

Abstract

A dental composition which contains a glass powder composite that contains a first glass powder and a second glass powder that differs in solubility due to pH from the first glass powder, and wherein both the first glass powder and the second glass powder have ion slow release properties.

Description

TECHNICAL FIELD

[0001] The present application relates to a dental composition and a method for producing a dental composition. BACKGROUND

[0002] In the dental field, a technique of using an ion-releasing glass having a function of releasing functional ions is known. For example, Patent Literature 1 discloses a deodorant composition containing an ion-releasing glass that releases one or more kinds of ions having a valence of 1 to 4. Further, Patent Literature 2 discloses a dental aqueous hydraulic temporary sealing material composition containing an ion-releasing glass that releases fluoride ions.

[0003]

Prior Art Documents

[0004]

Patent Literature

[0005]

Patent Literature 1

[0006]

Patent Literature 2

[0007]

Problems to be Solved by the Invention

[0008] A dental composition using an ion-releasing glass sometimes fails to obtain a function of releasing ions when the acidity (pH) in the oral cavity environment changes, because it is used in an oral cavity environment in which the acidity is not constant.

[0009] An object of the present application is to provide a dental composition that releases ions in accordance with the environment in the oral cavity.

[0010]

Means for Solving the Problems

[0011] One embodiment of the present application relates to a dental composition containing a glass powder composite containing a first glass powder and a second glass powder that is different from the first glass powder in solubility depending on pH, both of which have ion-releasing properties.

[0012]

Effects of the Invention

[0013] According to one embodiment of the present application, it is possible to provide a dental composition that releases ions in accordance with the environment in the oral cavity. DETAILED DESCRIPTION

[0014] Hereinafter, a detailed description will be given of an embodiment of the present application. The dental composition according to the present embodiment contains a glass powder composite. In the present specification, the dental composition means a composition used in the dental field. The glass powder composite means a glass powder containing at least two kinds of glass.

[0015] The glass powder composite contained in the dental composition contains a first glass powder, and a second glass powder different from the first glass powder in solubility depending on pH, and both the first glass powder and the second glass powder have ion release properties.

[0016] In the present specification, "glass" includes non-crystalline, and also includes crystalline, and also includes glass-ceramics, which partially contain glass. The glass powder means a glass in powder form. Further, the size of the powder is preferably 0.02 μm or more and 100 μm or less, and more preferably 0.02 μm or more and 30 μm or less, in terms of the median diameter.

[0017] In the present specification, the glass different in solubility depending on pH means that the ease of dissolution in water differs between the first glass powder and the second glass powder depending on the acidity. The ion release properties mean the property that the components contained in the glass dissolve and slowly release in the state of ions.

[0018] The components of the first glass powder are not particularly limited. As the first glass powder, the powder of silicate glass is preferably used. The silicate glass is a glass which is more easily dissolved and more easily releases ions in an acidic state (pH 6.5 or less) than in a neutral state (more than pH 6.5, less than pH 8).

[0019] The silicate glass contains silicon (Si), and also contains sodium (Na) and / or potassium (K). Here, silicon plays a role of forming a network in the glass contained in the dental composition.

[0020] The content of silicon in the silicate glass is not particularly limited, and is preferably 15% by mass or more and 70% by mass or less, and more preferably 15% by mass or more and 50% by mass or less, in terms of the amount converted into silicon oxide (SiO2). By the content of silicon oxide in the silicate glass being 15% by mass or more, the glass contained in the dental composition is easily obtained, and by being 70% by mass or less, the dental composition containing the glass having a melting temperature which is not excessively high is easily obtained.

[0021] The content of sodium and / or potassium in the silicate glass is not particularly limited, and is preferably 0% by mass or more and 15% by mass or less, and more preferably 1% by mass or more and 10% by mass or less, in terms of the amount converted into sodium oxide (Na2O) and / or potassium oxide (K2O).

[0022] By the silicate glass containing sodium and / or potassium, the melting temperature of the glass contained in the dental composition is lowered, and the solubility of the glass is also improved. Further, by the content of sodium oxide and / or potassium oxide in the silicate glass being 15% by mass or less, the glass having a solubility in water which is not excessively high is easily obtained as the glass contained in the dental composition.

[0023] As specific examples of the silicate glass, there are soda-lime glass, aluminosilicate glass, borosilicate glass, lead glass, and the like. Among them, soda-lime glass and aluminosilicate glass are preferable in view of high ion release.

[0024] The first glass powder as the powder of the silicate glass contains at least one element other than silicon (Si), sodium (Na), and potassium (K). The element contained in the glass is an element that forms an ion released from the glass (hereinafter referred to as a release ion).

[0025] The element contained in the first glass powder is not particularly limited, and examples thereof include Li, Ca, Sr, Ba, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Ti, Zr, Ta, Cu, Ag, Zn, B, Al, Ga, Si, Sn, P, F, and the like. These elements can be contained in one kind or two or more kinds. Among them, Li, Ca, Sr, Cu, Ag, Zn, B, Ga, and F are preferable.

[0026] Further, the element contained in the first glass powder is preferably Ca and Sr in view of improving acid resistance of the release ion, and is preferably Zn in view of suppressing generation of acid. Further, it is preferable to contain Ca, Zn, and F in view of the dentin demineralization suppression effect of the release ion, and it is preferable to contain Ca and Sr in view of promoting bone formation. Further, it is preferable to contain Cu, Ag, Zn, B, Ga, and F in view of the antibacterial effect of the release ion, and it is preferable to contain Li in view of the anti-inflammatory effect of the release ion.

[0027] The content of Li contained in the first glass powder is not particularly limited, and is preferably 0% by mass or more and 10% by mass or less, and more preferably 1% by mass or more and 8% by mass or less, in terms of the amount converted into lithium oxide (LiO2). By containing Li in the first glass powder, an anti-inflammatory effect can be imparted, and by being 10% by mass or less, a glass having a water solubility that is not excessively high can be easily obtained as a glass contained in a dental composition.

[0028] The content of Ca contained in the first glass powder is not particularly limited, and is preferably 0% by mass or more and 40% by mass or less, and more preferably 1% by mass or more and 35% by mass or less, in terms of the amount converted into calcium oxide (CaO). By containing Ca in the first glass powder, an acid resistance effect, a dentin demineralization suppression effect, and a bone formation promotion effect can be imparted, and by being 40% by mass or less, a glass contained in a dental composition can be easily obtained.

[0029] The content of Sr contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 40 mass% or less, more preferably 1 mass% or more and 35 mass% or less, in terms of an amount converted into strontium oxide (SrO). By containing Sr in the first glass powder, an acid resistance effect and a bone formation promoting effect can be imparted, and by being 40 mass% or less, a dental composition containing a glass having a melting temperature that is not excessively high can be easily obtained.

[0030] The content of Cu contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 10 mass% or less, more preferably 0.1 mass% or more and 5 mass% or less, in terms of an amount converted into copper oxide (CuO). By containing Cu in the first glass powder, an antibacterial effect can be imparted, and by being 10 mass% or less, a glass contained in a dental composition can be easily obtained.

[0031] The content of Ag contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 5 mass% or less, more preferably 0.1 mass% or more and 3 mass% or less, in terms of an amount converted into silver oxide (Ag2O). By containing Ag in the first glass powder, an antibacterial effect can be imparted, and by being 5 mass% or less, a glass contained in a dental composition can be easily obtained.

[0032] The content of Zn contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 40 mass% or less, more preferably 1 mass% or more and 35 mass% or less, in terms of an amount converted into zinc oxide (ZnO). By containing Zn in the first glass powder, an acid generation suppression effect, a dentin demineralization suppression effect, and an antibacterial effect can be imparted, and by being 40 mass% or less, a glass contained in a dental composition can be easily obtained.

[0033] The content of B contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 10 mass% or less, more preferably 1 mass% or more and 8 mass% or less, in terms of an amount converted into boron oxide (B2O3). By containing B in the first glass powder, an antibacterial effect can be imparted, and by being 10 mass% or less, a dental composition containing a glass that suppresses phase separation can be easily obtained.

[0034] The content of Ga contained in the first glass powder is not particularly limited, and is preferably 0 mass% or more and 40 mass% or less, more preferably 1 mass% or more and 35 mass% or less, in terms of an amount converted into gallium oxide (Ga2O3). By containing Ga in the first glass powder, an antibacterial effect can be imparted, and by being 40 mass% or less, a glass contained in a dental composition can be easily obtained.

[0035] The F content of the first glass powder is not particularly limited, and is preferably 0 mass% or more and 25 mass% or less, and more preferably 1 mass% or more and 22 mass% or less. By containing F in the first glass powder, a dentin demineralization inhibitory effect and an antibacterial effect can be imparted, and by being 25 mass% or less, a glass contained in the dental composition can be easily obtained.

[0036] The components of the second glass powder are not particularly limited. As the second glass powder, a powder of a phosphate glass is preferably used. The powder of the phosphate glass is sometimes a glass that is more easily dissolved in an acidic solution (pH 6.5 or less) than in a neutral solution (more than pH 6.5 and less than pH 8) and more easily releases ions, and is sometimes a glass that is more easily dissolved in a neutral solution (more than pH 6.5 and less than pH 8) than in an acidic solution (pH 6.5 or less) and more easily releases ions.

[0037] The phosphate glass contains phosphoric acid (P2O5) and sodium (Na) and / or potassium (K). Here, the phosphoric acid functions to form a network in the glass contained in the dental composition.

[0038] The content of the phosphoric acid in the phosphate glass is not particularly limited, and is preferably 40 mass% or more and 80 mass% or less, and more preferably 40 mass% or more and 70 mass% or less. By the content of the phosphoric acid in the phosphate glass being 40 mass% or more, a glass contained in the dental composition can be easily obtained, and by being 80 mass% or less, a dental composition containing a glass having a water solubility that is not excessively high can be easily obtained.

[0039] The content of the sodium and / or potassium in the phosphate glass is not particularly limited, and is preferably 5 mass% or more and 30 mass% or less, and more preferably 5 mass% or more and 20 mass% or less, in terms of the amount converted into sodium oxide (Na2O) and potassium oxide (K2O).

[0040] By the content of the sodium and / or potassium in the phosphate glass being 5 mass% or more, the melting temperature of the glass contained in the dental composition can be reduced, and the solubility of the glass can also be improved. Furthermore, by the content of the sodium and / or potassium in the phosphate glass being 30 mass% or less, as the glass contained in the dental composition, a glass having a water solubility that is not excessively high can be easily obtained.

[0041] The second glass powder, which is the powder of the phosphate glass, contains at least one element other than phosphorus (P), sodium (Na), and potassium (K). The element contained in the glass is an element that forms a sustained-release ion.

[0042] The elements contained in the second glass powder are not particularly limited, and examples include Li, Ca, Sr, Ba, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Ti, Zr, Ta, Cu, Ag, Zn, B, Al, Ga, Si, Sn, P, F, and the like. These elements can be contained in one or two or more kinds. Among them, Li, Ca, Sr, Cu, Ag, Zn, B, Ga, F are preferable.

[0043] Further, the elements contained in the second glass powder are preferably Ca and Sr from the viewpoint of improving acid resistance by the elution of ions, and are preferably Zn from the viewpoint of suppressing the generation of acid. Further, Ca, Zn, and F are preferable from the viewpoint that the elution of ions has a dentin demineralization suppression effect, and Ca and Sr are preferable from the viewpoint of promoting bone formation. Further, Cu, Ag, Zn, B, Ga, and F are preferable from the viewpoint that the elution of ions has an antibacterial effect, and Li is preferable from the viewpoint that the elution of ions has an anti-inflammatory effect.

[0044] The content of Li contained in the second glass powder is not particularly limited, and is preferably 0% by mass or more and 20% by mass or less, and more preferably 1% by mass or more and 15% by mass or less, in terms of the amount converted into lithium oxide (LiO2). By containing Li in the second glass powder, an anti-inflammatory effect can be imparted, and by being 20% by mass or less, a glass having a water solubility that is not excessively high can be easily obtained as a glass contained in a dental composition.

[0045] The content of Ca contained in the second glass powder is not particularly limited, and is preferably 0% by mass or more and 40% by mass or less, and more preferably 1% by mass or more and 35% by mass or less, in terms of the amount converted into calcium oxide (CaO). By containing Ca in the second glass powder, an acid resistance effect, a dentin demineralization suppression effect, and a bone formation promotion effect can be imparted, and by being 40% by mass or less, a glass contained in a dental composition can be easily obtained.

[0046] The content of Sr contained in the second glass powder is not particularly limited, and is preferably 0% by mass or more and 40% by mass or less, and more preferably 1% by mass or more and 35% by mass or less, in terms of the amount converted into strontium oxide (SrO). By containing Sr in the second glass powder, an acid resistance effect and a bone formation promotion effect can be imparted, and by being 40% by mass or less, a dental composition containing a glass having a melting temperature that is not excessively high can be easily obtained.

[0047] The content of Cu contained in the second glass powder is not particularly limited, and is preferably 0% by mass or more and 10% by mass or less, and more preferably 0.1% by mass or more and 5% by mass or less, in terms of the amount converted into copper oxide (CuO). By containing Cu in the second glass powder, an antibacterial effect can be imparted, and by being 10% by mass or less, a glass contained in a dental composition can be easily obtained.

[0048] The Ag content contained in the second glass powder is not particularly limited, and is preferably 0 mass% or more and 5 mass% or less, more preferably 0.1 mass% or more and 3 mass% or less, in terms of the amount converted into silver oxide (Ag2O). By containing Ag in the second glass powder, an antibacterial effect can be imparted, and by being 5 mass% or less, a glass contained in the dental composition can be easily obtained.

[0049] The Zn content contained in the second glass powder is not particularly limited, and is preferably 0 mass% or more and 20 mass% or less, more preferably 1 mass% or more and 15 mass% or less, in terms of the amount converted into zinc oxide (ZnO). By containing Zn in the second glass powder, an acid generation inhibitory effect, a dentin demineralization inhibitory effect, and an antibacterial effect can be imparted, and by being 20 mass% or less, a glass contained in the dental composition can be easily obtained.

[0050] The B content contained in the second glass powder is not particularly limited, and is preferably 0 mass% or more and 10 mass% or less, more preferably 1 mass% or more and 8 mass% or less, in terms of the amount converted into boron oxide (B2O3). By containing B in the second glass powder, an antibacterial effect can be imparted, and by being 10 mass% or less, a dental composition containing a glass that inhibits phase separation can be easily obtained.

[0051] The Ga content contained in the second glass powder is not particularly limited, and is preferably 0 mass% or more and 25 mass% or less, more preferably 1 mass% or more and 20 mass% or less, in terms of the amount converted into gallium oxide (Ga2O3). By containing Ga in the second glass powder, an antibacterial effect can be imparted, and by being 25 mass% or less, a glass contained in the dental composition can be easily obtained.

[0052] The F content contained in the second glass powder is not particularly limited, and is preferably 0 mass% or more and 20 mass% or less, more preferably 1 mass% or more and 15 mass% or less. By containing F in the second glass powder, a dentin demineralization inhibitory effect and an antibacterial effect can be imparted, and by being 20 mass% or less, a glass contained in the dental composition can be easily obtained.

[0053] The mass ratio of the first glass powder and the second glass powder mixed in the glass powder composite is not particularly limited, and is, for example, 10:1 to 1:10, preferably 7:1 to 1:7, more preferably 5:1 to 1:5. When the mass ratio of the first glass powder and the second glass powder mixed in the glass powder composite is 10:1 to 1:10, the slow-release amount of the slow-release ions can be controlled according to the change in the acidity.

[0054] Further, the dental composition of the present embodiment can arbitrarily contain other components as long as the object of the present application is not impaired. As the other components, for example, a high molecule such as polyacrylic acid, a solidification accelerator such as a hydrochloride, a sulfate, an oily component such as a hydrocarbon, a higher fatty acid, an ester, a coloring agent of various inorganic or organic, an antibacterial material, a perfume, and the like can be contained.

[0055] In the dental composition of the present embodiment, at least one of the elements contained in the first glass powder can be the same as at least one of the elements contained in the second glass powder. For example, when the first glass powder contains zinc (Zn), the second glass powder also contains zinc (Zn).

[0056] In the dental composition of the present embodiment, at least one of the elements contained in the first glass powder can be different from the elements contained in the second glass powder, and at least one of the elements contained in the second glass powder can be different from the elements contained in the first glass powder. For example, when the first glass powder contains zinc (Zn) but does not contain strontium (Sr), the second glass powder does not contain zinc (Zn) but contains strontium (Sr).

[0057] In the dental composition of the present embodiment, it is preferable that the dissolution rate in the neutral region of the second glass powder be greater than the dissolution rate in the acidic region.

[0058] The dissolution rate is calculated by immersing the glass in an acetic acid-sodium acetate buffer solution and according to the following formula.

[0059] Dissolution rate (%) = [(weight before liquid immersion) - (weight after liquid immersion) / weight before liquid immersion] x 100

[0060] As described above in the present embodiment, the glass powder composite contained in the dental composition contains the first glass powder and the second glass powder having different solubilities depending on pH, and both the first glass powder and the second glass powder have ion release properties. Thereby, the amount of the released ions can be changed according to the change in the acidity in the oral cavity.

[0061] For example, the dental composition contains, as the glass powder composite, the first glass powder being a powder of silicate glass that releases zinc ions (Zn 2+ ) and the second glass powder being a powder of phosphate glass that releases zinc ions (Zn 2+ ). At this time, even if the acidity in the oral cavity changes, the amount of the released ions from the dental composition can be maintained or controlled according to the change.

[0062] Specifically, in the dental composition, when the acidity in the oral cavity is acidic (for example, pH 4.5), zinc ions (Zn 2+ ) are easily released from the first glass powder contained in the glass powder composite, but in neutral (for example, pH 7.5), it is difficult to release zinc ions (Zn2+ On the other hand, the zinc ions (Zn 2+ ) are released from the second glass powder contained in the glass powder composite, regardless of either the acidity (e.g., pH 4.5) or the neutral region (e.g., pH 7.5) of the acidity in the oral cavity.

[0063] As a result, the zinc ions (Zn 2+ ) are released from the dental composition as the sustained-release ions, regardless of either the acidity or the neutrality of the acidity in the oral cavity, and the sustained-release amount of the sustained-release ions in the oral cavity is maintained. Therefore, even if the acidity in the oral cavity changes, the antibacterial effect, the acid generation inhibitory effect, and the dentin demineralization inhibitory effect based on the zinc ions (Zn 2+ ) are maintained in the oral cavity.

[0064] In the present embodiment, the effect of changing the sustained-release amount of the sustained-release ions according to the change in the acidity is significantly obtained in the glass powder composite contained in the dental composition by using the powder of the silicate glass in the first glass powder and the powder of the phosphate glass in the second glass powder.

[0065] As described above in the present embodiment, the first glass powder and the second glass powder each contain at least one element selected from Li, Ca, Sr, Ga, Cu, Zn, B, and F. Thus, in the present embodiment, in the case of Li, the sustained-release ions can have an anti-inflammatory effect. In the case of Ca, the dentin demineralization inhibitory effect is obtained, the acid resistance is improved, and the bone formation is promoted. In the case of Sr, the acid resistance is improved, and the bone formation is promoted.

[0066] Further, in the present embodiment, in the case of Cu and Ag, the dental composition can be given the antibacterial effect. In the case of Zn, the dental composition can be given the antibacterial effect, the effect of inhibiting the generation of acid, and the dentin demineralization inhibitory effect. In the case of B and Ga, the antibacterial effect is obtained. In the case of F, the antibacterial effect and the dentin demineralization inhibitory effect are obtained.

[0067] In the dental composition of the present embodiment, as described above, at least one of the elements contained in the first glass powder is the same as at least one of the elements contained in the second glass powder, and thus, even if the acidity in the oral cavity changes, the same sustained-release ions are sustained-released in the oral cavity, and the sustained-release amount thereof can be maintained.

[0068] For example, when both the first glass powder and the second glass powder contain zinc (Zn), even if the environment in which the zinc ions (Zn 2+ ) are sustained-released changes from the acidic region to the neutral region, the sustained-release amount of the zinc ions (Zn 2+ ) can be maintained or increased or decreased.

[0069] In the present embodiment, as described above, at least one of the elements contained in the first glass powder is different from the elements contained in the second glass powder, and at least one of the elements contained in the second glass powder is different from the elements contained in the first glass powder, whereby different sustained-release ions can be released at different rates in accordance with changes in the acidity in the oral cavity.

[0070] In the dental composition of the present embodiment, as described above, the dissolution rate in the neutral region of the second glass powder is greater than the dissolution rate in the acidic region. Thus, in the present embodiment, even when the dissolution rate in the neutral region of the first glass powder is less than the dissolution rate in the acidic region, sustained-release ions are released from the second glass powder in the neutral region, and thus the amount of sustained-release ions released can be maintained even when the acidity changes from acidic to neutral.

[0071] The dental composition of the present embodiment can be used in various dental materials by virtue of the above-described effects. The dental composition of the present embodiment is not particularly limited in its use, and examples thereof include dental cements, dental adhesives (dental bonding agents), temporary dental sealants, temporary dental adhesives, dental primers, dental coating agents, root cover materials, dental composite resins, dental hard resins, dental resin materials for cutting, temporary dental restoratives, dental fillers, toothpastes, and the like.

[0072] The dental composition of the present embodiment can contain other components depending on the use. Examples of the other components include polymers, polymerization initiators, polymerization inhibitors, and the like. For example, an ionomer can be formed by mixing a polymer such as polyacrylic acid with the glass powder composite.

[0073] The polymer can be a product composed of a polymerizable monomer. Examples of the polymerizable monomer include homopolymers or copolymers of (meth)acrylate compounds. In the present specification, (meth)acrylate refers to at least one selected from the group consisting of acrylate and methacrylate.

[0074] In the present specification, a homopolymer refers to a polymer in which the constituent unit of a certain polymerization component is the main component. A copolymer refers to a polymer in which the constituent unit of a certain polymerization component and the constituent unit of another polymerization component are copolymerized. In addition, the homopolymer and the copolymer can contain other polymerization components that are inevitably mixed.

[0075] As the (meth)acrylate compound, for example, glycerol dimethacrylate (GDMA), bisphenol A diglycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA, di-2-methacryloyloxyethyl-2,2,4-trimethylhexamethylenediurethane), 2,2-bis(4-methacryloyloxyethoxyphenyl)propane (Bis-MEPP), tricyclodecanedimethanol dimethacrylate (DCP), triethylene glycol dimethacrylate (TEGDMA), neopentyl glycol dimethacrylate (NPG), and the like can be given. These (meth)acrylate compounds can be used singly, or two or more kinds can be used in combination.

[0076] The mixing amount of the homopolymer or copolymer of the (meth)acrylate compound contained in the dental composition of the present embodiment is, for example, preferably 3% by mass or more and 45% by mass or less, more preferably 4% by mass or more and 40% by mass or less, and further preferably 5% by mass or more and 30% by mass or less.

[0077] As the polymerization initiator, there is no particular limitation, and for example, camphorquinone (CQ), ethyl-p-dimethylaminobenzoate (EPA), (2,4,6-trimethylbenzoyl) diphenylphosphine oxide (TPO), 2-(2-hydroxy-5-methylphenyl)benzotriazole, and the like can be given.

[0078] The content of the polymerization initiator in the dental composition is not particularly limited, and for example, 0.01% by mass or more and 5% by mass or less, preferably 0.03% by mass or more and 2% by mass or less, and more preferably 0.05% by mass or more and 2% by mass or less.

[0079] As the polymerization inhibitor, there is no particular limitation, and for example, 6-tert-butyl-2,4-dimethylphenol, 2,6-di-tert-butyl-p-cresol, and the like can be given.

[0080] The content of the polymerization inhibitor in the dental composition is not particularly limited, and for example, 0.005% by mass or more and 5% by mass or less, preferably 0.01% by mass or more and 3% by mass or less, and more preferably 0.03% by mass or more and 1% by mass or less.

[0081] The production method of the dental composition to which the present embodiment relates is a method of substantially producing a dental composition containing the above-described glass powder composite. Specifically, there is a step of mixing a first glass powder and a second glass powder that differ in solubility depending on pH, and both the first glass powder and the second glass powder have ion release properties.

[0082] Further, when a high molecule is mixed in the dental composition, a monomer liquid in which a polymerizable monomer constituting the high molecule is mixed with a polymerization initiator, a polymerization inhibitor, and the like is prepared.

[0083] In the step of mixing the first glass powder and the second glass powder in the production method of the dental composition, the first glass powder and the second glass powder contained in the glass powder composite described above are used. Thus, the glass powder composite obtained in the production method according to the present embodiment achieves the effects of the glass powder composite described above.

[0084] That is, the dental composition obtained is as follows: the glass powder composite contained in the dental composition contains the first glass powder and the second glass powder that differ in solubility depending on pH, and both the first glass powder and the second glass powder have ion release properties. Thus, according to the production method according to the present embodiment, a dental composition can be obtained, in which the amount of ion release can be changed according to changes in acidity in the oral cavity.

[0085] [Examples]

[0086] Hereinafter, the present application will be further described using examples. In addition, various tests and evaluations were performed according to the following methods.

[0087] [Silicate glass]

[0088] The raw materials of the silicate glass were weighed and mixed in a mortar for 10 minutes, and then put into a platinum crucible and melted at 1350°C for 1 hour. The molten liquid was water-cooled and vitrified. The obtained glass was dried at 110°C for 5 hours, and then pulverized using a planetary mill (alumina balls of 15 mm, 150 rpm) for 30 minutes to 1 hour to obtain glass components S1 to S5. In addition, a commercially available quartz glass filler (hereinafter referred to as QG) was used.

[0089] [Phosphate glass]

[0090] The raw materials of the phosphate glass were weighed and mixed in a mortar for 10 minutes, and then put into a platinum crucible and melted at 1100°C for 1 hour. The molten liquid was cooled by pressing. The glass was pulverized using a ball mill (ethanol wet pulverization, alumina balls of 40 mm, 100 rpm) for 30 minutes, and then pulverized using a ball mill (ethanol wet pulverization, alumina balls of 5 mm, 100 rpm) for 30 minutes. Then, the glass powder was recovered by centrifugation, and dried under reduced pressure (-0.1 MPa, 40°C) to remove residual ethanol, to obtain glass components PN1, PN2, PA1, and PA2.

[0091] [Glass composition]

[0092] The glass powder was analyzed using a fluorescent X-ray analysis device (RIGAKU Corporation, ZSX Primus IV) to determine the composition of the glass powder (molded using a PVC ring). The evaluation results of the composition of the glass powder (unit: mass%) are shown in Tables 1 and 2.

[0093] [Particle size distribution]

[0094] The silicate glasses were measured for dispersion in distilled water and the phosphate glasses were measured for dispersion in ethanol using a laser diffraction / scattering type particle size distribution meter (Partica LA-960V2, manufactured by Horiba, Ltd.). It was also confirmed that the particle diameters of the glasses shown in Tables 1 to 4 were D50 (median diameter) at 10 ± 2 μm.

[0095] <Amount of dissolution (glass monomer)>

[0096] To 10 ml of a pH 4.5 acetic acid-sodium acetate buffer or a pH 7.5 hydroxyethylpiperazine ethanesulfonic acid (HEPES) buffer, 0.1 g of glass powder was added, and stirring was performed at 10 rpm while being stored at 37°C for 1 day. Then, filtration was performed using a glass filter paper, and the amount of dissolution was calculated from the weight of the residue using the following formula.

[0097] Dissolution rate (%) = [(weight before liquid immersion) - (weight after liquid immersion) / weight before liquid immersion] x 100

[0098] Table 1 shows the glass composition and dissolution rate of the silicate glasses (glass components S1 to S5, QG), and Table 2 shows the glass composition and dissolution rate of the phosphate glasses (glass components PN1, PN2, PA1, PA2).

[0099]

Table 1

[0100]

[0101]

Table 2

[0102]

[0103] <Amount of ion elution of glass monomer>

[0104] To 10 ml of a pH 4.5 acetic acid-sodium acetate buffer and a pH 7.5 HEPES buffer, 0.1 g of glass powder was added, and stirring was performed at 10 rpm while being stored at 37°C for 1 day. Then, after centrifugal separation at 2000 rpm for 10 minutes twice, the liquid filtered using a 0.2 μm membrane filter was measured for the concentration of each of Zn 2+ , Sr 2+ , Ca 2+ , Ga 3+ using an inductively coupled plasma optical emission spectrometry (ICP-OES: Inductively Coupled Plasma Optical Emission Spectrometry) (iCAP 7200Duo, manufactured by Thermo Fisher Scientific), and F -The concentration of each ion dissolved from the glass powder composite was measured by ICP-OES. Table 1 shows the ion dissolution amount of the silicate glass, and Table 2 shows the ion dissolution amount of the phosphate glass.

[0105] <Ion dissolution amount of glass powder composite>

[0106] To 10 ml of a pH 4.5 acetic acid-sodium acetate buffer and a pH 7.5 HEPES buffer, 2 kinds of glass powder (arbitrary amount) were added, and stirred at 10 rpm while being stored at 37°C for 1 day. Then, after centrifugation at 2000 rpm for 10 minutes twice, the liquid filtered with a 0.2 μm membrane filter was measured for the concentration of each of Zn 2+ , Sr 2+ , Ca 2+ , Ga 3+ by ICP-OES, and the concentration of F - by a fluorine electrode.

[0107] Table 3 shows the mixture and ion dissolution amount of the glass powder composite of Examples 1 to 5, and Table 4 shows the mixture and ion dissolution amount of the glass powder composite of Comparative Examples 1 to 5.

[0108] [Table 3]

[0109]

[0110] [Table 4]

[0111]

[0112] <Adhesive · composite resin>

[0113] As an example of the dental composition according to the present application, a glass monomer and a glass powder composite of an adhesive and a composite resin were prepared by the above-described method. Table 5 shows the glass composition and dissolution rate of the silicate glass (glass component S6 and commercially available particulate silica RX50), and Table 6 shows the glass composition and dissolution rate of the phosphate glass (glass components PA3, PA4).

[0114] [Table 5]

[0115]

[0116] [Table 6]

[0117]

[0118] <Ion dissolution amount of adhesive · composite resin>

[0119] The glass powder composite prepared by mixing the adhesive material and the composite resin was filled into a ring of Φ 10 mm and 2 mm in thickness, and light irradiation was performed with a light irradiator (G-Light Prima II plus, manufactured by GC Corporation) for 10 seconds at 9 points on the front and back surfaces, respectively, to cure the composition. The obtained cured body was polished on the test surface with a surface #1200-SiC water-resistant abrasive paper. The cured body was immersed in 3 mL of a pH 4.5 acetic acid-sodium acetate buffer and a pH 7.5 HEPES buffer, and stirred at 10 rpm while being stored at 37°C for 1 day. The liquid filtered with a 0.2 μm membrane filter was subjected to ICP-OES to measure the concentration of F 2+ , Sr 2+ , Ca 2+ , Ga 3+ , and the concentration of F - was measured with a fluorine electrode.

[0120] Table 7 shows the mixture of the adhesive material (Examples 1-1, 1-2 and Comparative Examples 1-1, 1-2) and the amount of ions eluted, and Table 8 shows the mixture of the composite resin (Examples 2-1 to 2-4 and Comparative Example 2-1) and the amount of ions eluted.

[0121] [Table 7]

[0122]

[0123] [Table 8]

[0124]

[0125] In addition, the abbreviations in Tables 7 and 8 are as follows.

[0126] Bis-GMA: Bisphenol A diglycidyl methacrylate

[0127] UDMA: Urethane dimethacrylate [di-2-methacryloyloxyethyl-2,2,4-trimethylhexamethylene dicarbamate]

[0128] GDMA: Glyceryl dimethacrylate

[0129] Bis-MEPP: 2,2-bis(4-methacryloyloxyethoxyphenyl)propane

[0130] DCP: Tricyclodecane dimethanol dimethacrylate

[0131] TEGDMA: Triethylene glycol dimethacrylate

[0132] NPG: Neopentyl glycol dimethacrylate

[0133] CQ: Camphorquinone

[0134] EPA: ethyl-p-dimethylaminobenzoate

[0135] TPO: (2,4,6-trimethylbenzoyl) diphenylphosphine oxide

[0136] Tinuvin P: 2-(2-hydroxy-5-methylphenyl)benzotriazole (manufactured by BASF, Tinuvin (registered trademark) P)

[0137] IA: 6-tert-butyl-2,4-dimethylphenol

[0138] BHT: 2,6-di-tert-butyl-p-cresol

[0139] RX50: particulate silica surface-treated with hexamethyldisilazane (manufactured by Aerosil, Aerosil (registered trademark) RX50)

[0140] SO-C2: silica (manufactured by Admatechs, ADMAFINE (registered trademark) SO-C2)

[0141] Further, in the examples of the adhesive material (Examples 1-1, 1-2) and the examples of the composite resin (Examples 2-1 to 2-4) in Tables 5 to 8, the amount of dissolution of at least one or more kinds of ions differs between the acidic and neutral, and the pH responsiveness is exhibited. In contrast, in the comparative examples of the adhesive material (Comparative Examples 1-1 to 1-3) and the comparative example of the composite resin (Comparative Example 2-1), the amount of dissolution of all the ions is greater in the neutral than in the acidic, or is smaller in the neutral than in the acidic, and the pH responsiveness is not exhibited.

[0142] Further, in the examples of the adhesive material (Examples 1-1, 1-2) and the examples of the composite resin (Examples 2-1 to 2-4) in Tables 5 to 8, the amount of dissolution of at least one or more kinds of ions differs between the acidic and neutral, and the pH responsiveness is exhibited. In contrast, in the comparative examples of the adhesive material (Comparative Examples 1-1 to 1-3) and the comparative example of the composite resin (Comparative Example 2-1), the amount of dissolution of all the ions is greater in the neutral than in the acidic, or is smaller in the neutral than in the acidic, and the pH responsiveness is not exhibited.

[0143] Based on these results, it is known that the glass powder composite contained in the dental composition contains the first glass powder and the second glass powder that differ in solubility depending on the pH, and both the first glass powder and the second glass powder have ion release properties, and thus the amount of release of the releaseable ions can be changed in accordance with the change in the acidity in the oral cavity.

[0144] The above-described embodiments include, for example, the following modes.

[0145] (Note 1)

[0146] A dental composition, wherein a glass powder composite is contained,

[0147] The glass powder composite contains a first glass powder, and a second glass powder different from the first glass powder in pH-dependent solubility,

[0148] The first glass powder and the second glass powder each have ion release properties.

[0149] (Paragraph 2)

[0150] The dental composition according to Paragraph 1, wherein the first glass powder is a powder of silicate glass,

[0151] The second glass powder is phosphate glass.

[0152] (Paragraph 3)

[0153] The dental composition according to Paragraph 1 or 2, wherein the first glass powder and the second glass powder each contain at least one element selected from Li, Ca, Sr, Cu, Ag, Zn, B, Ga, and F.

[0154] (Paragraph 4)

[0155] The dental composition according to any one of Paragraphs 1 to 3, wherein at least one of the elements contained in the first glass powder is the same as at least one of the elements contained in the second glass powder.

[0156] (Paragraph 5)

[0157] The dental composition according to any one of Paragraphs 1 to 4, wherein at least one of the elements contained in the first glass powder is different from the elements contained in the second glass powder,

[0158] and at least one of the elements contained in the second glass powder is different from the elements contained in the first glass powder.

[0159] (Paragraph 6)

[0160] The dental composition according to Paragraph 5, wherein the second glass powder has a higher solubility in a neutral region than in an acidic region.

[0161] (Paragraph 7)

[0162] A method for producing a dental composition containing a glass powder composite, wherein

[0163] has a step of mixing a first glass powder, and a second glass powder different from the first glass powder in pH-dependent solubility,

[0164] The first glass powder and the second glass powder each have ion release properties.

[0165] The present application has been described above by way of embodiment, but the present application is not limited to the specific embodiments, and various modifications and changes can be made within the scope of the application described in the patent claims.

[0166] This application claims priority from Japanese Patent Application No. 2023-056115 filed on March 30, 2023, the entire contents of which are incorporated herein by reference.

Claims

1. A dental composition, wherein, a glass powder composite, the glass powder composite contains a first glass powder, and a second glass powder different from the first glass powder in pH-dependent solubility, both the first glass powder and the second glass powder have ion release properties.

2. The dental composition according to claim 1, the first glass powder being a powder of silicate glass, the second glass powder being a phosphate glass.

3. The dental composition according to claim 1, both the first glass powder and the second glass powder contain at least one element selected from Li, Ca, Sr, Cu, Ag, Zn, B, Ga, and F.

4. The dental composition according to claim 1, at least one of the elements contained in the first glass powder is the same as at least one of the elements contained in the second glass powder.

5. The dental composition according to any one of claims 1 to 4, at least one of the elements contained in the first glass powder is different from the elements contained in the second glass powder, and at least one of the elements contained in the second glass powder is different from the elements contained in the first glass powder.

6. The dental composition according to claim 5, the second glass powder has a higher dissolution rate in a neutral region than in an acidic region.

7. A method for producing a dental composition, which is a method for producing a dental composition containing a glass powder composite, wherein there is a step of mixing a first glass powder and a second glass powder different from the first glass powder in pH-dependent solubility, both the first glass powder and the second glass powder have ion release properties.

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