A bactericidal composition and its preparation method and its uses

Abstract

This invention relates to the field of pesticide technology, specifically to a fungicidal composition, its preparation method, and its uses. The invention provides a fungicidal composition comprising an active ingredient, a first functional component, a second functional component, and an adjuvant; the active ingredient comprises fluthiazopyrone and cyazofamid; the first functional component comprises at least one selected from silica, titanium dioxide, and zinc oxide; the second functional component comprises at least one selected from citric acid, acetic acid, benzoic acid, urea, and triethanolamine. By introducing specific first and second functional components, this invention synergistically works with the active ingredient, effectively overcoming the key defects of fluthiazopyrone's easy photodegradation and cyazofamid's easy hydrolysis, thus improving the stability of the compound formulation; while ensuring the excellent control efficacy and resistance management advantages of both against oomycete diseases such as grape downy mildew, it extends the duration of action and weather resistance of the agent, providing a more stable, efficient, and long-lasting solution for field application.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, specifically to a bactericidal composition, its preparation method, and its uses. Background Technology

[0002] Downy mildew is one of the most serious diseases affecting grape production. It is caused by the oomycete pathogen *Plasmopara viticola*, primarily damaging young tissues such as leaves, shoots, flower clusters, and fruits. It easily breaks out and spreads under high humidity and low temperature conditions, often causing severe yield losses, making control extremely urgent. For this type of oomycete disease, cyazofamid and fluoxetine are two fungicides with unique and highly effective mechanisms of action. Cyazofamid, as a mitochondrial respiration inhibitor, acts on the Qi center of the cytochrome bc1 complex (Qil class), providing good control against all stages of oomycete growth. Fluoxetine, on the other hand, is an oxidized sterol-binding protein (OSBP) inhibitor, acting on a novel target with excellent systemic conductivity and protective activity, showing specific efficacy against downy mildew, late blight, and other oomycete diseases. The two have different mechanisms of action. Combining or alternating their use can not only improve the control effect on grape downy mildew and prolong the duration of effectiveness, but also help delay the development of pathogen resistance, which is in line with the integrated disease management and resistance management strategy.

[0003] However, in actual formulation development and field application, both cyazofamid and fluthiazopyrone exhibit significant chemical stability defects, restricting their full efficacy and long-term storage of formulation products. Cyazofamid's molecular structure is prone to hydrolysis in aqueous systems, leading to degradation of the active ingredient, especially under high temperature and humidity conditions. Fluthiazopyrone, on the other hand, is photosensitive and easily undergoes photolysis under light, resulting in reduced activity. These two instabilities not only affect the quality stability of the formulation during storage and transportation but may also lead to excessively rapid decomposition of the active ingredient after application, reducing the persistence and reliability of field efficacy. Therefore, developing a technical solution that can effectively overcome the hydrolysis of cyazofamid and the decomposition of fluthiazopyrone, and improve their stability in compound systems, has become a critical issue urgently needing to be addressed in this field. Summary of the Invention

[0004] This invention provides a bactericidal composition and preparation method, as well as its uses, to solve the above-mentioned problems.

[0005] In a first aspect, the present invention provides a bactericidal composition comprising an active ingredient, a first functional component, a second functional component, and an adjuvant;

[0006] The active ingredients include fluthiazopyrone and cypermethrin; The first functional component includes at least one of silica, titanium dioxide, and zinc oxide; The second functional component includes at least one of citric acid, acetic acid, benzoic acid, urea, and triethanolamine.

[0007] Optionally, the second functional component is selected according to the formulation.

[0008] In one optional embodiment, the dosage form of the bactericidal composition includes a suspension and a suspension emulsion; Optionally, when the dosage form is a suspension, the adjuvant includes at least one of antifreeze, dispersant, thickener, defoamer, fungicide, and water; Further optionally, the mass ratio of the antifreeze, dispersant, thickener, defoamer, mildew inhibitor, and water is (3-5):(2-5):(0.6-1.7):(0.2-0.8):(0.05-0.2):(5.7-87.35). Optionally, when the dosage form is a suspension emulsion, the adjuvant includes at least one of an oil solvent, an emulsifier, a dispersant, a thickener, an antifoaming agent, and water.

[0009] Further optionally, the mass ratio of the oil solvent, emulsifier, dispersant, thickener, defoamer and water is (62-78):(12-17):(6-11):(1-3):(0.2-0.6):(71.4-95.3).

[0010] Optionally, the dispersant includes at least one of phosphate ester wetting dispersants, polycarboxylate dispersants, and polyoxyethylene-polyoxypropylene block copolymers; Optionally, the thickener includes at least one of xanthan gum and magnesium aluminum silicate; Optionally, the antifreeze includes at least one of ethylene glycol, propylene glycol, and glycerol; Optionally, the defoamer includes silicone-based defoamers; Further optionally, the silicone defoamer includes at least one of Momentive SAG 1522, Dow AFE-1410, and Wacker SD670; Optionally, the antifungal agent includes at least one of benzoic acid, sodium benzoate, Kathon preservative, and 1,2-benzisothiazolin-3-one; Optionally, the emulsifier includes at least one of styrene-phenol polyoxyethylene ether, alkylphenol polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, cashew phenol polyoxyethylene ether, and polyol polyoxyethylene polyoxypropylene block copolymer. Optionally, the oil solvent includes at least one of aromatic solvent oil, mineral oil, methyl oleate, and soybean oil; Further optionally, the aromatic solvent oil has a flash point of 69°C.

[0011] In one alternative embodiment, the bactericidal composition is formulated as a suspension or an emulsion.

[0012] Secondly, the present invention provides a method for preparing a suspension comprising the above-mentioned bactericidal composition, comprising the following steps: S1, mix and grind the fluthiazopyrone, cyazofamid, antifreeze, dispersant, thickener-1, first functional component, second functional component, and defoamer-1 to obtain mixed slurry A; S2, Thickener-2, mildew inhibitor and defoamer-2 are added to mixed slurry A and mixed to form a suspension of the bactericidal composition.

[0013] In one alternative embodiment, the mixing includes stirring; Optionally, the stirring time is 28-32 minutes; In one alternative embodiment, the grinding includes grinding to a D90 < 5 μm.

[0014] In one optional embodiment, the mass ratio of thickener-1 to thickener-2 is (0.5-1.5):(0.1-0.2). Optionally, the thickener-1 and thickener-2 may be the same or different; And / or, the mass ratio of the defoamer-1 to the defoamer-2 is (0.1-0.3):(0.1-0.5).

[0015] Optionally, the defoamer-1 and defoamer-2 may be the same or different.

[0016] Thirdly, the present invention provides a method for preparing a suspension emulsion comprising the above-mentioned bactericidal composition, comprising the following steps: S1, mix and grind the oil solvent, emulsifier, dispersant A, fluthiazopyr acetone, thickener A, and the first functional component to obtain fluthiazopyr acetone oil suspension; S2, Dispersant B, cyazofamid, thickener B, defoamer A, second functional component and water are mixed and ground to obtain cyazofamid suspension; S3, mix cyazofamid suspension, water, defoamer B, and fluthiazopyr acetone oil suspension to obtain a suspension emulsion of the bactericidal composition.

[0017] In one optional embodiment, the mass ratio of dispersant A to dispersant B is (1-5):(5-6). Optionally, dispersant A and dispersant B may be the same or different; And / or, the mass ratio of thickener A to thickener B is (0.5-2):(0.5-1.0); Optionally, the thickener A and thickener B may be the same or different; And / or, the mass ratio of defoamer A to defoamer B is (0.1-0.3):(0.1-0.3); Optionally, the defoamer A and defoamer B may be the same or different.

[0018] In one optional implementation, the mass ratio of water in S2 to water in S3 is (65.7-71.4):(5.7-13.9).

[0019] Fourthly, the present invention also provides the application of the above-mentioned bactericidal composition, or the suspension of the above-mentioned bactericidal composition, or the emulsion of the above-mentioned bactericidal composition in the control of grape downy mildew.

[0020] The technical solution of this invention has the following advantages: 1. This invention provides a fungicidal composition comprising an active ingredient, a first functional component, a second functional component, and an adjuvant; the active ingredient comprises fluthiazopyrone and cyazofamid; the first functional component comprises at least one selected from silica, titanium dioxide, and zinc oxide; the second functional component comprises at least one selected from citric acid, acetic acid, benzoic acid, urea, and triethanolamine. This invention, by introducing specific first and second functional components that synergistically act on the active ingredient, effectively overcomes the key defects of fluthiazopyrone's susceptibility to photodegradation and cyazofamid's susceptibility to hydrodegradation, significantly improving the chemical and storage stability of the compound formulation. Furthermore, it can also act as a thickener and pH adjuster, simplifying the formulation and facilitating production and use. While ensuring the excellent control efficacy and resistance management advantages of both fluthiazopyrone and cyazofamid against oomycete diseases such as grape downy mildew, it extends the duration of action and weather resistance of the agents, providing a more stable, efficient, and long-lasting solution for field application.

[0021] 2. The method for preparing the suspension of the bactericidal composition provided by this invention, through step S1, first co-grinds the core active ingredient and key functional adjuvants, ensuring the extreme refinement of the effective ingredients and the uniform construction of a stable system, fundamentally improving the physical and chemical stability of the product; after step S2, thickeners and other adjuvants are added, which can precisely control the rheological properties of the final formulation, avoid abnormal viscosity, ensure that the product does not settle or clump during storage, and is easy to dilute and disperse during use. This process design is scientific and reasonable, not only enabling the functions of each component to work synergistically, but also improving production reproducibility and batch stability, making it suitable for large-scale production.

[0022] 3. The method for preparing the suspension emulsion of the bactericidal composition provided by the present invention involves preparing fluthiazopyrone and cyazofamid as oil suspension and suspension respectively, and then compounding them into a suspension emulsion. This process effectively isolates two active ingredients with different physicochemical properties and stability requirements, and specifically solves the problems of photolysis of fluthiazopyrone and hydrolysis of cyazofamid, ensuring that each component is independently constructed and its function is fully preserved. The final product has the advantages of good dispersibility, strong adhesion and long-lasting effect of suspension emulsion formulation, and the production process is stable and controllable, easy to scale up, and provides a new pesticide formulation that is efficient, stable and convenient to use for the control of diseases such as grape downy mildew. Detailed Implementation

[0023] The following embodiments are provided to better understand the present invention, but the following embodiments do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the scope of protection of the present invention.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the application; the terms “comprising” and “having” and any variations thereof in the text of this application are intended to cover non-exclusive inclusion.

[0025] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0026] The "range" disclosed in this application is defined by a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, which define the boundaries of the specific range. Ranges defined in this way can include or exclude endpoints and can be arbitrarily combined; that is, any lower limit can be combined with any upper limit to form a range. In this application, unless otherwise stated, the numerical range "ab" represents a shortened representation of any combination of real numbers from a to b, where a and b are real numbers. For example, the numerical range "0-5" indicates that all real numbers between "0-5" have been listed herein, and "0-5" is merely a shortened representation of these numerical combinations. Furthermore, when a parameter is described as an integer ≥ 2, it is equivalent to disclosing that the parameter can be, for example, integers 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0027] In the description of the embodiments of this application, the term "and / or" is merely a description of the relationship between related objects, indicating that there can be three relationships. For example, A and / or B can represent three situations: A exists alone, A and B exist simultaneously, and B exists alone.

[0028] In the description of the embodiments of this application, the term "at least one" refers to one or more (including two).

[0029] Unless otherwise specified, all steps in this application may be performed sequentially or randomly, preferably sequentially. For example, the method includes steps (a) and (b), indicating that the method may include steps (a) and (b) performed sequentially, or it may include steps (b) and (a) performed sequentially. For example, the mention that the method may also include step (c) indicates that step (c) may be added to the method in any order. For example, the method may include steps (a), (b), and (c), or it may include steps (a), (c), and (b), or it may include steps (c), (a), and (b), etc.

[0030] Unless otherwise specified, all experimental steps or conditions in the examples were performed according to conventional experimental procedures and conditions in the art. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0031] The dispersants used include phosphate ester wetting and dispersing agents and polycarboxylate dispersants, wherein the phosphate ester wetting and dispersing agent is purchased from Solvay's Soprophor SC and the polycarboxylate dispersant is purchased from Huntsman's TERSPERSE 2500. The antifungal agent used was purchased from Lonza's PROXEL GXL; The defoamer used was purchased from Momentive's SAG 1522; The oil solvents used were purchased from Suzhou Fengbei methyl oleate. The emulsifier used was purchased from Yunfa Chemical's EC2200 emulsifier; The dispersant A used was purchased from Yunfa Chemical's EP60P emulsifying dispersant.

[0032] Example 1 This embodiment provides a method for preparing a suspension of a bactericidal composition, and the specific steps and parameter settings are as follows: S1, after homogenizing the following ingredients for 30 minutes: fluoxetine, cyazofamid, antifreeze (propylene glycol), dispersant (TERSPERSE 2500 and Soprophor SC in a mass ratio of 5:3), thickener-1 (magnesium aluminum silicate), second functional component (citric acid), first functional component (fumed silica), defoamer-1 (SAG 1522), and water, the mixture was transferred to a horizontal sand mill and ground until D90 < 5µm to obtain mixed slurry A; The mass ratio of the following components is 5:10:4:4:1:0.4:0.8:0.2:74.16; S2, add thickener-2 (xanthan gum), antifungal agent (PROXEL GXL) and defoamer-2 (SAG1522) to the mixed slurry A, and shear until the product is uniform to obtain a suspension of the bactericidal composition; The mass ratio of the mixed slurry A, thickener-2, mildew inhibitor and defoamer-2 is 100:0.14:0.5:0.3.

[0033] Example 2 This embodiment provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, wherein the mass ratio of the fluoxetine, cyazofamid, antifreeze, dispersant, thickener-1, second functional component, first functional component, defoamer-1 and water is 5:20:4.5:3:1.2:0.5:0.7:0.15:64.75; S2, the mass ratio of the mixed slurry A, thickener-2, mildew inhibitor, and defoamer-2 is 100:0.15:0.15:0.2; The remaining steps are the same as in Example 1.

[0034] Example 3 This embodiment provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, wherein the mass ratio of the fluoxetine, cyazofamid, antifreeze, dispersant, thickener-1, second functional component, first functional component, defoamer-1 and water is 1:50:3:5:0.5:0.6:0.6:0.3:38.6; S2, the mass ratio of the mixed slurry A, thickener-2, mildew inhibitor, and defoamer-2 is 100:0.1:0.2:0.1; The remaining steps are the same as in Example 1.

[0035] Example 4 This embodiment provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, wherein the mass ratio of the fluoxetine, cyazofamid, antifreeze, dispersant, thickener-1, second functional component, first functional component, defoamer-1 and water is 30:5:5:2:1.5:0.2:1:0.1:54.45; S2, the mass ratio of the mixed slurry A, thickener-2, mildew inhibitor and defoamer-2 is 100:0.2:0.05:0.5; The remaining steps are the same as in Example 1.

[0036] Example 5 This embodiment provides a method for preparing a suspension emulsion of a bactericidal composition, the specific steps and parameter settings are as follows: S1. The oil solvent (methyl oleate), emulsifier (EC2200 emulsifier), dispersant A (EP60P emulsifying dispersant), fluthiazopyr acetone, thickener A (organic bentonite), first functional component (silica) and water are homogenized for 30 minutes and then transferred to a horizontal sand mill to grind to D90 < 5µm to obtain fluthiazopyr acetone oil suspension. The mass ratio of the oil solvent, emulsifier, dispersant A, fluoxetine, thickener A, and the first functional component is 69:15:3:10:1.5:1.5; S2, after homogenizing dispersant B (TERSPERSE 2500 and Soprophor SC in a mass ratio of 3:8), cyazofamid, thickener B (magnesium aluminum silicate), defoamer A (SAG 1522), second functional component (citric acid) and water for 30 minutes, the mixture was transferred to a horizontal sand mill and ground until D90 < 5µm to obtain cyazofamid suspension; The mass ratio of dispersant B, cyazofamid, thickener B, defoamer A, the second functional component, and water is 5.5:25:0.8:0.2:0.3:68.2. S3, add cyazofamid suspension, water, and defoamer B (SAG 1522) to the mixing tank in sequence, start stirring, and then slowly pour fluthiazopyr acetone oil suspension into the mixing tank. Stir and homogenize for 30 minutes to obtain the suspension emulsion of the bactericidal composition. The mass ratio of the cyazofamid suspension, water, defoamer B, and fluthiazopyr acetone oil suspension is 40:9.8:0.2:50.

[0037] Example 6 This embodiment provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S1, wherein the mass ratio of the oil solvent, emulsifier, dispersant A, fluoxetine, thickener A, and the first functional component is 69:16:2:11:1:1; S2, wherein the mass ratio of dispersant B, cyazofamid, thickener B, defoamer A, second functional component (citric acid) and water is 5.8:26:0.7:0.15:0.3:67.05; S3, the mass ratio of the cyazofamid suspension, water, defoamer B and fluthiazopyr acetone oil suspension is 41:10:0.15:51; The remaining steps are the same as in Example 5.

[0038] Example 7 This embodiment provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S1, wherein the mass ratio of the oil solvent, emulsifier, dispersant A, fluoxetine, thickener A, and the first functional component is 72.5:12:5:8:2:0.5; S2, wherein the mass ratio of dispersant B, cyazofamid, thickener B, defoamer A, second functional component (citric acid) and water is 6:23:1.0:0.1:0.3:69.6; S3, the mass ratio of the cyazofamid suspension, water, defoamer B and fluthiazopyr acetone oil suspension is 42:5.9:0.1:52; The remaining steps are the same as in Example 5.

[0039] Example 8 This embodiment provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S1, wherein the mass ratio of the oil solvent, emulsifier, dispersant A, fluoxetine, thickener A, and the first functional component is 67.5:17:1:12:0.5:2; S2, wherein the mass ratio of dispersant B, cyazofamid, thickener B, defoamer A, second functional component (citric acid) and water is 5:27:0.5:0.3:0.3:66.9; S3, the mass ratio of the cyazofamid suspension, water, defoamer B and fluthiazopyr acetone oil suspension is 38:13.7:0.3:48; The remaining steps are the same as in Example 5.

[0040] Comparative Example 1 This comparative example provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, the second functional component is replaced with an equal mass of phosphoric acid; The remaining steps are the same as in Example 1.

[0041] Comparative Example 2 This comparative example provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, the first functional component is replaced with an equal mass of magnesium aluminum silicate; The remaining steps are the same as in Example 1.

[0042] Comparative Example 3 This comparative example provides a method for preparing a suspension of a bactericidal composition, which differs from Example 1 only in that: S1, the second functional component is replaced with an equal mass of phosphoric acid, and the first functional component is replaced with an equal mass of magnesium aluminum silicate. The remaining steps are the same as in Example 1.

[0043] Comparative Example 4 This comparative example provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S1, the first functional component is replaced with an equal mass of magnesium aluminum silicate; The remaining steps are the same as in Example 5.

[0044] Comparative Example 5 This comparative example provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S2, the second functional component is replaced with an equal mass of phosphoric acid; The remaining steps are the same as in Example 5.

[0045] Comparative Example 6 This comparative example provides a method for preparing a suspension emulsion of a bactericidal composition, which differs from Example 5 only in that: S1, replace the first functional component with an equal mass of magnesium aluminum silicate; S2, replace the second functional component with an equal mass of phosphoric acid; The remaining steps are the same as in Example 5.

[0046] Experimental Example 1 The stability performance of the suspensions of the bactericidal compositions prepared in Examples 1-4 and Comparative Examples 1-3 was tested.

[0047] The room temperature stability was tested according to NY / T 1427-2016 "General Rules for Stability Testing of Pesticides at Room Temperature".

[0048] The thermal storage stability was tested according to GB / T 19136-2021 "Determination of Thermal Storage Stability of Pesticides".

[0049] The specific test results are shown in the table below: Table 1. Test data on the room temperature stability of the suspension.

[0050] Table 2 Test data on the thermal storage stability of the suspension.

[0051] Analysis of the results from Examples 1-4 shows that changes in the amount of the second functional component increase the decomposition rate of cyazofamid when the pH of the suspending agent is too low or too high; a decrease in the amount of the first functional component increases the decomposition rate of fluoxetine; dispersants and thickeners affect the suspension rate, and overall, the results from the examples are the best.

[0052] Analysis of the results from Example 1 and Comparative Example 1 (replacing the second functional component), Comparative Example 2 (replacing the first functional component), and Comparative Example 3 (replacing the first functional component and replacing the second functional component) shows that the content at room temperature is slightly reduced; the first functional component can stabilize the photolysis of fluthiazopyrone in water, which does indeed lead to an increase in the decomposition of fluthiazopyrone; when the second functional component is replaced with citric acid, which is a moderately strong acid, the pH of the suspension is too low, and the decomposition of cyazopyr in water increases; replacing or changing these two components will significantly increase the decomposition of the two original drugs.

[0053] Experiment Example 2 The stability properties of the suspension emulsions of the bactericidal compositions prepared in Examples 5-8 and Comparative Examples 4-6 were tested.

[0054] The room temperature stability was tested according to NY / T 1427-2016 "General Rules for Stability Testing of Pesticides at Room Temperature".

[0055] The thermal storage stability was tested according to GB / T 19136-2021 "Determination of Thermal Storage Stability of Pesticides".

[0056] The dispersion stability was tested using the dispersion stability test method in section 4.11 of HG / T 2467.11-2003 "Standard for Writing Product Standards for Pesticide Suspension Emulsions", wherein the suspension emulsion was diluted 50 times in water.

[0057] The specific test results are shown in the table below: Table 3. Test data on the room temperature stability of suspension emulsions

[0058] Table 4 Test data on the thermal storage stability of suspension emulsions

[0059] Table 5. Test data on the dispersion stability of suspension emulsions

[0060] Analysis of the results from Examples 5-8 shows that the second functional component can stabilize the content and decomposition rate of cyazofamid; the higher the level of the first functional component, the less photolysis occurs in fluoxetine, and it plays a greater role in thickening and rheology in methyl oleate. When it is not properly combined with organobentonite, its dispersion stability will deteriorate. In summary, the results from Example 5 are the best.

[0061] Analysis of the results from Example 5 and Comparative Example 4 (replacing the second functional component), Comparative Example 5 (replacing the first functional component), and Comparative Example 6 (replacing the first functional component and the second functional component) shows that the content at room temperature decreased to varying degrees; when the second functional component, citric acid, was replaced with phosphoric acid, a moderately strong acid, the pH of the suspension decreased, and the decomposition of cyazofamid in water increased; replacing the first functional component increased the decomposition rate of fluoxetine, while significantly worsening the dispersion stability; replacing either of these components significantly increased the decomposition of both active pharmaceutical ingredients and drastically worsened their dispersion stability.

[0062] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A bactericidal composition, characterized in that, It includes active ingredients, primary functional components, secondary functional components, and adjuvants; The active ingredients include fluthiazopyrone and cypermethrin; The first functional component includes at least one of silica, titanium dioxide, and zinc oxide; The second functional component includes at least one of citric acid, acetic acid, benzoic acid, urea, and triethanolamine.

2. The bactericidal composition according to claim 1, characterized in that, The bactericidal composition is available in the form of a suspension concentrate and a suspension emulsion. Optionally, when the dosage form is a suspension, the adjuvant includes at least one of antifreeze, dispersant, thickener, defoamer, fungicide, and water; Optionally, when the dosage form is a suspension emulsion, the adjuvant includes at least one of an oil solvent, an emulsifier, a dispersant, a thickener, an antifoaming agent, and water.

3. The bactericidal composition according to claim 2, characterized in that, When the dosage form is a suspension, the mass ratio of the antifreeze, dispersant, thickener, defoamer, antifungal agent and water is (3-5):(2-5):(0.6-1.7):(0.2-0.8):(0.05-0.2):(5.7-87.35).

4. The bactericidal composition according to claim 2, characterized in that, When the dosage form is a suspension emulsion, the mass ratio of the oil solvent, emulsifier, dispersant, thickener, defoamer and water is (62-78): (12-17): (6-11): (1-3): (0.2-0.6): (71.4-95.3).

5. A method for preparing a suspension comprising the bactericidal composition of claim 3, characterized in that, Includes the following steps: S1, mix and grind the fluthiazopyrone, cyazofamid, antifreeze, dispersant, thickener-1, first functional component, second functional component, and defoamer-1 to obtain mixed slurry A; S2, Thickener-2, mildew inhibitor and defoamer-2 are added to mixed slurry A and mixed to form a suspension of the bactericidal composition.

6. The preparation method according to claim 5, characterized in that, The mass ratio of thickener-1 to thickener-2 is (0.5-1.5):(0.1-0.2). And / or, the mass ratio of the defoamer-1 to the defoamer-2 is (0.1-0.3):(0.1-0.5).

7. A method for preparing a suspension emulsion comprising the bactericidal composition of claim 4, characterized in that, Includes the following steps: S1, mix and grind the oil solvent, emulsifier, dispersant A, fluthiazopyr acetone, thickener A, and the first functional component to obtain fluthiazopyr acetone oil suspension; S2, Dispersant B, cyazofamid, thickener B, defoamer A, second functional component and water are mixed and ground to obtain cyazofamid suspension; S3, mix cyazofamid suspension, water, defoamer B, and fluthiazopyr acetone oil suspension to obtain a suspension emulsion of the bactericidal composition.

8. The preparation method according to claim 7, characterized in that, The mass ratio of dispersant A to dispersant B is (1-5):(5-6); And / or, the mass ratio of thickener A to thickener B is (0.5-2):(0.5-1.0); And / or, the mass ratio of the defoamer A to the defoamer B is (0.1-0.3):(0.1-0.3).

9. The preparation method according to claim 7, characterized in that, The mass ratio of water in S2 to water in S3 is (65.7-71.4):(5.7-13.9).

10. The application of a fungicidal composition according to any one of claims 1-4, or a suspension of the fungicidal composition prepared by the method according to any one of claims 5-6, or a suspension emulsion of the fungicidal composition prepared by the method according to any one of claims 7-9, in the control of grape downy mildew.

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