Method for promoting skin repair by using sponge spicule to assist exosome transdermal delivery
By using sponge spicule pretreatment and liposome fusion freeze-drying technology, the problems of easy inactivation of exosomes at room temperature and low transdermal efficiency were solved, achieving a highly efficient skin repair effect.
CN121015548AActive Publication Date: 2025-11-28SHENZHEN BAIYUE BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202511320789.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-16
- Publication Date
- 2025-11-28
- Estimated Expiration
- 2045-09-16
AI Technical Summary
Technical Problem
Exosomes are easily inactivated at room temperature and have low transdermal delivery efficiency, making them difficult to use effectively for skin repair under normal conditions.
Method used
The skin is pretreated with sponge-like bone needles to create micron-level physical channels. These channels are then fused with liposomes and exosome membranes to form lyophilized vesicles. Functional phospholipids such as DC-PT-PE and PEG-PT-PE are combined to improve the in vitro storage stability and transdermal utilization of exosomes.
Benefits of technology
Exosome vesicles maintained an activity rate of over 83% after 30 days of storage at room temperature and 80% after 180 days of storage, significantly improving transdermal delivery efficiency and skin repair effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a method for promoting skin repair by assisting exosome transdermal delivery through a sponge spicule. The method comprises the following steps: pretreating skin by using a composition containing the sponge spicule; mixing the exosome vesicle freeze-dried powder with a redissolving medium at 5-40 DEG C, and then applying the mixture to the skin; the exosome vesicle freeze-dried powder is obtained by performing membrane fusion on exosome and liposome to obtain exosome vesicles and then performing freeze drying. According to the invention, the skin is pretreated by using the composition containing the sponge bone needle, the skin barrier resistance is reduced, the skin repair response is stimulated, and then the exosome vesicles are re-dissolved and then applied to the skin surface, so that the transdermal utilization rate of exosome contents is promoted. The exosome vesicle provided by the invention has good in-vitro storage stability, and after the exosome vesicle is stored at 0-5 DEG C for 180 days, the activity retention rate after redissolution is 80% or above.
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