Allergen-reducing agent, and coating material, master batch, product, and allergen-reducing method using same

Abstract

Provided is an allergen-reducing agent having an excellent allergen-reducing effect. The allergen-reducing agent according to the present invention contains magnesium oxide as an active ingredient, preferably at least one magnesium oxide selected from the group consisting of light calcined magnesium oxide, dead calcined magnesium oxide, and fused magnesium oxide, and thus can exhibit an excellent allergen-reducing effect, and the allergen-reducing agent according to the present invention can be used for reducing allergens by containing the allergen-reducing agent according to the present invention in a substrate. An allergen-reduced product having an excellent allergen-reducing effect can be produced.

Description

Technical Field

[0001] This invention relates to allergen reducers, allergen-reducing coatings, synthetic resin molding masterbatches, allergen-reducing products, and allergen-reducing methods. Background Technology

[0002] In recent years, atopic dermatitis, bronchial asthma, allergic rhinitis, and other allergic diseases have become a problem. The main causes of these allergic diseases include allergens from mites living in homes, especially house dust mites (Der1, Der2) which are abundant in indoor dust, and allergens from Japanese cedar pollen (Cryj1, Cryj2) which are mainly suspended in the air during spring.

[0003] Therefore, there is a need for technologies that remove allergens from living spaces or denature them to deactivate them.

[0004] Patent Document 1 discloses a cellulose fiber with allergen treatment capability, characterized in that it carries an allergen treatment agent containing a nitrogen-containing compound or its solvate having a given chemical structure in its active ingredient.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2007-31889 Summary of the Invention

[0008] The problem the invention aims to solve

[0009] However, the allergen treatment ability (allergen reduction effect) of the allergen treatment agent disclosed in Patent Document 1 is not sufficient, and what is needed is an allergen reducing agent that can exert a superior allergen reduction effect.

[0010] This invention provides an allergen reducer with excellent allergen-reducing effects. This invention also provides allergen-reducing coatings, synthetic resin molding masterbatches, allergen-reducing articles, and allergen-reducing methods using the above-mentioned allergen reducer.

[0011] Problem Solving Methods

[0012] The allergen reducer of the present invention contains magnesium oxide as an active ingredient.

[0013] The allergen-reducing coating of the present invention comprises the above-mentioned allergen reducer, synthetic resin and solvent.

[0014] The synthetic resin molding masterbatch of the present invention comprises the above-mentioned allergen reducer and synthetic resin.

[0015] The allergen-reducing article of the present invention comprises a substrate and the allergen-reducing agent contained in the substrate.

[0016] The allergen reduction method of the present invention includes a step of contacting the allergen reducing agent with the allergen.

[0017] The effects of the invention

[0018] The allergen reducer of the present invention contains magnesium oxide as an active ingredient, thus exhibiting excellent allergen-reducing effects. Detailed Implementation

[0019] In the numerical ranges described in this specification, the upper or lower limit of a certain stage's numerical range can be arbitrarily combined with the upper or lower limits of other stages' numerical ranges. The upper or lower limit of the numerical ranges described in this specification can also be replaced with the values ​​shown in the embodiments or values ​​that can be unambiguously derived from the embodiments. In this specification, numerical values ​​connected by "~" refer to the numerical range including the values ​​before and after "~" as the lower and upper limits.

[0020] The allergen reducer of the present invention contains magnesium oxide as an active ingredient.

[0021] [Magnesium oxide]

[0022] Allergen reducers contain magnesium oxide as an active ingredient. Magnesium oxide can be used alone or in combination with two or more other ingredients.

[0023] The magnesium oxide content in the allergen reducer is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0024] The content of lightly calcined magnesium oxide in the allergen reducer is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0025] The content of calcined magnesium oxide in the allergen reducer is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0026] The content of fused magnesium oxide in the allergen reducer is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0027] For the purpose of improving the allergen-reducing effect of the allergen reducer, the magnesium oxide preferably contains at least one magnesium oxide selected from light-burned magnesium oxide, dark-burned magnesium oxide and fused magnesium oxide, and preferably light-burned magnesium oxide or fused magnesium oxide.

[0028] The content of lightly calcined magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0029] The content of reburned magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0030] The content of fused magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0031] Lightly calcined magnesium oxide is obtained by calcining a mineral with at least one of magnesium carbonate and magnesium hydroxide as its main components at 600~1000℃.

[0032] The MgO content in light-burned magnesium oxide is preferably 80% by mass or more, more preferably 85% by mass or more, and even more preferably 90% by mass or more. The MgO content in light-burned magnesium oxide is preferably 99.9% by mass or less. When the MgO content in light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved.

[0033] The CaO content in light-burned magnesium oxide is preferably 0-3% by mass, more preferably 0-2.5% by mass, even more preferably 0-2% by mass, even more preferably 0.01-2% by mass, and even more preferably 0.01-1% by mass. When the CaO content in light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "CaO content of 0% by mass" means that it does not contain CaO.

[0034] The SiO2 content in lightly calcined magnesium oxide is preferably 0-5% by mass, more preferably 0-3% by mass, and even more preferably 0-2% by mass. When the SiO2 content in lightly calcined magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "SiO2 content of 0% by mass" means that it does not contain SiO2.

[0035] The Fe2O3 content in light-burned magnesium oxide is preferably 0-1% by mass, more preferably 0-0.5% by mass, even more preferably 0-0.4% by mass, even more preferably 0.0001-0.1% by mass, and even more preferably 0.0005-0.05% by mass. When the Fe2O3 content in light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "Fe2O3 content of 0% by mass" means that it does not contain Fe2O3.

[0036] It should be noted that the contents of MgO, CaO, SiO2, and Fe2O3 in magnesium oxide can be determined using an energy-dispersive X-ray fluorescence analyzer via the Fundamental Parameter (FP) method. For example, an energy-dispersive X-ray fluorescence analyzer commercially available from PHILIPS under the trade name "PW1404" can be used.

[0037] Reburned magnesium oxide is obtained by firing a mineral with at least one of magnesium carbonate and magnesium hydroxide as the main components at a temperature above 1500°C.

[0038] Fused magnesium oxide refers to a material manufactured by pulverizing magnesium oxide or magnesium compounds such as magnesium hydroxide and magnesium carbonate obtained by electro-melting magnesium oxide as needed.

[0039] The MgO content in fused magnesium oxide is preferably 85% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, and more preferably 96% by mass or more. The MgO content in fused magnesium oxide is preferably 99.9% by mass or less, more preferably 99.0% by mass or less. When the MgO content in fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved.

[0040] The CaO content in fused magnesium oxide is preferably 0-3% by mass, more preferably 0.001-2.5% by mass, even more preferably 0.002-2% by mass, even more preferably 0.005-1.5% by mass, even more preferably 0.01-1% by mass, and even more preferably 0.05-0.8% by mass. When the CaO content in fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "CaO content of 0% by mass" means that it does not contain CaO.

[0041] The SiO2 content in fused magnesium oxide is preferably 0-5% by mass, more preferably 0.02-2% by mass, even more preferably 0.03-1% by mass, and even more preferably 0.04-0.5% by mass. When the SiO2 content in fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "SiO2 content of 0% by mass" means that it does not contain SiO2.

[0042] The Fe2O3 content in fused magnesium oxide is preferably 0-1% by mass, more preferably 0.01-0.5% by mass, even more preferably 0.02-0.4% by mass, even more preferably 0.025-0.3% by mass, and even more preferably 0.03-0.1% by mass. When the Fe2O3 content in fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen reducer is improved. "Fe2O3 content of 0% by mass" means that it does not contain Fe2O3.

[0043] The preferred specific surface area of ​​magnesium oxide is 0.1 m². 2 / g or more, more preferably 1m 2 / g or more, preferably 5m 2 / g or more, more preferably 10m 2 / g or more, more preferably 20m 2 / g or more, preferably 30m 2 / g or more, preferably 40m 2 / g or more, preferably 50m 2 / g or more, more preferably 100m 2 / g or more. The preferred specific surface area of ​​magnesium oxide is 300m². 2 / g or less, more preferably 250m 2 / g or less, more preferably 200m 2 / g or less. The specific surface area of ​​magnesium oxide is 10m². 2 When the concentration is above a certain level (e.g., g), the allergen-reducing effect of the allergen reducer increases. The specific surface area of ​​the allergen reducer is 300 m². 2 When the concentration is below a certain level, the aggregation of allergen reducers can be reduced, allowing them to be uniformly contained in the substrate, thus making it easier for the appearance of the allergen-reducing product to improve.

[0044] The specific surface area of ​​magnesium oxide refers to the value measured by the BET method based on ASTM D3037-93.

[0045] The D50 particle size of magnesium oxide is preferably 0.1 μm or more, more preferably 0.4 μm or more. The D50 particle size of magnesium oxide is preferably 50 μm or less, more preferably 40 μm or less, more preferably 30 μm or less, more preferably 20 μm or less, more preferably 10 μm or less, more preferably 9 μm or less, and more preferably 8 μm or less. When the D50 particle size of magnesium oxide is 0.1 μm or more, the aggregation of allergen reducers is reduced, allowing them to be uniformly contained in the substrate, thus easily resulting in a better appearance of the allergen-reducing article. When the D50 particle size of magnesium oxide is 50 μm or less, the surface area of ​​the allergen reducer increases, thus easily improving the allergen-reducing effect of the allergen reducer.

[0046] The D50 particle size of magnesium oxide refers to the particle size at which the cumulative frequency (accumulation from the smallest particle size) reaches 50% in the volumetric particle size distribution based on laser scattering (50% cumulative particle size).

[0047] Allergen reducers preferably contain sulfonate compounds or sulfate compounds. The presence of sulfonate compounds or sulfate compounds enhances the allergen-reducing effect against mite allergens.

[0048] Sulfonate compounds are salts (-SO3X) having one or more sulfonyl groups within the molecule. X is a monovalent counter cation. X is not particularly limited, and examples include sodium ions, potassium ions, lithium ions, and ammonium ions. Sodium ions are preferred for the purpose of improving the allergen-reducing effect against mite allergens.

[0049] It should be noted that, in this specification, compounds having the structure represented by Formula 1 within the molecule are classified as sulfate ester compounds. Z is a monovalent counter cation. Z is not particularly limited, and examples include sodium ions, potassium ions, lithium ions, ammonium ions, etc., but sodium ions are preferred for the purpose of improving the allergen-reducing effect against mite allergens. * indicates a binding arm and is a single bond.

[0050] [Chemical Formula 1]

[0051]

[0052] The sulfonate compound is not particularly limited, and examples include: alkane sulfonates, linear alkylbenzene sulfonates, α-olefin sulfonates, alkyl diphenyl ether sulfonates, polymers whose side chains of linear polymers have sulfonation groups, salts of polystyrene sulfonic acid, salts of sulfonated (styrene-divinylbenzene copolymer), salts of sulfonated polyether sulfone, etc. For the reason of improving the allergen reduction effect against mite allergens, alkane sulfonates are preferred, and sodium alkane sulfonate is more preferred.

[0053] Examples of alkane sulfonates include: sodium octane sulfonate, sodium decane sulfonate, sodium undecane sulfonate, sodium dodecane sulfonate, sodium tridecane sulfonate, sodium tetradecane sulfonate, sodium pentadecane sulfonate, sodium hexadecane sulfonate, sodium octadecane sulfonate, etc.; potassium alkane sulfonates such as potassium undecane sulfonate; lithium alkane sulfonates such as lithium decane sulfonate, etc.

[0054] Examples of linear alkylbenzene sulfonates include sodium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, sodium tridecylbenzene sulfonate, ammonium tridecylbenzene sulfonate, sodium tetradecylbenzene sulfonate, and ammonium tetradecylbenzene sulfonate.

[0055] The alkyl group of the linear alkylbenzene sulfonate preferably has 10 or more carbon atoms, more preferably 11 or more, and even more preferably 12 or more. The alkyl group of the linear alkylbenzene sulfonate preferably has 25 or less carbon atoms, more preferably 20 or less, and even more preferably 18 or less. When the number of carbon atoms of the alkyl group is within the above range, the allergen reduction effect against mite allergens is improved.

[0056] Examples of α-olefin sulfonates include sodium α-olefin sulfonate (C12-C22), potassium α-olefin sulfonate (C12-C22), and ammonium α-olefin sulfonate (C12-C22).

[0057] The α-olefin of the α-olefin sulfonate preferably has 12 or more carbon atoms, more preferably 14 or more. The α-olefin of the α-olefin sulfonate preferably has 22 or less carbon atoms, more preferably 18 or less. When the number of carbon atoms of the α-olefin is within the above range, the allergen reduction effect against mite allergens is improved.

[0058] Examples of alkyl diphenyl ether sulfonates include, for example, sodium, potassium, ammonium, and lithium salts of alkyl diphenyl ether sulfonates with alkyl groups of C6 to C24.

[0059] The alkyl group of the alkyl diphenyl ether sulfonate preferably has 6 or more carbon atoms, more preferably 8 or more, and even more preferably 10 or more. The alkyl group of the alkyl diphenyl ether sulfonate preferably has 24 or fewer carbon atoms, more preferably 18 or fewer. When the number of carbon atoms of the alkyl group is within the above range, the allergen reduction effect against mite allergens is improved.

[0060] Sulfate salt compounds only need to have the structure represented by Formula 1 below within the molecule. It should be noted that in Formula 1, Z is as described above. * indicates a binding arm and is a single bond.

[0061] [Chemical Formula 2]

[0062]

[0063] There are no particular limitations on the type of sulfate salt; examples include alkyl sulfate salts and polyoxyethylene alkyl sulfate salts, with alkyl sulfate salts being preferred.

[0064] Examples of alkyl sulfate salts include sodium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, and sodium hexadecyl sulfate, with lauryl sulfate salts being preferred, and sodium lauryl sulfate being more preferred.

[0065] The alkyl group of the alkyl sulfate salt preferably has 5 or more carbon atoms, more preferably 6 or more, more preferably 7 or more, more preferably 8 or more, more preferably 9 or more, more preferably 10 or more, and more preferably 11 or more. The alkyl group of the alkyl sulfate salt preferably has 20 or fewer carbon atoms, more preferably 18 or fewer, more preferably 16 or fewer, more preferably 14 or fewer, and more preferably 13 or fewer. When the number of carbon atoms in the alkyl group of the alkyl sulfate salt is within the above range, the allergen reduction effect against mite allergens is improved.

[0066] Polyoxyethylene alkyl sulfate salts have the structure represented by Formula 2 below.

[0067] [Chemical Formula 3]

[0068]

[0069] In Formula 2, R is an alkyl group with 5 or more carbon atoms, n is the number of repeating units and is a natural number, and Z 1 It is a monovalent counter cation.

[0070] In Formula 2, R can be, for example, octyl, nonyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, etc. The alkyl group preferably has 8 to 18 carbon atoms.

[0071] In Equation 2, n is preferably 1 to 5, more preferably 1 to 4, and even more preferably 1 to 3. In Equation 2, Z is... 1 Examples include sodium ions, potassium ions, lithium ions, and ammonium ions.

[0072] In the allergen reducer, the content of the sulfonate compound relative to 100 parts by mass of magnesium oxide is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more. In the allergen reducer, the content of the sulfonate compound relative to 100 parts by mass of magnesium oxide is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less. When the content of the sulfonate compound is within the above range, the allergen-reducing effect against mite allergens is improved.

[0073] In the allergen reducer, the content of the sulfate salt compound relative to 100 parts by mass of magnesium oxide is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more. In the allergen reducer, the content of the sulfate salt compound relative to 100 parts by mass of magnesium oxide is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less. When the content of the sulfate salt compound is within the above range, the allergen-reducing effect against mite allergens is improved.

[0074] When the allergen reducer contains sulfonate compounds and sulfate compounds, the total content of sulfonate compounds and sulfate compounds in the allergen reducer is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more, relative to 100 parts by mass of magnesium oxide. When the allergen reducer contains sulfonate compounds and sulfate compounds, the total content of sulfonate compounds and sulfate compounds in the allergen reducer is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less, relative to 100 parts by mass of magnesium oxide. When the total content of sulfonate compounds and sulfate compounds is within the above range, the allergen reduction effect against mite allergens is improved.

[0075] Sulfonate or sulfate compounds are preferably supported on the surface of magnesium oxide. When sulfonate or sulfate compounds are supported on the surface of magnesium oxide, the allergen reducer exhibits excellent allergen-reducing effects against mite allergens and has excellent processability as a powder.

[0076] The sulfonate compound supported on the surface of magnesium oxide is preferably 60% or more by mass, more preferably 70% or more by mass, more preferably 80% or more by mass, more preferably 90% or more by mass, more preferably 95% or more by mass, and more preferably 100% by mass (total amount) in 100% by mass of the sulfonate compound.

[0077] The sulfate ester salt compound supported on the surface of magnesium oxide is preferably 60% or more by mass, more preferably 70% or more by mass, more preferably 80% or more by mass, more preferably 90% or more by mass, more preferably 95% or more by mass, and more preferably 100% by mass (total amount) of 100% by mass of the sulfate ester salt compound.

[0078] Here, allergen reducers refer to substances that have an allergen-reducing effect. Regarding the allergen-reducing effect, when the allergen reduction rate of cedar pollen allergen (Cryj1) or mite allergen (Derf1) is measured using the following criteria, a reduction rate of 60% or more for at least one allergen can be considered as having an allergen-reducing effect.

[0079] The allergen reduction rate of the allergen reducer can be determined by the following points. An allergen-reducing coating is prepared by mixing 6 parts by weight of the allergen reducer with 94 parts by weight of a UV-curable acrylic coating.

[0080] Next, a polyester film was prepared as the substrate. An allergen-reducing coating was applied to one side of the substrate at a thickness of 18 μm, and the coating was then subjected to curing at 25°C to achieve a cumulative light intensity of 500 mJ / cm². 2 The method involves irradiating the substrate with ultraviolet light of 365nm wavelength to cure the UV-curable acrylic coating, thereby creating an allergen-reducing substrate with a coating film of 18μm thickness on one side.

[0081] Dissolve the allergen in purified water to prepare an allergen aqueous solution containing 10 μg / mL of allergen. Then, add phosphate-buffered saline (pH 7.4, hereinafter referred to as "PBS-T") containing 0.05 w / v% polysorbate 20 to the allergen aqueous solution and mix thoroughly to prepare an allergen solution containing 15 ng / mL of allergen.

[0082] It should be noted that, for example, the product commercially available from IITEA under the trade name "Cryj1" (Cryptocybe pollen extract, code 10103) can be used as a cypress pollen allergen. Similarly, the product commercially available from IITEA under the trade name "Derf1" (Derf1) can be used as a mite allergen.

[0083] Cut out a 5cm square shape from the allergen-reducing substrate, drop 0.4mL of the allergen solution onto the top of the coating, and then place it at 25°C for 24 hours after covering it with a 4cm square polyethylene film to prepare the test solution.

[0084] Next, the presence of the cedar pollen allergen (Cryj1) in the above test solution was determined by ELISA using an allergen assay kit, with the amount W1 (ng / mL).

[0085] Instead of allergen-reducing coatings, blank coatings containing only UV-curable acrylic paints were used. Furthermore, blank substrates with a coating formed on one side were prepared following the same procedures as described above. Using blank substrates instead of allergen-reducing substrates, the amount of allergen W0 (ng / mL) in the test solution was determined following the same procedures as described above. The allergen reduction rate (%) was calculated based on the following formula.

[0086] Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0087] The allergen reduction rate of the allergen reducer is preferably 70% or more, more preferably 80% or more, more preferably 85% or more, more preferably 90% or more, and more preferably 95% or more.

[0088] The antibody effect in the allergen reducer is preferably 12% or less, more preferably 10% or less, and even more preferably 9% or less.

[0089] The effect of antibodies in allergen reducers can be determined by the following steps. Allergen-reducing substrates are prepared using the same steps as when determining the allergen reduction rate. 0.4 mL of PBS-T is added to the coating of the allergen-reducing substrate and allowed to contact it. The substrate is then covered with a 4 cm square polyethylene film and incubated at 25°C for 24 hours to prepare the test solution.

[0090] Add 100 μL of the above test solution to the wells of the antibody-immobilized 96-well plate included in the allergen assay kit, and incubate at 25°C for 1 hour. Next, wash the wells three times with PBS-T using a plate washer.

[0091] Next, an ELISA assay was performed using the wells described above to determine the amount of allergen W2 (ng / mL) in an allergen solution containing 15 ng / mL of allergen. The effect on antibody (%) was calculated based on the following formula.

[0092] Effect on antibody (%) = 100 - (W2 / 15) × 100

[0093] [Allergen reducer]

[0094] Allergen reducers contain magnesium oxide as an active ingredient. There are no particular limitations on the manufacturing method of allergen reducers; they can be manufactured by mixing magnesium oxide, the active ingredient, with compounds added as needed, according to general principles.

[0095] Next, the key points for using the above-mentioned allergen reducers will be explained. Allergen reducers exert their allergen-reducing effect through the action of magnesium oxide against various allergens. Allergen reducers exert their allergen-reducing effect through contact with allergens.

[0096] Examples of allergens that act as allergen reducers include: house dust mite allergens (Der1, Der2), animal allergens such as canf1 and feld1 from dogs and cats, airborne cedar pollen allergens (Cryj1, Cryj2), and plant allergens such as pollen. As particularly effective animal allergens, mites (mites are organisms belonging to the phylum Arthropoda, class Arachnida, order Acari, mainly divided into 7 suborders: dorsal spiracles represented by *Opilioacarida*, tetraspiracles represented by *Ixodes ovatus*, posterior spiracles represented by *Argas japonicus*, mesospiracles represented by *Ornithonyssus bacoti* and *Dermanyssus hirundinis*, anterior spiracles represented by *Cheyletus malaccensis* and *tarsonemus granarius*, house dust mites such as *Dermatophagoides farinae*, aspiracles represented by *Tyrophagus putrescentiae*, and *Haplochthonius simplex*) are allergens. Any species of house dust mites (such as Willman mites and those with hidden spiracles, such as Cosmochthonius reticulatus) can be targeted, but it is particularly effective against house dust mites, which are abundant in indoor dust, especially in bedding, and are a cause of allergies.

[0097] Allergen reducers can be included in a substrate to which an allergen-reducing effect is desired, thereby constituting an allergen-reducing article. The substrate containing the allergen reducer exhibits an allergen-reducing effect as an allergen-reducing article. There are no particular limitations on the manner in which the allergen reducer is contained in the substrate; for example, methods such as (1) attaching the allergen reducer to the surface of the substrate, or (2) incorporating the allergen reducer into the substrate, etc., can be used to make the substrate contain the allergen reducer.

[0098] For allergen-reducing articles, the content of magnesium oxide constituting the allergen reducer is preferably 0.1 parts by mass or more, more preferably 0.5 parts by mass or more, and even more preferably 1 part by mass or more, relative to 100 parts by mass of the base material. For allergen-reducing articles, the content of magnesium oxide constituting the allergen reducer is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and even more preferably 10 parts by mass or less, relative to 100 parts by mass of the base material.

[0099] Allergen-reducing solutions can be prepared by dissolving or dispersing allergens in a solvent and then applied to a substrate, thereby allowing the allergen-reducing agents to adhere to the substrate surface. It should be noted that allergen-reducing solutions may also contain additives such as water-based solvents, oils, emulsions, and suspending agents, as needed.

[0100] It should be noted that, for example, the solvents mentioned above include: water (preferably ion-exchanged water), alcohols (methanol, ethanol, propanol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.), and ethers (diethyl ether, tetrahydrofuran, etc.). Alkanes, ketones (acetone, methyl ethyl ketone, etc.), amides (N,N-dimethylformamide, etc.), etc.

[0101] The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 1% by mass or more. The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the allergen reducing solution is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

[0102] As a substrate containing allergen reducers, there are no particular limitations as long as it can contain allergen reducers. Examples include: synthetic resin molded bodies, coatings, wallpaper, decorative sheets, flooring materials, fibers, fiber products (fabricated fabrics, non-woven fabrics, woven fabrics), interior products and interior materials for vehicles (e.g., cars, airplanes, ships, etc.) (seats, child seats and the foams that make them up), kitchenware, baby products, building interior materials, etc.

[0103] The synthetic resins constituting the molded synthetic resin body are not particularly limited, but can include, for example: thermoplastic resins (e.g., polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, TEFLON (registered trademark), acrylonitrile butadiene styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefins, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polyimide, polyamide-imide, etc.), and thermosetting resins (e.g., phenolic resin, epoxy resin, melamine resin, urea-formaldehyde resin, unsaturated polyester resin, alkyd resin, silicone resin, polyurethane, thermosetting polyimide, etc.). It should be noted that synthetic resins can be used alone or in combination of two or more.

[0104] Allergen reducers can also be incorporated into synthetic resins. One method for incorporating allergen reducers into synthetic resins is to prepare a resin composition by mixing the allergen reducer with a synthetic resin used as a raw material. Using this resin composition, an allergen-reducing article of the desired shape is obtained in the form of a molded article using a common synthetic resin molding method. Examples of common synthetic resin molding methods include extrusion molding, injection molding, and blow molding. Alternatively, a synthetic resin and an allergen reducer can be mixed to prepare a synthetic resin molding masterbatch, which is then mixed with a synthetic resin used as a raw material. An allergen-reducing article is then manufactured in the form of a molded article using a common synthetic resin molding method.

[0105] The content of magnesium oxide constituting the allergen reducer in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more. The content of magnesium oxide constituting the allergen reducer in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

[0106] The content of magnesium oxide, which constitutes an allergen reducer, in 100% by mass of the synthetic resin molding masterbatch is preferably 20% by mass or more, more preferably 30% by mass or more, and even more preferably 50% by mass or more. The content of magnesium oxide, which constitutes an allergen reducer, in 100% by mass of the synthetic resin molding masterbatch is preferably 80% by mass or less, more preferably 70% by mass or less, and even more preferably 60% by mass or less.

[0107] A method for physically bonding an allergen reducer to a fiber will be described. Examples of methods for physically bonding an allergen reducer to a fiber include: (1) preparing an allergen-reducing solution by dissolving or dispersing the allergen reducer in a solvent, and then impregnating the fiber with the allergen-reducing solution; (2) coating or spraying the aforementioned allergen-reducing solution onto the surface of the fiber; (3) impregnating the fiber with an adhesive prepared by dissolving or dispersing the aforementioned allergen reducer, and then bonding the allergen reducer to the fiber using the adhesive; (4) coating or spraying the aforementioned adhesive prepared by dissolving or dispersing the aforementioned allergen reducer onto the surface of the fiber, and then bonding the allergen reducer to the fiber using the adhesive, etc. It should be noted that in methods (1) and (2) above, the allergen-reducing solution may contain an adhesive. The solvent is the same as described above, therefore, its description is omitted.

[0108] As an adhesive, there are no particular limitations as long as it can bond the allergen reducer to the fiber surface. Examples of adhesives include: urethane resins such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, epoxy acrylate resins, and other synthetic resin adhesives, with urethane resins being preferred.

[0109] As coatings, conventionally known coatings can be used, such as oil-based coatings (e.g., blended coatings, oil-based varnishes, etc.), cellulose coatings, synthetic resin coatings, etc. Coatings also include photocurable coatings that polymerize and generate binder components through irradiation with ultraviolet or other radiation.

[0110] The coating contains binders and solvents. The binders and solvents can be the same substances described above. The coating may contain additives such as pigments, plasticizers, curing agents, thickeners, fillers, anti-aging agents, thickeners, and surfactants, without impairing its physical properties. It should be noted that, as a method for producing an allergen-reducing coating by including an allergen reducer in the coating, for example, a method of supplying the allergen reducer and the coating to a dispersing device and mixing them uniformly can be cited. It should be noted that, for example, a high-speed mill, a ball mill, or a sand mill can be cited as a dispersing device.

[0111] The content of magnesium oxide constituting the allergen reducer in 100% by mass of the allergen-reducing coating is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 1% by mass or more. The content of magnesium oxide constituting the allergen reducer in 100% by mass of the allergen-reducing coating is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

[0112] There are no specific limitations on interior building materials; examples include flooring materials, wallpaper, ceiling materials, paint, door handles, switches, switch covers, wax, etc.

[0113] There are no specific limitations on vehicle interior products and materials, but examples include: seats, child seats, seat belts, seat cushions, seat covers, doors, headliner materials, floor mats, door trim, dashboard, console, glove box, grab handles, armrests, etc.

[0114] Example

[0115] The present invention will be described in more detail below using examples, but the invention is not limited thereto. The specific numerical values ​​of proportions (including proportions), physical property values, parameters, etc. used in the following description can be replaced with the upper limit values ​​(defined in the form of "below" or "less than") or lower limit values ​​(defined in the form of "above" or "more than") of the corresponding proportions (including proportions), physical property values, parameters, etc. described in the above-mentioned "Method for Solving the Problem" and "Specific Embodiments" sections.

[0116] The compounds used in the manufacture of the allergen reducers in the examples and comparative examples are shown below.

[0117] [Magnesium oxide]

[0118] • Lightly calcined magnesium oxide 1 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KYOWAMAG 30", MgO: 98% by mass, CaO: 0.63% by mass, and Fe2O3: 0.018% by mass)

[0119] • Lightly calcined magnesium oxide 2 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KYOWAMAG MF30", MgO: 99.7% by mass, CaO: 0.06% by mass, and Fe2O3: 0.0012% by mass)

[0120] • Lightly calcined magnesium oxide 3 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KYOWAMAG 150", MgO: 98% by mass, CaO: 0.78% by mass, and Fe2O3: 0.018% by mass)

[0121] • Lightly calcined magnesium oxide 4 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KYOWAMAG MF150", MgO: 99.6% by mass, CaO: 0.06% by mass, and Fe2O3: 0.0012% by mass)

[0122] • Lightly calcined magnesium oxide 5 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "PYROKISUMA 5301", MgO: 99.9% by mass, CaO: 0.03% by mass, Fe2O3: 0.0025% by mass)

[0123] • Lightly calcined magnesium oxide 6 (manufactured by Tateho Chemical Industries, trade name "TATEHOMAG700", MgO: 99.2% by mass, CaO: 0.42% by mass, SiO2: 0.16% by mass, Fe2O3: 0.03% by mass)

[0124] • Lightly calcined magnesium oxide 7 (manufactured by Tateho Chemical Industries, trade name "TATEHOMAG500", MgO: 99% by mass, CaO: 0.42% by mass, SiO2: 0.11% by mass, Fe2O3: 0.04% by mass)

[0125] • Lightly calcined magnesium oxide 8 (manufactured by Tateho Chemical Industries, trade name "TATEHOMAG H-10", MgO: 98.9% by mass, CaO: 0.4% by mass, SiO2: 0.1% by mass, Fe2O3: 0.04% by mass)

[0126] • Lightly calcined magnesium oxide 9 (manufactured by Tateho Chemical Industries, trade name "TATEHOMAG1100", MgO: 98.7% by mass, CaO: 0.47% by mass, SiO2: 0.12% by mass, Fe2O3: 0.03% by mass)

[0127] • Lightly calcined magnesium oxide 10 (trade name "UC-95HT" manufactured by Ube Materials Co., Ltd.), MgO: 97.9% by mass, CaO: 0.54% by mass, SiO2: 0.06% by mass, Fe2O3: 0.03% by mass

[0128] • Fused magnesium oxide 1 (trade name "DENMAG KMAOH-F" manufactured by Tateho Chemical Industries), MgO: 98.8% by mass, CaO: 0.43% by mass, SiO2: 0.1% by mass, Fe2O3: 0.05% by mass

[0129] • Fused magnesium oxide 2 (trade name "DENMAG RA-F" manufactured by Tateho Chemical Industries), MgO: 98.8% by mass, CaO: 0.55% by mass, SiO2: 0.26% by mass, Fe2O3: 0.07% by mass)

[0130] [Magnesium hydroxide]

[0131] Magnesium hydroxide 1 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "200-06H")

[0132] Magnesium hydroxide 2 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KISUMA5A")

[0133] Magnesium hydroxide 3 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "KISUMA8SN")

[0134] Magnesium hydroxide 4 (trade name "MAGSTAR 20" manufactured by Tateho Chemical Industries)

[0135] Magnesium hydroxide 5 (trade name "MAGSTAR 7" manufactured by Tateho Chemical Industries)

[0136] For magnesium oxide and magnesium hydroxide, the D50 particle size and specific surface area were measured according to the above-mentioned points, and the results are shown in Table 1.

[0137] [Sulfonate compounds]

[0138] • Sodium alkane sulfonate (manufactured by Kao Chemical Co., Ltd., trade name "LATEMUL PS")

[0139] [Sulfate compounds]

[0140] • Sodium lauryl sulfate (manufactured by Kao Chemical Co., Ltd., trade name "EMAL 10PT")

[0141] (Examples 1-12 and Comparative Examples 1-5)

[0142] The types of magnesium oxide or magnesium hydroxide shown in Table 1 were used to prepare allergen reducers.

[0143] (Examples 13-15)

[0144] 100 parts by mass of magnesium oxide of the types shown in Table 3, and 50 parts by mass of sulfonate compounds or sulfate compounds of the types shown in Table 3 were prepared. 100 parts by mass of magnesium oxide and 50 parts by mass of sulfonate compounds or sulfate compounds were fed to 1050 parts by mass of pure water and mixed thoroughly to prepare a dispersion. Next, the dispersion was pulverized using a spray dryer at an atomizer speed of 20,000 rpm, so that the sulfonate compounds or sulfate compounds were attached (carried) to the surface of the magnesium oxide. Then, it was pulverized using a jet mill (Nisshin Engineering Co., Ltd., trade name "SJ-500") under operating conditions of a raw material supply rate of 1 kg / h and a compressed air pressure of 0.75 MPa, to obtain magnesium oxide with the complete amount of sulfonate compounds or sulfate compounds attached to its surface, which was then used as an allergen reducer.

[0145] For the allergen reducing agents of the Examples and Comparative Examples, the allergen reduction rate and the effect on antibodies were measured by the following key points, and the results are shown in Tables 1 and 3.

[0146] [Anti-allergen test (coating)]

[0147] [Determination of allergen reduction rate of Cryptomeria japonica pollen allergen (Cryj1) (coating)]

[0148] An allergen-reducing coating was prepared by mixing 6 parts by weight of the allergen reducer with 94 parts by weight of a UV-curable acrylic coating (trade name "AI-N2" manufactured by COAT TECH) obtained in the Examples and Comparative Examples. Next, a polyester film was prepared as the substrate. Using a bar coater ♯8, the allergen-reducing coating was applied to one side of the substrate to a thickness of 18 μm. Then, a UV transfer device ("ECS301G1" manufactured by EYE GRAPHICS) was used at 25°C to achieve a cumulative light intensity of 500 mJ / cm². 2 The UV-curable acrylic coating was cured by irradiating it with ultraviolet light of 365nm wavelength, thus creating an allergen-reducing substrate with a coating film of 18μm thickness on one side.

[0149] A freeze-dried powder of cedar pollen allergen (Cryj1) (ITEA trade name "Cedar Pollen Extract, Code 10103") was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of cedar pollen allergen (Cryj1). Then, PBS-T (phosphate buffer containing 0.05% by weight of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd., pH 7.4) was added to the allergen aqueous solution and mixed thoroughly to prepare an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1).

[0150] The allergen-reducing substrate was cut into a planar square shape with a side length of 5 cm. 0.4 mL of the allergen solution was dropped onto the top of the coating. The solution was then wrapped with a planar square polyethylene film with a side length of 4 cm and placed at 25°C for 24 hours to prepare the test solution.

[0151] Next, the presence of cedar pollen allergen (Cryj1) in the above test solution was determined by ELISA using the cedar pollen allergen assay kit (ITEA trade name "cedar pollen allergen (Cryj1) ELISA kit, code 10204"). The concentration W1 (ng / mL) was determined by ELISA.

[0152] Instead of the allergen-reducing coating, a blank coating consisting only of UV-curable acrylic paint was used. Furthermore, a blank substrate with a coating formed on one side was prepared following the same procedures as described above. Using the blank substrate instead of the allergen-reducing substrate, the amount W0 (ng / mL) of the cedar pollen allergen (Cryj1) in the test solution was determined following the same procedures as described above. The allergen reduction rate (%) was calculated based on the following formula. See the "Reduction Rate (%)" column for "Pollen (Cryj1) (Coating)" in Tables 1 and 3.

[0153] Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0154] [Determination of the effect of Cryptomeria japonica pollen allergen (Cryj1) on antibodies (coating)]

[0155] An allergen-reducing substrate was prepared using the same methods as those used in determining the allergen reduction rate of cedar pollen allergen (Cryj1). 0.4 mL of PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH 7.4) was added to the coating of the allergen-reducing substrate and allowed to come into contact with it. The substrate was then covered with a 4 cm square polyethylene film and incubated at 25°C for 24 hours to prepare the test solution.

[0156] 100 μL of the above-mentioned test solution was added to the wells of a 96-well plate immobilized with the antibody contained in the aforementioned Cryptorchidica pollen allergen assay kit (ITEA trade name "Cryj1 Pollen Allergen ELISA Kit, code 10204"), and incubated at 25°C for 1 hour. Next, the wells were washed three times with PBS-T using a plate washer (Tecan trade name "HydroFlexPlus").

[0157] Next, an ELISA assay was performed using the wells described above to determine the amount W2 (ng / mL) of cedar pollen allergen (Cryj1) in an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1). The effect on antibody (%) was calculated based on the following formula and is recorded in the "Antibody Effect (%)" column of "Pollen (Cryj1) (Coating)" in Tables 1 and 3.

[0158] Effect on antibody (%) = 100 - (W2 / 15) × 100

[0159] [Determination of reduction rate of mite allergen (Derf1) (coating) and its effect on antibodies (coating)]

[0160] Freeze-dried powder of mite allergen (Derf1) (ITEA trade name "Mite (Df) Culture Medium Extract, Code 10102") was used instead of freeze-dried powder of cedar pollen allergen (Cryj1), and a mite allergen assay kit (ITEA trade name "Mite Allergen (Derf1) ELISA Kit, Code 10205") was used instead of cedar pollen allergen assay kit (ITEA trade name "Cryj1 Pollen Allergen (Cryj1) ELISA Kit, Code 10204"). Otherwise, the allergen reduction rate (%) and antibody effect (%) of mite allergen (Derf1) were calculated using the same methods as for determining the reduction rate (%) and antibody effect (%) of cedar pollen allergen (Cryj1), and are recorded in the "Reduction Rate (%)" and "Antibody Effect (%)" columns of "Mite (Derf1) (Coating)" in Tables 1 and 3, respectively.

[0161] [Allergen Resistance Test (Fiber)]

[0162] [Determination of allergen reduction rate of Cryptomeria japonica pollen allergen (Cryj1) (fiber)]

[0163] Purified water was added to 1g of the allergen reducer from Examples 6-8, 10-12 and Comparative Example 4 and mixed evenly to prepare an allergen-reducing aqueous solution containing 1% by mass of the allergen reducer.

[0164] Next, as the base material, polyester fiber (manufactured by Shikissensha under the trade name "Polyester Tropical Toray", with a unit area weight of 120g / m²) was prepared. 2The above-mentioned fibers were continuously immersed in 100g of the above-mentioned allergen-reducing aqueous solution for 2 minutes. The impregnated polyester fibers were then squeezed using a manual squeegee and dried continuously at 120°C for 10 minutes to produce allergen-reducing fibers in which the allergen reducer was bonded to the polyester fibers. In the allergen-reducing fibers, at a concentration of 1g / m 2 It contains allergen reducers.

[0165] A freeze-dried powder of cedar pollen allergen (Cryj1) (ITEA trade name "Cedar Pollen Extract, Code 10103") was dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of cedar pollen allergen (Cryj1). Then, PBS-T (phosphate buffer containing 0.05% by weight of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd., pH 7.4) was added to the allergen aqueous solution and mixed thoroughly to prepare an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1).

[0166] 0.4g of allergen-reducing fiber was placed in a zip-locked plastic bag, 1mL of the above allergen solution was added, the bag was sealed, and the bag was placed at 25°C for 2 hours to prepare the test solution.

[0167] Next, the presence of cedar pollen allergen (Cryj1) in the above test solution was determined by ELISA using the cedar pollen allergen assay kit (ITEA trade name "cedar pollen allergen (Cryj1) ELISA kit, code 10204"). The concentration W1 (ng / mL) was determined by ELISA.

[0168] Except that no allergen-reducing fibers were added to the zip-top plastic bag, the presence of cedar pollen allergen W0 (ng / mL) in the test solution was determined using the same criteria as described above. The allergen reduction rate (%) was calculated based on the following formula and is recorded in the "Reduction Rate (%)" column of "Pollen (Cryj1) (Fiber)" in Table 2.

[0169] Allergen reduction rate (%) = 100 - (W1 / W0) × 100

[0170] [Determination of the effect of Cryptomeria japonica pollen allergen (Cryj1) on antibodies (fiber)]

[0171] Allergen-reducing fibers were prepared using the same methods as those used in determining the allergen reduction rate of cedar pollen allergen (Cryj1). 0.4 g of the allergen-reducing fibers was placed in a zip-locked plastic bag, and 1 mL of PBS-T (phosphate buffer containing 0.05% by mass Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH 7.4) was added to bring it into contact with the bag. The bag was then sealed and placed at 25°C for 30 seconds to prepare the test solution.

[0172] 100 μL of the above-mentioned test solution was added to the wells of a 96-well plate immobilized with the antibody contained in the aforementioned Cryptorchidica pollen allergen assay kit (ITEA trade name "Cryj1 Pollen Allergen ELISA Kit, code 10204"), and incubated at 25°C for 1 hour. Next, the wells were washed three times with PBS-T using a plate washer (Tecan trade name "HydroFlexPlus").

[0173] Next, an ELISA assay was performed using the wells described above to determine the amount W2 (ng / mL) of cedar pollen allergen (Cryj1) in an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1). The effect on antibodies (%) was calculated based on the following formula and is recorded in the "Antibody Effect (%)" column of "Pollen (Cryj1) (Fiber)" in Table 2. It can be considered that the smaller the effect on antibodies (%), the less influence the allergen reducer has on antibodies.

[0174] Effect on antibody (%) = 100 - (W2 / 15) × 100

[0175]

[0176]

[0177]

[0178] Industrial applicability

[0179] The allergen reducer of the present invention contains magnesium oxide as an active ingredient, thereby exhibiting excellent allergen-reducing effects. By incorporating the allergen reducer of the present invention into various substrates, allergen-reducing effects can be imparted to the substrates, thereby producing allergen-reducing articles.

[0180] (Cross-reference to related applications)

[0181] This application claims priority based on Japanese Patent Application No. 2023-144669, filed on September 6, 2023, the disclosure of which is incorporated herein by reference in its entirety.

Claims

1. An allergen reducer containing magnesium oxide as an active ingredient.

2. The allergen reducer according to claim 1, wherein, The magnesium oxide comprises at least one magnesium oxide selected from light-burned magnesium oxide, heavy-burned magnesium oxide, and fused magnesium oxide.

3. The allergen reducer according to claim 1 or 2, wherein, The specific surface area of ​​the magnesium oxide is 0.1~300m². 2 / g.

4. The allergen reducer according to any one of claims 1 to 3, wherein, The D50 particle size of the magnesium oxide is 0.1~50μm.

5. The allergen reducer according to any one of claims 1 to 4, further comprising a sulfonate compound or a sulfate salt compound.

6. The allergen reducer according to claim 5, wherein, The sulfonate compound or the sulfate ester compound is supported on the surface of the magnesium oxide.

7. An allergen-reducing coating, comprising: Paint, and The coating contains any one of the allergen reducers according to claims 1 to 6.

8. A masterbatch for molding synthetic resin, comprising: Allergen reducer as described in any one of claims 1 to 6, and Synthetic resins.

9. An allergen-reducing chemical product comprising: Substrate, and The allergen reducer contained in any one of claims 1 to 6 in the substrate.

10. A method for reducing allergens, comprising: A process of contacting the allergen reducer according to any one of claims 1 to 6 with the allergen.

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