Extraction device for pyrimidine compound production

Abstract

The invention relates to the technical field of pyrimidine compound production equipment, in particular to an extraction device for pyrimidine compound production, which comprises an extraction tower and a micro-interface purification and recovery unit, a microwave and ultrasonic synergistic reactor and an intelligent sensing and control system are arranged on the extraction tower, and a functional gradient filler module is arranged in the extraction tower. The microwave and ultrasonic synergistic reactor, the intelligent sensing and control system and the functional gradient filler module are organically combined, so that the long-standing problems of low efficiency, easiness in emulsification, high energy consumption and insufficient intelligent level in the pyrimidine compound extraction process are solved, the extraction rate and the extraction yield are improved, the production cost is reduced, and the device is compact in structure and convenient to operate. The energy utilization efficiency is high, operation is stable, and the service life is long.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pyrimidine compound production equipment, in particular to an extraction device for pyrimidine compound production. BACKGROUND

[0002] Pyrimidine compounds are a class of important nitrogen-containing heterocyclic compounds, widely used in the fields of medicine, pesticides, dyes and polymer materials as core structural units. In the pharmaceutical industry, many active ingredients of anticancer, antiviral and anti-inflammatory drugs contain pyrimidine ring structures.

[0003] In the post-processing of pyrimidine compound synthesis, extraction is a key unit operation for separating and purifying target products. Traditional extraction processes are usually carried out in stirred tanks or conventional packed columns, relying on physical mixing and mass transfer of two-phase liquids.

[0004] Pyrimidine compounds have strong polarity and often coexist with similar by-products in synthesis liquids. The mass transfer power provided by traditional mechanical stirring or packed columns is limited, and the two phases are difficult to achieve sufficient and efficient micro-mixing, resulting in slow extraction rate, low yield, and unsatisfactory selective separation of target products. Due to the amphiphilic nature of pyrimidine compounds, under strong shear action, the extraction system is prone to form stable emulsions, making it difficult to separate the heavy and light phases, which not only prolongs the operation cycle, but also causes product loss and solvent waste, seriously affecting the continuity and economy of production. To achieve sufficient mass transfer, traditional methods often need to extend the mixing time or increase the stirring intensity, resulting in increased energy consumption. At the same time, due to the unclear phase separation and entrainment phenomenon, the solvent loss also increases the production cost and environmental burden. No solutions have been proposed to address these related technical problems. SUMMARY

[0005] To overcome the above technical problems existing in the prior art, the present application proposes an extraction device for pyrimidine compound production, which organically combines a microwave and ultrasonic synergistic reactor, an intelligent sensing and control system, and a functional gradient packing module. The present application solves the problems of low efficiency, easy emulsification, high energy consumption, and insufficient intelligence level in the extraction process of pyrimidine compounds, improves the extraction rate and yield, reduces production costs, has a compact structure, high energy utilization efficiency, stable operation, and long service life.

[0006] In order to achieve the above object, the present application provides the following technical scheme: an extraction device for producing a pyrimidine compound, comprising an extraction tower, a feed inlet and a solvent inlet are arranged on one side of the extraction tower, a heavy phase outlet is arranged at the bottom of the extraction tower, and a light phase outlet is arranged at the top of the extraction tower, characterized in that a microwave and ultrasonic synergistic reactor and an intelligent sensing and control system are arranged on the extraction tower, the microwave and ultrasonic synergistic reactor and the intelligent sensing and control system are signal connected, and a functional gradient packing module is arranged in the extraction tower.

[0007] Preferably, the microwave and ultrasonic synergistic reactor comprises a microwave generating unit and an ultrasonic generating unit, the microwave generating unit comprises a microwave transmitting antenna array arranged around the outer wall of the extraction tower, and the ultrasonic generating unit comprises a plurality of ultrasonic transducers mounted on the inner wall of the extraction tower.

[0008] Preferably, the functional gradient packing module comprises a strong hydrophilic packing unit, a transition zone packing unit and a hydrophobic packing unit, the strong hydrophilic packing unit is one or more of a stainless steel wire mesh and a hydrophilic ceramic short ring, the transition zone packing unit is one or more of a theta ring and a square saddle ring, and the hydrophobic packing unit is one or more of a metal theta ring and a Paul ring, and the strong hydrophilic packing unit, the transition zone packing unit and the hydrophobic packing unit are arranged in sequence from bottom to top.

[0009] Preferably, the intelligent sensing and control system comprises a multi-parameter sensor array, a central processing unit and an actuator driving unit, the multi-parameter sensor array is mounted on the inner wall of the extraction tower, the central processing unit is connected with the multi-parameter sensor array and the actuator driving unit respectively, and the actuator driving unit is connected with the microwave and ultrasonic synergistic reactor.

[0010] Preferably, the intelligent sensing and control system comprises a multi-parameter sensor array, a central processing unit and an actuator driving unit, the multi-parameter sensor array is mounted on the inner wall of the extraction tower, the central processing unit is connected with the multi-parameter sensor array and the actuator driving unit respectively, and the actuator driving unit is connected with the microwave and ultrasonic synergistic reactor.

[0011] Preferably, the extraction tower has a composite shielding structure, and from inside to outside, the tower wall comprises a corrosion-resistant alloy lining, a microwave transmission and pressure-resistant layer, a distributed ultrasonic transducer array and an electromagnetic shielding and heat insulation layer.

[0012] Preferably, the working frequency of the microwave transmitting antenna array is one of 2400-2500 MHz and 890-940 MHz, and the working frequency of the ultrasonic transducer is 20-40 kHz.

[0013] Preferably, the surface of the metal θ ring is coated with a fluoride coating, the Pall ring is made of polypropylene, and both the θ ring and the rectangular saddle ring are made of polytetrafluoroethylene.

[0014] Compared with the prior art, the beneficial effects of the present invention are:

[0015] (1) This invention is an extraction device for the production of pyrimidine compounds. By setting up a microwave and ultrasonic synergistic reactor on the extraction tower, the energy fields are synergistically enhanced. The microwave field can selectively heat the molecules of highly polar pyrimidine compounds, reducing the energy barrier for their diffusion from the aqueous phase to the organic phase. The high-speed microjets and strong turbulence generated by the ultrasonic cavitation effect can greatly reduce the size of the dispersed phase droplets and increase the mass transfer specific surface area. The synergistic effect of the two energy fields at the microscopic molecular level and the macroscopic fluid level overcomes the problem of high mass transfer resistance of pyrimidine compounds, resulting in a significant improvement in extraction rate and extraction yield.

[0016] (2) This invention is an extraction device for the production of pyrimidine compounds. By setting up a functional gradient packing module, and with the strong hydrophilic packing unit, the transition zone packing unit and the hydrophobic packing unit arranged sequentially from bottom to top, it can actively adapt to the extraction process. At the bottom of the column, the hydrophilic packing promotes the dispersion of the organic phase and triggers efficient mass transfer; at the top of the column, the hydrophobic packing provides a friendly interface for the aggregation of organic phase droplets and significantly accelerates phase separation. This fundamentally solves the problems of easy emulsification and difficult phase separation caused by the amphiphilicity of pyrimidine compounds, and ensures the continuity and stability of the operation.

[0017] (3) The present invention is an extraction device for the production of pyrimidine compounds. By setting up an intelligent sensing and control system, the device uses a multi-parameter sensor array to sense changes in key parameters such as dielectric constant, temperature, and interface in the extraction tower in real time. The central processing unit dynamically adjusts the power and mode of microwave and ultrasound and the solvent flow rate according to the built-in model to ensure the entire extraction process and significantly improve the consistency of product quality and the reliability of process operation.

[0018] (4) This invention is an extraction device for the production of pyrimidine compounds. The synergistic effect of the energy field enables the extraction efficiency to be improved with low energy consumption. The micro-interface purification and recovery unit realizes the efficient recovery and recycling of solvent through deep processing and online monitoring of the outlet logistics. When the solvent purity monitor detects that the solvent purity is qualified, it is guided to product collection; if it does not meet the standard, it is automatically returned to the system for reuse through the solvent recovery branch, which reduces the amount of fresh solvent replenishment and waste solvent treatment, and reduces production costs.

[0019] (5) The present invention is an extraction device for the production of pyrimidine compounds. By setting the microwave generator outside the extraction tower and the ultrasonic transducer inside the extraction tower and combining it with the tower wall of the composite shielding structure, it not only ensures the efficient transmission of microwave energy and electromagnetic safety, but also ensures that the ultrasonic energy can be efficiently coupled into the process fluid. At the same time, the tower wall lining provides excellent corrosion resistance, has a compact structure, high energy utilization efficiency, stable operation, and long service life. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall cross-section of the present invention;

[0021] Figure 2 This is a schematic diagram of the extraction tower of the present invention;

[0022] Figure 3 This is a schematic diagram of the cross-section of the extraction tower of the present invention. Attached image description:

[0024] 1. Extraction tower; 101. Corrosion-resistant alloy lining; 102. Microwave transmission and pressure-resistant layer; 103. Distributed ultrasonic transducer array; 104. Electromagnetic shielding and heat insulation layer; 2. Feed inlet; 3. Solvent inlet; 4. Heavy phase outlet; 5. Light phase outlet; 6. Microwave and ultrasonic co-processing reactor; 601. Microwave generating unit; 602. Ultrasonic generating unit; 7. Intelligent sensing and control system; 701. Multi-parameter sensor array; 702. Central processing unit; 703. Actuator drive unit; 8. Micro-interface purification and recovery unit; 801. Precision coalescer; 802. Solvent purity monitor; 803. Solvent recovery branch; 9. Functionally graded packing module. Detailed Implementation

[0025] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0026] Example

[0027] Please see Figures 1-3This invention proposes a technical solution for an extraction device for the production of pyrimidine compounds: an extraction device for the production of pyrimidine compounds includes an extraction tower 1, with a feed inlet 2 and a solvent inlet 3 respectively provided on one side of the extraction tower 1, a heavy phase outlet 4 provided at the bottom of the extraction tower 1, and a light phase outlet 5 provided at the top of the extraction tower 1. The extraction tower 1 is characterized by being equipped with a microwave and ultrasonic co-reactor 6 and an intelligent sensing and control system 7, which are signal-connected. The extraction tower 1 is internally equipped with a functionally graded packing module 9. Specifically, the microwave and ultrasonic co-reactor 6 is used to apply microwave energy and ultrasonic energy to the material inside the extraction tower 1, and the intelligent sensing and control system 7 is used to dynamically control the emission parameters of microwaves and ultrasound according to the real-time state of the material inside the extraction tower 1, and to receive and process sensor data. The physicochemical properties of the functionally graded packing module 9 change in a gradient along the height of the tower to adapt to the polarity changes of pyrimidine compounds during the extraction process.

[0028] Please see Figure 1 As shown, the microwave and ultrasonic co-processing reactor 6 further includes a microwave generating unit 601 and an ultrasonic generating unit 602. The microwave generating unit 601 includes a microwave transmitting antenna array surrounding the outer wall of the extraction tower 1, and the ultrasonic generating unit 602 includes a plurality of ultrasonic transducers installed on the inner wall of the extraction tower 1.

[0029] In this embodiment, the intelligent sensing and control system 7 controls the microwave generating unit 601 and the ultrasonic generating unit 602 to operate in an alternating pulse mode or a synchronous composite mode.

[0030] The microwave generating unit 601 is a microwave transmitting antenna array (such as a magnetron antenna) tightly wrapped around the outer wall of the extraction tower 1 in a ring or spiral shape, avoiding the need for openings in the wall of the extraction tower 1, ensuring the structural strength and sealing of the equipment, and facilitating maintenance; microwaves are electromagnetic waves that can selectively and bulk-phase instantaneously heat polar molecules (such as pyrimidine compounds and water). This "internal heating" effect can significantly reduce the activation energy of target molecules diffusing from the aqueous phase to the organic phase, improve the mass transfer driving force, and at the same time avoid local overheating caused by traditional heating methods;

[0031] The ultrasonic generating unit 602 is an ultrasonic transducer that is directly embedded in the inner wall of the extraction tower 1 through a special sealing structure (such as a flange seal). Its emitting surface is flush with the inner wall of the extraction tower 1 to maximize energy transfer efficiency and prevent material retention.

[0032] Microwaves and ultrasound work together. Microwaves "soften" the mass transfer barrier at the molecular level, while ultrasound provides a powerful hybrid power at the fluid level. The two work together to achieve a mass transfer enhancement effect of 1+1>2. It is suitable for easily emulsified systems. First, ultrasound is started for high-intensity dispersion. Then, the ultrasound is turned off and microwaves are started. The thermal effect and molecular stirring are used to promote phase separation. This cycle is repeated to balance efficiency and stability.

[0033] Please see Figure 1 As shown, the functional gradient packing module 9 further includes a strongly hydrophilic packing unit, a transition zone packing unit, and a hydrophobic packing unit. The strongly hydrophilic packing unit is one or more of stainless steel wire mesh and hydrophilic ceramic short rings. The transition zone packing unit is one or more of θ rings and rectangular saddle rings. The hydrophobic packing unit is one or more of metal θ rings and Pall rings. The strongly hydrophilic packing unit, the transition zone packing unit, and the hydrophobic packing unit are arranged sequentially from bottom to top.

[0034] In this embodiment, the strongly hydrophilic packing unit is a stainless steel wire mesh or hydrophilic ceramic short ring grafted with carboxyl or sulfonic acid groups by a silanizing agent. It is preferentially wetted by the aqueous phase to form a water film, tearing the organic phase into fine droplets and maximizing the mass transfer area in the early stage of mass transfer. The surface roughening treatment of the transition zone packing unit, with polytetrafluoroethylene itself having moderate wettability, further increases the probability of droplet collision and surface renewal, and is responsible for receiving dispersed droplets from the bottom of the column and completing the core solute transfer. The hydrophobic packing unit is preferentially wetted by the organic phase and promotes the coalescence of small organic phase droplets, thereby achieving clear and rapid phase separation and preventing light phase entrainment.

[0035] The functionally graded packing module 9 works in conjunction with the energy field. The energy field (especially ultrasound) is responsible for creating an excellent initial dispersion state, while the graded packing is responsible for guiding and maintaining this state, and actively promoting phase separation when mass transfer is nearing completion, thus resolving the contradiction between "mixing" and "separation" in traditional extraction.

[0036] Please see Figure 1 As shown, the intelligent sensing and control system 7 further includes a multi-parameter sensor array 701, a central processing unit 702, and an actuator drive unit 703. The multi-parameter sensor array 701 is installed on the inner wall of the extraction tower 1. The central processing unit 702 is connected to the multi-parameter sensor array 701 and the actuator drive unit 703 respectively. The actuator drive unit 703 is connected to the microwave and ultrasonic co-processing reactor 6.

[0037] In this embodiment, the multi-parameter sensor array 701 includes a dielectric constant sensor, a temperature sensor, and a pH sensor. The dielectric constant directly reflects the changes in the polarity and composition of the material at different heights within the extraction tower 1, and is a direct indicator for judging the mass transfer process and emulsification state. The multi-parameter sensor array 701 is set at different heights within the extraction tower 1 to monitor the dielectric constant, acoustic impedance, temperature, pH value, and two-phase interface in real time. The central processing unit 702 can reverse-calculate the current mass transfer rate, extraction efficiency, and whether it is close to the emulsification critical point based on real-time sensing data (such as dielectric constant gradient), thereby making advanced predictions. The actuator drive unit 703 is used to adjust the parameters of the microwave and ultrasonic co-processing reactor 6, as well as the flow rates of the feed pump and solvent, according to the instructions of the central processing unit 702.

[0038] Based on the initial dielectric constant of the feed solution, the microwave generator unit 601 is activated for low-power preheating, and the ultrasonic generator unit 602 is activated for initial dispersion at low intensity. When the sensor detects the formation of a stable emulsion layer in the extraction tower 1, the system switches to a microwave-ultrasonic synchronous composite mode and gradually increases the ultrasonic power to reduce the droplet size. At the same time, the microwave power is adjusted to selectively heat the target pyrimidine compound molecules. When the sensor detects that the mass transfer is close to equilibrium, the microwave is turned off, and the ultrasonic power is switched to a low-frequency, intermittent mode to promote the coalescence and phase separation of the micro-droplets. The dielectric constant gradient at different tower heights is compared in real time, and the flow rate of the solvent inlet 3 is dynamically adjusted to maintain the optimal mass transfer driving force.

[0039] Please see Figure 1 As shown, it further includes a micro-interface purification and recovery unit 8. The inlet of the micro-interface purification and recovery unit 8 is connected to the heavy phase outlet 4 and the light phase outlet 5 through branch pipes respectively. The micro-interface purification and recovery unit 8 includes a precision coalescer 801, a solvent purity monitor 802 and a solvent recovery branch 803. The two ends of the solvent recovery branch 803 are connected to the solvent purity monitor 802 and the solvent inlet 3 respectively.

[0040] In this embodiment, the precision coalescer 801 is used to remove trace amounts of another phase droplets entrained in the effluent phase. The precision coalescer 801 is filled with a special fiber membrane or sintered metal material, which can remove trace amounts (<10μm) of another phase droplets entrained in the effluent phase through collision, interception and other mechanisms, ensuring the purity of the effluent product. When the solvent purity monitor 802 detects that the solvent purity is not up to standard due to entrainment or trace decomposition, the system will automatically guide it back to the system instead of entering the subsequent distillation section, thereby reducing the energy consumption and solvent consumption of subsequent processing.

[0041] Please see Figure 3As shown, the tower wall of the extraction tower 1 is a composite shielding structure, which includes, from the inside out, a corrosion-resistant alloy lining 101, a microwave transmission and pressure-resistant layer 102, a distributed ultrasonic transducer array 103, and an electromagnetic shielding and heat insulation layer 104.

[0042] In this embodiment, the corrosion-resistant alloy liner 101 is in direct contact with harsh chemical materials to ensure the equipment's lifespan; the microwave transmission and pressure-resistant layer 102 must have sufficient mechanical strength to withstand the pressure inside the tower, while also being transparent to microwaves and having a small loss tangent; the distributed ultrasonic transducer array 103 serves as the mounting base and wiring layer for the ultrasonic transducers, and must ensure good heat dissipation and insulation; the electromagnetic shielding and heat insulation layer 104 prevents microwave leakage, ensures operator safety, and reduces heat loss.

[0043] Furthermore, the microwave transmitting antenna array operates at one of the frequencies of 2400MHz to 2500MHz and 890MHz to 940MHz, and the ultrasonic transducer operates at a frequency of 20kHz to 40kHz.

[0044] In this embodiment, the 2450MHz frequency is higher and the heating rate is faster, making it suitable for small towers or rapid start-up; the 915MHz wavelength is longer and has stronger penetration, making it suitable for large equipment or high-viscosity systems, ensuring that effective microwave energy can also be obtained in the central region of extraction tower 1; the power density of the ultrasonic transducer is adjustable from 0.1 to 1.5 W / cm². 2 Ultrasonic waves in the frequency range of ultrasonic transducers can generate a strong cavitation effect, leading to the rapid formation, growth, and violent collapse of microbubbles in the liquid. The cavitation effect generates extremely high instantaneous temperatures and pressures at the microscopic level, accompanied by strong shock waves and high-speed microjets, which break the dispersed liquid phase into micron or even nanometer-sized droplets, greatly increasing the mass transfer specific surface area. The microjets can effectively scour the phase interface and reduce mass transfer resistance. Cavitation can temporarily change the solvation layer of pyrimidine compound molecules, promoting their phase transfer.

[0045] Furthermore, the surface of the metal θ ring is coated with a fluoride coating, the Pall ring is made of polypropylene, and both the θ ring and the rectangular saddle ring are made of polytetrafluoroethylene.

[0046] Working principle of the invention:

[0047] Step 1: System Initialization and Feeding

[0048] The intelligent sensing and control system 7 is activated, and all sensors and actuators complete self-checks. The microwave and ultrasonic co-processing reactor 6 and the micro-interface purification and recovery unit 8 enter standby mode. The crude product solution containing the target pyrimidine compound is continuously pumped into the upper part of the extraction column 1 through the feed pump from the feed inlet 2; simultaneously, the selected organic extractant is pumped into the lower part of the column through another pipeline from the solvent inlet 3. Due to the density difference, the two phases begin to flow countercurrently within the extraction column 1.

[0049] Step 2: Initialize Distributed and Intelligent Startup

[0050] The heavy phase (usually aqueous phase) and the light phase (organic phase) meet inside the tower and begin to mix under the influence of gravity and initial flow. The multi-parameter sensor array 701 of the intelligent sensing and control system 7 detects the initial dielectric constant and temperature of the material in real time. Based on the initial data, the central processing unit 702 instructs the microwave generating unit 601 to start in low-power mode through the actuator drive unit 703 to gently preheat the polar molecules. At the same time, it instructs the ultrasonic generating unit 602 to operate in low-intensity, pulsed mode to begin initially dispersing the organic phase into smaller droplets, creating initial conditions for efficient mass transfer.

[0051] Step 3: Synergistically Enhance Mass Transfer

[0052] The mixture flows through the strongly hydrophilic packing unit at the bottom of the functionally graded packing module 9. Here, the hydrophilic surface is preferentially wetted by the aqueous phase. Under the cavitation effect of ultrasound, the organic phase is further broken up, forming a huge mass transfer specific surface area. When the sensor detects that a stable emulsion layer has formed in the column and mass transfer is in progress, the central processing unit 702 determines that the mass transfer enhancement stage has begun. The microwave generating unit 601 increases its power to selectively heat the pyrimidine compound molecules, reducing their phase transfer energy barrier; the ultrasonic generating unit 602 simultaneously increases its power, generating a strong cavitation effect and microjets, drastically renewing the phase interface and maintaining the micro-dispersion state of the droplets. Microwaves and ultrasound work synergistically at both the molecular and fluid scales, and the mass transfer rate reaches its peak. The material continues to flow upward, passing sequentially through the transition zone packing unit and the hydrophobic packing unit. The physicochemical properties of the packing surface gradually change from hydrophilic to oleophilic, perfectly adapting to the change in system polarity during the transfer of pyrimidine compounds from the aqueous phase to the organic phase, providing a continuously optimized interfacial environment for mass transfer.

[0053] Step 4: Promote phase separation and intelligent control

[0054] When the multi-parameter sensor array 701 detects that mass transfer is close to equilibrium and subtle emulsification signs appear in the top region of the column, the central processing unit 702 determines that the phase separation promotion stage has begun. The microwave generator unit 601 is shut down, and the ultrasonic generator unit 602 is switched to a low-frequency, intermittent operating mode. This mode effectively promotes the coalescence of micron-sized droplets while avoiding re-emulsification. The system compares the dielectric constant gradient at different heights within the column in real time and dynamically fine-tunes the feed flow rate at the solvent inlet 3 to maintain optimal mass transfer driving force at all times.

[0055] Step 5:

[0056] After extraction and phase separation, the raffinate (heavy phase) is discharged from the heavy phase outlet 4 at the bottom of the column, while the extract phase (light phase) carrying the target product is discharged from the light phase outlet 5 at the top of the column. The two phase streams then enter the micro-interface purification and recovery unit 8. First, the stream flows through a precision coalescer 801, where special fibers or sintered metal materials remove trace amounts (<10μm) of the other phase droplets entrained in the material through collision and retention mechanisms, ensuring the purity of the outlet product. The purified stream then flows through a solvent purity monitor 802 (such as an online spectrometer) for real-time analysis. The stream is then directed to a subsequent distillation column or product collection tank. The intelligent sensing and control system 7 will control the valves to return this impure solvent to the main pipeline before the solvent inlet 3 via the solvent recovery branch 803. After mixing with fresh solvent, it re-enters the extraction column 1 for recycling, forming a closed-loop quality system that significantly reduces solvent consumption and waste liquid treatment costs.

[0057] In the description of this invention, it should be understood that the terms "coaxial," "bottom," "one end," "top," "middle," "other end," "upper," "side," "top," "inner," "front," "center," "both ends," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention.

[0058] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "setting," "connection," "fixing," "screw connection," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0059] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An extraction apparatus for the production of pyrimidine compounds, characterized in that, The extraction tower (1) includes an extraction tower (1) with a feed inlet (2) and a solvent inlet (3) on one side, a heavy phase outlet (4) at the bottom and a light phase outlet (5) at the top. The extraction tower (1) is characterized by having a microwave and ultrasonic co-processing reactor (6) and an intelligent sensing and control system (7) on the extraction tower (1), the microwave and ultrasonic co-processing reactor (6) and the intelligent sensing and control system (7) being signal-connected, and a functional gradient packing module (9) being installed inside the extraction tower (1).

2. The extraction apparatus for producing pyrimidine compounds according to claim 1, characterized in that, The microwave and ultrasonic co-processing reactor (6) includes a microwave generating unit (601) and an ultrasonic generating unit (602). The microwave generating unit (601) includes a microwave transmitting antenna array surrounding the outer wall of the extraction tower (1), and the ultrasonic generating unit (602) includes a plurality of ultrasonic transducers installed on the inner wall of the extraction tower (1).

3. The extraction apparatus for producing pyrimidine compounds according to claim 1, characterized in that, The functional gradient packing module (9) includes a strongly hydrophilic packing unit, a transition zone packing unit, and a hydrophobic packing unit. The strongly hydrophilic packing unit is one or more of stainless steel wire mesh and hydrophilic ceramic short rings. The transition zone packing unit is one or more of θ rings and rectangular saddle rings. The hydrophobic packing unit is one or more of metal θ rings and Pall rings. The strongly hydrophilic packing unit, the transition zone packing unit, and the hydrophobic packing unit are arranged sequentially from bottom to top.

4. The extraction apparatus for producing pyrimidine compounds according to claim 1, characterized in that, The intelligent sensing and control system (7) includes a multi-parameter sensor array (701), a central processing unit (702), and an actuator drive unit (703). The multi-parameter sensor array (701) is installed on the inner wall of the extraction tower (1). The central processing unit (702) is connected to the multi-parameter sensor array (701) and the actuator drive unit (703) respectively. The actuator drive unit (703) is connected to the microwave and ultrasonic co-processing reactor (6).

5. An extraction apparatus for producing pyrimidine compounds according to claim 1, characterized in that, It also includes a micro-interface purification and recovery unit (8), the inlet of which is connected to the heavy phase outlet (4) and the light phase outlet (5) respectively through branch pipes. The micro-interface purification and recovery unit (8) includes a precision coalescer (801), a solvent purity monitor (802) and a solvent recovery branch (803), the two ends of which are connected to the solvent purity monitor (802) and the solvent inlet (3) respectively.

6. An extraction apparatus for producing pyrimidine compounds according to claim 1, characterized in that, The extraction tower (1) has a composite shielding structure, which includes a corrosion-resistant alloy lining (101), a microwave transmission and pressure-resistant layer (102), a distributed ultrasonic transducer array (103), and an electromagnetic shielding and heat insulation layer (104) from the inside out.

7. An extraction apparatus for producing pyrimidine compounds according to claim 2, characterized in that, The microwave transmitting antenna array operates at one of the frequencies of 2400MHz to 2500MHz and 890MHz to 940MHz, and the ultrasonic transducer operates at a frequency of 20kHz to 40kHz.

8. An extraction apparatus for producing pyrimidine compounds according to claim 3, characterized in that, The surface of the metal θ ring is coated with a fluoride coating, the Pall ring is made of polypropylene, and both the θ ring and the rectangular saddle ring are made of polytetrafluoroethylene.

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