Processing technology for improving stability of baicalin in liquid preparation and processing equipment thereof

Abstract

The invention relates to a processing technology and processing equipment for improving stability of baicalin in a liquid preparation, and the processing technology comprises the following specific operation steps: optimizing a prescription: controlling the pH value of the preparation to be 5.5-6.0 by adopting a phosphate buffer system, and meanwhile, adding vitamin E as an antioxidant; improving the process: sterilizing by adopting a two-stage filtration sterilization technology; during filling, nitrogen is filled through the filling device to replace oxygen; packaging improvement: selecting an oral liquid medicinal high-density polyethylene bottle containing an opacifying agent as a packaging material; quality control: monitoring the pH value of the preparation in real time in the production process, and setting that the baicalin content is reduced to 90% of the labeled amount as a quality warning line; the pH is accurately controlled within the optimal stable interval of 5.5-6.0, and vitamin E is supplemented for resisting oxidation, so that hydrolysis and oxidation pathways of baicalin are chemically and essentially inhibited.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, and particularly relates to a processing technology for improving the stability of baicalin in liquid preparation and a processing device thereof. BACKGROUND

[0002] Baicalin is the core effective component of traditional Chinese medicine Huangqi, but its stability in liquid preparation is poor, and it is easily affected by factors such as pH value, oxygen and light to cause hydrolysis and oxidative degradation, resulting in a decrease in content and a decrease in efficacy.

[0003] The existing production process is improved at a certain link, such as single pH adjustment or addition of an antioxidant, and lacks a systematic solution from the prescription, sterilization, filling to packaging, especially in the filling link, the conventional method is difficult to effectively exclude the oxygen in the container and continuously isolate the air in the filling process, so that the baicalin starts to oxidize at the initial stage of storage. SUMMARY

[0004] The problem solved by the present application is to provide a processing technology for improving the stability of baicalin in liquid preparation and a processing device thereof, which systematically inhibits the degradation of baicalin by accurately controlling the pH value, adding a specific antioxidant, using mild sterilization, and combining nitrogen filling protection at three stages before, during and after filling.

[0005] In order to achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0006] A processing technology for improving the stability of baicalin in liquid preparation, the specific operation steps of the processing technology are as follows:

[0007] Step one, prescription optimization: the pH value of the preparation is controlled in the interval of 5.5-6.0 by using a phosphate buffer system, and vitamin E is added as an antioxidant;

[0008] Step two, process improvement: sterilization is performed by using a two-stage filtration sterilization technology; when filling, nitrogen gas is filled by a filling device to replace oxygen;

[0009] Step three, packaging improvement: an oral liquid medicinal high-density polyethylene bottle containing a light shielding agent is selected as a packaging material;

[0010] Step four, quality control: the pH value of the preparation is monitored in real time during the production process, and the content of baicalin is set to 90% of the marked amount as the quality warning line.

[0011] Preferably, the addition amount of vitamin E is 0.1% of the total mass of the preparation.

[0012] Preferably, the secondary filter sterilization technology includes pipeline sterilization filter and terminal sterilization filter, the filter membrane material of the secondary filter sterilization technology is polytetrafluoroethylene, and the pore size is 0.2 μm.

[0013] Preferably, the oxygen concentration in the container after filling nitrogen is less than 0.5%, and the light transmittance of the packaging material is less than 10%.

[0014] Preferably, the filling device comprises a rack, an annular bottom plate is arranged on the rack, a side baffle is arranged outside the annular bottom plate, and a feeding opening and a discharging opening are formed in the side baffle, two wheels are mounted at both ends of the rack, a synchronous belt is drivingly mounted between the two wheels, a plurality of transmission blocks are equidistantly mounted outside the synchronous belt, a limiting plate is formed in the transmission block, a limiting groove is formed in the limiting plate, an adjusting ring seat is mounted on one end of the side baffle through a support arm, a rotating seat is mounted on one of the wheels, a plurality of mounting arms are equiangularly mounted outside the rotating seat, and the mounting arms are connected with the front nitrogen filling mechanism, the front nitrogen filling mechanism corresponds to the transmission block, a rear nitrogen filling seat and an arc-shaped sealing seat are mounted on the other end of the side baffle, a nitrogen filling nozzle is mounted at the bottom side of the rear nitrogen filling seat, a bottle opening groove is formed in the arc-shaped sealing seat, and a nitrogen hole is formed in the bottle opening groove.

[0015] An electric sliding rail is mounted on the side wall of the side baffle, an electric sliding arm is slidingly mounted on the electric sliding rail, a mounting frame is mounted on the electric sliding arm, an air cylinder is mounted on the mounting frame, a lifting seat is mounted at the extension end of the air cylinder, a plurality of filling heads are equidistantly mounted at the bottom side of the lifting seat, a fixing frame is mounted on the side wall of the mounting frame, a plurality of annular spray seats are equidistantly mounted on the fixing frame, and the filling heads penetrate through the annular spray seats, and a plurality of downwardly inclined spray holes are equiangularly formed in the inner side of the annular spray seat.

[0016] Preferably, a speed reducer is mounted at the bottom side of the rack, and the output end of the speed reducer is connected with one of the wheels, and the input end of the speed reducer is connected with the output end of the motor.

[0017] Preferably, the adjusting ring seat comprises a separation section, a gradual change section and a pressing section, the gradual change section is arranged between the separation section and the pressing section, and the height of the separation section is higher than that of the pressing section.

[0018] Preferably, the front nitrogen filling mechanism comprises a sleeve connected with the mounting arm, a multi-edge shaft is elastically penetrated in the sleeve, a sealing seat is mounted at the bottom end of the multi-edge shaft, a bottle opening pressing hole is formed in the sealing seat, a ball seat is mounted at the top end of the multi-edge shaft, and balls rolling along the bottom side of the adjusting ring seat are mounted on the ball seat.

[0019] A lifting baffle is mounted on the multi-edge shaft and in the sleeve, a spring is sleeved outside the multi-edge shaft and in the sleeve, and the spring is located between the bottom wall of the sleeve and the lifting baffle.

[0020] Preferably, the first rotary joint and the second rotary joint are installed in the transposition, the fixed end of the first rotary joint is connected with the sealing seat through a plurality of first connecting pipes, the fixed end of the second rotary joint is connected with the sealing seat through a plurality of second connecting pipes, and the first connecting pipes and the second connecting pipes are both provided with control valves.

[0021] Preferably, the rotating end of the first rotary joint is provided with a first nitrogen pipe, the rotating end of the second rotary joint is connected with the vacuum pump on the belt wheel through a pipeline, the rear nitrogen filling seat and the arc-shaped sealing seat are both provided with a second nitrogen pipe, and the first nitrogen pipe, the second nitrogen pipe and the annular spraying seat are connected with a nitrogen pump.

[0022] The beneficial effects of the present application are:

[0023] Systematically improve stability: by accurately controlling the pH in the best stable interval of 5.5-6.0, and supplemented by vitamin E antioxidant, the hydrolysis and oxidation pathways of baicalin are inhibited from the chemical nature, the baicalin content retention rate of the product after the treatment of the method can be improved from 75% to more than 93% after 12 months of storage at 25℃, the destruction of baicalin by high-temperature sterilization is completely avoided by adopting 0.2 μm polytetrafluoroethylene filter membrane for secondary filtration and sterilization, and the loss of heat-sensitive ingredients is reduced by about 30%; nitrogen filling before filling effectively eliminates the oxidation effect of oxygen, and forms a whole-chain stability guarantee system from the inside prescription (pH, antioxidant) → production process (sterilization, oxygen isolation) → external packaging (light shielding), which solves the limitations of single measure;

[0024] Extreme oxygen isolation during filling: through the triple protection of "pre-vacuum nitrogen filling → nitrogen curtain protection during filling → supplementary nitrogen filling after filling", oxygen is maximally excluded and isolated, and the oxidation bottleneck in the filling link is solved;

[0025] Automation and intelligentization: the filling device has high automation degree, realizes continuous operation of nitrogen filling, filling and sealing, and is combined with online pH monitoring, content alarm line and other quality control means, so that the uniformity and reliability of product quality are guaranteed;

[0026] Production efficiency and environmental protection: mild filtration and sterilization avoid the destruction of effective components by high temperature, and precise nitrogen filling reduces nitrogen consumption, and the automatic production line improves the overall efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0027] Figure 1 It is a degradation rate curve diagram of baicalin under different pH conditions in the present application;

[0028] Figure 2 It is a comparison diagram of baicalin component retention rate under light conditions by using ordinary packaging and light shielding packaging in the present application.

[0029] Figure 3 The first structure schematic view of the filling device of the present application;

[0030] Figure 4 The second structure schematic view of the filling device of the present application;

[0031] Figure 5 The side view of the filling device of the present application;

[0032] Figure 6 The first structure schematic view of the adjusting ring seat of the present application;

[0033] Figure 7 The second structure schematic view of the adjusting ring seat of the present application;

[0034] Figure 8 The structure schematic view of the front nitrogen charging mechanism of the present application.

[0035] Legend:

[0036] 1, rack; 2, annular bottom plate; 3, side baffle; 4, upper and lower feeding port; 5, pulley; 6, synchronous belt; 7, transmission block; 8, limiting plate; 9, speed reducer; 10, motor; 11, supporting arm; 12, adjusting ring seat; 13, separation section; 14, gradual change section; 15, pressing section; 16, rotating seat; 17, mounting arm; 18, front nitrogen charging mechanism; 19, sleeve; 20, polygonal shaft; 21, sealing seat; 22, bottle mouth pressing hole; 23, ball seat; 24, ball; 25, limiting plate; 26, spring; 27, first rotary joint; 28, second rotary joint; 29, first connecting pipe; 30, second connecting pipe; 31, control valve; 32, first nitrogen pipe; 33, vacuum pump; 34, electric sliding rail; 35, electric sliding arm; 36, mounting frame; 37, pneumatic cylinder; 38, lifting seat; 39, filling head; 40, fixed frame; 41, annular spraying seat; 42, rear nitrogen charging seat; 43, nitrogen charging spraying head; 44, arc-shaped sealing seat; 45, bottle mouth groove; 46, second nitrogen pipe. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0038] The specific embodiments are given below.

[0039] Reference is made to Figure 1 and Figure 2A method for improving the stability of baicalin content in liquid preparation, comprising the following steps:

[0040] Step 1, prescription optimization: the pH value of the preparation is accurately controlled in the stable interval of 5.5-6.0 by using phosphate buffer system, and vitamin E is added as antioxidant at 0.1% of the total mass of the preparation;

[0041] Step 2, process improvement: sterilization is performed by using secondary filtration sterilization technology, the filter membrane material of the secondary filter is polytetrafluoroethylene, and the pore size is 0.2 μm; nitrogen is filled into the liquid preparation and the packaging container before filling, and oxygen is replaced, so that the oxygen concentration in the container is less than 0.5%;

[0042] Step 3, packaging improvement: high-density polyethylene bottles containing light shielding agent for oral liquid medicine are selected as packaging materials, and the light transmittance of the packaging materials is less than 10%;

[0043] Step 4, quality control: the pH value of the preparation is monitored in real time during production to ensure that it is stable in the range of 5.5-6.0, the decrease of baicalin content to 90% of the labeled amount is set as the quality warning line, and a warning mechanism is established.

[0044] See Figures 3-8The filling device comprises a rack 1, an annular bottom plate 2 arranged on the rack 1, side baffles 3 arranged outside the annular bottom plate 2, and feeding and discharging openings 4 arranged on the side baffles 3, two pulleys 5 installed at the two ends of the rack 1, a synchronous belt 6 drivingly installed between the two pulleys 5, a plurality of transmission blocks 7 installed at equal intervals outside the synchronous belt 6, a limiting plate 8 arranged on the transmission block 7, and a limiting groove arranged on the limiting plate 8, a speed reducer 9 installed at the bottom side of the rack 1, with the output end of the speed reducer 9 connected with one of the pulleys 5, the input end of the speed reducer 9 connected with the output end of a motor 10, the motor 10 driving the synchronous belt 6 to circularly rotate on an annular path through the speed reducer 9, thus forming a continuous conveying system, realizing automatic feeding, circulation and discharging of the filling containers, greatly improving the production efficiency, and providing a fixed position for each filling container through the limiting plate 8 on the transmission block 7 and the limiting groove, thus ensuring that the containers will not be inclined or tilted during the conveying process. The annular bottom plate 2 and the side baffles 3 jointly form a closed conveying channel, thus ensuring the accuracy and stability of the container movement path, laying a foundation for accurate operation of subsequent stations. The side baffles 3 are installed with an adjusting ring seat 12 at one end through a support arm 11, the adjusting ring seat 12 comprises a separation section 13, a gradual change section 14 and a pressing section 15, the gradual change section 14 is arranged between the separation section 13 and the pressing section 15, and the height of the separation section 13 is higher than that of the pressing section 15. One of the pulleys 5 is installed with a rotating seat 16, a plurality of mounting arms 17 are installed at equal angles outside the rotating seat 16, and the mounting arms 17 are connected with a front nitrogen filling mechanism 18 corresponding to the transmission block 7. The front nitrogen filling mechanism 18 comprises a sleeve 19 connected with the mounting arm 17, a multi-edge shaft 20 elastically penetrating through the sleeve 19, a sealing seat 21 installed at the bottom end of the multi-edge shaft 20, a bottle opening pressing hole 22 arranged in the sealing seat 21, a ball seat 23 installed at the top end of the multi-edge shaft 20, balls 24 rolling along the bottom side of the adjusting ring seat 12 installed on the ball seat 23, a lifting baffle 25 installed on the multi-edge shaft 20 and located in the sleeve 19, a spring 26 sleeved outside the multi-edge shaft 20 and located in the sleeve 19 between the bottom wall of the sleeve 19 and the lifting baffle 25, a first rotary joint 27 and a second rotary joint 28 installed in the rotating seat 16, a fixed end of the first rotary joint 27 connected with the sealing seat 21 through a plurality of first connecting pipes 29, a fixed end of the second rotary joint 28 connected with the sealing seat 21 through a plurality of second connecting pipes 30, and control valves 31 installed on the first connecting pipes 29 and the second connecting pipes 30. Through the ingenious mechanical structure, the adjusting ring seat 12 controls the lifting of the balls 24, and then drives the sealing seat 21 to press the bottle opening through the multi-edge shaft 20. Combined with a vacuum pump 33 and a nitrogen source, the full-automatic operation of vacuumizing the container first and then filling nitrogen into the container is realized, which can maximize the removal of oxygen in the container and prevent the oxidation of liquid medicine from the source. The spring 26 provides stable pressing force to ensure that the sealing seat 21 is tightly combined with the bottle opening to prevent leakage. The design of the multi-edge shaft 20 prevents the rotation of the mechanism itself, thus ensuring the reliability of the action.The use of the rotary joint enables the fixed pipeline to continuously provide vacuum and nitrogen for multiple nitrogen filling heads in the rotating station, and the structure is ingenious and realizes dynamic sealing.

[0045] The other end of the side baffle 3 is provided with a rear nitrogen filling seat 42 and an arc-shaped sealing seat 44. The bottom side of the rear nitrogen filling seat 42 is provided with a nitrogen filling nozzle 43. The arc-shaped sealing seat 44 is provided with a bottle opening groove 45, and the bottle opening groove 45 is provided with a nitrogen hole. The rotating end of the first rotary joint 27 is provided with a first nitrogen pipe 32. The rotating end of the second rotary joint 28 is connected with a vacuum pump 33 on the belt wheel 5 through a pipeline. The rear nitrogen filling seat 42 and the arc-shaped sealing seat 44 are both provided with a second nitrogen pipe 46. The first nitrogen pipe 32, the second nitrogen pipe 46 and the annular nozzle seat 41 are connected with a nitrogen pump.

[0046] The side wall of the side baffle 3 is provided with an electric sliding rail 34. The electric sliding rail 34 is slidably provided with an electric sliding arm 35. The electric sliding arm 35 is provided with a mounting bracket 36. The mounting bracket 36 is provided with a pneumatic cylinder 37. The pneumatic cylinder 37 is provided with a lifting seat 38 at the extension end. The bottom side of the lifting seat 38 is provided with a plurality of filling heads 39 at equal intervals. The side wall of the mounting bracket 36 is provided with a fixing frame 40. The fixing frame 40 is provided with a plurality of annular nozzle seats 41 at equal intervals. The filling heads 39 penetrate the annular nozzle seats 41. A plurality of downwardly inclined nozzles are formed at equal angles in the inner side of the annular nozzle seat 41. The annular nozzle seat 41 forms a downward nitrogen curtain outside the filling head 39, effectively preventing air from being drawn into the filling process. After filling, the rear nitrogen filling seat 42 supplements nitrogen to the space above the liquid surface, replacing the possible air entering. Subsequently, the arc-shaped sealing seat 44 performs the last nitrogen sealing on the bottle opening before the gland, realizing the oxygen-free environment protection from the beginning of filling to the gland, realizing precise and anti-dripping filling. The pneumatic cylinder 37 drives the filling head 39 to stably ascend and descend, and accurately inserts into the bottle. The nitrogen flow of the annular nozzle seat 41 can also blow off the residual liquid drops on the surface of the filling head 39 when it is lifted, preventing liquid hanging and cross contamination, ensuring filling accuracy and hygiene. The electric sliding rail 34 and the electric sliding arm 35 allow the entire filling unit to move, facilitating the adjustment of the station or the adaptation to different specifications of the production line, enhancing the adaptability and automation degree of the equipment.

[0047] The working principle of the filling device is as follows: the filling container is conveyed to the limiting groove of the limiting plate 8 through the feeding machine, the motor 10 drives the belt pulley 5 to rotate, and then drives the synchronous belt 6 to drive the transmission block 7 and the limiting plate 8 to move, and then drives the filling container to move on the annular bottom plate 2, and is blocked by the side baffle 3, when the filling container moves to the lower side of the front nitrogen charging mechanism 18, at this time, the corresponding ball 24 of the front nitrogen charging mechanism 18 moves from the separation section 13 of the adjusting ring seat 12 to the compression section 15, the ball 24 enters the compression section 15 through the gradual change section 14, at this time, the ball 24 and the ball seat 23 drive the multi-edge shaft 20 to move downward, the lifting baffle 25 is compressed by the spring 26 at the same time, the bottle opening pressing hole 22 of the sealing seat 21 is pressed on the filling container, and the filling container is sealed, at this time, the control valve 31 corresponding to the filling container is opened, the vacuum pump 33 works, the air in the filling container is pumped out through the second rotary joint 28 and the second connecting pipe 30, then nitrogen is delivered to the filling container through the first nitrogen pipe 32, and the front nitrogen charging operation of the filling container is completed, when the filling container moves to the filling station with the device, at this time, the ball 24 enters the separation section 13 through the gradual change section 14, the compressed spring 26 restores the original state to drive the lifting baffle 25 and the multi-edge shaft 20 to move upward, at this time, the sealing seat 21 is separated from the bottle opening of the filling container, the lifting seat 38 and the filling head 39 are lifted by the pneumatic cylinder 37, during filling, the filling head 39 is lowered and inserted into the filling container, after filling is completed, the filling head 39 is separated from the filling container, and in the filling process of the filling head 39, nitrogen is sprayed in the annular spray seat 41, which can not only prevent air from entering the filling container, but also blow the solution on the surface of the filling head 39 into the filling container during the lifting of the filling head 39, so as to avoid residue on the filling head 39, when the filling container moves to the rear filling station with the device, at this time, the nitrogen injection head 43 of the rear nitrogen charging seat 42 injects nitrogen into the filling container, then the bottle opening is located in the bottle opening groove 45 of the arc-shaped sealing seat 44 when the filling container continues to move, nitrogen is continuously sprayed in the arc-shaped sealing seat 44 to prevent air from entering the filling container, when the filling container moves out of the arc-shaped sealing seat 44, the capping device is used to complete the capping work, and finally the filling container is discharged from the upper and lower discharge ports 4.

[0048] The above is only a preferred specific embodiment of the present application, but the protection scope of the present application is not limited thereto, any person skilled in the art can make equivalent replacement or change according to the technical scheme and the inventive concept of the present application within the technical range disclosed by the present application, which should be covered in the protection scope of the present application.

Claims

1. A process for improving the stability of baicalin in a liquid formulation, characterized in that, Specific operation steps of the processing technology are as follows: Step one, prescription optimization: the pH value of the preparation is controlled in the interval of 5.5-6.0 by adopting phosphate buffer system, and vitamin E is added as an antioxidant; Step two, process improvement: sterilization is carried out by adopting secondary filtration sterilization technology; when filling, nitrogen is filled by filling device to replace oxygen; Step three, package improvement: high-density polyethylene bottles containing light-shielding agent for oral liquid medicine are selected as packaging materials; Step four, quality control: the pH value of the preparation is monitored in real time during production, and the content of baicalin is set to decrease to 90% of the marked amount as a quality warning line.

2. The process for improving the stability of baicalin in liquid preparation according to claim 1, characterized in that, The added amount of vitamin E is 0.1% of the total mass of the preparation.

3. The process for improving the stability of baicalin in liquid preparation according to claim 2, characterized in that, The secondary filtration sterilization technology comprises a pipeline sterilization filter and a terminal sterilization filter, and the filter membrane material of the secondary filtration sterilization technology is polytetrafluoroethylene with a pore size of 0.2 μm.

4. The process for improving the stability of baicalin in a liquid preparation according to claim 3, characterized in that, The oxygen concentration in the container after filling nitrogen is lower than 0.5%, and the light transmittance of the packaging material is lower than 10%.

5. The process for improving the stability of baicalin in a liquid preparation according to claim 4, characterized in that, The filling device comprises a rack (1), an annular bottom plate (2) is arranged on the rack (1), a side baffle (3) is arranged outside the annular bottom plate (2), and an upper and lower feeding opening (4) is formed in the side baffle (3), two pulleys (5) are installed at the two ends of the rack (1), a synchronous belt (6) is drivingly installed between the two pulleys (5), a plurality of transmission blocks (7) are installed at equal intervals outside the synchronous belt (6), a limiting plate (8) is formed in the transmission block (7), and a limiting groove is formed in the limiting plate (8), an adjusting ring seat (12) is installed on one end of the side baffle (3) through a support arm (11), a rotating seat (16) is installed on one of the pulleys (5), a plurality of mounting arms (17) are installed at equal angles outside the rotating seat (16), and the mounting arms (17) are connected with a front nitrogen filling mechanism (18), the front nitrogen filling mechanism (18) corresponds to the transmission block (7), a rear nitrogen filling seat (42) and an arc-shaped sealing seat (44) are installed on the other end of the side baffle (3), a nitrogen filling nozzle (43) is installed at the bottom side of the rear nitrogen filling seat (42), a bottle opening groove (45) is formed in the arc-shaped sealing seat (44), and a nitrogen hole is formed in the bottle opening groove (45); An electric sliding rail (34) is installed on the side wall of the side baffle (3), an electric sliding arm (35) is slidingly installed on the electric sliding rail (34), a mounting frame (36) is installed on the electric sliding arm (35), an air cylinder (37) is installed on the mounting frame (36), a lifting seat (38) is installed at the extension end of the air cylinder (37), a plurality of filling heads (39) are installed at equal intervals at the bottom side of the lifting seat (38), a fixing frame (40) is installed on the side wall of the mounting frame (36), a plurality of annular spray seats (41) are installed at equal intervals on the fixing frame (40), and the filling heads (39) penetrate through the annular spray seats (41), a plurality of inclined downward spray holes are formed at equal angles in the inner side of the annular spray seat (41).

6. The process for improving the stability of baicalin in a liquid preparation according to claim 5, characterized in that, The rack (1) is provided with a speed reducer (9) on the bottom side, and the output end of the speed reducer (9) is connected with one of the pulleys (5), and the input end of the speed reducer (9) is connected with the output end of the motor (10).

7. The process for improving the stability of baicalin in a liquid preparation according to claim 6, characterized in that, The adjusting ring seat (12) comprises a separation section (13), a gradual change section (14) and a pressing section (15), the gradual change section (14) is arranged between the separation section (13) and the pressing section (15), and the height of the separation section (13) is higher than that of the pressing section (15).

8. The process for improving the stability of baicalin in a liquid preparation according to claim 7, characterized in that, The front nitrogen filling mechanism (18) comprises a sleeve (19) connected with the mounting arm (17), a multi-edge shaft (20) is elastically arranged in the sleeve (19), a sealing seat (21) is arranged at the bottom end of the multi-edge shaft (20), a bottle opening pressing hole (22) is arranged in the sealing seat (21), a ball seat (23) is arranged at the top end of the multi-edge shaft (20), and a ball (24) rolling along the bottom side of the adjusting ring seat (12) is arranged on the ball seat (23). The multi-edge shaft (20) is provided with a lifting baffle (25) arranged in the sleeve (19), and a spring (26) is arranged outside the multi-edge shaft (20) and in the sleeve (19), and the spring (26) is arranged between the bottom wall of the sleeve (19) and the lifting baffle (25).

9. The process for improving the stability of baicalin in a liquid preparation according to claim 8, characterized in that, The rotating joint (27) and the rotating joint (28) are arranged in the rotating seat (16), the fixed end of the rotating joint (27) is connected with the sealing seat (21) through a plurality of first connecting pipes (29), the fixed end of the rotating joint (28) is connected with the sealing seat (21) through a plurality of second connecting pipes (30), and the first connecting pipe (29) and the second connecting pipe (30) are provided with a control valve (31).

10. The process for improving the stability of baicalin in a liquid formulation according to claim 9, wherein the process is characterized by, The rotating end of the rotating joint (27) is provided with a first nitrogen pipe (32), the rotating end of the rotating joint (28) is connected with the vacuum pump (33) on the pulley (5) through a pipeline, the rear nitrogen filling seat (42) and the arc-shaped sealing seat (44) are provided with a second nitrogen pipe (46), and the first nitrogen pipe (32), the second nitrogen pipe (46) and the annular spraying seat (41) are connected with a nitrogen pump.

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