Low-molecular-weight sparassis crispa polysaccharide microspheres for relieving fatigue as well as preparation method and application of low-molecular-weight sparassis crispa polysaccharide microspheres

By combining steam explosion, high-voltage pulsed electric field, compound enzymatic hydrolysis, and ultrafiltration membrane separation with electrospray layer-by-layer self-assembly technology, low molecular weight *Hydnocarpus sylvestris* polysaccharide microspheres with high efficiency extraction, enhanced activity, and targeted delivery to the colon were prepared, solving the problems of low extraction rate and poor stability, and achieving significant anti-fatigue effects.

CN122075419APending Publication Date: 2026-05-26FUJIAN AGRI & FORESTRY UNIV
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Patent Information

Application Number
CN202610054732.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-15
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies struggle to efficiently extract low molecular weight Hydnocarpus polysaccharides and achieve targeted delivery to the colon, resulting in low bioavailability and an inability to effectively alleviate fatigue.

Method used

Low molecular weight *Hydrangea hydrangea* polysaccharides were prepared using a combination of steam explosion and high-voltage pulsed electric field treatment, along with enzymatic hydrolysis, ultrasonic treatment, and ultrafiltration membrane separation. Subsequently, core-shell structured microspheres were constructed using electrospraying and layer-by-layer self-assembly techniques to ensure the stability of the polysaccharides in the gastrointestinal tract and achieve colon-targeted release.

Benefits of technology

It significantly improved the extraction rate and bioactivity of *Hydrangea macrophylla* polysaccharides, ensuring the targeted release of low molecular weight polysaccharides in the colon, thus achieving a highly effective fatigue relief effect.

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Abstract

The invention belongs to the technical field of food processing, and particularly relates to a low-molecular-weight sparassis crispa polysaccharide microsphere for relieving fatigue and a preparation method and application thereof, and the preparation method comprises the following steps: (1) extracting crude sparassis crispa polysaccharide; (2) degrading; and (3) embedding: dropwise adding the low-molecular-weight sparassis crispa polysaccharide obtained in the step (2) into a CaCl2 solution through electrospray treatment to form a gel core, and coating the gel core to obtain the low-molecular-weight sparassis crispa polysaccharide microspheres. The sparassis crispa polysaccharide has the beneficial effects that the sparassis crispa polysaccharide is efficiently extracted through cooperation of steam explosion and a pulsed electric field, 10-20 kDa high-activity low-molecular-weight fragments are accurately prepared through composite enzymolysis, ultrasonic treatment and ultrafiltration, and finally the colon-targeted microspheres are constructed through electrospray-layer-by-layer self-assembly. The microspheres can protect the active ingredients from directly reaching the colon to be released, and the bioavailability and the anti-fatigue effect of the polysaccharide are remarkably improved.
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