Nano vesicle, preparation method and application of nano vesicle in preparation of endometrial injury repair medicine

By preparing nanovesicles derived from the ethanol extract of American cockroaches, the problems of unstable raw material sources and limited applications of nanovesicles in existing technologies have been solved, enabling the effective application of high-purity nanovesicles in the repair of endometrial damage and significantly restoring the structure and function of the endometrium.

CN121129904APending Publication Date: 2025-12-16SHENZHEN LUOHU PEOPLELS HOSPITAL
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Patent Information

Application Number
CN202511647376.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-11
Publication Date
2025-12-16

AI Technical Summary

Technical Problem

Current technologies have not systematically developed methods for obtaining American cockroach-derived nanovesicles using ethanol extracts as starting materials through artificial enrichment, and these nanovesicles have not been applied to the field of endometrial injury. Traditional treatment methods have limited effectiveness in treating endometrial injury.

Method used

Using American cockroach ethanol extract as raw material, nanovesicles are prepared through steps such as dilution, differential centrifugation, filtration and ultracentrifugation to remove mucus and macromolecular aggregates, thereby improving purity and yield. This method is suitable for endometrial damage repair.

Benefits of technology

The prepared nanovesicles have high purity and are suitable for large-scale production. They can significantly restore endometrial thickness, increase glandular number, and improve collagen deposition structure, thus exhibiting good endometrial regeneration effects.

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Abstract

The invention relates to the technical field of modernization of traditional Chinese medicines, in particular to a nano-vesicle, a preparation method and application of the nano-vesicle in preparation of an endometrial injury repairing medicine. The preparation method comprises the following steps: taking a periplaneta americana ethanol extracting solution, and adding a buffer solution to prepare diluted homogenate; performing differential centrifugal treatment on the homogenate; filtering the supernatant obtained by the differential centrifugation treatment, and then centrifuging for 60-120 minutes by 100000g of the supernatant to obtain a precipitate; and re-suspending the precipitate to obtain the periplaneta americana ethanol extract source nano-vesicles. The periplaneta americana ethanol extract is used as a starting material to enrich the nano-vesicles for the first time, the combined process of differential centrifugation, membrane filtration and ultracentrifugation is adopted, the obtained nano-vesicles can be applied to the field of endometrial injury repair, especially treatment of gynecological diseases such as intrauterine adhesion and infertility with thin intima, and the blank in the technical field is filled.
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