Transmembrane pressure regulation control method, device and storage medium for tangential flow filtration

Abstract

The present application relates to the technical field of tangential flow filtration, and particularly relates to a transmembrane pressure adjustment control method and device for tangential flow filtration and a storage medium, which can obtain a TMP set value and an allowable tolerance range; a pressure signal and a pressure control valve opening degree are collected in real time, an actual TMP value is calculated according to the pressure signal; when the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening degree reaches a maximum value, the flow rate of a circulating pump is controlled to decrease, otherwise, the pressure control valve opening degree is adjusted in real time according to the TMP set value and the actual TMP value. It can be understood that the control mode breaks through the single valve adjustment capacity boundary by auxiliary adjustment of the circulating pump on the basis of the adjustment of the TMP value by the pressure control valve without changing the original hardware conditions of the tangential flow filtration system, and realizes continuous and stable operation under extreme working conditions.

Description

Transmembrane pressure regulation and control method, device and storage medium for tangential flow filtration Technical Field

[0001] This invention relates to the field of tangential flow filtration technology, and more specifically to a transmembrane pressure regulation and control method, device, and storage medium for tangential flow filtration. Background Technology

[0002] Tangential flow filtration is a high-end fluid separation technology used in biopharmaceutical and other fields. Its core is to allow the feed liquid to flow tangentially along the membrane surface. By controlling the transmembrane pressure (TMP), the target components and impurities are separated efficiently, while reducing membrane surface clogging and ensuring separation efficiency and membrane lifespan.

[0003] Transmembrane pressure (TMP) is calculated from the inlet pressure, return pressure, and outlet pressure. Increased membrane fouling or higher feed viscosity leads to increased TMP. In tangential flow filtration systems, traditional control methods regulate TMP solely through pressure control valves. For example, a TMP setpoint is first set, and based on the actual TMP value, a PID controller is used to derive control commands to adjust the opening of the pressure control valve. If the actual TMP value deviates significantly from the TMP setpoint, an alarm is triggered to prompt manual intervention.

[0004] Traditional TMP control methods rely solely on pressure control valves. If membrane fouling is severe or the feed solution viscosity is high, the pressure control valve must be continuously opened to reduce the TMP value, eventually reaching near full opening. At this point, further adjustment becomes ineffective in reducing pressure, leading to persistently high TMP levels, potentially causing protein denaturation or batch failure. Therefore, when the pressure control valve reaches saturation, the system becomes uncontrollable and cannot recover automatically. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a transmembrane pressure regulation and control method, device and storage medium for tangential flow filtration, so as to solve the problems of single control actuator in the existing TMP value control method, which is prone to regulation saturation and system runaway.

[0006] According to a first aspect of the present invention, a transmembrane pressure regulation and control method for tangential flow filtration is provided, applied to a tangential flow filtration system, comprising:

[0007] Obtain TMP settings and allowable tolerance range;

[0008] Real-time acquisition of pressure signals and pressure control valve opening, and calculation of actual TMP value based on pressure signals;

[0009] If the actual TMP value is higher than the allowable tolerance range of the TMP setting value for a preset time, and the pressure control valve opening reaches the maximum value, the flow rate of the circulating pump will decrease. Otherwise, the pressure control valve opening will be adjusted in real time according to the TMP setting value and the actual TMP value.

[0010] Preferably, the method further includes:

[0011] Obtain the setpoint for the circulating pump flow rate; collect the real-time flow rate of the circulating pump;

[0012] If the actual TMP value is lower than the allowable tolerance range of the TMP setting value, and the real-time flow rate of the circulating pump is less than the circulating pump flow rate setting value, then the flow rate of the circulating pump will be increased.

[0013] Preferably, the opening of the pressure control valve is adjusted in real time based on the TMP set value and the actual TMP value, including:

[0014] When the actual TMP value is higher than the allowable tolerance range of the TMP setting value, and the pressure control valve opening has not reached the maximum value, the pressure control valve opening is increased.

[0015] Preferably, the opening of the pressure control valve is adjusted in real time based on the TMP set value and the actual TMP value, including:

[0016] When the actual TMP value is lower than the allowable tolerance range of the TMP setting value, and the real-time flow rate of the circulating pump is not less than the circulating pump flow rate setting value, the opening of the pressure control valve is reduced.

[0017] Preferably, when controlling the flow rate of the circulating pump to decrease, the method includes: controlling the flow rate of the circulating pump to decrease linearly until the corresponding condition is no longer met; when controlling the flow rate of the circulating pump to increase, the method includes: controlling the flow rate of the circulating pump to increase linearly until the corresponding condition is no longer met.

[0018] Preferably, controlling the flow rate reduction of the circulating pump includes: when the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening reaches the maximum value, generating a single-trigger circulating pump deceleration command to reduce the flow rate of the circulating pump to a first value.

[0019] Controlling the flow rate increase of the circulating pump includes: if the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is less than the circulating pump flow rate set value, generating a single-trigger circulating pump speed-up command to increase the flow rate of the circulating pump to the circulating pump flow rate set value.

[0020] Preferably, pressure signals are acquired in real time, and the actual TMP value is calculated based on the pressure signals, including:

[0021] Sensors are used to collect inlet pressure, backflow pressure, and filter outlet pressure in real time.

[0022] The actual TMP value is calculated based on the inlet pressure, return pressure, and filter outlet pressure.

[0023] Preferably, the opening of the pressure control valve is adjusted in real time based on the TMP set value and the actual TMP value, including:

[0024] The TMP setpoint and actual TMP value are input to the PID controller, and the opening of the pressure control valve is adjusted using the adjustment signal output by the PID controller.

[0025] According to a second aspect of the present invention, a transmembrane pressure regulation and control device for tangential flow filtration is provided, comprising:

[0026] The main controller, and sensors, pressure control valves, circulation pumps and memory connected to the main controller;

[0027] The memory stores program instructions;

[0028] The main controller is used to execute program instructions stored in the memory and perform any of the methods described above.

[0029] According to a third aspect of the present invention, a computer-readable storage medium is provided, which stores a computer program that, when executed by a processor, implements the method described in any of the preceding claims.

[0030] The technical solution provided by this invention may include the following beneficial effects:

[0031] It is understood that the technical solution presented in this invention obtains the TMP setpoint and allowable tolerance range; it collects pressure signals and the opening degree of the pressure control valve in real time, and calculates the actual TMP value based on the pressure signal; when the actual TMP value is higher than the allowable tolerance range of the TMP setpoint for a preset time, and the opening degree of the pressure control valve reaches its maximum value, the flow rate of the circulating pump is controlled to decrease; otherwise, the opening degree of the pressure control valve is adjusted in real time according to the TMP setpoint and the actual TMP value. It is understood that this control method, without changing the original hardware conditions of the tangential flow filtration system, breaks through the single-valve adjustment capability boundary by using the circulating pump for auxiliary adjustment based on the TMP value adjustment of the pressure control valve, and achieves continuous and stable operation under extreme conditions.

[0032] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and are not intended to limit the invention. Attached Figure Description

[0033] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0034] Figure 1 is a schematic diagram of the steps of a transmembrane pressure regulation control method for tangential flow filtration according to an exemplary embodiment;

[0035] Figure 2 is a schematic diagram of a tangential flow filtration system according to an exemplary embodiment;

[0036] Figure 3 is a schematic flowchart illustrating a transmembrane pressure regulation control method for tangential flow filtration according to an exemplary embodiment. Detailed Implementation

[0037] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numerals in different drawings denote the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Rather, they are merely examples of apparatuses and methods consistent with some aspects of the invention as detailed in the appended claims.

[0038] In one embodiment, FIG1 is a schematic diagram of the steps of a transmembrane pressure regulation and control method for tangential flow filtration according to an exemplary embodiment. Referring to FIG1, a transmembrane pressure regulation and control method for tangential flow filtration is provided, applied to a tangential flow filtration system, including:

[0039] Step S11: Obtain the TMP setting value and allowable tolerance range.

[0040] This technical solution illustrates a transmembrane pressure regulation and control method for tangential flow filtration. When applied to a tangential flow filtration system, all hardware components are standard for the tangential flow filtration system, requiring no additional hardware devices. See Figure 2.

[0041] In this step, the TMP setting value and allowable tolerance range are first manually entered. The TMP setting value is the TMP value that should be maintained under normal operating conditions. The specific value of this value should be set according to the specific actual situation.

[0042] For example, in biopharmaceuticals, 0.5-2.0 bar is commonly used as the TMP setpoint, and the allowable tolerance range for this TMP setpoint can be ±0.1 bar.

[0043] Step S12: Real-time acquisition of pressure signals and pressure control valve opening, and calculation of the actual TMP value based on the pressure signals.

[0044] It should be noted that sensors can be used to collect inlet pressure, return pressure, and filter outlet pressure in real time; the actual TMP value can be calculated based on the inlet pressure, return pressure, and filter outlet pressure.

[0045] For example, the actual TMP value can be calculated using the TMP calculation formula:

[0046] TMP = (Pf + Pr) / 2 - Pp

[0047] Wherein, Pf is the inlet pressure, Pp is the outlet pressure, and Pr is the return pressure. In the tangential flow filtration system shown in Figure 2, the labels Pf, Pp, and Pr in Figure 2 represent the pressure sensors on the feed side, permeate side, and return side, respectively.

[0048] Regarding the factors affecting the actual TMP value, under a fixed flow rate, the smaller the opening of the pressure control valve, the larger the TMP value; under a fixed pressure control valve opening, the greater the liquid flow rate, the larger the TMP value.

[0049] Step S13: When the actual TMP value is higher than the allowable tolerance range of the TMP setting value for a preset time, and the opening of the pressure control valve reaches the maximum value, the flow rate of the circulating pump is reduced; otherwise, the opening of the pressure control valve is adjusted in real time according to the TMP setting value and the actual TMP value.

[0050] The actual TMP value is higher than the allowable tolerance range of the TMP setting value. For example, if the actual TMP value is 2.3 bar, the TMP setting value is 2 bar, and the allowable tolerance range is ±0.1 bar, then 2.3 bar > 2 + 0.1 = 2.1 bar.

[0051] This step is the core of the control method. For ease of explanation, the condition that "the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening reaches the maximum value" is considered as the first condition.

[0052] During normal system operation, if the TMP value is within the allowable tolerance range of the TMP setting, no adjustment is made, and the system maintains its current state. If the actual TMP value is outside the allowable tolerance range, but the first condition has not been met, the pressure control valve opening is adjusted in real time based on the TMP setting and the actual TMP value. For example, if the actual TMP value is less than the allowable tolerance range of the TMP setting, the actual TMP value should be increased, thus decreasing the pressure control valve opening. Conversely, if the actual TMP value is greater than the allowable tolerance range of the TMP setting, the actual TMP value should be decreased, thus increasing the pressure control valve opening.

[0053] When membrane fouling worsens or feed viscosity increases in the system, the actual TMP value will continue to rise. If the actual TMP value exceeds the TMP set value, the system will continuously increase the opening of the pressure control valve. However, the opening of the pressure control valve has a limit. When the opening of the pressure control valve reaches its maximum value, if the actual TMP value continues to rise, it will inevitably exceed the allowable tolerance range of the TMP set value. After a preset time, the first condition is met.

[0054] Once the first condition is met, the system needs to activate the coordinated control of the circulating pump. The flow rate of the circulating pump is controlled to decrease, thereby reducing the total system pressure and actively lowering the TMP value. Continuing to actively lower the TMP value will cause the actual TMP value to fall back into the allowable tolerance range of the TMP set value. At this point, the first condition is no longer met, and the entire system continues to operate under control, adjusting the opening of the pressure control valve in real time.

[0055] Figure 2 shows the tangential flow filtration system. In Figure 2, P01 is a diaphragm pump, P02 is a peristaltic pump, WT01 and WT02 are feed / collection containers with integrated weighing modules, PCV01 and PCV02 are proportional pinch valves, with PCV01 serving as a pressure control valve; Pf, Pp, and Pr are pressure sensors on the feed side, permeate side, and return side, respectively, and the core component among the three is the tangential flow filtration membrane pack.

[0056] The system provides stable fluid power through a diaphragm pump / peristaltic pump, and uses a weighing module to monitor changes in container mass in real time to precisely control the concentration factor and replacement volume. A proportional pinch valve is used to regulate the back pressure on the reflux and permeate sides in a closed loop, stabilizing the transmembrane pressure (TMP) and circulation flow rate, ensuring filtration efficiency and preventing membrane fouling or damage. The feed solution flows tangentially on the membrane surface. Under pressure, the solvent and small molecule solutes pass through the filtration membrane to form the permeate, while large molecules are retained to form the concentrate, thereby efficiently achieving process objectives such as concentration, liquid replacement (dialysis), or purification.

[0057] In one embodiment, the P01 diaphragm pump can be used as a circulation pump, and the PCV01 can be used as a pressure control valve.

[0058] Several preferred embodiments are shown below, and the corresponding flowcharts are shown in Figure 3.

[0059] Understandably, this technical solution, without changing the original hardware conditions of the tangential flow filtration system, breaks through the single valve adjustment capability boundary by using a circulating pump to assist in the adjustment of the TMP value through the pressure control valve, thereby achieving continuous and stable operation under extreme conditions.

[0060] In a preferred embodiment, the method further includes:

[0061] Obtain the setpoint for the circulation pump flow rate; collect the real-time flow rate of the circulation pump.

[0062] If the actual TMP value is lower than the allowable tolerance range of the TMP setting value, and the real-time flow rate of the circulating pump is less than the circulating pump flow rate setting value, then the flow rate of the circulating pump will be increased.

[0063] In the specific implementation of this embodiment, the setpoint for the circulation pump flow rate is first obtained. This setpoint represents the flow rate of the circulation pump during normal system operation. Simultaneously, the actual flow rate of the circulation pump can be collected in real time via sensors for subsequent adjustment of the circulation pump flow rate.

[0064] For ease of explanation, the condition "if the actual TMP value is lower than the allowable tolerance range of the TMP setting value, and the real-time flow rate of the circulation pump is less than the circulation pump flow rate setting value" is considered as the second condition.

[0065] After the circulating pump flow rate is actively reduced, the system adjusts the pressure control valve opening in real time as the flow rate decreases. If the second condition is met, the circulating pump flow rate is increased. If the actual TMP value remains lower than the TMP set value, the circulating pump flow rate will rise to the set value, at which point the circulating pump's coordinated operation ceases. If the first condition is not met, the system enters normal operating mode.

[0066] In a preferred embodiment, adjusting the opening of the pressure control valve in real time based on the TMP set value and the actual TMP value includes: when the actual TMP value is higher than the allowable tolerance range of the TMP set value, and the opening of the pressure control valve has not reached the maximum value, increasing the opening of the pressure control valve.

[0067] During the real-time adjustment of the pressure control valve opening, if the actual TMP value is higher than the allowable tolerance range of the TMP set value, but the pressure control valve opening has not reached the maximum value, it means that the actual TMP value can be adjusted by controlling the pressure control valve. By increasing the opening of the pressure control valve, the actual TMP value can be reduced.

[0068] In a preferred embodiment, adjusting the opening of the pressure control valve in real time according to the TMP set value and the actual TMP value includes: when the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is not less than the circulating pump flow rate set value, then reducing the opening of the pressure control valve.

[0069] In practice, during the real-time adjustment of the pressure control valve opening, if the actual TMP value is within the allowable tolerance range of the TMP setting, it indicates that the TMP value is correct and no adjustment of the pressure control valve is needed. If the actual TMP value is lower than the allowable tolerance range of the TMP setting, it indicates that the pressure control valve opening needs to be reduced. However, if the real-time flow rate of the circulating pump is lower than the circulating pump flow rate setting, the circulating pump flow rate should be restored first. Therefore, the actual TMP value should only be increased by reducing the pressure control valve opening when the real-time flow rate of the circulating pump is not lower than the setting value and the actual TMP value is lower than the allowable tolerance range of the TMP setting.

[0070] In one embodiment, when controlling the flow rate of the circulating pump to decrease, the method includes: controlling the flow rate of the circulating pump to decrease linearly until the corresponding condition is no longer met; when controlling the flow rate of the circulating pump to increase, the method includes: controlling the flow rate of the circulating pump to increase linearly until the corresponding condition is no longer met.

[0071] In this embodiment, the system collects relevant data in real time. If the conditions for the flow rate of the circulating pump to decrease or increase are always met, the flow rate is linearly adjusted to decrease or increase according to the set ratio until the conditions for the flow rate of the circulating pump to decrease or increase are no longer met.

[0072] In one embodiment, controlling the flow rate of the circulating pump to decrease includes: when the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening reaches its maximum value, generating a single-trigger circulating pump deceleration command to reduce the flow rate of the circulating pump to a first value. Controlling the flow rate of the circulating pump to increase includes: if the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is less than the circulating pump flow rate set value, generating a single-trigger circulating pump acceleration command to increase the flow rate of the circulating pump to the circulating pump flow rate set value. In this embodiment, if the conditions for decreasing or increasing the flow rate of the circulating pump are met, the flow rate of the circulating pump will be controlled to decrease or increase to a certain value.

[0073] In one embodiment, adjusting the opening of the pressure control valve in real time according to the TMP setpoint and the actual TMP value includes: inputting the TMP setpoint and the actual TMP value to a PID controller, and adjusting the opening of the pressure control valve using the adjustment signal output by the PID controller.

[0074] The technical solution presented in this invention can overcome the control limitations of a single actuator. When the PCV01 pressure control valve's regulating capacity is saturated, it actively reduces the total system pressure by decreasing the speed of the circulating pump, achieving precise TMP reduction and solving the problem of traditional methods being unable to adjust the pressure. This technical solution requires no new hardware, fully reusing the existing pressure sensor, PCV01 pressure control valve, and circulating pump in the system. Functional enhancement is achieved solely through control algorithm upgrades, resulting in low cost and easy deployment. Simultaneously, it improves process stability and continuity, avoiding alarm shutdowns caused by persistently high TMP, ensuring continuous operation of high-value batches in biopharmaceuticals and other industries, and meeting GMP requirements for process consistency.

[0075] In another embodiment, a transmembrane pressure regulation and control device for tangential flow filtration is provided, comprising:

[0076] The main controller, and sensors, pressure control valves, circulation pumps and memory connected to the main controller;

[0077] The memory stores program instructions;

[0078] The main controller is used to execute program instructions stored in the memory and perform any of the methods described above.

[0079] In another embodiment, a computer-readable storage medium is provided storing a computer program that, when executed by a processor, implements the method described in any of the preceding embodiments.

[0080] It is understood that the same or similar parts in the above embodiments can be referred to each other, and the contents not described in detail in some embodiments can be referred to the same or similar contents in other embodiments.

[0081] It should be noted that in the description of this invention, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Furthermore, in the description of this invention, unless otherwise stated, "a plurality of" means at least two.

[0082] Any process or method description in the flowchart or otherwise herein can be understood as representing a module, segment, or portion of code comprising one or more executable instructions for implementing a particular logical function or process, and the scope of the preferred embodiments of the invention includes additional implementations in which functions may be performed not in the order shown or discussed, including substantially simultaneously or in reverse order depending on the functions involved, as will be understood by those skilled in the art to which embodiments of the invention pertain.

[0083] It should be understood that various parts of the present invention can be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, multiple steps or methods can be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, it can be implemented using any one or a combination of the following techniques known in the art: discrete logic circuits having logic gates for implementing logical functions on data signals, application-specific integrated circuits (ASICs) having suitable combinational logic gates, programmable gate arrays (PGAs), field-programmable gate arrays (FPGAs), etc.

[0084] Those skilled in the art will understand that all or part of the steps of the methods in the above embodiments can be implemented by a program instructing related hardware. The program can be stored in a computer-readable storage medium, and when executed, the program includes one or a combination of the steps of the method embodiments.

[0085] Furthermore, the functional units in the various embodiments of the present invention can be integrated into a processing module, or each unit can exist physically separately, or two or more units can be integrated into a module. The integrated module can be implemented in hardware or as a software functional module. If the integrated module is implemented as a software functional module and sold or used as an independent product, it can also be stored in a computer-readable storage medium.

[0086] The storage media mentioned above can be read-only memory, disk, or optical disk, etc.

[0087] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0088] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A transmembrane pressure regulation and control method for tangential flow filtration, applied to a tangential flow filtration system, characterized in that, include: Obtain TMP settings and allowable tolerance range; The system collects pressure signals and pressure control valve openings in real time, and calculates the actual TMP value based on the pressure signals. If the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening reaches its maximum value, the system controls the flow rate of the circulating pump to decrease. Otherwise, it adjusts the pressure control valve opening in real time based on the TMP set value and the actual TMP value. The system also acquires the circulating pump flow rate set value and collects the real-time flow rate of the circulating pump. If the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is lower than the circulating pump flow rate set value, the system controls the flow rate of the circulating pump to increase.

2. The method according to claim 1, characterized in that, The pressure control valve opening is adjusted in real time based on the TMP set value and the actual TMP value, including: when the actual TMP value is higher than the allowable tolerance range of the TMP set value, and the pressure control valve opening has not reached the maximum value, the pressure control valve opening is increased.

3. The method according to claim 1, characterized in that, The pressure control valve opening is adjusted in real time based on the TMP set value and the actual TMP value, including: when the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is not less than the circulating pump flow rate set value, the pressure control valve opening is reduced.

4. The method according to claim 1, characterized in that, When controlling the flow rate of the circulating pump to decrease, the method includes: controlling the flow rate of the circulating pump to decrease linearly until the corresponding condition is no longer met; when controlling the flow rate of the circulating pump to increase, the method includes: controlling the flow rate of the circulating pump to increase linearly until the corresponding condition is no longer met.

5. The method according to claim 1, characterized in that, Controlling the flow rate of the circulating pump to decrease includes: when the actual TMP value is higher than the allowable tolerance range of the TMP set value for a preset time, and the pressure control valve opening reaches its maximum value, generating a single-trigger circulating pump deceleration command to reduce the flow rate of the circulating pump to a first value; controlling the flow rate of the circulating pump to increase includes: if the actual TMP value is lower than the allowable tolerance range of the TMP set value, and the real-time flow rate of the circulating pump is less than the circulating pump flow rate set value, generating a single-trigger circulating pump acceleration command to increase the flow rate of the circulating pump to the circulating pump flow rate set value.

6. The method according to claim 1, characterized in that, Real-time acquisition of pressure signals and calculation of the actual TMP value based on the pressure signals include: real-time acquisition of inlet pressure, return pressure and filter end pressure using sensors; and calculation of the actual TMP value based on the inlet pressure, return pressure and filter end pressure.

7. The method according to claim 1, characterized in that, The pressure control valve opening is adjusted in real time based on the TMP setpoint and the actual TMP value, including: inputting the TMP setpoint and the actual TMP value to the PID controller, and using the adjustment signal output by the PID controller to adjust the pressure control valve opening.

8. A transmembrane pressure regulation and control device for tangential flow filtration, characterized in that, include: The main controller, and sensors, pressure control valves, circulation pumps and memory connected to the main controller; The memory stores program instructions; the master controller is used to execute the program instructions stored in the memory to perform the method as described in any one of claims 1 to 7.

9. A computer-readable storage medium storing a computer program, characterized in that, When the computer program is executed by a processor, it implements the method as described in any one of claims 1 to 7.

Images