Semen ziziphi spinosae compound superfine powder and preparation method thereof

Abstract

The invention provides spina date seed compound superfine powder and a preparation method thereof, and relates to the field of traditional Chinese medicine compositions. The spina date seed compound superfine powder comprises the following raw materials in parts by weight: 20-30 parts of spina date seeds, 5-10 parts of lucid ganoderma, 5-10 parts of fructus alpiniae oxyphyllae, 1-5 parts of peach kernels, 1-5 parts of chrysanthemums and 50-60 parts of coconut milk powder. The preparation method comprises the following steps: S1, pretreating the raw materials except the coconut milk powder, and coarsely crushing to 80 meshes to obtain coarse medicine powder; s2, respectively adding the coarse medicine powder treated in the step S1 into a jet mill, and carrying out superfine grinding to obtain fine powder; and S3, uniformly mixing the coconut milk powder with the fine powder obtained in the step S2 to obtain the superfine powder. The superfine powder is small in powder particle size, large in specific surface area, more sufficient in active ingredient release and beneficial to human body absorption.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine compositions, and more specifically, to a compound ultrafine powder of jujube seed and its preparation method. Background Technology

[0002] Sour jujube seed is a plant belonging to the genus Ziziphus of the family Rhamnaceae. It has the effect of nourishing the heart and calming the mind, and is a core medicinal material for treating insomnia. Common prescriptions include Sour Jujube Seed Decoction (with Anemarrhena asphodeloides and Poria cocos) for insomnia due to deficiency and restlessness; Sour jujube seed combined with Astragalus membranaceus and Schisandra chinensis for treating excessive sweating due to physical weakness; and Sour jujube seed combined with cinnabar and frankincense for resolving phlegm, calming the nerves, and soothing the mind.

[0003] For traditional Chinese medicine prescriptions, the traditional preparation is a decoction, in which the active ingredients dissolve in the decoction; the second is a powder preparation, in which the raw materials are directly pulverized into fine powder for consumption. Traditional Chinese medicine powder preparation has problems such as low cell wall breakage rate (usually <90%), insufficient release of active ingredients, and easy oxidation and deterioration, especially for raw materials containing oils (such as jujube seed) or heat-sensitive raw materials (such as chrysanthemum). Summary of the Invention

[0004] The purpose of this invention is to provide a compound ultrafine powder of jujube seed, which has a small particle size, a large specific surface area, and more complete release of active ingredients, making it easier for the human body to absorb.

[0005] Another objective of this invention is to provide a method for preparing compound ultrafine powder of jujube seed, which can effectively retain the effective components of each raw material through coarse grinding and ultrafine grinding.

[0006] The technical problem solved by this invention is achieved by the following technical solution.

[0007] On one hand, embodiments of the present invention provide a compound ultrafine powder of jujube seed, which, by weight, includes the following raw materials: 20-30 parts of jujube seed, 5-10 parts of Ganoderma lucidum, 5-10 parts of Alpinia oxyphylla, 1-5 parts of peach kernel, 1-5 parts of chrysanthemum, and 50-60 parts of coconut milk powder.

[0008] In some embodiments of the present invention, the ingredients include the following by weight: 30 parts of jujube seed, 10 parts of Ganoderma lucidum, 10 parts of Alpinia oxyphylla, 5 parts of peach kernel, 5 parts of chrysanthemum, and 60 parts of coconut milk powder.

[0009] In some embodiments of the present invention, the ingredients include the following by weight: 20 parts of jujube seed, 5 parts of Ganoderma lucidum, 5 parts of Alpinia oxyphylla, 1 part of peach kernel, 1 part of chrysanthemum and 50 parts of coconut milk powder.

[0010] In some embodiments of the present invention, the ingredients, by weight, also include [other ingredients].

[0011] In some embodiments of the present invention, the ingredients include the following by weight: 25 parts of jujube seed, 8 parts of Ganoderma lucidum, 10 parts of Alpinia oxyphylla, 3 parts of peach kernel, 3 parts of chrysanthemum, 60 parts of coconut milk powder, 8 parts of lily bulb, 1 part of Platycladus orientalis seed, and 5 parts of Poria cocos.

[0012] On the other hand, embodiments of the present invention provide a method for preparing compound ultrafine powder of jujube seed, which includes the following steps:

[0013] S1. Pre-treat the raw materials other than coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse powder.

[0014] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder;

[0015] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0016] In some embodiments of the present invention, in step S1,

[0017] The pretreatment of Ganoderma lucidum includes the following steps: removing impurities, then drying at a constant temperature of 55℃ for 5 hours, and then raising the temperature to 65℃ and drying for 2 hours;

[0018] The pretreatment of Alpinia oxyphylla includes the following steps: removing impurities, then drying at a constant temperature of 45°C for 3 hours, and then raising the temperature to 55°C to dry until the moisture content of Alpinia oxyphylla is ≤5wt%.

[0019] The pretreatment of peach kernels includes the following steps: removing impurities, and then drying at 50℃ until the moisture content of the peach kernels is ≤5wt%.

[0020] Chrysanthemum pretreatment includes the following steps: removing impurities, and then drying at 45°C until the moisture content of the chrysanthemum is ≤5wt%.

[0021] The pretreatment of jujube kernels includes the following steps: removing impurities, then stir-frying at 120-150℃ until the surface is golden brown, and cooling to room temperature.

[0022] In some embodiments of the present invention, in step S2, the pulverizing pressure of the airflow pulverizer is 0.7-1.2 MPa; the feeding rate is 2-5 kg / h; and the gas medium is nitrogen.

[0023] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0024] The compound ultrafine powder of jujube seed provided by this invention uses jujube seed as the main component, combined with Ganoderma lucidum, Alpinia oxyphylla and other components, and has the effect of nourishing the heart and calming the mind. By using airflow pulverization, the effective components of the raw materials can be retained while the raw materials can be fully pulverized, reducing the particle size of the raw materials, and the active ingredients of the raw materials can be released more fully, which is conducive to human absorption. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0026] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to specific embodiments.

[0027] On one hand, embodiments of the present invention provide a compound ultrafine powder of jujube seed, which, by weight, includes the following raw materials: 20-30 parts of jujube seed, 5-10 parts of Ganoderma lucidum, 5-10 parts of Alpinia oxyphylla, 1-5 parts of peach kernel, 1-5 parts of chrysanthemum, and 50-60 parts of coconut milk powder.

[0028] A preferred formulation, by weight, includes the following ingredients: 30 parts jujube seed, 10 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 5 parts peach kernel, 5 parts chrysanthemum, and 60 parts coconut milk powder.

[0029] A preferred formulation, by weight, includes the following ingredients: 20 parts jujube seed, 5 parts Ganoderma lucidum, 5 parts Alpinia oxyphylla, 1 part peach kernel, 1 part chrysanthemum, and 50 parts coconut milk powder.

[0030] A preferred embodiment, by weight, also includes 5-10 parts of lily bulb, 1-5 parts of cypress seed, and 1-5 parts of poria cocos.

[0031] The preferred formulation, by weight, includes the following ingredients: 25 parts jujube seed, 8 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 3 parts peach kernel, 3 parts chrysanthemum, 60 parts coconut milk powder, 8 parts lily bulb, 1 part Platycladus orientalis seed, and 5 parts Poria cocos.

[0032] The effects of each ingredient are as follows:

[0033] Sour jujube seed (25 portions): Sour jujube seed is the dried mature seed of the sour jujube plant of the Rhamnaceae family. It has a sweet and sour taste, is neutral in nature, and enters the heart, liver, and gallbladder meridians. Its effective components are sour jujube seed saponins A / B and flavonoids, which regulate γ-aminobutyric acid (GABA) receptors, nourish the heart and liver, calm the mind and soothe the nerves, astringe sweat and promote body fluid production. It is mainly used to treat insomnia, palpitations and dreaminess caused by deficiency and restlessness.

[0034] Reishi (8 portions) is the dried fruiting body of Ganoderma lucidum or Ganoderma sinense, a fungus of the Polyporaceae family. It is sweet in taste and neutral in nature, and enters the heart, lung, liver and kidney meridians. Its effective components are Ganoderma lucidum polysaccharides and triterpenoids (such as ganoderic acid). It inhibits the excitability of the central nervous system, reduces cortisol levels, replenishes qi and calms the mind, relieves cough and asthma, and delays aging. It is suitable for insomnia, low immunity and cardiovascular protection.

[0035] Alpinia oxyphylla (10 parts), the dried mature fruit of Alpinia oxyphylla, a plant of the ginger family, has a pungent taste and warm nature. It enters the spleen and kidney meridians, warms the spleen to stop diarrhea, warms the kidneys to consolidate essence, and can improve kidney deficiency, enuresis, sexual dysfunction, etc.

[0036] Peach kernel (3 parts): the dried mature seed of peach or wild peach, a plant of the Rosaceae family. It tastes bitter and sweet, is neutral in nature, and enters the heart, liver, and large intestine meridians. It promotes blood circulation, removes blood stasis, moistens the intestines and relieves constipation. It is often used for amenorrhea, dysmenorrhea, and constipation due to intestinal dryness.

[0037] Chrysanthemum (3 parts): the flower of a perennial herbaceous plant of the Asteraceae family; it dispels wind-heat, calms the liver and improves eyesight, and is mainly used to treat wind-heat colds, headaches and dizziness.

[0038] Coconut milk powder (60 servings) is a powdered product made from fresh coconut meat through processes such as crushing, shelling, peeling, stirring, concentrating, and drying. It supplements nutrition, enhances immunity, and beautifies the skin, and is rich in vitamin E and minerals.

[0039] Lily (8 portions), the active ingredients are lily saponins and polysaccharides, which moisten the lungs and relieve cough, calm the mind and soothe the nerves, and improve insomnia, anxiety and dry cough due to yin deficiency.

[0040] Arborvitae seed kernel (1 part), the effective ingredients are fatty oil (containing linoleic acid) and arborvitae seed saponins, which nourish the heart and calm the mind, moisten the intestines and promote bowel movement, and assist in the treatment of palpitations, insomnia and constipation due to intestinal dryness.

[0041] Poria cocos (5 parts), the effective components are poria cocos polysaccharide and triterpenic acid, which promote diuresis and eliminate dampness, strengthen the spleen and calm the mind, regulate the retention of dampness and restlessness.

[0042] The combination of jujube seed and Ganoderma lucidum: saponins and polysaccharides synergistically enhance the inhibition of GABAergic nerves and improve insomnia;

[0043] Lily bulbs and cypress seeds, when combined, can regulate the heart and lungs, and are especially suitable for menopausal hot flashes and insomnia.

[0044] The combination of Poria cocos and coconut milk powder: strengthens the spleen and eliminates dampness, prevents greasy and cloying substances from hindering the stomach, and ensures the absorption of sedative drugs.

[0045] On the other hand, embodiments of the present invention provide a method for preparing compound ultrafine powder of jujube seed, which includes the following steps:

[0046] S1. Pre-treat the raw materials other than coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse powder.

[0047] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder;

[0048] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0049] In some embodiments of the present invention, in step S1,

[0050] The pretreatment of Ganoderma lucidum includes the following steps: removing impurities, then drying at a constant temperature of 55℃ for 5 hours, and then raising the temperature to 65℃ and drying for 2 hours;

[0051] The pretreatment of Alpinia oxyphylla includes the following steps: removing impurities, then drying at a constant temperature of 45°C for 3 hours, and then raising the temperature to 55°C to dry until the moisture content of Alpinia oxyphylla is ≤5wt%.

[0052] The pretreatment of peach kernels includes the following steps: removing impurities, and then drying at 50℃ until the moisture content of the peach kernels is ≤5wt%.

[0053] Chrysanthemum pretreatment includes the following steps: removing impurities, and then drying at 45°C until the moisture content of the chrysanthemum is ≤5wt%.

[0054] The pretreatment of jujube kernels includes the following steps: removing impurities, then stir-frying at 120-150℃ until the surface is golden brown, and cooling to room temperature.

[0055] The pretreatment of cypress seed kernels includes the following steps: stir-frying at 150-170℃ for 15 minutes, and then cooling to room temperature.

[0056] In some embodiments of the present invention, in step S2, the pulverizing pressure of the airflow pulverizer is 0.7-1.2 MPa; the feeding rate is 2-5 kg / h; and the gas medium is nitrogen.

[0057] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0058] Example 1

[0059] Prepare the ingredients according to the following proportions:

[0060] 30 parts jujube seed, 10 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 5 parts peach kernel, 5 parts chrysanthemum, and 60 parts coconut milk powder.

[0061] The ultrafine powder of this embodiment was prepared according to the following method:

[0062] S1. Pre-treat the raw materials other than coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse powder.

[0063] Among them, the Ganoderma lucidum pretreatment is as follows: remove impurities, then dry at a constant temperature of 55℃ for 5 hours, and then raise the temperature to 65℃ and dry for 2 hours;

[0064] Pretreatment of Alpinia oxyphylla: Remove impurities, then dry at a constant temperature of 45℃ for 3 hours, then raise the temperature to 55℃ and dry until the moisture content of Alpinia oxyphylla is ≤5wt%.

[0065] Peach kernel pretreatment: Remove impurities, and then dry at 50℃ until the moisture content of the peach kernel is ≤5wt%.

[0066] Chrysanthemum pretreatment: remove impurities, and then dry at 45℃ until the moisture content of the chrysanthemum is ≤5wt%.

[0067] Pretreatment of jujube seeds: Remove impurities, then stir-fry at 140-150℃ until the surface is golden brown, and cool to room temperature.

[0068] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder; wherein, the grinding pressure of the air jet mill is 1.2MPa; the feeding speed is 3Kg / h; and the gas medium is nitrogen.

[0069] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0070] Example 2

[0071] Prepare the ingredients according to the following proportions:

[0072] 20 parts jujube seed, 5 parts Ganoderma lucidum, 5 parts Alpinia oxyphylla, 1 part peach kernel, 1 part chrysanthemum, and 50 parts coconut milk powder.

[0073] The ultrafine powder of this embodiment was prepared according to the following method:

[0074] S1, pre-treat the raw materials except coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse medicinal powder; wherein, the pre-treatment methods of Ganoderma lucidum, Alpinia oxyphylla, peach kernel, chrysanthemum and jujube kernel are the same as those in Example 1.

[0075] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder; wherein, the grinding pressure of the air jet mill is 0.8MPa; the feeding speed is 2Kg / h; and the gas medium is nitrogen.

[0076] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0077] Example 3

[0078] Prepare the ingredients according to the following proportions:

[0079] 25 parts of jujube seed, 8 parts of Ganoderma lucidum, 10 parts of Alpinia oxyphylla, 3 parts of peach kernel, 3 parts of chrysanthemum, 60 parts of coconut milk powder, 8 parts of lily bulb, 1 part of cypress seed, and 5 parts of Poria cocos.

[0080] The ultrafine powder of this embodiment was prepared according to the following method:

[0081] S1, pre-treat the raw materials except coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse medicinal powder; wherein, the pre-treatment methods of Ganoderma lucidum, Alpinia oxyphylla, peach kernel, chrysanthemum and jujube kernel are the same as those in Example 1.

[0082] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder; wherein, the grinding pressure of the air jet mill is 0.7MPa; the feeding speed is 2Kg / h; and the gas medium is nitrogen.

[0083] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0084] Example 4

[0085] Prepare the following ingredients in the following proportions: 30 parts jujube seed, 10 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 5 parts peach kernel, 5 parts chrysanthemum, 60 parts coconut milk powder, 10 parts lily bulb, 5 parts cypress seed, and 5 parts Poria cocos.

[0086] The ultrafine powder of this embodiment was prepared according to the following method:

[0087] S1, pre-treat the raw materials except coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse medicinal powder; wherein, the pre-treatment methods of Ganoderma lucidum, Alpinia oxyphylla, peach kernel, chrysanthemum and jujube kernel are the same as those in Example 1.

[0088] S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder; wherein, the grinding pressure of the air jet mill is 1.2MPa; the feeding speed is 5Kg / h; and the gas medium is nitrogen.

[0089] S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

[0090] Example 5

[0091] Prepare the ingredients according to the following proportions: 20 parts jujube seed, 5 parts Ganoderma lucidum, 5 parts Alpinia oxyphylla, 1 part peach kernel, 1 part chrysanthemum, 50 parts coconut milk powder, 8 parts lily bulb, 1 part cypress seed, and 5 parts Poria cocos.

[0092] The ultrafine powder of this embodiment was prepared according to the method of Example 1.

[0093] Experimental Example

[0094] Using the ultrafine powders from Examples 1-5 as test subjects, 10g was added to drinking water at 50℃ and stirred evenly to obtain a mixed liquid;

[0095] Fifty healthy volunteers with normal taste and smell were randomly divided into 5 groups to evaluate the mixed liquids of Examples 1-5. The results are shown in Table 1.

[0096] Table 1

[0097]

[0098]

[0099] The taste evaluation criteria are as follows: smooth and without graininess 9-10 points; smooth taste with slight graininess 7-8 points; rough taste with obvious graininess 5-6 points; rough taste with large grains 4-5 points.

[0100] As can be seen from Table 1, the compound ultrafine powder of jujube seed provided in Examples 1-5 of the present invention has a delicate taste and no obvious particle feel after being mixed with water, and has good solubility, so that there is no obvious particle feel when eating.

[0101] In summary, the compound ultrafine powder of jujube seed provided in this embodiment of the invention uses jujube seed as the main component, combined with Ganoderma lucidum, Alpinia oxyphylla and other components, and has the effect of nourishing the heart and calming the mind. By using airflow pulverization, the effective components of the raw materials can be retained while the raw materials can be fully pulverized, reducing the particle size of the raw materials, and the active ingredients of the raw materials can be released more fully, which is conducive to human absorption.

[0102] The embodiments described above are some, but not all, embodiments of the present invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

Claims

1. A compound ultrafine powder of jujube seed, characterized in that, By weight, it includes the following ingredients: 20-30 parts jujube seed, 5-10 parts Ganoderma lucidum, 5-10 parts Alpinia oxyphylla, 1-5 parts peach kernel, 1-5 parts chrysanthemum, and 50-60 parts coconut milk powder.

2. The compound ultrafine powder of jujube seed according to claim 1, characterized in that, By weight, it includes the following ingredients: 30 parts jujube seed, 10 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 5 parts peach kernel, 5 parts chrysanthemum, and 60 parts coconut milk powder.

3. The compound ultrafine powder of jujube seed according to claim 1, characterized in that, By weight, it includes the following ingredients: 20 parts jujube seed, 5 parts Ganoderma lucidum, 5 parts Alpinia oxyphylla, 1 part peach kernel, 1 part chrysanthemum, and 50 parts coconut milk powder.

4. The compound ultrafine powder of jujube seed according to claim 1, characterized in that, By weight, it also includes 5-10 parts of lily bulb, 1-5 parts of cypress seed, and 1-5 parts of poria cocos.

5. The method for preparing compound ultrafine powder of jujube seed according to claim 4, characterized in that, By weight, it includes the following ingredients: 25 parts jujube seed, 8 parts Ganoderma lucidum, 10 parts Alpinia oxyphylla, 3 parts peach kernel, 3 parts chrysanthemum, 60 parts coconut milk powder, 8 parts lily bulb, 1 part cypress seed, and 5 parts Poria cocos.

6. A method for preparing the compound ultrafine powder of jujube seed as described in any one of claims 1-5, characterized in that, It includes the following steps: S1. Pre-treat the raw materials other than coconut milk powder, and then coarsely grind them to 80 mesh to obtain coarse powder. S2, the coarse powder processed in step S1 is added to an air jet mill for ultra-fine grinding into fine powder; S3, mix the coconut milk powder with the fine powder from step S2 until uniform, and the ultrafine powder is obtained.

7. The preparation method of the compound ultrafine powder of jujube seed according to claim 6, characterized in that, In step S1, The pretreatment of Ganoderma lucidum includes the following steps: removing impurities, then drying at a constant temperature of 55℃ for 5 hours, and then raising the temperature to 65℃ and drying for 2 hours; The pretreatment of Alpinia oxyphylla includes the following steps: removing impurities, then drying at a constant temperature of 45°C for 3 hours, and then raising the temperature to 55°C to dry until the moisture content of Alpinia oxyphylla is ≤5wt%. The pretreatment of peach kernels includes the following steps: removing impurities, and then drying at 50℃ until the moisture content of the peach kernels is ≤5wt%. Chrysanthemum pretreatment includes the following steps: removing impurities, and then drying at 45°C until the moisture content of the chrysanthemum is ≤5wt%. The pretreatment of jujube kernels includes the following steps: removing impurities, then stir-frying at 120-150℃ until the surface is golden brown, and cooling to room temperature.

8. The preparation method of the compound ultrafine powder of jujube seed according to claim 6, characterized in that, In step S2, the pulverizing pressure of the air jet mill is 0.7-1.2 MPa; the feeding rate is 2-5 kg / h; and the gas medium is nitrogen.

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