Peroxynitroso anion fluorescent probe with AIE effect as well as synthesis method and application of peroxynitroso anion fluorescent probe

By synthesizing a peroxynitroso anion fluorescent probe TPS with AIE effect, the problem of insufficient sensitivity and selectivity in the detection of ONOO- in the prior art has been solved, realizing the detection of ONOO- with high selectivity and sensitivity, which is suitable for detection under physiological environment.

CN122301855APending Publication Date: 2026-06-30XUCHANG UNIV
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Patent Information

Application Number
CN202610519259.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-20
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing fluorescent probes lack sufficient sensitivity and selectivity when detecting peroxynitroso anions (ONOO-), and cannot be effectively detected under physiological conditions, failing to meet the requirements for high spatiotemporal resolution and non-destructive detection.

Method used

A peroxynitroso anion fluorescent probe TPS with aggregation-induced emission (AIE) effect was designed and synthesized. The probe was prepared through a specific chemical synthesis route. It is nearly colorless under ultraviolet light and emits bright yellow fluorescence after reacting with ONOO-, thus achieving high selectivity and sensitivity for detection.

Benefits of technology

It achieves high selectivity and sensitivity for ONOO-, with good time response and concentration linearity, a detection limit of 0.08232 µmol·L-1, and operates stably within the physiological pH range. It has "naked eye" recognition capability and is suitable for detection under physiological conditions.

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Abstract

The invention discloses a peroxynitroso anion fluorescent probe with an AIE effect as well as a synthesis method and application of the peroxynitroso anion fluorescent probe. The near-infrared fluorescent probe TPS is designed and synthesized, is almost colorless under the illumination of an ultraviolet lamp, and can emit bright yellow fluorescence after reacting with peroxynitroso anions. Through detection, the response time of the TPS and the ONOO <-> is 100 minutes in a system in which the ratio of HEPES to acetonitrile is 1: 1, and 120 uL of 0.5 * 10 <-3 > mol.L <-1 > ONOO <-1 > is added to completely react. The TPS has strong specificity, only reacts with peroxynitroso anions in various anions, and has high sensitivity. When the pH value is between 4 and 8, the response of the TPS and the ONOO <-> ions has good stability, the response of the TPS to the ONOO <-> has a good linear relation, and the detection limit reaches 0.08 232 mol.L <-1 >. After the reaction of the probe TPS and ONOO <->, a typical AIE effect is presented at different concentrations of THF.
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