Manganese salt adjuvant system based on dextran particle capsule shrinkage as well as preparation method and application of manganese salt adjuvant system

By encapsulating manganese ions within dextran particles to prepare a manganese salt adjuvant system, the problems of manganese adjuvant diffusion and high dosage in vivo were solved, achieving efficient systemic and mucosal immune activation, especially specific immune regulation against respiratory viruses.

CN122005777APending Publication Date: 2026-05-12NANKAI UNIV
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Patent Information

Application Number
CN202512055627.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-31
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

Existing manganese adjuvants have problems such as poor targeting to immune organs, easy diffusion, and the need for high doses when used in vivo, resulting in high toxicity risks and limiting their adjuvant effects.

Method used

Manganese ions were encapsulated within yeast-derived hollow spherical β-glucan particles to form manganese hydroxide colloid, thus preparing a manganese salt adjuvant system of encapsulated glucan particles. This system was then administered subcutaneously or via nasal drops to induce systemic and mucosal immune responses.

Benefits of technology

It significantly enhances immune activation, strengthens humoral and cellular immune responses, reduces manganese salt dosage, and induces long-lasting immune memory and mucosal immune responses, with a particularly specific immunomodulatory effect against respiratory viruses.

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Abstract

The invention belongs to the technical field of immunology, and discloses a manganese salt adjuvant system based on dextran particle capsule shrinkage and a preparation method and application thereof.The manganese salt adjuvant system comprises beta-dextran particles GPs of a hollow spherical shell structure from yeast and manganese hydroxide colloid encapsulated in the dextran particles, the preparation method comprises the following steps: soaking the GPs in a MnCl2 solution, after the inner cavity of the GPs fully absorbs the MnCl2 solution, separating the GPs adsorbing MnCl2, then adding the GPs into a NaOH solution, forming stable manganese hydroxide colloid by manganese ions in the inner cavity of the GPs, and washing after separation to obtain the dextran particle encapsulated manganese salt adjuvant system. The GPMnOH particles carry various antigens at the same time in various modes such as electrostatic adsorption, chemical coupling or hydrophobic interaction, and an ideal carrier is provided for co-delivery immunization of the antigens and adjuvants.
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