Chromatograph rapid heating method and system, intelligent terminal and storage medium

Abstract

The invention relates to the technical field of chromatographic analysis, and discloses a chromatographic instrument rapid heating method and system, an intelligent terminal and a storage medium, and the method comprises the following steps: applying a high-frequency alternating current to a peripheral electromagnetic coil of a chromatographic column, and generating heating power by virtue of an eddy current; carrying out forced heat exchange on the carrier gas and the outer surface of the chromatographic column to form a convective heat exchange field; the heating power generates temperature gradient to excite the thermoelectric effect of the metal tube wall to generate thermoelectric electromotive force; inverting the current average temperature and temperature difference trend based on the calibration relation, and cooperatively regulating the current and the carrier gas flow to construct a composite thermal field; when the current average temperature reaches the preset target temperature and the temperature difference trend information shows that the temperature distribution tends to be steady, switching the regulation and control parameters of the high-frequency alternating current and the preheated carrier gas to a steady-state maintenance mode, and enabling the chromatographic column to enter a constant-temperature control stage; according to the invention, the rapid heating efficiency of the chromatograph can be improved.

Description

Technical Field

[0001] This invention relates to the field of chromatographic analysis technology, and in particular to a rapid heating method, system, intelligent terminal, and storage medium for a chromatograph. Background Technology

[0002] Traditional chromatographs often rely on a single heating mechanism, which is prone to significant heat loss and uneven heat distribution during the heating process. This results in a slow column heating rate, making it difficult to quickly reach the target analytical temperature. Furthermore, the temperature gradient control during heating is not precise enough, and the heat exchange between the metal tube wall and the carrier gas lacks coordination. This not only prolongs the sample preparation time but may also affect the separation effect and the reliability of the detection data due to poor temperature stability.

[0003] In existing technologies, the response lag of temperature feedback and control systems is quite significant, lacking precise capture and dynamic adjustment of temperature difference trends during the heating process. The thermal efficiency of the carrier gas preheating stage is low, failing to form an efficient convective heat transfer field, further restricting the increase in heating rate and increasing energy consumption. Therefore, how to improve the rapid heating efficiency of the chromatograph has become an urgent problem to be solved. Summary of the Invention

[0004] This disclosure provides a method, system, intelligent terminal, and storage medium for rapid temperature rise in a chromatograph.

[0005] In a first aspect, this disclosure provides a method for rapid temperature rise in a chromatograph, comprising: S1. Apply a high-frequency alternating current to the electromagnetic coil surrounding the chromatographic column in the chromatographic instrument to obtain eddy currents in the chromatographic column, and generate heating power for the chromatographic column from the eddy currents; S2. The carrier gas in the gas source system of the chromatograph is thermally energized to obtain the preheated carrier gas of the chromatograph, and the preheated carrier gas is subjected to forced heat exchange with the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. S3. Apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate the thermoelectric potential of the chromatographic column. S4. Based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, the thermoelectric potential is quantitatively inverted to obtain the current average temperature and temperature trend information of the chromatographic column. S5. Based on the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow rate parameter of the preheating carrier gas are coordinated and controlled to construct a coordinated composite thermal field of the chromatographic column. S6. When the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the constant temperature control stage.

[0006] In a preferred embodiment, applying a high-frequency alternating current to an electromagnetic coil surrounding the chromatographic column in the chromatogram to generate eddy currents in the chromatographic column, and using these eddy currents to generate heating power for the chromatographic column, includes: An adjustable drive signal with adjustable amplitude and frequency is input to the high-frequency power supply to generate a high-frequency alternating current of the high-frequency power supply. The high-frequency alternating current is applied to the electromagnetic coil outside the chromatographic column in the chromatograph to excite the alternating magnetic field inside the electromagnetic coil. The magnetic field lines of the alternating magnetic field penetrate the metal wall of the chromatographic column, and perform electromagnetic field-eddy current coupling on the conductive material of the metal wall to obtain a closed eddy current loop of the chromatographic column. Based on the inherent resistance of the metal tube wall, Joule heating is performed on the closed eddy current loop to obtain the heating power of the chromatographic column.

[0007] In a preferred embodiment, the step of thermally energizing the carrier gas in the gas source system of the chromatograph to obtain a preheated carrier gas for the chromatograph, and then forcibly exchanging the preheated carrier gas with the outer surface of the chromatographic column to obtain a convective heat transfer field for the chromatographic column, includes: The carrier gas output from the gas source system in the chromatograph is guided to the preheating chamber around the chromatographic column, and the carrier gas is electrically heated in the preheating chamber to obtain the preheated carrier gas of the chromatograph. The preheated carrier gas is injected into the annular flow guide structure of the chromatographic column; Within the annular flow guiding structure, the flow field of the preheated carrier gas is shaped and optimized to obtain a directional high-speed gas flow for the chromatographic column; The directional high-speed gas flow is subjected to gas-solid interface heat transfer with the outer wall surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column.

[0008] In a preferred embodiment, applying the heating power to the chromatographic column to generate a temperature gradient in the column, and based on the temperature gradient, exciting the thermoelectric effect of the metal wall in the chromatographic column to generate a thermoelectric electromotive force of the column, includes: The heating power is used to perform non-uniform thermal deposition inside the metal tube wall to obtain the temperature gradient of the chromatographic column. Based on the temperature gradient, a stable thermodynamic driving force is established between the two ends of the metal tube wall; Based on the aforementioned thermodynamic driving force, charge carriers in the metal tube wall migrate in a directional manner to trigger the Seebeck effect in the metal tube wall. The potential difference generated by the Seebeck effect is collected by electrodes placed at both ends of the metal tube wall to generate the thermoelectric potential of the chromatographic column.

[0009] In a preferred embodiment, the step of quantitatively inverting the thermoelectric potential based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and temperature difference trend information of the chromatographic column includes: Based on the material properties of the metal tube wall, the thermoelectric potential is linearly regressed and fitted with the reference average temperature of the chromatographic column to obtain the calibration relationship between the thermoelectric potential and the reference average temperature. Based on the calibration relationship, the thermoelectric potential is mapped to the corresponding original temperature value; The original temperature value is corrected for thermoelectric nonlinearity to obtain the current average temperature of the chromatographic column; The current average temperature is collected at different times, and the instantaneous gradient of the current average temperature at adjacent times is calculated to obtain the instantaneous change in axial temperature of the chromatographic column. The formula for calculating the instantaneous change in axial temperature is as follows: ; In the formula, For a moment The instantaneous change in axial temperature. For a moment The current average temperature collected. For the immediate preceding moment The current average temperature collected. The preset fixed time interval for data collection This is the preset thermal inertia correction factor. It is a natural constant. The thermal diffusion time constant of the metal tube wall; The directionality and convergence of the instantaneous axial temperature change are extracted to obtain the temperature difference trend information of the chromatographic column.

[0010] In a preferred embodiment, the step of synergistically controlling the current parameter of the high-frequency alternating current and the flow rate parameter of the preheated carrier gas based on the current average temperature and temperature difference trend information to construct a synergistic composite thermal field for the chromatographic column includes: The difference between the current average temperature and the preset target temperature is mapped by error to obtain the first amplitude adjustment command of the high-frequency alternating current and the first flow rate adjustment command of the preheating carrier gas flow rate; Based on the temperature change direction indicated by the temperature difference trend information, the first amplitude adjustment command and the first flow rate adjustment command are corrected to be in the same direction to obtain the second amplitude adjustment command and the second flow rate adjustment command of the chromatographic column. Based on the temperature change rate indicated by the temperature difference trend information, the response timing of the second amplitude adjustment command and the second flow rate adjustment command is registered to obtain the target current control parameters and target flow rate control parameters of the chromatographic column. Based on the target current control parameters, the high-frequency alternating current of the electromagnetic coil is adjusted, and based on the target flow control parameters, the preheating carrier gas of the chromatographic column is adjusted. The induced eddy current heat generated by the adjusted high-frequency alternating current is coupled and superimposed with the forced convection heat formed by the adjusted preheated carrier gas to construct the synergistic composite thermal field of the chromatographic column.

[0011] In a preferred embodiment, when the current average temperature reaches a preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady-state, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the isothermal control stage, including: When the current average temperature reaches the preset target temperature and the temperature change rate of the temperature difference trend information is continuously lower than the preset stable threshold, it is determined that the temperature distribution of the chromatographic column has reached the quasi-steady-state condition. Based on the aforementioned quasi-steady-state condition, the current amplitude of the high-frequency alternating current is switched from dynamic adjustment mode to narrow-amplitude fluctuation mode, and the flow rate of the preheated carrier gas is switched from adjustment mode to constant flow supply mode. In the narrow-amplitude fluctuation mode and the constant flow supply mode, the amplitude of the high-frequency alternating current is directionally corrected based on the deviation between the current average temperature and the preset target temperature. When the corrected current average temperature is within the range of the preset target temperature and the temperature change rate of the temperature difference trend information is lower than the preset stability threshold, the chromatographic column is confirmed to have entered the isothermal control stage.

[0012] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention generates eddy current heating by applying a high-frequency alternating current to the electromagnetic coil around the chromatographic column, while simultaneously thermally energizing the carrier gas and achieving forced heat exchange, thus constructing a synergistic composite thermal field. The dual heating mechanisms are efficiently superimposed, significantly improving the heating rate of the chromatograph. Furthermore, the directional high-speed airflow optimizes the uniformity of heat exchange, reduces temperature distribution deviation, and creates a stable thermal environment for sample separation.

[0013] 2. This invention generates a thermoelectric electromotive force by stimulating the thermoelectric effect of the metal tube wall. Combined with calibration relationships, it accurately inverts the current average temperature and temperature difference trend, providing a reliable basis for parameter control. By coordinating the adjustment of current and carrier gas flow parameters, it achieves dynamic adaptation during the heating process, rapidly reaching the target temperature and then stably switching to isothermal mode. This ensures temperature control accuracy while reducing energy consumption, effectively improving the analytical efficiency and reliability of the chromatograph, and adapting to diverse analytical scenarios. Attached Figure Description

[0014] The present disclosure will be described in more detail below based on embodiments and with reference to the accompanying drawings: Figure 1 The flowchart of a rapid temperature rise method for a chromatograph according to Embodiment 1 of the present invention is shown. Figure 2 This diagram shows a functional block diagram of a rapid temperature rise system for a chromatograph according to Embodiment 2 of the present invention; Figure 3 The diagram shows the structural composition of the intelligent terminal for implementing the rapid heating method for a chromatograph according to Embodiment 3 of the present invention. Detailed Implementation

[0015] To enable those skilled in the art to better understand the technical solutions of this disclosure, and to fully understand and implement the process of how this disclosure applies technical means to solve technical problems and achieve corresponding technical effects, the technical solutions in the embodiments of this disclosure will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this disclosure, not all embodiments. The embodiments of this disclosure and the various features within them can be combined with each other without conflict, and the resulting technical solutions are all within the protection scope of this disclosure. All other embodiments obtained by those skilled in the art based on the embodiments of this disclosure without creative effort should fall within the protection scope of this disclosure.

[0016] It should be noted that the steps shown in the flowchart in the accompanying drawings can be executed in a computer system such as a set of computer-executable instructions, and although a logical order is shown in the flowchart, in some cases the steps shown or described may be executed in a different order than that shown here.

[0017] Example 1 Figure 1 This is a schematic flowchart illustrating a rapid temperature-raising method for a chromatograph, provided as an embodiment of this disclosure. Figure 1 As shown, a rapid temperature rise method for a chromatograph includes: S1. Apply a high-frequency alternating current to the electromagnetic coil surrounding the chromatographic column in the chromatographic instrument to obtain eddy currents in the chromatographic column, and generate heating power for the chromatographic column from the eddy currents; In this embodiment of the invention, applying a high-frequency alternating current to the electromagnetic coil surrounding the chromatographic column in the chromatogram to obtain eddy currents in the chromatographic column, and generating heating power for the chromatographic column from the eddy currents, includes: An adjustable drive signal with adjustable amplitude and frequency is input to the high-frequency power supply to generate a high-frequency alternating current of the high-frequency power supply. The high-frequency alternating current is applied to the electromagnetic coil outside the chromatographic column in the chromatograph to excite the alternating magnetic field inside the electromagnetic coil. The magnetic field lines of the alternating magnetic field penetrate the metal wall of the chromatographic column, and perform electromagnetic field-eddy current coupling on the conductive material of the metal wall to obtain a closed eddy current loop of the chromatographic column. Based on the inherent resistance of the metal tube wall, Joule heating is performed on the closed eddy current loop to obtain the heating power of the chromatographic column.

[0018] A high-precision function signal generator, wired to the high-frequency power supply signal input, pre-sets a fixed amplitude range and frequency interval for the electrical signal. The oscillation circuit inside the high-precision function signal generator continuously generates a stable electrical signal according to the set parameters. This electrical signal is directly transmitted to the signal receiving port of the high-frequency power supply through a shielded wire. The rectifier circuit, filter circuit, and power amplifier circuit inside the high-frequency power supply process the received drive signal in sequence. First, the signal is rectified into a DC signal. After filtering to remove noise, the signal output capability is enhanced by the power amplifier circuit, and finally, a high-frequency alternating current with corresponding amplitude and frequency is output.

[0019] The conductors are made of copper, which has low resistivity and good conductivity. The current output terminal of the high-frequency power supply is connected one-to-one with the two terminals of the electromagnetic coil on the periphery of the chromatographic column. The connection is fixed by silver brazing, and a dense alloy layer is formed at the weld, ensuring that there is no leakage or excessive contact resistance during current transmission. The high-frequency alternating current flows continuously through the multi-turn dense winding of the electromagnetic coil through the conductors. When the current flows in the winding, a magnetic field is generated. The direction of the magnetic field is reversed as the polarity of the current is reversed, and the intensity changes synchronously with the magnitude of the current. The number of alternations per second is kept within a preset range, thereby exciting a stable alternating magnetic field inside the electromagnetic coil.

[0020] The alternating magnetic field generated inside the electromagnetic coil radiates outward in a ring shape with magnetic lines of force. These lines of force can pass through the stainless steel metal tube wall of the chromatography column without obstruction. Due to the good conductivity of the stainless steel tube wall, the periodic change of the magnetic lines of force will induce a closed electric field in the conductive material of the metal tube wall according to the law of electromagnetic induction. This induced electric field will generate a directional electric force, driving free electrons in the conductive material to move directionally along the circumference of the tube wall. These directionally moving free electrons form a closed current path that is close to the inner side of the tube wall without any breaks, thus obtaining a closed eddy current loop.

[0021] The inherent resistance of the metal tube wall is determined by its material properties. When the current in the closed eddy current loop flows through the metal tube wall, it is hindered by this inherent resistance. The free electrons in the current collide with the atoms of the tube wall material, which intensifies the thermal motion of the atoms and converts electrical energy into heat energy. This heat energy diffuses evenly from the outer layer of the tube wall to the inner layer and from both ends to the middle through thermal conduction, covering the entire tube wall and the stationary phase carrier inside the column. This direct conversion of electrical energy into heat energy is called Joule heating. There is no additional energy loss in the conversion process. The physical quantity generated after the conversion that can provide continuous energy for heating the column is the heating power of the column.

[0022] The beneficial effects are that, through a clear and reproducible signal transmission, current loading, magnetic field excitation and energy conversion process, the high-frequency alternating current is stably generated and the output fluctuation range of heating power is controlled within ±2%. The entire process depends on the specific device selection, connection method and physical action. Without complex control, the continuous and stable output of heating energy can be guaranteed. The heating power is directly applied to the core area of ​​the chromatographic column, providing stable and reliable energy support for the subsequent rapid heating and uniform temperature distribution of the chromatographic column, and improving the consistency and controllability of the chromatograph heating process.

[0023] S2. The carrier gas in the gas source system of the chromatograph is thermally energized to obtain the preheated carrier gas of the chromatograph, and the preheated carrier gas is subjected to forced heat exchange with the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. In this embodiment of the invention, the step of thermally energizing the carrier gas in the gas source system of the chromatograph to obtain a preheated carrier gas for the chromatograph, and then forcibly exchanging the preheated carrier gas with the outer surface of the chromatographic column to obtain a convective heat transfer field for the chromatographic column, includes: The carrier gas output from the gas source system in the chromatograph is guided to the preheating chamber around the chromatographic column, and the carrier gas is electrically heated in the preheating chamber to obtain the preheated carrier gas of the chromatograph. The preheated carrier gas is injected into the annular flow guide structure of the chromatographic column; Within the annular flow guiding structure, the flow field of the preheated carrier gas is shaped and optimized to obtain a directional high-speed gas flow for the chromatographic column; The directional high-speed gas flow is subjected to gas-solid interface heat transfer with the outer wall surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column.

[0024] The outlet of the gas supply system of the chromatograph is connected to the inlet of the preheating chamber around the column using corrosion-resistant stainless steel tubing. Fluororubber sealing gaskets are installed at the tubing connections to seal the end faces and prevent carrier gas leakage. The preheating chamber adopts a double-layer vacuum insulation structure, with multiple sets of nickel-chromium alloy heating wires evenly embedded in the inner wall. The heating wires are connected to an external controllable power supply through high-temperature resistant wires. After the carrier gas enters the preheating chamber smoothly through the tubing, the controllable power supply is turned on to power the heating wires. The heating wires convert electrical energy into heat energy and conduct it to the carrier gas through the chamber wall. The heating continues until the carrier gas temperature reaches the preset preheating temperature that matches the target temperature rise stage of the chromatographic column. At this point, the preheated carrier gas is obtained.

[0025] The air outlet of the preheating chamber is fixedly connected to the annular air inlet of the annular guide structure via a flange with a sealing groove. Under the pressure output by the air source system, the preheating carrier gas flows continuously from the air outlet pipe of the preheating chamber. The end of the pipe is precisely connected to the air inlet channel of the annular guide structure. The carrier gas is smoothly injected into the interior of the annular guide structure along the air inlet channel. The air inlet end of the annular guide structure is equipped with a diffuser chamber, which can buffer the pressure fluctuations during carrier gas injection and ensure that the carrier gas injection process is smooth and turbulent. In addition, the inner wall of the annular guide structure is polished to reduce the frictional resistance during carrier gas flow.

[0026] Twenty titanium alloy guide vanes with fixed tilt angles are evenly arranged along the circumference inside the annular guide structure. The vanes form a 30-degree angle with the column axis. After the preheated carrier gas enters the annular guide structure, the originally chaotic radial flow is sorted out and transformed into a unidirectional flow along the column axis under the mechanical guidance of the guide vanes. At the same time, the outlet section of the annular guide structure adopts a contraction channel design. The cross-sectional area of ​​the channel gradually decreases from the inlet end to the outlet end in a fixed proportion. The carrier gas is accelerated due to space compression during the flow process, and finally a directional high-speed airflow with uniform velocity and direction parallel to the column axis is formed.

[0027] A directional high-speed airflow continuously flows out from the outlet end of the annular guide structure, sweeping parallel across the outer surface of the chromatographic column. The airflow forms a tight gas-solid interface with the outer wall of the column. The heat energy carried by the airflow is transferred to the outer wall of the column through heat conduction. At the same time, the airflow continuously exchanges heat with the column wall during the flow process. Due to the consistent airflow direction and stable flow velocity, the heat is evenly distributed on the outer wall of the column, forming a continuous heat exchange region covering the entire length of the column. The heat transfer within this heat exchange region is efficient and uniform, which is the convective heat transfer field of the chromatographic column.

[0028] The beneficial effects are that through clear pipeline connections, heating methods, flow guiding structure design and heat transfer process, stable preheating, directional flow and efficient heat exchange of carrier gas are achieved, ensuring a uniform and continuous convective heat transfer field, providing stable auxiliary heating support for the chromatographic column, and accelerating the heating rate of the chromatographic column when working in conjunction with eddy current heating, while ensuring uniform temperature distribution of the chromatographic column, and improving the stability and controllability of the chromatograph heating process.

[0029] S3. Apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate the thermoelectric potential of the chromatographic column. In this embodiment of the invention, applying the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, exciting the thermoelectric effect of the metal wall in the chromatographic column to generate a thermoelectric potential difference in the chromatographic column, includes: The heating power is used to perform non-uniform thermal deposition inside the metal tube wall to obtain the temperature gradient of the chromatographic column. Based on the temperature gradient, a stable thermodynamic driving force is established between the two ends of the metal tube wall; Based on the aforementioned thermodynamic driving force, charge carriers in the metal tube wall migrate in a directional manner to trigger the Seebeck effect in the metal tube wall. The potential difference generated by the Seebeck effect is collected by electrodes placed at both ends of the metal tube wall to generate the thermoelectric potential of the chromatographic column.

[0030] The heating power is continuously applied to the metal tube wall through Joule heat conversion. Since the eddy current distribution of the metal tube wall is concentrated in the surface area near the electromagnetic coil, and the heat exchange efficiency of the convective heat transfer field on the tube wall surface varies slightly along the axial direction, the heat transfer rate inside the tube wall is different. The heat is preferentially deposited in the dense eddy current area and then gradually diffuses to the inner layer of the tube wall and both ends. Finally, a temperature distribution state is formed in which the temperature of the tube wall decreases sequentially from one end to the other axially and from the surface to the inner layer radially, thus obtaining the temperature gradient of the chromatographic column.

[0031] The temperature gradient of the chromatographic column clearly defines the temperature difference between the two ends of the metal tube wall. The particles at the higher temperature end have more intense thermal motion and a higher energy state, while the particles at the lower temperature end have relatively lower energy. This stable difference in energy state between the two ends creates a force that drives the particles to move towards the energy equilibrium direction. This force is continuous and fixed in direction, establishing a stable thermodynamic driving force between the two ends of the metal tube wall.

[0032] Inside the metal tube wall, there are a large number of free electrons as charge carriers. A stable thermodynamic driving force will exert a directional force on these free electrons, pushing them to move continuously from the higher temperature end to the lower temperature end. This directional migration of charge carriers meets the triggering condition of the Seebeck effect, that is, the potential difference generated by the movement of charges between different temperature regions will trigger the Seebeck effect in the metal tube wall.

[0033] Two platinum electrodes with a purity of 99.99% are fixed at the center of the two end faces of the metal tube wall using laser welding. The electrodes are tightly fitted to the tube wall without gaps. The lead wires of the electrodes are connected to a high-precision voltage acquisition device, which can capture the difference in charge distribution at both ends of the metal tube wall due to the Seebeck effect in real time and directly acquire the voltage difference between the two ends. This acquired voltage difference is the thermoelectric potential of the chromatographic column.

[0034] The beneficial effects are that, through a clear thermal deposition mechanism, thermodynamic driving force formation principle, Seebeck effect triggering path, and potential difference acquisition method, the stable generation and accurate acquisition of thermoelectric potential are ensured. The entire process is based on the physical properties and energy transfer laws of the metal tube wall, without the need for complex control. The generated thermoelectric potential can truly reflect the temperature state of the chromatographic column, providing reliable signal support for subsequent temperature inversion analysis and improving the accuracy and stability of temperature detection.

[0035] S4. Based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, the thermoelectric potential is quantitatively inverted to obtain the current average temperature and temperature trend information of the chromatographic column. In this embodiment of the invention, the step of quantitatively inverting the thermoelectric potential based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and temperature difference trend information of the chromatographic column includes: Based on the material properties of the metal tube wall, the thermoelectric potential is linearly regressed and fitted with the reference average temperature of the chromatographic column to obtain the calibration relationship between the thermoelectric potential and the reference average temperature. Based on the calibration relationship, the thermoelectric potential is mapped to the corresponding original temperature value; The original temperature value is corrected for thermoelectric nonlinearity to obtain the current average temperature of the chromatographic column; The current average temperature is collected at different times, and the instantaneous gradient of the current average temperature at adjacent times is calculated to obtain the instantaneous change in axial temperature of the chromatographic column. The formula for calculating the instantaneous change in axial temperature is as follows: ; In the formula, For a moment The instantaneous change in axial temperature. For a moment The current average temperature collected. For the immediate preceding moment The current average temperature collected. The preset fixed time interval for data collection This is the preset thermal inertia correction factor. It is a natural constant. The thermal diffusion time constant of the metal tube wall; The directionality and convergence of the instantaneous axial temperature change are extracted to obtain the temperature difference trend information of the chromatographic column.

[0036] First, the material composition, thermal conductivity, and Seebeck coefficient of the metal tube wall are determined using material testing equipment to fix the material properties. Then, with the column unloaded, the column is stabilized at ten different preset reference temperature points using a temperature control device. Each temperature point is spaced ten degrees Celsius apart and covers the commonly used analytical temperature range of the chromatograph from fifty to three hundred degrees Celsius. At each reference temperature point, the thermoelectric potential is continuously collected three times and the average value is taken to obtain ten sets of one-to-one thermoelectric potential data and reference average temperature data. These ten sets of data are input into a data processing device, and a fitting straight line is formed by connecting the data sets to make the straight line as close as possible to all data points. The correspondence between the thermoelectric potential represented by this straight line and the reference average temperature is the calibration relationship.

[0037] The real-time collected thermoelectric potential (TEP) values ​​are compared with the established calibration relationship. If the collected TEP values ​​exactly match a known value in the calibration relationship, the reference average temperature corresponding to that value is directly retrieved as the original temperature value. If the collected TEP values ​​are between two sets of known values, the corresponding temperature value is determined by proportional conversion of adjacent values ​​according to the linear law of the calibration relationship. This value is the original temperature value.

[0038] The thermoelectric nonlinear deviation of the metal tube wall in different temperature ranges is determined in advance through experiments. A deviation correction table is established, which specifies the correction amount corresponding to different original temperature values. The obtained original temperature values ​​are matched between ranges to find the corresponding correction amount. The original temperature value and the correction amount are added or subtracted. When the original temperature value is higher than the true value, the correction amount is subtracted, and when it is lower than the true value, the correction amount is added. The temperature value obtained after this adjustment process is the current average temperature of the chromatographic column.

[0039] A fixed temperature acquisition interval of one second was set. This interval was determined through comparative experiments of twenty different time intervals, taking into account the conventional heating rate range of the chromatographic column and the thermal response characteristics of the metal tube wall. This ensures complete capture of instantaneous temperature changes without generating invalid redundant data. The temperature acquisition device continuously acquires the current average temperature of the chromatographic column at this interval, recording temperature data at different times sequentially. The average temperature of two adjacent times is selected, with the temperature data of the later time being recorded as the second average temperature. The collected current average temperature, with the temperature data from the previous moment being the most recent moment. Furthermore, the average temperature obtained at the previous acquisition moment, one second apart, is calculated by subtracting the previous temperature value from the temperature value at the next moment, and then dividing by the fixed time interval of one second. Simultaneously, a preset thermal inertia correction factor is introduced. This correction factor is determined by conducting heating experiments in ten different temperature ranges, recording the deviation between the actual temperature change in each range and the theoretical calculation value without considering thermal inertia, and statistically analyzing all deviation data. It is specifically used to compensate for calculation errors caused by thermal inertia and the thermal diffusion time constant of the metal pipe wall. This thermal diffusion time constant is determined by accurately measuring the metal... The material composition, wall thickness, thermal conductivity, and other material properties of the tube wall were determined through a heat conduction experiment conducted at a constant temperature of 25 degrees Celsius. The time taken for the temperature difference between all points on the tube wall to be less than 0.1 degrees Celsius after being heated from one end was recorded. Based on this experimental data and fixed natural constants in mathematics, the temperature was corrected by dividing the difference by the time interval and then multiplying it by (1 minus the product of the thermal inertia correction factor and the natural constant, where the time interval with a negative exponent is the ratio of the thermal diffusion time constant). The final value obtained is the instantaneous change in axial temperature of the chromatographic column within that adjacent time interval.

[0040] The instantaneous changes in axial temperature collected continuously are analyzed one by one. The sign of each change is determined to identify the direction of temperature change. Positive values ​​represent the direction of heating, and negative values ​​represent the direction of cooling. At the same time, the absolute values ​​of five consecutive instantaneous changes in axial temperature are counted. If these five values ​​decrease sequentially and the last value is less than the preset threshold of 0.1℃ / second, the temperature change is considered to be converging. The combination of the direction of temperature change and the convergence state forms a combination of information including "heating / cooling" and "tending to stabilize / continuous change". This combination of information is the temperature difference trend information of the chromatographic column.

[0041] The beneficial effects are as follows: through a clear process of material property determination, data fitting, numerical mapping, nonlinear correction, and trend extraction, combined with a calculation method for the instantaneous change in axial temperature with clear parameter sources and rigorous logic, the measurement accuracy of the current average temperature is ensured to be controlled within ±0.2℃. The temperature difference trend information can accurately reflect the temperature change status of the chromatographic column. The entire process is based on reproducible physical operation and data processing logic, without the need for complex algorithms. The calculation process offsets the temperature change delay caused by the thermal inertia of the metal tube wall, so that the instantaneous change in axial temperature can truly reflect the real-time change of the axial temperature of the chromatographic column. This provides accurate and reliable temperature data support for the subsequent coordinated control of high-frequency alternating current and preheated carrier gas, ensuring the controllability and stability of the chromatograph's heating process.

[0042] S5. Based on the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow rate parameter of the preheating carrier gas are coordinated and controlled to construct a coordinated composite thermal field of the chromatographic column. In this embodiment of the invention, the step of synergistically regulating the current parameter of the high-frequency alternating current and the flow rate parameter of the preheated carrier gas based on the current average temperature and temperature difference trend information to construct a synergistic composite thermal field for the chromatographic column includes: The difference between the current average temperature and the preset target temperature is mapped by error to obtain the first amplitude adjustment command of the high-frequency alternating current and the first flow rate adjustment command of the preheating carrier gas flow rate; Based on the temperature change direction indicated by the temperature difference trend information, the first amplitude adjustment command and the first flow rate adjustment command are corrected to be in the same direction to obtain the second amplitude adjustment command and the second flow rate adjustment command of the chromatographic column. Based on the temperature change rate indicated by the temperature difference trend information, the response timing of the second amplitude adjustment command and the second flow rate adjustment command is registered to obtain the target current control parameters and target flow rate control parameters of the chromatographic column. Based on the target current control parameters, the high-frequency alternating current of the electromagnetic coil is adjusted, and based on the target flow control parameters, the preheating carrier gas of the chromatographic column is adjusted. The induced eddy current heat generated by the adjusted high-frequency alternating current is coupled and superimposed with the forced convection heat formed by the adjusted preheated carrier gas to construct the synergistic composite thermal field of the chromatographic column.

[0043] The user pre-sets a fixed target temperature according to the analytical requirements of the chromatograph. The current average temperature of the chromatographic column is obtained through a temperature acquisition device. The difference between the current average temperature and the target temperature is calculated. A correspondence table between the difference and the adjustment command is pre-established. The table specifies the high-frequency alternating current amplitude adjustment and the preheating carrier gas flow rate adjustment corresponding to different difference ranges. The calculated difference is matched with the correspondence table, and the command generation circuit outputs the corresponding electrical signal command. This electrical signal command is the first amplitude adjustment command of the high-frequency alternating current and the first flow rate adjustment command of the preheating carrier gas.

[0044] The direction of temperature change is extracted from the temperature difference trend information to determine whether the current chromatographic column is in the direction of heating or cooling. The adjustment directions of the first amplitude adjustment command and the first flow rate adjustment command are compared with the direction of temperature change. If the direction of temperature change is heating and the current average temperature is lower than the preset target temperature, the current adjustment amount of the first amplitude adjustment command and the flow rate adjustment amount of the first flow rate adjustment command are increased. If the direction of temperature change is cooling and the current average temperature is higher than the preset target temperature, the current adjustment amount of the first amplitude adjustment command and the flow rate adjustment amount of the first flow rate adjustment command are decreased to ensure that the adjustment commands are consistent with the direction of temperature change. The commands obtained after this adjustment process are the second amplitude adjustment command and the second flow rate adjustment command for the chromatographic column.

[0045] The temperature change rate is extracted from the temperature difference trend information. Three temperature change rate intervals are preset, each corresponding to a different delay time for the execution of adjustment commands. The first interval corresponds to a delay of 0.5 seconds, the second interval to a delay of 0.3 seconds, and the third interval to a delay of 0.1 seconds. The extracted temperature change rates are assigned to the corresponding intervals, and the execution delay time of each interval is obtained. The second amplitude adjustment command and the second flow rate adjustment command are executed synchronously according to the delay time, so that the adjustment actions of the two are synchronized in time. The parameters obtained after time registration are the target current control parameters and target flow rate control parameters of the chromatographic column.

[0046] The target current control parameters are transmitted to the control module of the high-frequency power supply. The control module adjusts the output current by changing the resistance value of the internal circuit, so that the amplitude of the high-frequency alternating current output by the high-frequency power supply is consistent with the target current control parameters. At the same time, the target flow control parameters are transmitted to the electromagnetic flow control valve of the gas source system. The electromagnetic flow control valve adjusts the valve opening according to the parameters. The valve opening is proportional to the carrier gas flow rate. The larger the opening, the larger the flow rate. By precisely adjusting the valve opening, the flow rate of the preheated carrier gas is made to meet the requirements of the target flow control parameters.

[0047] After the adjusted high-frequency alternating current is applied to the electromagnetic coil, a stronger or weaker alternating magnetic field is generated, which in turn forms a corresponding induced eddy current heat inside the metal tube wall. This heat is conducted from the inside of the metal tube wall to the core area of ​​the chromatographic column. The adjusted preheated carrier gas forms a stable directional high-speed airflow through the annular flow guide structure, and performs efficient heat exchange with the outer wall of the chromatographic column to generate forced convection heat. The induced eddy current heat and the forced convection heat act on the chromatographic column at the same time. The internal heat and the external heat are superimposed and work together to form a thermal field that covers the entire length of the chromatographic column and has a uniform temperature distribution. This thermal field is the synergistic composite thermal field of the chromatographic column.

[0048] The beneficial effects are that, through a clear process of difference matching, direction correction, timing registration, parameter adjustment, and thermal coupling, precise and coordinated control of high-frequency alternating current and preheating carrier gas flow is achieved, ensuring uniform temperature distribution of the coordinated composite thermal field and rapid adaptation to the heating requirements of the chromatographic column. The entire process is based on reproducible physical operations and logical matching, without the need for complex control, effectively improving the heating efficiency and temperature stability of the chromatographic column, and laying a good foundation for the subsequent isothermal control stage.

[0049] S6. When the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the constant temperature control stage.

[0050] In this embodiment of the invention, when the current average temperature reaches a preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady-state, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the isothermal control stage, including: When the current average temperature reaches the preset target temperature and the temperature change rate of the temperature difference trend information is continuously lower than the preset stable threshold, it is determined that the temperature distribution of the chromatographic column has reached the quasi-steady-state condition. Based on the aforementioned quasi-steady-state condition, the current amplitude of the high-frequency alternating current is switched from dynamic adjustment mode to narrow-amplitude fluctuation mode, and the flow rate of the preheated carrier gas is switched from adjustment mode to constant flow supply mode. In the narrow-amplitude fluctuation mode and the constant flow supply mode, the amplitude of the high-frequency alternating current is directionally corrected based on the deviation between the current average temperature and the preset target temperature. When the corrected current average temperature is within the range of the preset target temperature and the temperature change rate of the temperature difference trend information is lower than the preset stability threshold, the chromatographic column is confirmed to have entered the isothermal control stage.

[0051] The current average temperature of the chromatographic column is monitored in real time using a high-precision platinum resistance temperature sensor. The sensor has a measurement accuracy of ±0.01℃ and a sampling frequency of 1Hz. The preset target temperature is set by the user within the commonly used range of 50℃-300℃ according to the chromatographic analysis requirements. The absolute difference between the current average temperature and the preset target temperature is calculated. When the difference is less than or equal to 0.3℃, the current average temperature is determined to have reached the preset target temperature. At the same time, the temperature change rate in the temperature difference trend information is extracted. The preset stability threshold is fixed at 0.05℃ / second. The temperature change rate is collected three times consecutively at time t, t+1 seconds, and t+2 seconds. If all three values ​​are lower than 0.05℃ / second, the condition that the temperature change rate is continuously lower than the preset stability threshold is met. At this time, it is directly determined that the temperature distribution of the chromatographic column has reached the quasi-steady-state condition.

[0052] After the quasi-steady-state condition is triggered, the mode switching operation is performed through an electronic switch electrically connected to the high-frequency power supply. In the dynamic adjustment mode, the current amplitude can be flexibly adjusted within the range of 50%-150% of the initial amplitude according to the temperature deviation. In the narrow-range fluctuation mode after switching, the average amplitude of the last three high-frequency alternating currents under the quasi-steady-state condition is first calculated, and this average value is used as the reference amplitude. The current amplitude only fluctuates slightly within ±5% of the reference amplitude to avoid large changes from impacting the temperature stability of the chromatographic column. At the same time, the flow mode is switched through the electromagnetic locking valve in the gas source system pipeline. The average flow rate of the last three preheated carrier gas under the quasi-steady-state condition is first recorded, and this average value is used as the fixed flow rate value. This switches the preheated carrier gas from the adjustment mode, which can be continuously changed within the range of 10-50 mL / min according to the adjustment command, to the constant flow supply mode where the fixed flow rate value remains unchanged, ensuring the stability of the heat exchange efficiency between the carrier gas and the outer wall of the chromatographic column.

[0053] In the narrow-range fluctuation mode, the temperature acquisition device acquires the current average temperature of the chromatographic column once per second at a sampling frequency of 1Hz. After each acquisition, the difference between the current average temperature and the preset target temperature is calculated immediately. If the calculation result is positive and the positive value is greater than 0.1℃, the control module of the high-frequency power supply outputs an adjustment signal to reduce the amplitude of the high-frequency alternating current by 0.5%. If the calculation result is negative and the absolute value of the negative value is greater than 0.1℃, the control module outputs a reverse adjustment signal to increase the amplitude of the high-frequency alternating current by 0.5%. If the calculation result is within the range of -0.1℃ to 0.1℃, the control module does not output an adjustment signal and keeps the current current amplitude unchanged. This dynamic adjustment process based on the difference is the directional correction based on the deviation. During the correction, the preheated carrier gas is always supplied at a constant flow rate, and the flow rate fluctuation range is controlled within ±0.1mL / min.

[0054] The preset target temperature range is clearly set from the preset target temperature minus 0.1℃ to the preset target temperature plus 0.1℃. After directional correction, the temperature acquisition device continuously acquires the current average temperature of the chromatographic column at a frequency of 1Hz. When the temperature values ​​acquired twice consecutively at times t3 and t3+1 seconds both fall within this range, and the temperature change rate in the temperature difference trend information at the same time is lower than the preset stable threshold of 0.05℃ / second, the control module, which is electrically connected to both the temperature acquisition device and the high-frequency power supply, immediately sends a high-level electrical signal as a constant temperature confirmation signal to confirm that the chromatographic column has entered the constant temperature control stage. During this stage, the current narrow fluctuation mode and constant flow supply mode will be maintained until the chromatographic analysis process ends.

[0055] The beneficial effects include a smooth transition from the heating stage to the isothermal stage through clear selection of high-precision detection equipment, specific numerical judgment standards, reproducible mode switching mechanisms, and precise deviation correction logic. The transition time does not exceed 3 seconds, ensuring that the temperature fluctuation range after the chromatographic column enters the isothermal control stage is strictly controlled within ±0.1℃. The entire process is based on the precise collaboration and fixed logic of physical hardware, without the need for complex control algorithms. This effectively ensures the temperature stability required for component separation in chromatographic analysis, reduces peak distortion caused by temperature fluctuations, significantly improves the analytical accuracy of the chromatograph and the reliability of the detection results, and is suitable for various high-precision chromatographic analysis scenarios.

[0056] Example 2 like Figure 2 As shown in the figure, this embodiment also provides a functional block diagram of a chromatograph rapid heating system.

[0057] The rapid heating system 100 for a chromatograph described in this embodiment can be installed in a smart terminal. Depending on the functions implemented, the rapid heating system 100 may include an eddy current induction heating module 101, a forced gas-thermal convection module 102, a thermoelectric signal generation module 103, a temperature inversion analysis module 104, a collaborative thermal field construction module 105, and a constant temperature maintenance switching module 106. The module described in this invention can also be called a unit, referring to a series of computer program segments that can be executed by the smart terminal processor and perform a fixed function, stored in the smart terminal's memory.

[0058] In this embodiment, the functions of each module / unit are as follows: The eddy current induction heating module 101 is used to apply a high-frequency alternating current to the electromagnetic coil around the chromatographic column in the chromatographic instrument to obtain the eddy current of the chromatographic column, and generate the heating power of the chromatographic column from the eddy current. The forced convection module 102 is used to thermally energize the carrier gas in the gas source system of the chromatograph to obtain the preheated carrier gas of the chromatograph, and to force heat exchange between the preheated carrier gas and the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. The thermoelectric signal generation module 103 is used to apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, to excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate the thermoelectric electromotive force of the chromatographic column. The temperature inversion analysis module 104 is used to quantitatively invert the thermoelectric potential based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, so as to obtain the current average temperature and temperature trend information of the chromatographic column. The collaborative thermal field construction module 105 is used to collaboratively regulate the current parameter of the high-frequency alternating current and the flow parameter of the preheated carrier gas according to the current average temperature and temperature difference trend information, so as to construct the collaborative composite thermal field of the chromatographic column. The constant temperature maintenance switching module 106 is used to switch the control parameters of the high-frequency alternating current and the preheated carrier gas to the steady-state maintenance mode when the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, so that the chromatographic column enters the constant temperature control stage.

[0059] Example 3 like Figure 3 As shown, this embodiment also provides a computer intelligent terminal, which may include a processor 10, a memory 11, a communication bus 12 and a communication interface 13, and may also include a computer program stored in the memory 11 and capable of running on the processor 10, such as a chromatograph rapid heating program.

[0060] In some embodiments, the processor 10 may be composed of integrated circuits, such as a single packaged integrated circuit or multiple integrated circuits with the same or different functions, including combinations of one or more central processing units (CPUs), microprocessors, digital processing chips, graphics processors, and various control chips. The processor 10 is the control unit of the smart terminal, connecting various components of the smart terminal via various interfaces and lines. It executes programs or modules stored in the memory 11 (e.g., executing a chromatograph rapid heating program) and calls data stored in the memory 11 to perform various functions and process data for the smart terminal.

[0061] The memory 11 includes at least one type of medium, including flash memory, portable hard drive, multimedia card, card-type memory (e.g., SD or DX memory), magnetic memory, magnetic disk, optical disk, etc. In some embodiments, the memory 11 can be an internal storage unit of a smart terminal, such as the portable hard drive of the smart terminal. In other embodiments, the memory 11 can also be an external storage device of the smart terminal, such as a plug-in portable hard drive, smart media card (SMC), secure digital (SD) card, flash card, etc., equipped on the smart terminal. Furthermore, the memory 11 can include both internal storage units and external storage devices of the smart terminal. The memory 11 can be used not only to store application software and various types of data installed on the smart terminal, such as the code of a chromatograph rapid heating program, but also to temporarily store data that has been output or will be output.

[0062] The communication bus 12 can be a peripheral component interconnect (PCI) bus or an extended industry standard architecture (EISA) bus, etc. This bus can be divided into an address bus, a data bus, a control bus, etc. The bus is configured to enable communication between the memory 11 and at least one processor 10, etc.

[0063] The communication interface 13 is used for communication between the aforementioned smart terminal and other smart terminals, including a network interface and a user interface. Optionally, the network interface may include a wired interface and / or a wireless interface (such as a Wi-Fi interface, Bluetooth interface, etc.), typically used to establish a communication connection between the smart terminal and other smart terminals. The user interface may be a display, an input unit (such as a keyboard), or optionally, a standard wired or wireless interface. Optionally, in some embodiments, the display may be an LED display, a liquid crystal display, a touch-sensitive liquid crystal display, or an OLED (Organic Light-Emitting Diode) touchscreen, etc. The display may also be appropriately referred to as a screen or display unit, used to display information processed in the smart terminal and to display a visual user interface.

[0064] The figure only shows a smart terminal with components. Those skilled in the art will understand that the structure shown in the figure does not constitute a limitation on the smart terminal, and may include fewer or more components than shown, or combine certain components, or have different component arrangements.

[0065] For example, although not shown, the smart terminal may also include a power supply (such as a battery) to power the various components. Preferably, the power supply can be logically connected to the at least one processor 10 through a power management system, thereby enabling functions such as charging management, discharging management, and power consumption management through the power management system. The power supply may also include one or more DC or AC power supplies, a recharging system, a power fault detection circuit, a power converter or inverter, a power status indicator, or any other components. The smart terminal may also include various sensors, Bluetooth modules, Wi-Fi modules, etc., which will not be described in detail here.

[0066] It should be understood that the embodiments described are for illustrative purposes only and are not limited to this structure in the scope of the patent application.

[0067] The chromatograph rapid temperature rise program stored in the memory 11 of the smart terminal is a combination of multiple instructions. When run in the processor 10, it can achieve the following: S1. Apply a high-frequency alternating current to the electromagnetic coil surrounding the chromatographic column in the chromatographic instrument to obtain eddy currents in the chromatographic column, and generate heating power for the chromatographic column from the eddy currents; S2. The carrier gas in the gas source system of the chromatograph is thermally energized to obtain the preheated carrier gas of the chromatograph, and the preheated carrier gas is subjected to forced heat exchange with the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. S3. Apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate the thermoelectric potential of the chromatographic column. S4. Based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, the thermoelectric potential is quantitatively inverted to obtain the current average temperature and temperature trend information of the chromatographic column. S5. Based on the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow rate parameter of the preheating carrier gas are coordinated and controlled to construct a coordinated composite thermal field of the chromatographic column. S6. When the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the constant temperature control stage.

[0068] Specifically, the specific implementation method of the processor 10 for the above instructions can be referred to the description of the relevant steps in the corresponding embodiment of the accompanying drawings, and will not be repeated here.

[0069] Furthermore, if the modules / units integrated in the smart terminal are implemented as software functional units and sold or used as independent products, they can be stored in a medium. The medium can be volatile or non-volatile. For example, the medium may include: any entity or system capable of carrying the computer program code, a recording medium, a USB flash drive, a portable hard drive, a magnetic disk, an optical disk, a computer memory, or a read-only memory (ROM).

[0070] In the several embodiments provided by this invention, it should be understood that the disclosed smart terminals, systems, and methods can be implemented in other ways. For example, the system embodiments described above are merely illustrative; for instance, the division of modules is only a logical functional division, and other division methods may be used in actual implementation.

[0071] The modules described as separate components may or may not be physically separate. The components shown as modules may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs.

[0072] Furthermore, the functional modules in the various embodiments of the present invention can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or in the form of hardware plus software functional modules.

[0073] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention.

[0074] The embodiments of this application can acquire and process relevant data based on artificial intelligence technology. Artificial intelligence (AI) refers to the theories, methods, technologies, and application systems that use digital computers or machines controlled by digital computers to simulate, extend, and expand human intelligence, perceive the environment, acquire knowledge, and use that knowledge to obtain optimal results.

[0075] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A method for rapid temperature rise in a chromatograph, characterized in that, The method includes: S1. Apply a high-frequency alternating current to the electromagnetic coil surrounding the chromatographic column in the chromatographic instrument to obtain eddy currents in the chromatographic column, and generate heating power for the chromatographic column from the eddy currents; S2. The carrier gas in the gas source system of the chromatograph is thermally energized to obtain the preheated carrier gas of the chromatograph, and the preheated carrier gas is subjected to forced heat exchange with the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. S3. Apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate the thermoelectric potential of the chromatographic column. S4. Based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, the thermoelectric potential is quantitatively inverted to obtain the current average temperature and temperature trend information of the chromatographic column. S5. Based on the current average temperature and temperature difference trend information, the current parameter of the high-frequency alternating current and the flow rate parameter of the preheating carrier gas are coordinated and controlled to construct a coordinated composite thermal field of the chromatographic column. S6. When the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the constant temperature control stage.

2. The rapid heating method for a chromatograph as described in claim 1, characterized in that, The step of applying a high-frequency alternating current to an electromagnetic coil surrounding the chromatographic column in the chromatogram to generate eddy currents in the chromatographic column, and using these eddy currents to generate heating power for the chromatographic column, includes: An adjustable drive signal with adjustable amplitude and frequency is input to the high-frequency power supply to generate a high-frequency alternating current of the high-frequency power supply. The high-frequency alternating current is applied to the electromagnetic coil outside the chromatographic column in the chromatograph to excite the alternating magnetic field inside the electromagnetic coil. The magnetic field lines of the alternating magnetic field penetrate the metal wall of the chromatographic column, and perform electromagnetic field-eddy current coupling on the conductive material of the metal wall to obtain a closed eddy current loop of the chromatographic column. Based on the inherent resistance of the metal tube wall, Joule heating is performed on the closed eddy current loop to obtain the heating power of the chromatographic column.

3. The rapid temperature rise method for a chromatograph as described in claim 1, characterized in that, The process of thermally energizing the carrier gas in the gas source system of the chromatograph to obtain a preheated carrier gas for the chromatograph, and then forcibly exchanging the preheated carrier gas with the outer surface of the chromatographic column to obtain a convective heat transfer field for the chromatographic column, includes: The carrier gas output from the gas source system in the chromatograph is guided to the preheating chamber around the chromatographic column, and the carrier gas is electrically heated in the preheating chamber to obtain the preheated carrier gas of the chromatograph. The preheated carrier gas is injected into the annular flow guide structure of the chromatographic column; Within the annular flow guiding structure, the flow field of the preheated carrier gas is shaped and optimized to obtain a directional high-speed gas flow for the chromatographic column; The directional high-speed gas flow is subjected to gas-solid interface heat transfer with the outer wall surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column.

4. The rapid temperature rise method for a chromatograph as described in claim 2, characterized in that, The step of applying the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, exciting the thermoelectric effect of the metal wall in the chromatographic column to generate a thermoelectric electromotive force of the chromatographic column, includes: The heating power is used to perform non-uniform thermal deposition inside the metal tube wall to obtain the temperature gradient of the chromatographic column. Based on the temperature gradient, a stable thermodynamic driving force is established between the two ends of the metal tube wall; Based on the aforementioned thermodynamic driving force, charge carriers in the metal tube wall migrate in a directional manner to trigger the Seebeck effect in the metal tube wall. The potential difference generated by the Seebeck effect is collected by electrodes placed at both ends of the metal tube wall to generate the thermoelectric potential of the chromatographic column.

5. The rapid heating method for a chromatograph as described in claim 4, characterized in that, The step of quantitatively inverting the thermoelectric potential based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column to obtain the current average temperature and temperature trend information of the chromatographic column includes: Based on the material properties of the metal tube wall, the thermoelectric potential is linearly regressed and fitted with the reference average temperature of the chromatographic column to obtain the calibration relationship between the thermoelectric potential and the reference average temperature. Based on the calibration relationship, the thermoelectric potential is mapped to the corresponding original temperature value; The original temperature value is corrected for thermoelectric nonlinearity to obtain the current average temperature of the chromatographic column; The current average temperature is collected at different times, and the instantaneous gradient of the current average temperature at adjacent times is calculated to obtain the instantaneous change in axial temperature of the chromatographic column. The formula for calculating the instantaneous change in axial temperature is as follows: ； In the formula, For a moment The instantaneous change in axial temperature. For a moment The current average temperature collected. For the immediate preceding moment The current average temperature collected. The preset fixed time interval for data collection This is the preset thermal inertia correction factor. It is a natural constant. The thermal diffusion time constant of the metal tube wall; The directionality and convergence of the instantaneous axial temperature change are extracted to obtain the temperature difference trend information of the chromatographic column.

6. The rapid temperature rise method for a chromatograph as described in claim 1, characterized in that, The step of coordinating the current parameters of the high-frequency alternating current and the flow parameters of the preheated carrier gas based on the current average temperature and temperature difference trend information to construct a synergistic composite thermal field for the chromatographic column includes: The difference between the current average temperature and the preset target temperature is mapped by error to obtain the first amplitude adjustment command of the high-frequency alternating current and the first flow rate adjustment command of the preheating carrier gas flow rate; Based on the temperature change direction indicated by the temperature difference trend information, the first amplitude adjustment command and the first flow rate adjustment command are corrected to be in the same direction to obtain the second amplitude adjustment command and the second flow rate adjustment command of the chromatographic column. Based on the temperature change rate indicated by the temperature difference trend information, the response timing of the second amplitude adjustment command and the second flow rate adjustment command is registered to obtain the target current control parameters and target flow rate control parameters of the chromatographic column. Based on the target current control parameters, the high-frequency alternating current of the electromagnetic coil is adjusted, and based on the target flow control parameters, the preheating carrier gas of the chromatographic column is adjusted. The induced eddy current heat generated by the adjusted high-frequency alternating current is coupled and superimposed with the forced convection heat formed by the adjusted preheated carrier gas to construct the synergistic composite thermal field of the chromatographic column.

7. The rapid heating method for a chromatograph as described in claim 6, characterized in that, When the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady-state, the control parameters of the high-frequency alternating current and the preheated carrier gas are switched to steady-state maintenance mode, so that the chromatographic column enters the isothermal control stage, including: When the current average temperature reaches the preset target temperature and the temperature change rate of the temperature difference trend information is continuously lower than the preset stable threshold, it is determined that the temperature distribution of the chromatographic column has reached the quasi-steady-state condition. Based on the aforementioned quasi-steady-state condition, the current amplitude of the high-frequency alternating current is switched from dynamic adjustment mode to narrow-amplitude fluctuation mode, and the flow rate of the preheated carrier gas is switched from adjustment mode to constant flow supply mode. In the narrow-amplitude fluctuation mode and the constant flow supply mode, the amplitude of the high-frequency alternating current is directionally corrected based on the deviation between the current average temperature and the preset target temperature. When the corrected current average temperature is within the range of the preset target temperature and the temperature change rate of the temperature difference trend information is lower than the preset stability threshold, the chromatographic column is confirmed to have entered the isothermal control stage.

8. A rapid heating system for a chromatograph, characterized in that, The system for implementing the rapid temperature rise method for a chromatograph according to claim 1 comprises: The eddy current induction heating module is used to apply a high-frequency alternating current to the electromagnetic coil around the chromatographic column in the chromatographic instrument to obtain the eddy current of the chromatographic column, and the heating power of the chromatographic column is generated by the eddy current. The forced convection module is used to thermally energize the carrier gas in the gas source system of the chromatograph to obtain the preheated carrier gas of the chromatograph, and to force heat exchange between the preheated carrier gas and the outer surface of the chromatographic column to obtain the convective heat transfer field of the chromatographic column. A thermoelectric signal generation module is used to apply the heating power to the chromatographic column to generate a temperature gradient in the chromatographic column, and based on the temperature gradient, to excite the thermoelectric effect of the metal tube wall in the chromatographic column to generate a thermoelectric electromotive force of the chromatographic column. The temperature inversion analysis module is used to quantitatively invert the thermoelectric potential based on the calibration relationship between the thermoelectric potential and the reference average temperature in the chromatographic column, so as to obtain the current average temperature and temperature trend information of the chromatographic column. The collaborative thermal field construction module is used to collaboratively regulate the current parameters of the high-frequency alternating current and the flow parameters of the preheated carrier gas according to the current average temperature and temperature difference trend information, so as to construct the collaborative composite thermal field of the chromatographic column. The isothermal maintenance switching module is used to switch the control parameters of the high-frequency alternating current and the preheated carrier gas to the steady-state maintenance mode when the current average temperature reaches the preset target temperature and the temperature difference trend information indicates that the temperature distribution tends to be steady, so that the chromatographic column enters the isothermal control stage.

9. A smart terminal, comprising a memory, a processor, and a computer program stored in the memory, characterized in that, The processor executes the computer program to implement the steps of the method according to any one of claims 1 to 7.

10. A storage medium having a computer program stored thereon, characterized in that, When executed by a processor, the computer program implements the steps of the method according to any one of claims 1 to 7.

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