Cooling compositions

Abstract

The present disclosure relates to the field of flavor or fragrance. More specifically, it relates to a liquid composition comprising a compound of formula (I), an oil containing carvyl ketone and optionally a solvent. The present disclosure also relates to the use of said composition in consumer products such as flavored products and body care products.

Description

[0001] Cross-reference to related applications

[0002] This application claims priority to U.S. Provisional Application No. 63 / 571,154, filed March 28, 2024, and European Application No. 24174251.9, filed May 6, 2024, the contents of which are incorporated herein by reference as if their entire contents were set forth herein. Technical Field

[0003] This disclosure relates to the field of flavorings or perfumes. More specifically, this disclosure relates to a composition comprising a cooling compound and at least one oil containing carvone, and optionally a solvent. This disclosure also relates to the use of said composition in consumer products such as flavored products and body care products. Background Technology

[0004] From simple metazoans to the most complex vertebrates, the entire animal kingdom possesses taste and sensory systems that provide sensory information about the chemical composition of the external world. This sensory information can encompass a wide range of taste sensations, including but not limited to a cooling sensation.

[0005] In the field of fragrances and flavorings, ingredients that impart a cold or cooling sensation are highly sought after. These cooling ingredients provide a refreshing and clean feeling, making them extremely popular in many flavored or aromatic consumer products. Over the past few decades, considerable effort has been devoted to finding and acquiring compounds with this cooling effect.

[0006] WO2012 / 061698 and WO2017 / 058594 report several highly potent cooling substances. These compounds are modulators of the transient receptor potential channel M8 (TRPM8), which is closely related to the generation of a cooling sensation. These compounds produce significant cooling effects even at extremely low concentrations; only trace amounts are needed to achieve the desired cooling sensation. However, these compounds are typically in the form of fine powders under ambient conditions (i.e., room temperature and normal pressure). They have low solubility in solvents commonly used in the flavoring and fragrance industries, and their potency makes them unsuitable for direct use (i.e., undiluted use), which poses difficulties for their processing and incorporation into consumer products.

[0007] Therefore, the industry continues to require suitable solvents to dissolve the aforementioned types of cooling compounds, so that these compounds can be provided in a more convenient diluted form. This disclosure provides a solution to the above problem by using an oil containing carvone. Summary of the Invention

[0008] The following forms disclosed herein are intended to address one or more of the problems described above.

[0009] In a first embodiment, this disclosure relates to a liquid composition comprising:

[0010] a) at least one compound of formula (I),

[0011]

[0012] The compound is in any of its stereoisomers; where R 1 Represents a phenyl group, which may optionally have one or two C atoms substituted. 1-3 alkyl or alkoxy or one or two halogen groups; R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which may optionally be substituted with one or two C atoms. 1-3 alkyl;

[0013] b) Oils containing carvone; and

[0014] c) Optional solvents.

[0015] In a second aspect, this disclosure relates to a consumer product comprising the liquid composition described herein. Detailed Implementation

[0016] The following detailed description illustrates the various forms and embodiments provided herein. This description is intended for reading by one of ordinary skill in the art. Therefore, information familiar to those of ordinary skill is not necessarily included. It will be apparent to one of ordinary skill that the various forms and embodiments provided herein can be combined in any manner without departing from the spirit of this disclosure.

[0017] Unless otherwise specified herein, the following terms and phrases have the meanings indicated below. This disclosure may employ other terms and phrases not expressly defined herein. Such other terms and phrases have the meanings that are appropriate to a person skilled in the art within the context of this disclosure. In some cases, a term or phrase may be defined in a singular or plural form. In such cases, it should be understood that any term in its singular form may include its plural form, and vice versa, unless the contrary is explicitly stated. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this specification pertains.

[0018] As used herein, unless otherwise stated, the terms “a,” “one,” or “the” mean “one or more” or “at least one.”

[0019] While compositions and methods are described as “comprising,” “containing,” or “including” various components or steps, they may also be described as “consistently composed of various components, substances, and steps” or “consistent with various components, substances, and steps.” As used herein, the term “consistently composed of” should be interpreted as including the listed components, substances, or steps, as well as any additional components, substances, or steps that do not materially affect the fundamental and novel properties of the composition or method. In some embodiments, compositions “consistently composed of the said components or substances” according to embodiments of this disclosure do not include any additional components or substances that alter the fundamental and novel properties of the composition.

[0020] It should be understood that any numerical range described herein is intended to include all subranges contained therein. For example, the range “1 to 10” is intended to include all subranges between the minimum value 1 and the maximum value 10; that is, a minimum value equal to or greater than 1 and a maximum value equal to or less than 10. Since the disclosed numerical ranges are continuous, they include every value between the minimum and maximum values. Unless otherwise expressly stated, the various numerical ranges specified in this application are approximate values.

[0021] As used herein, unless otherwise stated, the terms "about" or "approximately" refer to an acceptable error for a particular value as determined by those skilled in the art, depending in part on how the value is measured or determined. In some embodiments, the terms "about" or "approximately" mean within 1, 2, 3, or 4 standard deviations. In some embodiments, the terms "about" or "approximately" mean within 50%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.05% of a given value or range.

[0022] Throughout this disclosure, various publications may be incorporated by reference. If the meaning of any terminology in such cited publications conflicts with the meaning of terminology in this disclosure, the meaning of terminology in this disclosure shall prevail, unless otherwise stated.

[0023] As used herein, "solvent" refers to a compound formed through the interaction of one or more solvent molecules with one or more compounds described herein. In some embodiments, the solvate is an uptake-acceptable solvate, such as a hydrate.

[0024] As used in this article, where "a" and "b" are integers, "C" represents the integers. a To C b "or "C a-b The "" designation refers to the number of carbon atoms in a specified group. That is, the group can contain carbon atoms from "a" to "b" (inclusive). Therefore, for example, "C1 to C4 alkyl" or "C1-4 "Alkyl" refers to all alkyl groups having 1 to 4 carbons, namely CH3-, CH3CH2-, CH3CH2CH2-, (CH3)2CH-, CH3CH2CH2CH2-, CH3CH2CH(CH3)- and (CH3)3C-.

[0025] As used herein, "halogen" or "halogenated" refers to any of the radiation-stable atoms in column 7 of the periodic table, such as fluorine, chlorine, bromine, or iodine. In some embodiments, "halogen" or "halogenated" refers to fluorine or chlorine.

[0026] As used herein, “alkyl” refers to a fully saturated straight-chain or branched hydrocarbon chain (i.e., without double or triple bonds). In some embodiments, an alkyl group has 1 to 20 carbon atoms (wherever it appears herein, a numerical range such as “1 to 20” refers to every integer within a given range; for example, “1 to 20 carbon atoms” means that an alkyl group can consist of 1 carbon atom, 2 carbon atoms, 3 carbon atoms, etc., up to and including 20 carbon atoms, although this definition also covers the occurrence of the term “alkyl” where no numerical range is specified). An alkyl group can also be a medium-sized alkyl group having 1 to 9 carbon atoms. An alkyl group can also be a lower alkyl group having 1 to 4 carbon atoms. An alkyl group can be referred to as “C…” 1-4 Alkyl or similar names. For example only, "C" 1-4 "Alkyl" indicates the presence of 1 to 4 carbon atoms in an alkyl chain, meaning the alkyl chain is selected from the group consisting of methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, and tert-butyl. Typical alkyl groups include, but are by no means limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, and hexyl. Unless otherwise indicated, the term "alkyl" refers to an unsubstituted group.

[0027] As used herein, “alkoxy” refers to the part of the formula -OR, where R is an alkyl group as defined above, such as “C 1-9 "Alkoxy" includes, but is not limited to, methoxy, ethoxy, n-propoxy, 1-methylethoxy (isopropoxy), n-butoxy, isobutoxy, sec-butoxy, and tert-butoxy.

[0028] As used herein, a "heterocyclic group" refers to a non-aromatic ring or ring system containing at least one heteroatom in its ring backbone. Heterocyclic groups can be linked together by fusion, bridging, or helical connections. Heterocyclic groups can have any degree of saturation, provided that at least one ring in the ring system is not aromatic. Heteroatoms can be present in non-aromatic or aromatic rings of the ring system. In some embodiments, the heterocyclic group has 3 to 20 ring members (i.e., the number of atoms constituting the ring backbone, including carbon atoms and heteroatoms), although this definition also covers the occurrence of the term "heterocyclic group" where no numerical range is specified. Heterocyclic groups can also be of medium size with 3 to 10 ring members. Heterocyclic groups can also be heterocyclic groups with 3 to 6 ring members. Heterocyclic groups may be referred to as "3- to 6-membered heterocyclic groups" or similar names. In a preferred six-membered monocyclic heterocyclic group, the heteroatom is selected from one to at most three of O, N or S, and in a preferred five-membered monocyclic heterocyclic group, the heteroatom is selected from one or two heteroatoms selected from O, N or S. Examples of heterocyclic groups include, but are not limited to, azepinyl, acridine, carbazole, cinnolinyl, dioxolanyl, imidazolinyl, imidazoalkyl, morpholinyl, oxiranyl, oxepanyl, thiepanyl, piperidinyl, piperazinyl, dioxopiperazinyl, pyrrolidonyl, pyrrolidionyl, 4-piperidonyl, pyrazolinyl, pyrazolalkyl, 1,3-dioxinyl, 1,3-dioxane, 1,4-dioxinyl, 1,4-dioxane, and 1,3-oxathianyl. yl), 1,4-oxathiinyl, 1,4-oxathiinyl, 2H-1,2-oxazinyl, trioxane, hexahydro-1,3,5-triazinyl, 1,3-dioxolyl, 1,3-dioxolyl, 1,3-dithiolyl, 1,3-dithiopentane, isoxazoline The group includes: alkyl, isoxazolinyl, oxazolinyl, oxazolinyl, oxazolidinone, thiazolinyl, thiazolinyl, 1,3-oxathiolanyl, indololinyl, isoyindololinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, tetrahydro-1,4-thiazinyl, thiamorpholinyl, dihydrobenzofuranyl, benzimidazolinyl, and tetrahydroquinoline.

[0029] As used herein, "optionally" means that the events described below may or may not occur. In some embodiments, the optional event does not occur. In other embodiments, the optional event does occur once or more.

[0030] As used herein, the words “for example,” “such as,” “like,” or “including” are intended to introduce examples that further illustrate a more general subject. Unless otherwise expressly stated, such examples are provided only to aid in understanding the embodiments shown in this disclosure and are not intended to be limiting in any way. These phrases also do not indicate any kind of preference for the disclosed embodiments.

[0031] In a first embodiment, this disclosure relates to a liquid composition comprising:

[0032] a) at least one compound of formula (I),

[0033]

[0034] The compound is in any of its stereoisomers; where R 1 Represents a phenyl group, which may optionally have one or two C atoms substituted. 1-3 alkyl or alkoxy or one or two halogen groups; R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which may optionally be substituted with one or two C atoms. 1-3 alkyl;

[0035] b) Oils containing carvone; and

[0036] c) Optional solvents.

[0037] For clarity, the phrase "any stereoisomer thereof" or similar expressions refer to the common meaning understood by those skilled in the art, namely, that a compound of formula (I) can be any diastereomer, enantiomer, or mixture thereof. In other words, a compound of formula (I) can have an amide functional group, which can be cis, trans, or a mixture thereof. Furthermore, a compound of formula (I) can also have at least one stereocenter, which can have different stereochemical configurations (i.e., when a stereocenter is present, compound (I) can have an (R) or (S) configuration). Each stereocenter can have a relative configuration of R or S, or a mixture thereof. The compound of formula (I) can be in the form of a pure enantiomer or diastereomer, or a mixture of stereoisomers.

[0038] According to any of the above implementation schemes, R 1Represents a phenyl group, which may optionally have one or two C atoms substituted. 1-3 Alkyl or alkoxy or one or two halogen groups. In one embodiment, R 1 Represents a phenyl group, which has one or two C atoms as substitutions. 1-3 Alkyl or alkoxy or one or two halogen atoms. In another embodiment, R 1 Represents a phenyl group, which has one or two C atoms as substitutions. 1-2 Alkyl or alkoxy or one or two fluorine atoms. In yet another embodiment, R 1 This represents a phenyl group, which is substituted with one or two methyl, ethyl, methoxy, or fluorine atoms. The substituents on the phenyl group can be located relative to the oxygen atom and R. 1 The ortho, meta, and / or para positions of the bonds between groups. In one embodiment, R 1 It can be selected from the group consisting of p-tolyl, 4-ethylphenyl, 4-methoxyphenyl, 4-fluorophenyl, 3,4-dimethylphenyl, and m-tolyl. In another embodiment, R 1 It can be p-tolyl or 4-ethylphenyl. In yet another embodiment, R 1 It can be p-tolyl.

[0039] As used herein, the terms “ortho,” “meta,” and “para” are used in the usual sense in the art, namely, ortho refers to two substituents on a phenyl group occupying adjacent positions; meta refers to two substituents on a phenyl group occupying positions 1 and 3; and para refers to two substituents on a phenyl group occupying positions 1 and 4.

[0040] According to any of the above implementation schemes, R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which may optionally be substituted with one or two C atoms. 1-3 Alkyl group. In one embodiment, R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur. In another embodiment, R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen and sulfur.

[0041] According to any of the above implementation schemes, R 2 This represents a heterocyclic group containing one or two nitrogen atoms. In one embodiment, R 2 It represents the pyrazole group.

[0042] According to any of the above implementation schemes, R 3This represents a heterocyclic group containing one or two sulfur atoms. In one embodiment, R 3 Represents thiophene group.

[0043] According to any of the above embodiments, the compound of formula (I) can be selected from the group consisting of: N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide, 2-(4-fluorophenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, 2-(4-ethylphenoxy)-N-(1H-pyrazol-3-yl)-N- (thiophene-2-ylmethyl)acetamide, 2-(4-methoxyphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophene-2-ylmethyl)acetamide, N-(1H-pyrazole-3-yl)-N-(thiophene-2-ylmethyl)-2-(m-tolyloxy)acetamide, and 2-(3,4-dimethylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophene-2-ylmethyl)acetamide. The compounds all possess a pyrazole group. This group is known to exist in two tautomer forms, namely 1H-pyrazole-3-yl and 1H-pyrazole-5-yl. These two isomers readily reach equilibrium. In other words, when a composition contains N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-toluoxy)acetamide, the composition necessarily also contains N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)-2-(p-toluoxy)acetamide. The above conclusion also applies to the other compounds described herein. For example, 2-(4-fluorophenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is in equilibrium with 2-(4-fluorophenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-(4-ethylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is in equilibrium with 2-(4-ethylphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-(4-methoxyphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is in equilibrium with 2-( 4-Methoxyphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide is in equilibrium; N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(m-tolyloxy)acetamide is in equilibrium with N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)-2-(m-tolyloxy)acetamide; 2-(3,4-dimethylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide is in equilibrium with 2-(3,4-dimethylphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide. In one embodiment, the compound of formula (I) is N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide.

[0044] Surprisingly, it was discovered that the compound of formula (I) can be dissolved at a useful concentration using an oil containing carvone (and optionally a solvent), thereby obtaining a clear and homogeneous solution. The term "clear" means that the solution has 100% transmittance at a 1 cm optical path length in the visible light range (500–800 nm) with deionized water as a reference, without the addition of colorants or fluorescent agents. Therefore, in one embodiment, the liquid composition is a clear and homogeneous solution.

[0045] In one embodiment, the transparent and homogeneous solution is also stable. The term "stable" means that the liquid composition does not undergo phase separation and remains transparent without detectable turbidity, clouding, or precipitation at room temperature or within a certain temperature range (e.g., room temperature ± 10 to 20°C, typically between 10°C and 45°C, more typically between 3°C and 45°C), and remains stable over a relatively long period of time (typically at least a few days, more typically at least a few weeks, or even longer).

[0046] Oils containing carvone can be from any carvone source known to those skilled in the art. Oils containing carvone are generally naturally occurring oils known to those skilled in the art. Carvone (2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one) is a terpene compound that can be obtained from natural sources by chemical synthesis or extraction using known methods. Carvone has two enantiomers: R-(-)-carvone (also known as levorotatory (L)-carvone) and S-(+)-carvone (also known as dextrorotatory (D)-carvone). This disclosure contemplates racemic mixtures of carvone and its enantiomers and their resolved forms. Racemic mixtures of carvone and its enantiomers and their resolved forms can be pure, i.e., unmixed with other substances, or can be part of a mixture (e.g., an extract). In one embodiment, the oil containing carvone can be pure carvone, spearmint oil, caraway seed oil, or dill oil. Spearmint oil can be marketed as a mint spicata extract containing a certain amount of carvone, such as a mint spicata extract containing 60% carvone and a mint spicata China extract containing 80% carvone. In some embodiments, the oil containing carvone is food grade.

[0047] There is no particular limitation on the amount of carvone-containing oil used. However, in some embodiments, the amount of carvone-containing oil used is 1% to 99%, 5% to 99%, 10% to 99%, 15% to 99%, or 20% to 99% relative to the total weight of the liquid composition. In some embodiments, the amount of carvone-containing oil used is 1% to 80%, 5% to 80%, 10% to 80%, 15% to 80%, or 20% to 80% relative to the total weight of the liquid composition.

[0048] There is no particular limitation on the carvone content in oils containing carvone. However, in some embodiments, the carvone content is at least 20% of the total weight of the oil containing carvone. In some embodiments, the carvone content is 20% to 100% of the total weight of the oil containing carvone, typically 40% to 100%, and more typically 60% to 90%. In one particular embodiment, the carvone content is 80% to 90% of the total weight of the oil containing carvone.

[0049] There is no particular limitation on the content of carvone in the liquid composition. However, in some embodiments, the content of carvone in the liquid composition is at least 5%, at least 10%, at least 15%, at least 20%, or at least 25% of the total weight of the liquid composition. In some embodiments, the content of carvone in the liquid composition is 5% to 99%, 10% to 99%, 15% to 99%, 20% to 99%, or 25% to 99% of the total weight of the liquid composition. In some embodiments, the content of carvone in the liquid composition is 5% to 95%, 10% to 95%, 15% to 95%, 20% to 95%, or 25% to 95% of the total weight of the liquid composition.

[0050] In some embodiments, the optional solvent may include one or more solvents commonly used in the flavoring or fragrance industry, provided that these solvents do not negatively affect the transparency and homogeneity of the liquid composition. In one embodiment, the optional solvent comprises one or more solvents selected from: 1-propanol (n-propanol), 2-propanol (isopropanol), ethanol, 1,2-propanediol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol.

[0051] There are no particular limitations on the weight ratio of carvone-containing oil to an optional solvent (if any). However, in some embodiments, the weight ratio of carvone-containing oil to an optional solvent (if any) is 1:99 to 99:1, typically 10:90 to 90:10, and more typically 30:70 to 90:10. In some embodiments, the weight ratio of carvone-containing oil to an optional solvent (if any) is 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, or 90:10.

[0052] In one embodiment, the liquid composition comprises an oil containing carvone and one or more solvents selected from the group consisting of: 1-propanol (n-propanol), 2-propanol (isopropanol), ethanol, 1,2-propanediol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol. In another embodiment, the liquid composition comprises an oil containing carvone and a solvent selected from the group consisting of: 2-propanol (isopropanol), ethanol, and ethyl lactate.

[0053] There is no particular limitation on the amount of at least one compound of formula (I) in the compositions disclosed herein. However, in one embodiment, the amount of at least one compound of formula (I) is from 0.1% to 20% by weight, typically 5% to 15% by weight, relative to the total weight of the composition, while the amount of the carvone-containing oil is from 20% to 99.9% by weight. In some embodiments, the amount of at least one compound of formula (I) is from 0.1% to 20% by weight, typically 5% to 15% by weight, relative to the total weight of the composition, while the amount of the carvone-containing oil is from 80% to 99.9% by weight, typically 85% to 99.9% by weight.

[0054] The composition described herein is characterized by the temperature required to dissolve 10% by weight (relative to the weight of the composition) of the compound of formula (I) in an oil containing carvone and optionally a solvent. As used herein, the temperature required to dissolve 10% by weight (relative to the weight of the composition) of the compound of formula (I) in an oil containing carvone and optionally a solvent is referred to as the dissolution temperature. In one embodiment, the dissolution temperature is from 10°C to 40°C, typically from 15°C to 40°C.

[0055] In a second aspect, this disclosure relates to a consumer product comprising the liquid composition described herein.

[0056] The consumer product may also contain cooling compounds that are different from those in formula (I).

[0057] Exemplary cooling compounds include, but are not limited to, those selected from the following compounds: (-)-menthol, N-ethyl-p-menthyl-3-carboxamide, piperazine alcohol, isopreneol, 3-(L-menthoxy)propane-1,2-diol, cis / trans-p-menthane-3,8-diol, 3-(L-menthoxy)-2-methylpropane-1,2-diol, 2-[2-(p-menthane-3-yloxy)ethoxy]ethanol, menthol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl)ethene, (1R,2 R,5R)-N-ethyl-5-methyl-2-(prop-1-en-2-yl)-cyclohexaneformamide, N-(3-hydroxy-4-methoxyphenyl)-2-isopropyl-5,5-dimethyl-cyclohexaneformamide, N-[4-(cyanomethyl)phenyl]-2-isopropyl-5,5-dimethylcyclohexaneformamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-formamide, L-menthol lactate, (-)-menthol glycol carbonate, (-)-menthol 1,2-glycerol ketal, D / L-Menthone 1,2-glycerol ketal, (-)-Menthyl 1-propanediol carbonate, (-)-Menthyl 2-propanediol carbonate, D / L-Menthyl 1-propanediol carbonate, D / L-Menthyl 2-propanediol carbonate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexaneformamide, Menthyl acetamoxyoxalate, (E)-3-benzo[1,3]dioxacyclopenten-5-yl-N,N-diphenyl-2-acrylamide, 3,4-methylenedioxycinnamic acid N,N-diphenylamide, N,N-dimethyl(-)-menthylsuccinimide, (1R,2S,5R)-N-(4-(carbamoylmethyl)phenyl)-menthylformamide, (-)-menthylpyrrolidone carboxylate, L-dehydroepiandrosterone-menthylformamide, (1R,2S,5R)-N-(4-(cyanomethyl)phenyl)menthylformamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylformamide, 6-isopropyl-3,9-dimethyl-1,4-dioxanespiro[4].5] Decane-2-one, (1R,2R,4S)-dihydrosansine, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N,2,3-trimethylbutyramide, 3-(p-menthane-3-carboxamido)ethyl acetate, N-ethyl-2,2-diisopropylbutyramide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-dimethylbutyramide, N-cyclopropyl-5-methyl-2-isopropyl-cyclohexane Alkylformamide, acetoacetic acid (-)-menthyl ester, succinic acid (-)-menthyl ester, (S)-3-hydroxybutyric acid (-)-menthyl ester, glutaric acid (-)-menthyl ester, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidin-2-one, di-(-)-menthyl glutaric acid, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramide, and any combination thereof.

[0058] In one embodiment, the further cooling compound may be 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole, 5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole (including (3aR,5R,7S,7aR)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, (3aR,5R,7R,7aR)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, (3aR,5R,7S,7aS)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole), or any combination thereof.

[0059] The consumer product may contain a cooling-enhancing compound. As used herein, a "cooling-enhancing compound" can enhance the cooling sensation provided by a consumer product containing a cooling compound, but may also provide a cooling sensation on its own. Such cooling-enhancing compounds include, but are not limited to, compounds of natural origin, such as menthol or analogues thereof, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 9,394,287 and 10,421,727. Exemplary cooling-enhancing compounds include, but are not limited to, compounds selected from (E / Z)-2-methyl-2-butenal, (E / Z)-2-isopropyl-5-methyl-2-hexenal, and any combination thereof.

[0060] Consumer products can be flavored products, typically food products, beverage products, oral care products, or pharmaceutical products.

[0061] This flavored product may contain a sweetener. As used herein, a "sweetener" means a compound or its salt that produces a detectable sweet flavor in a subject, such as a compound that activates T1R2 / T1R3 receptors in vitro. The sweetener may be a low-calorie, zero-calorie, or high-intensity sweetener. The term "high-intensity sweetener" refers to a sweetener that is sweeter than sucrose, for example, at least 10 times, or at least 20 times, or at least 50 times, or at least 100 times, or at least 250 times, or at least 500 times, or at least 750 times, or at least 1000 times, or at least 2500 times, or at least 5000 times, or at least 7500 times, or at least 10000 times sweeter than sucrose. In this document, saying that a sweetener is x times sweeter than sucrose means that a concentration of the sweetener in an aqueous solution relative to 1 / x the weight of sucrose produces a sweetness equivalent to that of sucrose.

[0062] Examples of suitable sweeteners are described in more detail below. In some embodiments, the sweetener is sucralose, which refers to 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside. In some embodiments, the sweetener is sodium saccharin. Sodium saccharin may be present at any suitable concentration. In some embodiments, the concentration range of sodium saccharin is from 10 ppm to 10,000 ppm, or from 50 ppm to 5,000 ppm, or from 100 ppm to 3,000 ppm.

[0063] In one embodiment, the sweetener may comprise glucosylated natural steviol glycosides. As used herein, the term "natural steviol glycoside" refers to steviol glycosides naturally found in the plant species Stevia rebaudiana, Stevia phlebophylla, or Rubus chingii. Such compounds are glycosides of diterpenoid steviols. Some non-limiting examples include steviol glycosides, rebaudioside A, rebaudioside C, dulcoside A, etc. As used herein, the term "glucosylated natural steviol glycoside" refers to a compound obtained by enzymatically glucosylating a natural steviol glycoside to increase the degree of glucosylation. As used herein, the term "GSG" may be used interchangeably with "glucosylated natural steviol glycoside".

[0064] In embodiments where a GSG is present, any suitable GSG can be used. Therefore, the GSG can have any suitable degree of additional glucosylation, and any suitable type of glucosylation. In some embodiments, the GSG used has a glucosylation degree of at least 1.0, meaning that at least one mole of glucose has been enzymatically added to the natural steviol glycoside for every mole of natural steviol glycoside. In other embodiments, the GSG used has a glucosylation degree of at least 1.1, or at least 1.2, or at least 1.3, or at least 1.4, or at least 1.5, or at least 1.6, or at least 1.7, or at least 1.8, or at least 1.9, or at least 2.0, or at least 2.1, or at least 2.2, or at least 2.3, or at least 2.4, or at least 2.5. The glucosylation can be of any suitable type. For example, in some embodiments, the glucose enzymatically added to the natural steviol glycoside is α-glucose, β-glucose, or a combination thereof. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is α-glucose. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is β-glucose. In some embodiments, the glucose added enzymatically to the natural steviol glycoside is a combination of α-glucose and β-glucose. The glucose added via enzymatic glucosylation can be incorporated through any suitable linkage. Typically, the added glucose unit is linked to other glucose units already present on the natural steviol glycoside. In some embodiments, the enzymatically added glucose unit is added via a 1,6 bond, meaning the glucose unit is added via the 1-position of the added glucose unit and the 6-position of a glucose unit already present on the natural steviol glycoside. In some other embodiments, the enzymatically added glucose unit is added via a 1,4 bond. In some other embodiments, the enzymatically added glucose unit is added via a 1,2 bond.

[0065] In embodiments where GSG is present, GSG may be present at any suitable concentration. In some embodiments, GSG is present in concentration ranges of 1 ppm to 100 ppm, or 1 ppm to 50 ppm, or 1 ppm to 30 ppm, or 1 ppm to 20 ppm, or 1 ppm to 10 ppm.

[0066] In one embodiment, the sweetener may comprise a caloric sugar, such as sucrose, glucose, fructose (e.g., in the form of high-fructose corn syrup), or any combination thereof. In some embodiments, the sweetener comprises one or more rebaudine glycosides (e.g., rebaudine A, rebaudine D, rebaudine E, rebaudine M, or any combination thereof). Generally, the concentration of rebaudine glycosides (e.g., rebaudine A) is about 20 to 50 times higher than the concentration of sucralose described above. In some embodiments, the sweetener comprises one or more high-intensity artificial sweeteners, such as acesulfame potassium, aspartame, cyclamate, neotame, etc. When any such high-intensity artificial sweeteners are present, their concentrations will be substantially the same as those described for sucralose described above. In some other embodiments, the cooling effect modifying composition comprises one or more low-caloric carbohydrates or sugar alcohols, such as allulose, xylitol, erythritol, etc. In some other embodiments, the sweetener comprises mogrosides, for example as monk fruit juice or extract, or as mogroside III, mogroside IV, mogroside V, symmonoside I, isomogroside V, or mogroside IV. E Isomogroside IV E Isomogroside IV and mogroside III E One or more of the 1,6-α isomers of 1,1-oxomogroside V and symbioside I, and any combination thereof. Other mogroside compounds that may be suitably included in sweeteners are described in U.S. Patent Application Publication No. 2017 / 0119032.

[0067] The consumer products disclosed herein (typically flavored products) may also contain a variety of other sweeteners. Non-limiting examples include D-allulose, L-ribose, D-tagatose, L-glucose, L-fucose, L-arabinose, D-minobiose, D-leucobionic acid, isomaltitol, lactitol, mannitol, sorbitol, maltodextrin, saccharin, alitane, cyclamic acid, tagatose, maltose, galactose, mannose, lactose, D-tryptophan, glycine, maltitol, lactitol, isomaltitol, hydrogenated starch hydrolysate (HSH), chemically modified mogrosides (such as glucosylated mogroside), carrelame and other guanidine sweeteners, honey, Jerusalem artichoke syrup, licorice root, monk fruit (fruit, powder or extract), lucuma (fruit, powder or extract), maple sap (including, for example, from sugar maple). Sap from various trees including: saccharum, black maple (Acer nigrum), American red maple (Acer rubrum), silver maple (Acer saccharinum), Norway maple (Acer platanoides), ash-leaved maple (Acer negundo), large-leaved maple (Acer macrophyllum), coarse-toothed maple (Acer grandidentatum), Rocky Mountain maple (Acer glabrum), and maple (Acermono); maple syrup; maple sugar; walnut sap (including, for example, sap extracted from white walnut (Juglans cinerea), black walnut (Juglans nigra), ghost walnut (Juglans ailatifolia), and walnut (Juglans regia); and birch sap (including, for example, sap extracted from paper birch (Betula papyrifera), Canadian yellow birch (Betula alleghaniensis), mountain birch (Betula lenta), river birch (Betula nigra), grey birch (Betula populifolia), and weeping birch (Betula...). Sap extracted from *Pendula*, sycamore sap (e.g., sap extracted from *Platanus occidentalis*), ironwood sap (e.g., sap extracted from *Ostrya virginiana*), unrefined sucrose (mascobado), molasses (e.g., blackstrap molasses), molasses sugar, monalose, monellin, cane sugar (cane sugar)Sugar (also known as natural sugar, unrefined sucrose, or cane sugar), palm sugar, panocha, piloncillo, rapadura, raw sugar, rice syrup, sorghum, sorghum syrup, cassava syrup (also known as cassava starch syrup), thaumatin, yacon root, malt syrup, barley malt syrup, barley malt powder, beet sugar, cane sugar Sugar), crystallized fruit juice crystals, caramel, carob syrup, castor oil, hydrogenated starch hydrosol, hydrolyzed canned fruit juice, hydrolyzed starch, invert sugar, anethole, arabinogalactan, concentrated grape juice, syrup, P-4000, acesulfame potassium (also known as acetylsupan potassium or ace-K), aclame, advans, aspartame, baiyunosdie, neotame, benzamide derivatives, bernadame, aspartame alias (canderel), carrelame and other guanidine sweeteners, plant fiber, corn sugar, conjugated sugars, curculigosin, cyclohexylsulfamic acid salt, cyclocaryoside I, demerara, dextran, dextrin, diastatic malt.malt), dulcin, sucrol, valzin, dulcioside A, dulcioside B, emulin, enoxolone, maltodextrin, saccharin, estragole, ethyl maltol, glucin, gluconic acid, gluconolactone, glucosamine, glucuronic acid, glycerol, glycyphillin, glycyrrhizin, glycyrrhetinic acid monoglucuronide, golden sugar, yellow sugar, golden syrup, granulated sugar, Gynostemma pentaphyllum, hernandulcin, isomerized liquid sugar, jallab, chicory root dietary fiber, kynurenine derivatives (including N'-formyl-kynurenine, N'-acetyl-kynurenine) Amino acid, 6-chloro-kynurenine), galactitol, litesse, ligicane, lycasin, N-(4-cyanophenyl)-N-(2,3-methylenedioxybenzyl)guanidinacetic acid, guanidine, farernum syrup, areca nut protein I, areca nut protein II, maltol, crystalline maltitol, maltodextrin, maltotriol, mannosamine, miraculin, mizuame, mogrosides (including, for example, mogroside IV, mogroside V and neomogroside), mukurozioside, nanosugars. sugar), naringin dihydrochalcone, neohesperidin dihydrochalcone, nib sugar, black oligosaccharides, norbu, almond syrup, osladin, pekmez, pentadin, periandrin I, perillartine, petphyllum, phenylalanine, phloisosideside I, phlorodizin, phyllodulcin, polyglycitol syrup, polypodoside A, pterocaryoside A, pterocaryoside B, rebiana, refined syrup, rub syrup, rubusoside, selligueain A) Shugr, sermonoside I, monk fruit (Siraitia grosvenorii), soybean oligosaccharides, Splenda, SRIoximeV, steviol glycosides, steviol disaccharides, steviol glycosides, strogins 1, 2 and 4, sucronic acid, sucrononate, sugars, sodium suosan, phloridzin, super aspartame, tetrasaccharides, threitol, treacle, trilobtain, tryptophan and its derivatives (6-trifluoromethyl-tryptophan, 6-chloro-D-tryptophan), vanilla sugar, heptenetropeol, beet syrup, aspartame-acesulfame, assugrin, and any combination or blend of two or more of them.

[0068] In one particular implementation, the consumer product (typically a flavored product) contains a sweetener selected from sucrose, fructose, glucose, erythritol, sucralose, xylitol, and any combination thereof.

[0069] In one embodiment, the consumer product (typically a flavored product) may comprise 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or any suitable salt thereof. In some embodiments, the consumer products disclosed herein may comprise a hydrochloride salt of 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.

[0070] In some embodiments of any of the foregoing embodiments, the consumer product (typically a flavored product) may contain a lactone. Any suitable lactone or a combination of lactones may be used. In some embodiments, the lactone comprises a lactone ring having 3 to 8 members, such as a 3-membered, 4-membered, 5-membered, 6-membered, 7-membered, or 8-membered lactone ring.

[0071] In some embodiments, the lactone comprises a 5-membered lactone ring having or not having unsaturated bonds (excluding the degree of unsaturation in the oxygen substituents on the ring), such as carbon-carbon double bonds. In some embodiments, the lactone comprises a 5-membered lactone ring having at least one unsaturated bond (e.g., one carbon-carbon double bond). Non-limiting examples of lactones comprising a 5-membered lactone ring having at least one unsaturated bond include angelicin α, angelicin β, menthol, 5,5-dimethyl-2(5H)-furanone, 5-ethyl-2(5H)-furanone, 5-pentyl-2(5H)-furanone, 5-hexyl-2(5H)-furanone, 5-pentyl-2(3H)-furanone, 4-methyl-3-pentyl-2(5H)-furanone, and 2(5H)-furanone. In some embodiments, the lactone comprises a 5-membered lactone ring without any unsaturated bonds. Non-limiting examples of such lactones include butyrolactoneγ, valproiconeγ, caprolactoneγ, heptanolactoneγ, octylolactoneγ, undecylolactoneγ, decylolactoneγ, dihydrojasmone lactone, and dihydromenthyl lactone (3,6-dimethyl-hexahydro-2(3H)-benzofuranone). In some embodiments, the lactone is dihydromenthyl lactone.

[0072] In some embodiments, the lactone comprises a 6-membered lactone ring with or without unsaturated bonds. In some embodiments, the lactone comprises a 6-membered lactone ring having at least one unsaturated bond. Non-limiting examples of lactones comprising a 6-membered lactone ring having at least one unsaturated bond include δ-2-decenolactone, coumarin, and 6-methylcoumarin. In some other embodiments, the lactone comprises a 6-membered lactone ring without any unsaturated bonds. Non-limiting examples of lactones comprising a 6-membered lactone ring without any unsaturated bonds include decanolide δ, dodecalide δ, and cyclohexyllactone.

[0073] In one implementation, the consumer product (typically a flavored product) may contain one or more flavanones or flavanone derivatives belonging to the flavonoid family of compounds.

[0074] Exemplary flavanones or flavanone derivatives include, but are not limited to, hesperidin, naringenin, sterubin, 7-O-methylsterubin, aromadendrin, sterubin-3-O-acetate, or any salt or glycoside thereof.

[0075] Other exemplary flavanones or flavanone derivatives include, but are not limited to, naringin, hesperidin, (2R,3R)-3-acetoxy-5,7,4'-trihydroxyflavanone, (2R,3R)-3-acetoxy-5,7,3'-trihydroxy-4'-methoxyflavanone, 3-methoxy-5,3'-dihydroxy-4'-methoxyflavanone (racemic mixture), nobiletin, polymethoxyflavones, mixed methoxy and hydroxyflavones, quercetin, 7,4'-di-O-methylpersicogenin, or any salts or glycosides thereof.

[0076] In some embodiments, the consumer product (typically a flavored product) may contain one or more dihydrochalcones or dihydrochalcone derivatives of flavonoids. Non-limiting examples of suitable dihydrochalcones or dihydrochalcone derivatives include, but are not limited to, naringin dihydrochalcone, hesperidin dihydrochalcone, hesperidin dihydrochalcone 4'-O-glucoside, neohesperidin dihydrochalcone, and phlorizin.

[0077] In some implementations, the consumer product may contain any other ingredients or combinations of ingredients commonly used in such products, such as flavored products, including but not limited to:

[0078] Acids, including, for example, citric acid, phosphoric acid, ascorbic acid, sodium bisulfate, lactic acid, or tartaric acid;

[0079] Bitter components include, for example, caffeine, quinine, green tea, catechins, polyphenols, Robusta coffee bean extract, coffee bean extract, potassium chloride, menthol, or proteins (such as proteins and protein isolates derived from plants, algae, or fungi).

[0080] Coloring agents, including, for example, caramel color, red #40, yellow #5, yellow #6, blue #1, red #3, purple carrot, black carrot juice, purple sweet potato, vegetable juice, fruit juice, beta-carotene, curcumin, or titanium dioxide;

[0081] Preservatives, including, for example, sodium benzoate, potassium benzoate, potassium sorbate, sodium metabisulfite, sorbic acid, or benzoic acid;

[0082] Antioxidants, including, for example, ascorbic acid, calcium disodium EDTA, α-tocopherol, mixed tocopherols, rosemary extract, grape seed extract, resveratrol, or sodium hexametaphosphate;

[0083] Vitamins or functional ingredients, including, for example, resveratrol, Co-Q10, omega-3 fatty acids, theanine, choline chloride (citocoline), cellulose, inulin (chicory root), taurine, ginseng extract, guarana extract, ginger extract, L-phenylalanine, L-carnitine, L-tartrate, D-glucuronide, inositol, bioflavonoids, echinacea, ginkgo biloba, yerba mate, flaxseed oil, Garcinia cambogia peel extract, white tea extract, ribose, milk thistle (milk) Thistle extract, grape seed extract, pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12), nicotinamide (vitamin B3), biotin, calcium lactate, calcium pantothenate (pantothenic acid), calcium phosphate, calcium carbonate, chromium chloride, chromium polynicotinate, copper sulfate, folic acid, ferric pyrophosphate, iron, magnesium lactate, magnesium carbonate, magnesium sulfate, monopotassium phosphate, monosodium phosphate, phosphorus, potassium iodide, potassium phosphate, riboflavin, sodium sulfate, sodium gluconate, sodium polyphosphate, sodium bicarbonate, thiamine mononitrate, vitamin D3, vitamin A palmitate, zinc gluconate, zinc lactate or zinc sulfate;

[0084] Clouding agents include, for example, ester gum, brominated vegetable oil (BVO), or sucrose isobutyrate acetate (SAIB).

[0085] Buffer solutions, including, for example, sodium citrate, potassium citrate, or salts;

[0086] Flavors (food flavorings), such as natural flavorings, natural flavorings with other natural flavorings (WONF), natural and artificial flavorings, and artificial flavorings; or

[0087] Starch and stabilizers, including, for example, pectin, xanthan gum, carboxymethyl cellulose (CMC), polysorbate 60, polysorbate 80, medium-chain triglycerides, cellulose gel, cellulose gum, sodium caseinate, modified food starch, gum arabic (acacia gum), inulin, or carrageenan.

[0088] In some further embodiments, the consumer products disclosed herein (typically flavored products) comprise one or more other umami or rich flavor-enhancing compounds. Such umami-enhancing compounds include, but are not limited to, naturally derived compounds, such as (E)-3-(3,4-dimethoxyphenyl)-N-(4-methoxyphenylethyl)acrylamide, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 8,735,081, 8,124,121, and 8,968,708.

[0089] In some further embodiments, the consumer products disclosed herein (typically flavored products) may comprise one or more bitterness-blocking compounds. Such bitterness-blocking compounds include, but are not limited to, naturally derived compounds, such as menthol or analogues thereof, or synthetic compounds, such as any of the compounds described in U.S. Patent Nos. 8,076,491, 8,445,692, and 9,247,759.

[0090] In some further embodiments, the consumer products disclosed herein (typically flavored products) may contain one or more taste-modifying compounds. Such taste-modifying compounds include, but are not limited to, tannins, cellulose materials, bamboo powder, etc.

[0091] In some further embodiments, the consumer products disclosed herein (typically flavored products) may contain one or more flavor-masking compounds. Such flavor-masking compounds include, but are not limited to, cellulose materials, materials extracted from fungi, materials extracted from plants, citric acid, carbonic acid (or carbonates), etc.

[0092] In some embodiments, the consumer products disclosed herein (typically flavored products) may contain cyclosal. When cyclosal is present, its relative concentration is similar to that of the lactones described herein.

[0093] In one embodiment, the consumer product (typically a flavored product) contains one or more flavorings, or any other additives described in H. Mitchell, Sweeteners and Sugar Alternatives in Food Technology, Blackwell Publishing Ltd, 2006. As used herein, the term "flavoring" includes flavorings known to those skilled in the art, such as natural and artificial flavorings. These flavorings may be selected from synthetic flavoring oils and flavoring aromatic substances or from oils, oleoresins, and extracts of plants, leaves, flowers, fruits, etc., and combinations thereof. Non-limiting examples of flavoring oils include spearmint oil, cinnamon oil, deer hoof oil (methyl salicylate), peppermint oil, Japanese peppermint oil, clove oil, laurel oil, anise oil, eucalyptus oil, thyme oil, cedarwood leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, and cinnamon oil. Non-limiting examples of other flavors include natural and synthetic fruit flavorings such as vanilla and citrus oils, including lemon, orange, lime, grapefruit, yazu, and sudachi, as well as fruit essences, including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, melon, plum, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya, etc. Other potential flavorings include milk flavorings, butter flavorings, cheese flavorings, cream flavorings, and yogurt flavorings; vanilla flavorings; tea or coffee flavorings, such as green tea flavorings, oolong tea flavorings, tea flavorings, cocoa flavorings, chocolate flavorings, and coffee flavorings; mint flavorings, such as peppermint flavorings, spearmint flavorings, and Japanese mint flavorings; and spice flavorings, such as asafoetida flavorings, Indian anise flavorings, star anise flavorings, angelica flavorings, fennel flavorings, allspice flavorings, cinnamon flavorings, chamomile flavorings, mustard flavorings, cardamom flavorings, coriander flavorings, fennel flavorings, clove flavorings, pepper flavorings, and yellow pepper flavorings. Camphor flavoring, salty flavoring, Sichuan pepper flavoring, perilla flavoring, juniper berry flavoring, ginger flavoring, star anise flavoring, horseradish flavoring, thyme flavoring, tarragon flavoring, dill flavoring, bell pepper flavoring, nutmeg flavoring, basil flavoring, marjoram flavoring, rosemary flavoring, bay leaf flavoring, and wasabi (Japanese horseradish) flavoring; alcoholic flavorings, such as red wine flavoring, whiskey flavoring, brandy flavoring, rum flavoring, gin flavoring, and liqueur flavoring; floral flavorings; and vegetable flavorings, such as onion flavoring, garlic flavoring, cabbage flavoring, carrot flavoring, celery flavoring, mushroom flavoring, and tomato flavoring.These flavorings can be used in liquid or solid form and can be used alone or in combination. Commonly used flavorings include peppermint (such as peppermint, menthol, spearmint), artificial vanilla, cinnamon derivatives, and various fruit flavorings, whether used alone or in combination. Flavorings can also provide a fresh breath property, especially peppermint flavorings when used in combination with cooling agents.

[0094] Flavoring agents can also provide a fresh breath characteristic, especially minty flavorings when used in combination with cooling agents. These flavoring agents can be used in liquid or solid form and can be used alone or in combination. Other useful flavoring agents include aldehydes and esters, such as cinnamyl acetate, cinnamaldehyde, citral diethyl acetal, dihydrocarboxyl acetate, eugenol formate, p-methyl anisole, etc. Generally, any flavoring agent or food additive can be used, such as those described by the National Academy of Sciences in Chemicals Used in Food Processing, publication 1274, pages 63-258.

[0095] Other examples of aldehyde flavorings include, but are not limited to, acetaldehyde (apple), benzaldehyde (cherry, almond), anisaldehyde (licorice, fennel), cinnamaldehyde (cinnamon), citral (α-citral, lemon, lime), neraldehyde (β-citral, lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, butter), jasmine aldehyde (piperaldehyde, vanillin, butter), vanillin (vanilla, butter), α-pentylcinnamaldehyde (spicy fruit flavoring agent), butyraldehyde (butter, cheese), pentanalaldehyde (butter, cheese), and lemongrass. Aldehydes (modified products, various types), decanal (citrus fruits), aldehyde C-8 (citrus fruits), aldehyde C-9 (citrus fruits), aldehyde C-12 (citrus fruits), 2-ethylbutanal (berries), hexenal, i.e., trans-2 (berries), tolueneformin (cherries, almonds), veratral (vanilla), 2,6-dimethyl-5-hepten, i.e., melon aldehyde (melon), 2,6-dimethyloctanal (green fruits), and 2-dodecenal (citrus, oranges), cherry, grape, strawberry shortbread, and mixtures thereof. This list of flavorings is merely exemplary and is not intended to limit the scope of the term "flavoring" or the generally disclosed range.

[0096] Flavored products can be any flavored product according to the forms and embodiments described below. In some embodiments, the flavored product is a beverage product, such as enhanced sparkling beverages, cola, lemon-lime sparkling beverages, orange sparkling beverages, grape sparkling beverages, strawberry sparkling beverages, pineapple sparkling beverages, ginger ale, root beer, fruit juice, fruit-flavored fruit juice, fruit juice beverages, honey beverages, vegetable juice, vegetable-flavored juice, sports drinks, energy drinks, fortified water beverages, vitamin-fortified water, near-water beverages, coconut water, tea beverages, coffee, cocoa beverages, beverages containing milk ingredients, beverages containing cereal extracts, and smoothies. In some other embodiments, the flavored product is a food product, such as packaged foods, canned foods, meal replacement products, etc. In some embodiments, the flavored product is an oral care product, such as toothpaste, mouthwash, or teeth whitening compositions, such as those disclosed in U.S. Patent Application Publication No. 2019 / 0167545, which is incorporated herein by reference.

[0097] In embodiments where the flavored product is a beverage, the beverage can be selected from the group consisting of: enhanced effervescent beverages, cola, lemon-lime effervescent beverages, orange effervescent beverages, grape effervescent beverages, strawberry effervescent beverages, pineapple effervescent beverages, ginger ale, root beer, fruit juice, fruit-flavored fruit juice, fruit juice beverages, honey beverages, vegetable juice, vegetable-flavored juice, sports drinks, energy drinks, fortified water beverages, vitamin-fortified water, near-water beverages, coconut water, tea beverages, coffee, cocoa beverages, beverages containing milk ingredients, beverages containing cereal extracts, and smoothies. In some embodiments, the beverage can be a soft drink.

[0098] Flavored products can be in any suitable physical form. For example, in some embodiments, the flavoring composition can be in solid form, such as a powder. In a further such embodiment, the flavoring product is tooth powder, such as tooth powder used for whitening teeth, removing stains (e.g., tobacco stains), etc. In some other embodiments, the flavoring product can be a paste or slurry, such as toothpaste. In some other embodiments, the flavoring product can be in the form of a cream or gel, such as tooth gel, skin cream, or tooth cream. In some other embodiments, the flavoring product can be, for example, a liquid suspension or solution having an aqueous carrier. In some embodiments, the flavoring product can be in the form of an emulsion, such as a microemulsion or nanoemulsion, in which surfactants, emulsifiers, etc., may be present. In some embodiments, the flavoring product is a personal care product, such as a product for application to the skin, face, lips, gums, mouth, etc. Such personal products can be used for any suitable purpose, such as skin whitening, teeth whitening, etc.

[0099] In some implementations, the flavored product is an oral care product. "Oral care product" refers to a personal care product or other product that, during normal use, is not intentionally swallowed for the purpose of systemic application of a specific therapeutic agent, but rather remains in the oral cavity for a sufficient duration to contact substantially all tooth surfaces and / or oral tissues for oral activities. Oral care compositions can take many forms, including toothpaste, dental floss, dental gel, subgingival gel, mouthwash, mousse, foam, oral spray, lozenges, chewing tablets, chewing gum, or denture products. Oral care compositions may also be incorporated into strips or films for direct application or adhesion to oral surfaces.

[0100] In some implementations, the flavored product is a pharmaceutical product, such as a product designed to carry or deliver certain active pharmaceutical ingredients (APIs). Such APIs can be over-the-counter (OTC) medications, such as acetaminophen and other OTC cough and cold medications. In some implementations, the API is a prescription-based medication.

[0101] In some embodiments of any form and implementation of flavored products described herein, the flavored product is a non-naturally occurring product, such as a packaged food or beverage product.

[0102] Other non-limiting examples of food and beverage products or preparations include sweet coatings, frostings or icings of such products, or any entity comprising: soups, dry processed foods, beverages, ready-to-eat foods, canned or pickled foods, frozen processed foods, chilled processed foods, snack foods, baked goods, confectionery, dairy products, ice cream, meal replacements, pasta and noodles, and sauces, seasonings, condiments, baby food and / or spreads.

[0103] Generally, soups refer to canned / marinated, dehydrated, instant, refrigerated, UHT, and frozen soups. For the purposes of this definition, soup is a food made from meat, poultry, fish, vegetables, grains, fruits, and other ingredients, cooked in a liquid that may contain some or all of these ingredients in visible pieces. It may be clear (as broth) or thick (as chowder), smooth, mushy, or chunky, ready-to-eat, semi-concentrated, or concentrated, and can be served hot or cold as a first course or main course, or as a snack (sip) between meals. Soup can be used as an ingredient in the preparation of other dietary components, ranging from broth (consommé) to sauces (cream- or cheese-based soups).

[0104] Dehydrated and cooked food products generally refer to: (i) cooking aids, such as powdered, granular, paste-like, concentrated liquid products, including bouillon, broth, and broth-like products in compressed blocks, tablets, or powdered or granular form, sold separately as finished products or as ingredients in products, seasonings, and formulation mixtures (regardless of technology); (ii) dietary solution products, such as dehydrated soups and freeze-dried soups, including dehydrated soup mixtures, dehydrated instant soups, dehydrated ready-to-eat soups, dehydrated or self-heating preparations of ready-made dishes, meals, and single-serving main courses, including pasta, potatoes, and rice; and (iii) dietary garnish products, such as seasonings, marinades, salad dressings, salad toppings, dips, mixes, batter mixtures, storage-stable sauces, barbecue sauces, liquid formulation mixtures, concentrates, sauces or gravy mixtures, including salad formulation mixtures, sold as finished products or as ingredients in products, whether dehydrated, liquid, or frozen.

[0105] The beverage category generally refers to beverages, beverage mixtures, and concentrates, including but not limited to carbonated and non-carbonated beverages, alcoholic and non-alcoholic beverages, ready-to-drink beverages, liquid concentrates used to prepare beverages (such as soda water), and dry powder beverage precursor mixtures. The beverage category also includes alcoholic beverages, soft drinks, sports drinks, isotonic beverages, and hot beverages. Alcoholic beverages include, but are not limited to, beer, cider / pear liqueur, FABs, wine, and spirits. Soft drinks include, but are not limited to, carbonated beverages, such as cola and non-cola carbonated beverages; fruit juices, such as fruit juice, honey drinks, fruit juice beverages, and fruit-flavored beverages; bottled water, including soda water, spring water, and purified / catering water; functional beverages, which can be carbonated or non-carbonated, including sports drinks, energy drinks, or elixir beverages; and concentrates, such as ready-to-drink liquid and powder concentrates. Whether hot or cold, beverages include, but are not limited to, coffee or iced coffee, such as fresh, instant and blended coffee; tea or iced tea, such as black tea, green tea, white tea, oolong tea and flavored tea; and other beverages, including flavored, malt-based or plant-based powders, granules, blocks or tablets mixed with milk or water.

[0106] Snack foods generally refer to any food that can be served as a light meal, including but not limited to sweet and savory snacks and energy bars. Examples of snacks include, but are not limited to, fruit snacks, potato chips / crisps, puffed foods, tortilla chips / crustaceans, popcorn, pretzels, nuts, and other sweet and savory snacks. Examples of energy bars include, but are not limited to, granola bars / mixed cereal bars, breakfast bars, energy bars, fruit bars, and other energy bars.

[0107] Baked goods generally refer to any edible product whose preparation involves exposure to heat or excessive sunlight. Examples of baked goods include, but are not limited to, bread, buns, biscuits, muffins, cereals, toaster pastries, cakes, waffles, tortillas, soft biscuits, pies, bagels, egg tarts, quiche, cakes, any baked goods, and any combination thereof. Other examples include, but are not limited to: packaged / industrial bread, bulk / artificial bread, packaged / industrial cakes, bulk / artificial cakes, cookies, chocolate-coated biscuits, sandwich biscuits, savory biscuits and crackers, bread substitutes, breakfast cereals, instant cereals, family breakfast cereals, flakes, muesli, other cereals, children's breakfast cereals, and hot cereals.

[0108] Ice cream generally refers to frozen desserts containing cream, sugar, and flavorings. Examples of ice cream include, but are not limited to: instant ice cream; family-sized ice cream; frozen yogurt and artisanal ice cream; and ice cream based on soy, oats, legumes (such as red beans and mung beans), and rice. Further examples of ice cream include, but are not limited to, single-serving dairy ice cream, single-serving water ice cream, multi-serving dairy ice cream, multi-serving water ice cream, family-sized dairy ice cream, ice cream desserts, bulk ice cream, and family-sized water ice cream.

[0109] Confectionery generally refers to sweet-tasting edible products. Examples of confectionery include, but are not limited to, hard candy, gelatin, chocolate, sugared foods, chewing gum, and any combination thereof. Other examples include, but are not limited to: chocolate chips, countlines, selflines / softlines, boxed varieties, standard boxed varieties, twist-wrapped miniature chocolates, flavored chocolates, chocolates with toys, alfajores, other chocolate confectionery, mints, standard mints, strong mints, hard candy, soft lollipops, chewing gum, jelly and chewing candy, toffee, caramel and nougat, medicated candy, lollipops, licorice, and other sugared foods.

[0110] Meal replacement foods generally refer to any food designed to replace a regular diet, especially for those concerned about health or fitness. Examples of meal replacements include, but are not limited to, weight loss products and recovery products.

[0111] Ready-to-eat foods generally refer to any food that can be consumed as a meal without extensive preparation or processing. Ready-to-eat foods include products for which manufacturers have added recipe "skills," thus offering high levels of convenience, completeness, and readiness. Examples of ready-to-eat foods include, but are not limited to, canned / marinated, frozen, dried, and refrigerated ready-to-eat foods; dinner mixes; frozen pizzas; refrigerated pizzas; and pre-made salads.

[0112] Pasta and noodles include any pasta and / or noodles, including but not limited to canned, dried, and chilled / fresh pasta; as well as plain, instant, chilled, frozen, and snack noodles.

[0113] Canned / pickled foods include, but are not limited to, canned / pickled meat and meat products, fish / seafood, vegetables, tomatoes, beans, fruits, ready-to-eat foods, soups, pasta and other canned / pickled foods.

[0114] Frozen processed foods include, but are not limited to, frozen processed red meat, processed poultry, processed fish / seafood, processed vegetables, meat substitutes, processed potatoes, baked goods, desserts, ready-to-eat foods, pizzas, soups, noodles and other frozen foods.

[0115] Dry processed foods include, but are not limited to, rice, dessert mixes, dry ready-to-eat foods, dehydrated soups, instant soups, dried pasta, plain pasta, and instant noodles. Refrigerated processed foods include, but are not limited to, refrigerated processed meats, processed fish / seafood products, lunch boxes, fresh-cut fruit, ready-to-eat foods, pizzas, pre-made salads, soups, fresh pasta, and noodles.

[0116] Sauces, condiments and seasonings include, but are not limited to, tomato sauce and puree, broth / soup cubes, herbs and spices, monosodium glutamate (MSG), table sauces, soy sauces, pasta sauces, wet / cooking sauces, dry / powder mixtures, ketchup, mayonnaise, mustard, salad dressings, balsamic vinegar, dips, marinades, and other sauces, condiments and seasonings.

[0117] Infant food includes, but is not limited to, milk- or soy-based formula foods; as well as prepared, dried, and other infant foods.

[0118] Spreads include, but are not limited to, jams and preserves, honey, chocolate sauce, nut spreads, and yeast spreads.

[0119] Dairy products generally refer to edible products derived from the milk of mammals. Examples of dairy products include, but are not limited to, dairy drinks, cheese, yogurt and fermented milk beverages, and other dairy products. Further examples of dairy products include, but are not limited to, fresh / pasteurized milk, whole milk, semi-skimmed milk, extended shelf-life / UHT milk, whole milk, semi-skimmed milk, non-fat milk, goat milk, condensed milk, plain condensed milk, flavored, functional and other condensed milk, flavored milk beverages, dairy-only flavored milk beverages, flavored milk beverages with fruit juice, soy milk, fermented milk beverages, creamer for coffee, milk powder, flavored milk powder beverages, creamer, cheese, processed cheese, spreadable cheese, processed cheese that is difficult to spread, unprocessed cheese, spreadable unprocessed cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, plain / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinking yogurt, regular drinking yogurt and probiotic drinking yogurt.

[0120] In some implementations, flavored products include one or more candies, chocolates, chocolate chips, countlines, selflines / softlines, boxed varieties, standard boxed varieties, twist-wrapped miniature chocolates, flavored chocolates, toy-shaped chocolates, caramel milk sandwiches, other chocolate confectionery, mints, standard mints, strong mints, hard candy, soft lozenges, chewing gum, jelly and chewing candy, toffee, caramel and nougat, medicated candy, lollipops, licorice, other sugar foods, bread, packaged / industrial bread, bulk / artificial bread, pastries, cakes, packaged / industrial cakes, bulk / artificial cakes, cookies, and chocolate. Coated biscuits, sandwich biscuits, tart biscuits, savory biscuits and crispy biscuits, bread substitutes, breakfast cereals, instant cereals, family breakfast cereals, tortilla chips, mixed cereals, other cereals, children's breakfast cereals, hot cereals, ice cream, ready-to-eat ice cream, single-serving dairy ice cream, single-serving water ice cream, multi-pack dairy ice cream, multi-pack water ice cream, family-sized ice cream, family-sized dairy ice cream, ice cream desserts, bulk ice cream, family-sized water ice cream, frozen yogurt, artisanal ice cream, dairy products, milk, fresh / pasteurized milk, whole milk fresh / pasteurized milk, semi-skimmed fresh / pasteurized milk, extended shelf life / UHT milk, whole milk extended shelf life / UHT milk, semi-skimmed milk extended shelf life / UHT milk, fat-free milk Longer / UHT milk, goat milk, condensed milk / unsalted condensed milk, plain condensed milk / unsalted condensed milk, flavored, functional and other condensed milk, flavored milk beverages, dairy-only flavored milk beverages, flavored milk beverages with fruit juice, soy milk, yogurt beverages, fermented milk beverages, creamer for coffee, milk powder, flavored milk powder beverages, cream, cheese, processed cheese, spreadable cheese, non-spreadable processed cheese, unprocessed cheese, spreadable unprocessed cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, yogurt, plain / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinking yogurt, regular drinking yogurt, probiotic drinking yogurt, frozen and shelf-stable desserts, dairy-based desserts, soy-based desserts, frozen desserts, fresh cheese and quark cheese, plain fresh cheese and quark cheese Seasoned fresh cheese and quark cheese, savory fresh cheese and quark cheese, sweet and savory snacks, fruit snacks, potato chips / fries, puffed snacks, tortilla chips / corn chips, popcorn, pretzels, nuts, other sweet and delicious snacks, snack bars, granola, breakfast bars, energy bars, fruit bars, other snack bars, meal replacements, weight loss products, recovery drinks, ready-to-eat foods, canned ready-to-eat foods, frozen ready-to-eat foods, dried ready-to-eat foods, frozen ready-to-eat meals, dinner mixes, frozen pizzas, chilled pizzas, soups, canned soups, dehydrated soups, instant soups, cold soups, hot soups, frozen soups, pasta, canned pasta, dried pasta, frozen / fresh pasta, noodles, plain pasta, instant noodles, cup / bowl instant noodles, bagged instant noodles.Frozen noodles, snack noodles, canned foods, canned meat and meat products, canned fish / seafood, canned vegetables, canned tomatoes, canned beans, canned fruit, canned ready-to-eat foods, canned soup, canned pasta, other canned foods, frozen foods, frozen processed red meat, frozen processed poultry, frozen processed fish / seafood, frozen processed vegetables, frozen meat substitutes, frozen potatoes, oven-baked potato chips, other oven-baked potato products, non-oven frozen potatoes, frozen baked foods, frozen desserts, frozen ready-to-eat foods, frozen pizzas, frozen soups, frozen noodles, other frozen foods, dried foods, dessert mixtures, dried ready-to-eat foods, dehydrated soups, instant soups, dried pasta, plain noodles, instant noodles, cup / bowl instant noodles, bagged instant noodles, refrigerated foods, refrigerated processed meats, refrigerated fish / seafood products, refrigerated processed fish, refrigerated coated fish, refrigerated smoked fish, refrigerated lunch packs, refrigerated ready-to-eat foods Refrigerated pizza, refrigerated soup, refrigerated / fresh pasta, refrigerated noodles, oils and fats, olive oil, vegetable and seed oils, cooking fats, butter, margarine, spread oils and fats, functional spread oils and fats, sauces, seasonings and condiments, tomato paste and puree, broth / soup cubes, soup cubes, gravy granules, liquid soup bases and ingredients, herbs and spices, fermented sauces, soy sauces, pasta sauces, wet sauces, dry sauces / powder mixtures, tomato sauce, mayonnaise, regular mayonnaise, mustard, salad dressing, regular salad dressing, low-fat salad dressing, balsamic vinegar sauce, dips, marinades, other sauces, seasonings and condiments, baby food, formula milk powder, standard formula milk powder, growing-up formula milk powder, toddler formula milk powder, hypoallergenic formula, prepared baby food, dried baby food, other baby food, spreads, jams and preserves, honey, chocolate spread, nut spreads and yeast spreads.

[0121] Some embodiments provide a chewable flavored product that may or may not be intended for swallowing. In some embodiments, the chewable flavored product may be a gum, chewing gum, syrupy gum, sugar-free gum, functional gum, or bubble gum, which individually or in combination comprises compounds disclosed and described herein.

[0122] In some embodiments of any of the foregoing embodiments, the liquid composition may be included in a body care product, such as a product suitable for application to human hair or skin. Therefore, the consumer products of this disclosure can be body care products, typically beauty products, skin care products, or hair care products.

[0123] In some embodiments, the composition comprises one or more fragrances. In some embodiments, at least a portion of the fragrance may be encapsulated. Suitable fragrances include complex mixtures of fragrance compounds selected to provide any desired odor. In the context of this disclosure, the term “fragrance” is used synonymously with “perfume.” Fragrance compounds commonly used in the fragrance industry and suitable for the purposes of this disclosure are described more fully in S. Arctander’s *Perfume Flavors and Chemicals*, Vols. I and II (1969) and *The Merck Index*, 8th edition, Merck & Co., Inc., Rahway, NJ. The term “fragrance compound” encompasses naturally occurring and synthetic materials known for use in fragrances, as well as animal oils. Fragrance compounds may also be any natural oil or extract, or chemical compound, used in fragrance compositions. Natural oils and extracts are described in Guenther's *The Essential Oils 1949* and may include extracts, presses, collected exudates, and distillates from any of the following parts of a suitable plant: roots, rhizomes, bulbs, corms, stems, bark, heartwood, leaves, flowers, seeds, and fruits. Examples of such extracts and distillates include citrus fruit oils such as those of oranges, mandarins, grapefruits, limes, or lemons; tree oils such as those of pine or cedar; herbal oils such as those of peppermint, thyme, lavender, basil, rosemary, or cloves; or floral extracts such as those of rose, jasmine, lily of the valley, or geranium.

[0124] Other suitable fragrances, without limitation, include natural oils or naturally derived materials, as well as synthetic fragrances such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, ethers, nitriles, and polyfunctional compounds. Non-limiting examples of natural oils include the following: basil (Ocimum basilicum) oil, bay leaf (Pimento acris) oil, lemon balm (Monardadidyma, American peppermint) oil, bergamot (Citrus aurantium bergamia) oil, cardamom (Elettaria cardamomum) oil, cedarwood (Cedrus atlantica) oil, chamomile (Anthemis nobilis) oil, cinnamon (Cinnamomum cassia) oil, lemongrass (Cymbopogon nardus) oil, clary sage (Salvia sclarea) oil, clove (Eugenia caryophyllus) oil, clove leaf (Eufenia caryophyllus) oil, sedge (Cyperuses sculentus) oil, cypress (Cupressus sempervirens, Mediterranean cypress) oil, lemon eucalyptus (Eucalyptus citriodora) oil, and spotted geranium (Geranium) oil. maculatum oil, ginger (Zingiber officinale) oil, grapefruit (Citrus grandis) oil, hazelnut (Corylus avellana) nut oil, jasmine (Jasminum officinale) oil, juniper (Juniperus communis) oil, sour juniper tar (Juniperus oxycedrus tar), North American juniper (Juniperus virginiana) oil, kiwi (Actinidia chinensis) water, lavandin (Lavandula hybrida) oil, lavender (Lavandula angustifolia) oil, lavender (Lavandula angustifolia) water, lemon (Citrus medica limonum) oil, lemongrass (Cymbopogonschoenanthus) oil, lime (Citrus aurantifolia) oil, linden (Tilia) oil Cordata (European linden) oil, linden (Tilia cordata) water, citrus (Citrus nobilis)The ingredients include: Guangxi sand orange oil, nutmeg (Myristica fragrans) oil, orange (Citrus aurantium dulcis) flower oil, orange (Citrus aurantium dulcis) oil, orange (Citrus aurantium dulcis) water, patchouli (Pogostemon cablin) oil, peppermint (Menthe piperita) oil, peppermint (Menthe peperita) water, rosemary (Rosmarinus officinalis) oil, rose oil, rose (Rosa damascena, Damask rose) extract, rose (Rosa multiflora, rose) extract, rosewood (Aniba rosaeodora) extract, sage (Salvia officinalis) oil, sandalwood (Santalum album) oil, spearmint (Menthe viridis) oil, tea tree (Melaleuca alternifolia) oil, and ylang-ylang (Cananga odorata) oil. Some non-limiting examples of synthetic hydrocarbon fragrances include caryophyllene, β-farnesene, limonene, α-pinene, and β-pinene. Some non-limiting examples of synthetic alcohol fragrances include bacdanol, citronellol, linalool, phenethyl alcohol, and α-terpineol (R.dbd.H). Some non-limiting examples of synthetic aldehyde fragrances include 2-methylundecaldehyde, citral, hexylcinnamaldehyde, isocyclic citral, lily of the valley aldehyde, and 10-undecenal. Some non-limiting examples of synthetic ketone fragrances include cashmeran, α-ionone, isocyclemone E, koavone, muscone, and tunamus. Some non-limiting examples of synthetic ester fragrances include benzyl acetate, 4-tert-butylcyclohexyl acetate (cis and trans), cypress acetate, tricyclodecenyl acetate (cyclacet), isoborneol acetate, and α-terpineol acetate (R=acetyl). Some non-limiting examples of synthetic lactone fragrances include coumarin, jasmine lactone, muscone lactone, and peach aldehyde. Some non-limiting examples of synthetic ether fragrances include ambroxan, anther (carvone), and galacmus. Some non-limiting examples of synthetic nitrile fragrances include cinnamonitrile and geraniol. Finally, some non-limiting examples of synthetic polyfunctional fragrances include amyl salicylate, isoeugenol, hedione, heliotropine, lyral, and vanillin.

[0125] In some embodiments, the body care composition may contain one or more ingredients that provide active beneficial effects for hair or skin care, such as compounds with antioxidant activity. For example, in some embodiments, the body care product contains ascorbic acid, also known as vitamin C, which is an essential nutrient with antioxidant activity. In some embodiments, the body care composition contains vitamin E, which refers to eight structure-related antioxidant compounds exhibiting free radical scavenging activity. These compounds include four tocopherol compounds and four tocotrienol compounds. In some embodiments, the body care composition contains resveratrol, an antioxidant compound naturally found in grape skins. In some embodiments, the body care composition contains certain oligopeptides, such as acetyl hexapeptide-8 (also known as acetyl hexapeptide-3), which are synthetic peptides that loosen wrinkles. A variety of other such compounds may also be included, such as retinol, niacinamide, coenzyme Q10, and various polyphenols, such as flavonoids like catechins. The amounts of these active ingredients may be the same as those typically found in other body care products.

[0126] Body care products may contain any suitable type of excipient or carrier. Generally, the excipient or carrier will be dermatologically acceptable. Non-limiting examples of excipients or carriers include water, glycerin, alcohols, oils, silicone compounds, organosilicon compounds, and waxes. Variations and other suitable carriers will be apparent to those skilled in the art and are suitable for use in the body care compositions of this disclosure. In some embodiments, the concentrations and combinations of compounds, ingredients, and reagents can be selected such that these combinations are chemically compatible and do not form complexes that precipitate from the finished body care product.

[0127] The body care compositions disclosed herein can be constructed or formulated in a variety of different forms. Non-limiting examples include emulsions (e.g., water-in-oil, water-in-oil, water-in-oil, water-in-silicone, silicone-in-water, oil-in-water, silicone-in-oil emulsions, etc.), creams, lotions, solutions (e.g., aqueous or hydroalcoholic), anhydrous bases (e.g., lipsticks and powders), gels, masks, scrubs, body butters, exfoliating creams, and ointments. Variations and other structures will be apparent to those skilled in the art and are suitable for use in the body care compositions of this disclosure.

[0128] A variety of other ingredients can be used, such as those commonly used in cosmetics, skin care products, or hair care products. The CTFA INTERNATIONAL COSMETIC INGREDIENT DICTIONARY ANDHANDBOOK (2004 and 2008) describes a variety of non-limiting ingredients that can be used in the compositions disclosed in this invention. Examples of these ingredient categories include: fragrances (artificial and natural; e.g., gluconic acid, phenoxyethanol, and triethanolamine), dyes and pigments (e.g., Blue 1, Blue 1 Lake, Red 40, titanium dioxide, D&C Blue 4, D&C Green 5, D&C Orange 4, D&C Red 17, D&C Red 33, D&C Violet 2, D&C Yellow 10, and D&C Yellow 11), flavorings or fragrances (e.g., stevia). Beef rebaudiana (sweet leaf) extract and menthol), adsorbents, lubricants, solvents, humectants (including emollients, humectants, film-forming agents, occlusives, and agents that affect the skin's natural moisturizing mechanisms), water-reppelants, UV absorbers (physical and chemical absorbers, such as para-aminobenzoic acid (“PABA” and corresponding PABA derivatives, titanium dioxide, zinc oxide, etc.), essential oils, vitamins (such as B, D, E, and K), trace metals (such as zinc, calcium, and selenium), anti-irritants (such as steroidal and non-steroidal anti-inflammatory drugs), plant extracts (such as aloe vera, ... Chamomile, cucumber extract, ginkgo leaf, ginseng, and rosemary; antimicrobial agents; antioxidants (e.g., BHT and tocopherol); chelating agents (e.g., disodium and tetrasodium EDTA); preservatives (e.g., methylparaben and propylparaben); pH adjusters (e.g., sodium hydroxide and citric acid); absorbents (e.g., aluminum octenyl succinate, kaolin, corn starch, oat starch, cyclodextrin, talc, and zeolite); skin bleaching and whitening agents (e.g., hydroquinone and nicotinamide lactate); moisturizers (e.g., sorbitol, urea, methylglucose ether 20, saccharide isomers). (isomerate and mannitol), exfoliants, waterproofing agents (e.g., magnesium hydroxide stearate / aluminum hydroxide), skin conditioning agents (e.g., aloe vera extract, allantoin, bisabolol, ceramides, dimethicone, hyaluronic acid, biosaccharide gum-1, ethylhexylglycerin, pentylene glycol, hydrogenated polydecene, octyl dodecyl oleate, and dipotassium glycyrrhizate). Further non-limiting examples of some of these ingredients are provided in the following subsections.

[0129] In some embodiments, the body care composition comprises one or more UV absorbers or reflectors. Suitable UV absorbers or reflectors include chemical and physical sunscreens. Non-limiting examples of chemical sunscreens include para-aminobenzoic acid (PABA), PABA esters (PABA glyceryl ester, PABA pentyl dimethyl ester and PABA octyl dimethyl ester), PABA butyl ester, PABA ethyl ester, PABA ethyl dihydroxypropyl ester, benzophenones (hydroxybenzophenone, sulfonisobenzophenone, benzophenone and benzophenone 1 to 12), cinnamates / esters (oxtinoxate, isoamyl para-methoxycinnamate, octyl methoxycinnamate, cinoxate, diisopropyl methyl cinnamate, DEA salt of methoxycinnamate, ethyl diisopropyl cinnamate, glyceryl caprylate dimethoxycinnamate and ethyl methoxycinnamate), cinnamates, salicylates / esters (methyl methacrylate, benzyl salicylate, ethylene glycol salicylate, isopropyl benzyl salicylate, etc.), and anthranilic acid. Salts / esters, ethyl urethane, homosalate, octisalate, dibenzoylmethane derivatives (e.g., avobenzone), octocrylene, octyltriazinone, digalactotrioleate, glyceryl aminobenzoate, 2-hydroxy-1,4-naphthoquinone (lawsone) and dihydroxyacetone, ethylhexyltriazinone, dioctylbutyramide triazinone, benzylmalonate polysiloxane, terephthalimide dicamphor sulfonic acid, disodium phenyl dibenzimidazole tetrasulfonate, diethylaminohydroxybenzoyl benzoate, diethylaminohydroxybenzoyl benzoate, dibenzoxazolylphenylethylhexyliminotriazine, formyltrazol trisiloxane, methylene dibenzotriazolyl tetramethylbutylphenol, and diethylhexyloxyphenol methoxyphenyltriazine, 4-methylbenzimidyl camphor and isoamyl 4-methoxycinnamate. Non-limiting examples of physical sunscreens include kaolin, talc, petrolatum, and metal oxides (such as titanium dioxide and zinc oxide).

[0130] In some embodiments, the body care composition comprises one or more moisturizing agents. Non-limiting examples of moisturizing agents that may be used include amino acids, chondroitin sulfate, diglycerides, erythritol, fructose, glucose, glycerin, glycerol polymers, ethylene glycol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factors, PEG-15 butylene glycol, polyglycerol sorbitol, pyrrolidone carboxylic acid salts, potassium PCA, propylene glycol, sugar isomers, sodium glucuronide, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol. Other non-limiting examples include acetylated lanolin, acetylated lanolin alcohol, alanine, algae extracts, Aloe barbadensis, Aloe barbadensis extract, Aloe barbadensis gel, Althaea officinalis extract, Prunus armeniaca kernel oil, arginine, arginine aspartate salt / ester, Arnica montana extract, aspartic acid, Persea gratissima oil, barrier sphingolipids, butanol, beeswax, behenol, β-sitosterol, Betula alba bark extract, Borago officinalis extract, Ruscus aculeatus extract, butylene glycol, Calendula officinalis extract, calendula oil, and Euphorbia Cerifera wax, canola oil, caprylic / capric triglycerides, cardamom (Elettaria cardamomum) oil, coopernica cerifera wax, carrot (Daucus carota sativa) oil, castor (Ricinus communis) oil, ceramides, ceresin, cetearyl alcohol polyether-5, cetearyl alcohol polyether-12, cetearyl alcohol polyether-20, cetearyl caprylate, cetearyl alcohol polyether-20, cetearyl alcohol polyether-24, cetyl acetate, cetyl caprylate, cetyl palmitate, chamomile (Anthemis nobilis) oil, cholesterol, cholesterol esters, cholesterol hydroxystearate, citric acid, clary sage (Salvia sclarea) oil, cocoa (Theobroma cacao) butter, cocoa caprylate / capric acid ester, coconut (Cocos) Nucifera oil, collagen, collagen amino acids, corn (Zea)Mays oil, fatty acids, decyl oleate, polydimethylsiloxane copolyol, polydimethylsiloxane alcohol, dioctyl adipate, dioctyl succinate, dipentaerythritol hexacaprylate / hexacaprylate, DNA, erythritol, ethoxydiethylene glycol, ethyl linoleate, Eucalyptus globulus oil, Oenothera biennis oil, fatty acids, Geranium maculatum oil, glucosamine, glucosamine glutamate, glutamic acid, glyceryl polyether-26, glycerol, glycerol, distearate, hydroxystearate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate, glyceryl stearate SE, glycine, ethylene glycol stearate, ethylene glycol stearate SE, glucosamine, grape seed oil, hazelnut (Corylus) Americana (hazelnut) nut oil, Corylus avellana (European hazelnut) nut oil, hexanediol, hyaluronic acid, mixed safflower (Carthamus tinctorius) oil, hydrogenated castor oil, hydrogenated coconut oil glycerides, hydrogenated coconut oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm oil glycerides, hydrogenated palm kernel oil, hydrogenated soybean oil, hydrogenated tallow glycerides, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glucosamine, hydrolyzed keratin, hydrolyzed soybean protein, hydroxylated lanolin, hydroxyproline, isocetyl stearate, isocetyl stearoyl stearate, isodecanyl oleate, isopropyl isostearate, isopropyl lanolin, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearamide DEA, isostearic acid, isostearyl lactate, isostearyl neopentanoate, jasmine (Jasminum) Officinale oil, jojoba (Buxuschinensis) oil, giant kelp, kukui (Aleurites moluccana) nut oil, lactamide MEA, lanolin alcohol polyether-16, lanolin alcohol polyether-10 acetate, lanolin, lanolin acid, lanolin alcohol, lanolin oil, lanolin wax, lavender (Lavandula angustifolia) oil, lecithin, lemon (Citrus medica limonum) oil, linoleic acid, linolenic acid, macadamia nut (Macadamia) oilIngredients include: ternifolia oil, maltitol, Chamomillarecutita oil, methylglucose sesquistearate, methylsilanol PCA, mineral oil, mink oil, sphaeromonas oil, myristyl lactate, myristyl myristate, myristyl propionate, neopentyl glycol dicaprylate / dicaprylate, octyl dodecyl alcohol, octyl dodecyl myristate, octyl stearate, octyl hydroxystearate, octyl palmitate, octyl salicylate, octyl stearate, oleic acid, olive oil (Olea europaea), orange oil (Citrus aurantiumdulcis), palm oil (Elaeis guineensis), palmitic acid, panthenyl thioethylamine, panthenol, panthenol ethyl ether, paraffin wax, PCA, peach kernel oil (Prunus persica), peanut oil (Arachis hypogaea), and PEG-8. C12-18 ester, PEG-15 cocoalkylamine, PEG-150 distearate, PEG-60 isostearyl glyceride, PEG-5 stearyl glyceride, PEG-30 stearyl glyceride, PEG-7 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methylglucose sesquistearate, PEG-40 sorbitol oleate, PEG-5 soybean sterol, PEG-10 soybean sterol, PEG-2 stearate, PEG-8 stearate, PEG-20 stearate, PEG-32 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 stearate, pentadecyl lactone, peppermint (Mentha) Piperrita oil, Petrolatum, phospholipids, plankton extract, polyamino acid polysaccharide condensate, polyglycerol-3 diisostearate, polyquaternium-24, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, polysorbate 85, potassium myristate, potassium palmitate, propylene glycol, propylene glycol dicaprylate / dicaprylate, propylene glycol dicaprylate, propylene glycol dinonanoate, propylene glycol laurate, propylene glycol stearate, propylene glycol stearate SE, PVP, pyridoxine dipalmitate, retinol, retinol palmitate, rice bran oil (Oryza sativa), RNA, rosemary oil (Rosmarinus officinalis), rose oil, safflower oil (Carthamus tinctorius), sage oil (Salvia). Officinalis oil, sandalwood oil, serine, serum albumin, sesame oil, and shea butter.(Parki) oil, silk powder, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium polyglutamate, soluble collagen, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean (Glycine soja) oil, sphingolipids, squalane, squalene, stearamide MEA-stearate, stearic acid, stearoxydimethylsiloxane, stearoxytrimethylsilane, stearyl alcohol, glycyrrhetinic acid stearyl alcohol ester, heptanoate stearyl alcohol ester, sunflower (Helianthus annuus) seed oil, sweet almond (Prunus amygdalus) Dulcis oil, synthetic beeswax, tocopheryl acetate, tocopheryl linoleate, tribehenin, tridecyl pentoate, tridecyl stearate, triethanolamine, tristearate, urea, vegetable oil, water, wax, wheat (Triticum vulgare) germ oil and ylang-ylang (Canangaodorata) oil.

[0131] In some embodiments, the body care compositions disclosed herein comprise one or more antioxidants, for example, in addition to or in combination with those antioxidants disclosed above. For example, in some embodiments, one or more of these additional antioxidants may be used in combination with ascorbic acid, vitamin E, or combinations thereof. Non-limiting examples of antioxidants that may be used include acetylcysteine, ascorbic acid derivatives such as ascorbic acid peptides, ascorbic acid dipalmitate, ascorbic acid methylsilanol pectate, ascorbic acid palmitate, ascorbic acid stearate, BHA, BHT, tert-butylhydroquinone, cysteine, cysteine ​​HCl, dipentylhydroquinone, ditert-butylhydroquinone, diceryl thiodipropionate, dioleotocopherol methylsilanol, disodium ascorbate sulfate, distearate thiodipropionate, di(tridecyl) thiodipropionate, dodecyl gallate, isoascorbic acid, ascorbate, ethyl ferulic acid, ferulic acid, gallate, hydroquinone, isooctyl thioglycolate, kojic acid, magnesium ascorbate, magnesium ascorbate phosphate, methylsilanol ascorbate, and natural plant antioxidants. Chemicals such as green tea or grape seed extract, nordihydroguaiac acid, octyl gallate, phenyl thioglycolic acid, potassium ascorbate tocopheryl phosphate, potassium sulfite, propyl gallate, quinone, rosmarinic acid, sodium ascorbate, sodium bisulfite, sodium isoascorbate, sodium metabisulfite, sodium sulfite, superoxide dismutase, sodium thioglycolate, sorbitol furfural, thiodiethylene glycol, thiodiethylene glycolamide, thiodiethylene glycol acid, thioglycolic acid, thiolactic acid, thiosalicylic acid, tocopherol polyether-5, tocopherol polyether-10, tocopherol polyether-12, tocopherol polyether-18, tocopherol polyether-50, tocophersolan, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, and tris(nonylphenyl) phosphite.

[0132] In some embodiments, the body care composition comprises one or more structuring agents. In some embodiments, the structuring agent helps to provide the composition with rheological properties that contribute to stability. In some embodiments, the structuring agent may also act as an emulsifier or surfactant. Non-limiting examples of structuring agents include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, polyethylene glycol ethers of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, polyethylene glycol ethers of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.

[0133] In some embodiments, the body care composition comprises one or more emulsifiers. Emulsifiers can reduce interfacial tension between phases and improve the formulation and stability of the emulsion. Emulsifiers can be nonionic, cationic, anionic, and zwitterionic. Non-limiting examples include esters of glycerol, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydride, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols, alkyl phosphate esters, polyoxyethylene fatty ether phosphate esters, fatty acid amides, acyl lactates, soaps, TEA stearate, DEA oleyl alcohol polyether-3 phosphate, polyethylene glycol 20 dehydrated sorbitol monolaurate (polysorbate 20), polyethylene glycol 5 soybean sterol, stearyl alcohol polyether-2, stearyl alcohol polyether-20, stearyl... Cetearyl alcohol polyether-21, cetearyl alcohol polyether-20, cetearyl glucoside, cetearyl alcohol, C12-13 alkanol polyether-3, PPG-2 methyl gluconate distearate, PPG-5-cetearyl alcohol polyether-20, bis-PEG / PPG-20 / 20 polydimethylsiloxane, cetearyl alcohol polyether-10, polysorbate 80, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate, PEG-100 stearate, arachidyl alcohol, arachidyl glucoside, and mixtures thereof.

[0134] In some embodiments, the body care composition comprises one or more silicone-containing compounds. Non-limiting examples of silicone-containing compounds include any member of the family of polymer products whose molecular backbone consists of alternating silicon and oxygen atoms and side groups attached to the silicon atoms. By varying the -Si-O- chain length, side groups, and crosslinking, silicones can be synthesized into a variety of materials. Their consistency can vary from liquid to gel to solid. Silicone-containing compounds suitable for use in the body care compositions disclosed herein include, but are not limited to, those commonly known to those skilled in the art. Non-limiting examples include silicone oils (e.g., volatile and non-volatile oils), gels, and solids. In some embodiments, the silicone-containing compound includes silicone oils, such as polysiloxanes. Non-limiting examples of polyorganosiloxanes include polydimethylsiloxane, cyclodimethylsiloxane, polyorganosiloxane-11, phenyl polytrimethylsiloxane, trimethylsilylamino polydimethylsiloxane, stearoxytrimethylsilane, or mixtures of these materials with other organosiloxane materials in any given proportion to achieve the desired consistency and application properties for the intended application (e.g., for a specific area such as skin, hair, or eyes). "Volatile silicone oil" includes silicone oils with low heat of vaporization, such as silicone oils with less than about 50 calories per gram. Non-limiting examples of volatile silicone oils include cyclodimethylsiloxane; low-viscosity polydimethylsiloxanes, such as polydimethylsiloxanes with a viscosity of about 50 cst or less. Other non-limiting volatile silicone oils that may be used in the context of this invention include those available from manufacturers such as Dow Corning, General Electric, and SWS Silicones.

[0135] In some embodiments, the body care composition comprises one or more exfoliating agents. Exfoliating agents contain ingredients that remove dead skin cells from the outer surface of the skin. These agents can act mechanically, chemically, or otherwise. Non-limiting examples of mechanical exfoliating agents include abrasives such as pumice, silica, cloth, paper, seashells, beads, solid crystals, solid polymers, etc. Non-limiting examples of chemical exfoliating agents include acid and enzyme exfoliating agents. Acids that can be used as exfoliating agents include, but are not limited to, glycolic acid, lactic acid, citric acid, alpha-hydroxy acids, beta-hydroxy acids, etc. Other exfoliating agents known to those skilled in the art may also be considered for use in the context of the body care compositions disclosed herein.

[0136] In some embodiments, the body care composition comprises one or more essential oils. Essential oils include oils extracted from herbs, flowers, trees, and other plants. These oils typically exist as tiny droplets between plant cells and can be extracted by several methods known to those skilled in the art, such as steam distillation, enfleurage (e.g., by using fat extraction), maceration, solvent extraction, or mechanical pressing. When these types of oils are exposed to air, they tend to evaporate (e.g., volatile oils). Essential oils are generally insoluble in water but soluble in ethanol, ether, fixed oils (plants), and other organic solvents. Essential oils are usually named after the plant from which they are extracted. Non-limiting examples of essential oils that can be used in the body care compositions disclosed herein include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento oil, rose oil, anise oil, balsam oil, bergamot oil, rosewood oil, cedarwood oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper berry oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin orange oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, and rose tartare. Otto oil, rosemary oil, sandalwood oil, spearmint oil, spikenard oil, vetiver oil, wintergreen oil, and ylang-ylang. Other essential oils known to those skilled in the art are also considered suitable for use in the context of this invention.

[0137] In some embodiments, the body care composition comprises one or more thickening agents. Thickening agents, including thickeners or gelling agents, include substances that increase the viscosity of the composition. Thickeners include those that increase the viscosity of the composition without substantially modifying the efficacy of the active ingredients within the composition. Thickeners can also increase the stability of the composition. Commonly used thickeners include hydrogenated polyisobutylene, glyceryl trihydroxystearate, ammonium acryloyldimethyl taurate / vp copolymer, or combinations thereof. Other non-limiting examples of additional thickeners that may be used include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include crosslinked compounds containing one or more monomers derived from acrylic acid, substituted acrylic acid, and salts and esters of such acrylic acid and substituted acrylic acid, wherein the crosslinker contains two or more carbon-carbon double bonds and is derived from polyols. Examples of commercially available carboxylic acid polymers include carbomer, which is an acrylic homopolymer crosslinked with an allyl ether of sucrose or pentaerythritol. Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers. Non-limiting examples are described in U.S. Patent Nos. 5,100,660; 4,849,484; 4,835,206; 4,628,078; and 4,599,379. Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers, including substituted branched or unbranched polymers) include polyacrylamide, isoparaffins and lauryl ether-7, acrylamide and substituted acrylamides with acrylic acid and substituted acrylic acid in multi-block copolymers. Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is alkyl-substituted cellulose, wherein the hydroxyl groups of the cellulose polymer are hydroxyalkylated (e.g., hydroxyethylated or hydroxypropylated) to form hydroxyalkylated cellulose, and then C 10 -C 30 Straight-chain or branched alkyl groups are further modified via ether bonds. Typically, these polymers are C16-264 ... 10 -C 30Ethers of linear or branched alcohols with hydroxyalkyl cellulose. Other useful polysaccharides include sclerosanans, which consist of a linear chain of (1-3) linked glucose units, with (1-6) linked glucose units per three units. Non-limiting examples of gums that can be used include acacia gum, agar, alginate, alginic acid, ammonium alginate, branched starch, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimethylammonium chloride, lithium montmorillonite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar gum, ark tar gum, giant kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotinia gum, sodium carboxymethyl dextran, sodium carrageenan, astragalus gum, xanthan gum, and mixtures thereof.

[0138] In some embodiments, the body care composition comprises one or more preservatives. Non-limiting examples of preservatives that may be used in the context of this invention include quaternary ammonium preservatives, such as polyquaternium-1 and benzyl alkyl ammonium halides (e.g., benzalkonium chloride and benzalkonium bromide), parabens (e.g., methylparaben and propylparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, or combinations thereof.

[0139] In some embodiments, the body care composition comprises one or more emollients. Non-limiting examples of suitable emollients include: (a) silicone oils and their modifications, such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils; (b) fats and oils, including natural fats and oils such as jojoba oil, soybean oil, sunflower oil, rice bran oil, avocado oil, almond oil, olive oil, sesame oil, persic oil, castor oil, coconut oil, mink oil; cocoa butter; tallow, lard; hardened oils obtained by hydrogenation of the above oils; and synthetic monoglycerides, diglycerides, and triglycerides, such as glyceryl myristate and glyceryl 2-ethylhexanoate; (c) (d) Waxes, such as carnauba wax, cetearyl wax, beeswax, lanolin and their derivatives; (e) Hydrophobic plant extracts; (f) Hydrocarbons, such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristan and mineral oil; (g) Higher fatty acids, such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid, arachidonic acid and polyunsaturated fatty acids (PUFAs); (h) Higher alcohols, such as lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cholesterol and 2-hexyldecyl alcohol; (h) Esters, such as cetyl caprylate, Myristyl lactate, cetyl lactate, isopropyl myristate, myristyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, alkyl lactate, alkyl citrate, and alkyl tartrate; (i) essential oils and their extracts, such as peppermint oil, jasmine oil, camphor oil, white cedar oil, bitter orange peel oil, rye oil, turpentine oil, cinnamon oil, bergamot oil, Satsuma mandarin oil, calamus oil, pine oil, lavender oil, laurel oil, clove oil, cypress oil, eucalyptus oil, lemon... Lemon oil, borage oil, thyme oil, peppermint oil, rose oil, sage oil, sesame oil, ginger oil, basil oil, juniper oil, lemongrass oil, rosemary oil, rosewood oil, avocado oil, grape oil, grapeseed oil, myrrh oil, cucumber oil, watercress oil, calendula oil, elderberry oil, geranium oil, linden flower oil, amaranth oil, seaweed oil, ginkgo oil, ginseng oil, carrot oil, guarana oil, tea tree oil, jojoba oil, comfrey oil, oatmeal oil, cocoa butter, neroli oil, vanilla oil, green tea oil, pennywort oil. Royal oil, aloe vera oil, menthol, eucalyptol, eugenol, citral, citronellol oil, borneol, linalool, geraniol, evening primrose oil, camphor oil, thymol, spirantol oil, penene oil, limonene oil and terpene oils; (j) lipids, such as cholesterol, ceramides, sucrose esters and pseudoceramides;(k) Vitamins, minerals, and skin nutrients, such as vitamins A, E, and K; vitamin alkyl esters, including vitamin C alkyl esters; magnesium, calcium, and milk; (l) sunscreens, such as octyl methoxycinnamate and butyl methoxybenzoylmethane; (l) phospholipids; (m) polyols, such as glycerin, propylene glycol, etc.; and polyols, such as polyethylene glycol; (n) anti-aging compounds, such as α-hydroxy acids and β-hydroxy acids; and (o) mixtures of any of the foregoing components, etc.

[0140] In some embodiments, the body care composition comprises one or more tackifiers. Non-limiting examples of suitable tackifiers include aliphatic hydrocarbon resins, aromatic-modified aliphatic hydrocarbon resins, hydrogenated polycyclopentadiene resins, polycyclopentadiene resins, rosin, rosin esters, wood rosin, wood rosin esters, tall oil rosin, tall oil rosin esters, polyterpenes, aromatic-modified polyterpenes, terpene phenolic resins, aromatic-modified hydrogenated polycyclopentadiene resins, hydrogenated aliphatic resins, hydrogenated aliphatic aromatic resins, hydrogenated terpenes and modified terpenes, hydrogenated rosin acid, hydrogenated rosin esters, polyisoprene, partially or fully hydrogenated polyisoprene, polybutene, partially or fully hydrogenated polybutene, etc. The tackifier may be fully or partially hydrogenated. The tackifier may also be nonpolar, meaning that the tackifier substantially does not contain monomers with polar groups. In some embodiments, no polar groups are present. In some embodiments, the polar group is present in an amount of up to about 5% by weight, preferably up to about 2% by weight, and more preferably up to about 0.5% by weight.

[0141] In some embodiments, the body care composition comprises one or more colorants, such as pigments or dyes. Examples of suitable pigments include, but are not limited to, inorganic pigments, organic pigments, lakes, pearlescent pigments, iridescent or optically variable pigments, and mixtures thereof. The term "pigment" should be understood to refer to inorganic or organic, white or colored particles. Within the scope of this invention, the pigments may be surface-treated as appropriate, but are not limited to treatments such as those with silicones, perfluorinated compounds, lecithin, and amino acids.

[0142] In some embodiments, the body care composition comprises one or more surfactants. Surfactants that can be used as surfactant components in the compositions disclosed herein include nonionic, anionic, cationic, and amphoteric (ampholy) surfactants and can be used in combination with each other.

[0143] In some embodiments, the body care composition comprises one or more pH adjusters. pH adjusters include inorganic and organic acids and bases, particularly ammonia, citric acid, phosphoric acid, acetic acid, sodium hydroxide, lactic acid, levulinic acid, glycolic acid, tartaric acid, malic acid, pyrrolidone carboxylic acid (PCA), succinic acid, citric acid, glutamic acid, 2-amino-2-methyl-1-propanol (AMP), and triethanolamine (TEA).

[0144] In some embodiments, the body care composition comprises one or more reducing agents. Suitable reducing agents include, but are not limited to, salts of thiourea, thiosulfates, sulfites, bisulfites, metabisulfites, borosides, and hypophosphites (e.g., sodium salts), ascorbic acid and its salts, esters, and derivatives (e.g., ascorbate palmitate and ascorbate polypeptides), and tocopherol and its salts, esters, and derivatives (e.g., tocopheryl acetate). Other well-known reducing agents may also be used, such as those listed in the INCI manual.

[0145] In some embodiments, the body care composition comprises one or more foaming agents. Foaming agents include, for example, sodium lauryl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglyceride sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerol fatty acid esters, fatty acid diethanolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters. These foaming agents can be used alone or in combination of two or more.

[0146] In some embodiments, the body care composition comprises one or more tanning agents. Suitable tanning agents include, but are not limited to, α-hydroxy aldehydes and ketones, glyceraldehyde and related alcohol aldehydes, various indoles, imidazoles and their derivatives, and various approved pigmenting agents. Other suitable tanning agents include, but are not limited to, methylglyoxal, glyceraldehyde, erythritol, alloxan, 2,3-dihydroxysuccinaldehyde, 2,3-dimethoxysuccinaldehyde, 2-amino-3-hydroxysuccinaldehyde, and 2-benzylamino-3-hydroxysuccinaldehyde.

[0147] In some embodiments, the body care composition comprises one or more astringents. Suitable astringents include, but are not limited to, aluminum citrate, aluminum lactate, birch extract, coffee extract, evening primrose extract, grape extract, henna extract, ivy extract, lemon extract, witch hazel extract, ammonium alum and potassium alum, aluminum triphosphate, aluminum glycinate and aluminum phenol sulfate, aluminum cloxa, aluminum allantoin, aluminum stearate, aluminum sulfate and aluminum citrate, sodium aluminum phosphate, sodium alum, sodium aluminum chlorohydroxylactate, calcium lactate, calcium chloride, calcium sulfate hydrate, sodium aluminum lactate, zinc acetate, zinc chloride, zinc sulfate, zinc lactate, zinc zeolite, zinc phenolsulfonate, and combinations thereof.

[0148] In some embodiments, the body care composition comprises one or more antiseptics. Suitable antiseptics include, but are not limited to, methyl, ethyl, propyl, or butyl parabens; phenoxyethanol; o-phenylphenol; dehydroacetic acid or its salts; p-cresol; m-cresol; o-chloro-m-xylenol; peppermint oil; echinacea; bloodroot; cayenne pepper; tea tree oil; wild bergamot; chaparral; stinging metal; laurel; myrrh; gamboge bark; toothache tree; calendula; chamomile; mupirocin; neomycin sulfate; bacitracin; polymyxin B; 1-ofloxacin; tetracyclines (chlortetracycline hydrochloride, oxytetracycline hydrochloride, and tetracycline hydrochloride). hydrochoride), clindamycin phosphate, gentamicin sulfate, benzalkonium chloride, benzyl chloride, hexylresorcinol, methylbenzyl chloride, phenol, quaternary ammonium compounds, triclocarban, triclosan, and tea tree oil.

[0149] In some embodiments, the body care composition comprises one or more deodorants or antiperspirants. Suitable antiperspirants and deodorants include, but are not limited to, zinc salts such as zinc sulfate and zinc chloride, glycine salts such as zirconium aluminum glycinate, aluminum chloride hydrate, zirconium aluminum tetrachloride hydrate, zinc carbonate, o-phenylphenol, and quaternary ammonium compounds such as dimethyl benzyl ammonium chloride and hexamethyl diammonium chloride.

[0150] In some embodiments, the body care composition comprises one or more lightening agents. Examples of lightening agents include, but are not limited to, hydroquinone, kojic acid, licorice or derivatives thereof, ascorbic acid or derivatives thereof, arbutin, bearberry extract, Glycyrrhiza glabra and its derivatives, Chlorella vulgaris extract, perilla extract, coconut extract and / or other decolorizing agents.

[0151] In some embodiments, the body care composition comprises one or more biocides. Examples of biocides include, but are not limited to, triclosan, 3,4,4'-triclocarben (triclocarban); 3,4,4'-trifluoromethyl-4,4'-diclocarben (chlorofluorocarban); 5-chloro-2-methyl-4-isothiazolin-3-one; iodopropynyl butylcarbamate; 8-hydroxyquinoline; 8-hydroxyquinoline citrate; 8-hydroxyquinoline sulfate; 4-chloro-3,5-dimethylphenol (chloroxylenol); 2-bromo-2-nitropropane-1,3-diol; diazolidinyl urea; butoconazole; nystatin; terconazole; nitrofurantoin; phenazopyridine; acyclovir; clotrimazole. imazole); chloroxylenol; chlorhexidine; miconazole; terconazole; butyl paraben; ethyl paraben; methyl paraben; methyl chloroisothiazoline; methylisothiazoline; a mixture of 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin and 3-iodo-2-propynyl butylcarbamate; hydroxyquinoline; EDTA (ethylenediaminetetraacetic acid); tetrasodium EDTA; parabens; alkylpyridine compounds; cocophosphatidyl PG-dimethylammonium chloride; chlorhexidine gluconate; chlorhexidine digluconate; chlorhexidine acetate; chlorhexidine hydroxyethylsulfonic acid; chlorhexidine hydrochloride; benzalkonium chloride; benzyl chloride; polyhexamethylene biguanide; and mixtures thereof.

[0152] It may also include other ingredients commonly used in body care compositions, such as skin care or hair care products.

[0153] In some implementation schemes, body care products include shampoos, shower gels, soaps, exfoliating scrubs, moisturizers, facial serums, antiperspirants, deodorants, lotions, body oils, sunscreens, or sun enhancers.

[0154] In some implementations, body care products are personal care or beauty products. Personal care and beauty products include products that can be applied to the skin, hair, and nails, and can be leave-on or rinse-off products. In the context of this disclosure, "rinse-off" means a product intended for application to the skin and / or hair, followed by rinsing or wiping the product off the skin or hair within seconds to minutes of application. Personal care and beauty products include powders, creams, emulsions, lotions, gels, and oils for application to the skin (face, hands, feet, etc.), color bases (liquids and pastes), and liquid-soaked tissues; products for applying and removing makeup to the face and eyes; hair care products, including hair tints and hair bleaches; products for perming, straightening, styling, and fixing hair; shaving products, including creams, mousses, and hair removal products; tanning products and products that allow tanning without sunlight; deodorants and antiperspirants.

[0155] In some implementations, personal care or beauty products are selected from the group consisting of: shaving aids, shampoos, hair care products, leave-in skin care products, skin cleansing or washing products (e.g., wash-off skin cleansing or washing products), wipes, and body sprays, deodorants, or antiperspirants. Shaving aids specifically include foams, gels, creams, and soap bars (see, for example, U.S. Patent Nos. 7,069,658, 6,944,952, 6,594,904, 6,182,365, 6,185,822, 6,298,558, and 5,113,585). Shampoos and hair care products specifically include 2-in-1 shampoos and shampoos formulated for dry or oily hair, or shampoos containing additives such as anti-dandruff agents. Hair care products can be either shampoo-free or leave-in, and also include hair tonics, bleaching agents, colorants, setting products, and styling products. See, for example, U.S. Patent Nos. 6,162,423, 5,968,286, 5,935,561, 5,932,203, 5,837,661, 5,776,443, 5,756,436, 5,661,118, and 5,618,523. Leave-in skincare products include eau de toilette, perfume, cologne, wipes, body sprays, deodorants, and antiperspirants. Skin cleansing products specifically include beauty and hygiene soap bars, shower gels, liquid soaps, body washes, exfoliating gels, and creams (see, for example, US Patent Nos. 3,697,644; 4,065,398; and 4,387,040). Wipes specifically include skin cleansing wipes, baby wipes, makeup remover wipes, and skin refreshing wipes (see, for example, US Patent Nos. 4,775,582; WO 02 / 07701; WO 2007 / 069214 and WO 95 / 16474). Body sprays, deodorants, and antiperspirants specifically include sticks, liquid roll-on applicators, and pressurized sprays.

[0156] The compositions and consumer products based on this disclosure are further illustrated by the following non-limiting examples.

[0157] Example

[0158] Solubility measurement:

[0159] Compound N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide of formula (I) was mixed with a liquid solvent or a mixture of solvents and transferred to an 8 mL vial equipped with a top-mounted stirrer. The sample was placed in a Crystalline PV instrument (Technobis, Netherlands). Heating and cooling steps were performed with mechanical stirring, and the transparency of the sample was monitored by an LED beam passing through the vial. Complete (100%) transparency was considered achieved when N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide was completely dissolved in the solvent. Conversely, when the measured transparency value was less than 100%, the dissolution process was considered incomplete.

[0160] Determination of dissolution temperature:

[0161] First, set the temperature to 0℃ and allow the sample to stand for 5 minutes to reach equilibrium without stirring. Then, start stirring and heat at a slow rate (+0.1℃ / min) to dissolve the sample under quasi-isothermal conditions. Monitor the change in sample transparency over time during the heating process. The dissolution process is complete when the transparency reaches 100%, and this temperature is the dissolution temperature.

[0162] The solubility of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide in various solvents at 22 °C was determined using pre-established solubility curves (fitted from the solubility temperatures of at least four different concentrations of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide samples in different solvents). These solubility curves were fitted to an exponential function. The solubility at 22 °C was obtained by extrapolation or interpolation of this exponential function.

[0163] The percentages (%) shown in the examples are the weight percentages of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide in the total liquid composition.

[0164] Example 1. Solvent Comparison

[0165] The compound N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-toluoxy)acetamide of formula (I) was dissolved in various solvents and solvent blends. The mass percentage of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-toluoxy)acetamide dissolved at 22 °C and the dissolution temperature of a 10% solution of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-toluoxy)acetamide were determined. Table 1 summarizes the dissolution results of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide in classical solvents, and Table 2 summarizes the dissolution results of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide in carvone alone and in blends of carvone and cosolvents.

[0166] Table 1.

[0167]

[0168] Table 2.

[0169]

[0170] Example 2. Further Comparison of Solvents

[0171] Following the method described in Example 1, compound N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide of formula (I) was dissolved in various solvent blends. Table 3 summarizes the results obtained.

[0172] Table 3.

[0173]

[0174] The disclosed subject matter has been described with reference to specific details of particular embodiments. These details should not be construed as limiting the scope of the disclosed subject matter unless they are included in the appended claims.

[0175] Therefore, the exemplary embodiments described herein are well-suited to achieving the stated objects and advantages, as well as those inherent therein. The specific embodiments disclosed above are merely illustrative, as the exemplary embodiments described herein can be modified and practiced in different but equivalent ways, as will be apparent to those skilled in the art who benefit from the teachings herein. Furthermore, the details of the constructions or designs shown herein are not limiting, except as set forth in the following claims. Therefore, it is apparent that the specific illustrative embodiments disclosed above can be changed, combined, or modified, and all such changes are considered to be within the scope and spirit of the exemplary embodiments described herein. The exemplary embodiments illustratively disclosed herein can be appropriately practiced in the absence of any elements not specifically disclosed herein and / or any optional elements disclosed herein.

Claims

1. A liquid composition comprising: a) at least one compound of formula (I), The compound is in any of its stereoisomers; where R 1 Represents a phenyl group, which may optionally have one or two C atoms substituted. 1-3 alkyl or alkoxy or one or two halogen groups; R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen, oxygen, and sulfur, which may optionally be substituted with one or two C atoms. 1-3 alkyl; b) Oils containing carvone; and c) Optional solvents.

2. The composition according to claim 1, wherein R 1 Represented by one or two Cs 1-3 A phenyl group substituted with an alkyl or alkoxy group or one or two halogen groups.

3. The composition according to any one of claims 1 to 2, wherein R 1 Represented by one or two Cs 1-2 Alkyl or alkoxy or one or two fluorine-substituted phenyl groups.

4. The composition according to any one of claims 1 to 3, wherein R 1 It represents a phenyl group that has been substituted with one or two methyl, ethyl, methoxy, or fluorine groups.

5. The composition according to any one of claims 1 to 4, wherein R 2 and R 3 Each of these groups independently represents a heterocyclic group containing one to three heteroatoms selected from nitrogen and sulfur.

6. The composition according to any one of claims 1 to 5, wherein R 2 This represents a heterocyclic group containing one or two nitrogen atoms.

7. The composition according to any one of claims 1 to 6, wherein R 2 It represents the pyrazole group.

8. The composition according to any one of claims 1 to 7, wherein R 3 This represents a heterocyclic group containing one or two sulfur atoms.

9. The composition according to any one of claims 1 to 8, wherein R 3 It represents the thiophene group.

10. The composition according to any one of claims 1 to 9, wherein the compound of formula (I) is N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide, N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide, 2-(4-ethylphenoxy)-N-(1H-pyrazol-5-yl)-N-(thiophen-2-ylmethyl)acetamide or 2-(4-ethylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide.

11. The composition according to any one of claims 1 to 10, wherein the oil containing carvone is pure carvone, spearmint oil, caraway seed oil, or dill oil.

12. The composition according to any one of claims 1 to 10, wherein the composition comprises a solvent selected from the group consisting of 1-propanol, 2-propanol, ethanol, 1,2-propanediol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate and benzyl alcohol, typically a solvent selected from the group consisting of 2-propanol, ethyl lactate and ethanol.

13. The composition according to any one of claims 1 to 12, wherein the content of the at least one compound of formula (I) is from 0.1% to 20% by weight, typically from 5% to 15% by weight, relative to the total weight of the composition, and the content of the carvone-containing oil is from 20% to 99.9% by weight.

14. The composition according to any one of claims 1 to 13, wherein the composition is a transparent and homogeneous solution.

15. A consumer product comprising a liquid composition according to any one of claims 1 to 14.

16. The consumer product of claim 15, wherein the consumer product is a flavored product, typically a food product, beverage product, oral care product, or pharmaceutical product, or a body care product, typically a beauty product, skin care product, or hair care product.

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