An antibacterial peptide derived from the skin of bullfrog and application thereof

By combining the antimicrobial peptide GSVGPVGPR derived from bullfrog skin with retinoic acid, bacterial cell membranes are disrupted, overcoming the limitations of using high-concentration retinoic acid alone. This achieves a rapid and thorough sterilization effect against Staphylococcus aureus, making it suitable for use in antimicrobial drugs and feed additives.

CN121991173BActive Publication Date: 2026-06-23GUANGZHOU TAIWEI FEED CO LTD
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Patent Information

Application Number
CN202610426219.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-04-01
Publication Date
2026-06-23
Estimated Expiration
2046-04-01

AI Technical Summary

Technical Problem

In existing technologies, high concentrations of retinoic acid have an inhibitory effect on Staphylococcus aureus, but the effective concentration is high, and the value of using it alone is limited. In addition, there is a risk of drug resistance. It is necessary to develop new antimicrobial peptides to solve this problem and to use them in combination with retinoic acid to improve antimicrobial efficiency.

Method used

An antimicrobial peptide, GSVGPVGPR, derived from bullfrog skin, is provided. By disrupting bacterial cell membranes and combining with the effects of retinoic acid, it forms a synergistic effect, achieving rapid and thorough sterilization.

Benefits of technology

The combination of this antimicrobial peptide and retinoic acid significantly improves the sterilization speed and efficiency, reduces the concentration used, and decreases cytotoxicity and cost. It is suitable for the preparation of antimicrobial drugs and feed additives and has broad application prospects.

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Abstract

The application discloses an antibacterial peptide derived from the skin of bullfrog and application thereof, and the amino acid sequence of the antibacterial peptide is GSVGPVGPR (as shown in SEQ ID NO:1), and the molecular weight is 824.4504 g / mol. The antibacterial peptide has obvious inhibiting effect on Staphylococcus aureus, and can be used for preparing a medicine for preventing or inhibiting Staphylococcus aureus infection. Meanwhile, the antibacterial peptide and vitamin A have a significant synergistic bactericidal effect on Staphylococcus aureus. The antibacterial peptide and vitamin A can significantly reduce the use concentration of single component, improve the antibacterial efficiency, overcome the bacterial drug resistance problem, and can be used for preparing antibacterial medicines, skin external preparation, medical dressings, feed additives and food preservatives.
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