Cup device for histological and morphological detection of human tissues

Abstract

The utility model discloses a cup device for histological and morphological detection of human tissues, which is characterized in that the cup device is in a cap shape and comprises a cup body and a connecting body which are made of transparent materials and are connected into a whole; the cross section of the cup body from the center is semicircular or semi-arc-shaped, and a plurality of circulating holes are uniformly formed in the cup body; the connecting body is annular, and a plurality of connecting grooves are evenly formed in the connecting body. According to the cup device, the shape of human body / breast tissue in the detection process can be kept in the detection process; the cup device has the advantages that the cup device can support and fix the position of the tissue in the detection space and prevent the tissue from deviating in the detection process, and meanwhile, the material and the thickness of the cup device can guarantee certain light transmittance and sound transmission rate, so that signal-to-noise interference (such as reflection and the like) can be reduced as much as possible.

Description

Technical Field

[0001] The utility model belongs to the field of photoacoustic imaging and ultrasonic imaging, and particularly relates to a cup device which can support a part to be examined, circulate ultrasonic coupling agent, and perform histological and morphological examinations on human tissues. Background Art

[0002] Breast disease is a common disease among women. The severity of the disease varies depending on the type. Breast cancer is a malignant tumor that occurs in the breast epithelial tissue. There are many types of breast cancer, which require clinical pathological examinations to confirm.

[0003] Breast tumor is a relatively general term. Breast tumors include benign tumors and malignant tumors. The most important malignant breast tumor is breast cancer, and benign tumors include breast fibroadenoma, intraductal papilloma, etc.

[0004] Breast cancer is a phenomenon in which mammary epithelial cells proliferate uncontrollably under the influence of multiple carcinogenic factors. In the early stages of the disease, symptoms include breast lumps, nipple discharge, and enlarged axillary lymph nodes. In the late stages, cancer cells may metastasize to distant sites, leading to multi-organ lesions and directly threatening the patient's life.

[0005] Breast cancer is often called the "pink killer". Its incidence rate ranks first among female malignant tumors, while male breast cancer is relatively rare. However, with the improvement of medical level, breast cancer has become one of the solid tumors that can be treated with good efficacy.

[0006] Ultrasonic imaging methods (including ultrasonic imaging and photoacoustic imaging, etc.) have become an important means of medical diagnosis. Ultrasonic detection relies on receiving ultrasonic signals with ultrasonic transducers. When ultrasonic waves are incident on the interface between two different media, the greater the difference in acoustic impedance between the two media, the greater the reflection coefficient, and the less energy the ultrasonic waves have to pass through the interface into the other medium. If there is an air gap between the ultrasonic transducer and the inspected part, or if there is direct "dry contact", the air layer between the ultrasonic probe and the inspected part will have a strong reflection effect, making it impossible for the ultrasonic waves to propagate effectively. In the process of ultrasonic imaging, ultrasonic signals need to be mediated by ultrasonic coupling agents to reduce ultrasonic reflection and increase ultrasonic transmission. For photoacoustic tomography and ultrasonic tomography used for certain human tissues (such as breasts), the transducer array size is relatively large, so there is a certain distance between the transducer surface and the human skin surface, and a large amount of ultrasonic coupling agents is required at this time; common coupling agents include water and ultrasonic coupling gel, etc. The ultrasonic coupling agent is filled inside the device where the ultrasonic transducer is installed, and then the human body's inspected part is placed in the ultrasonic coupling agent so that the ultrasonic transducer can receive the tissue's photoacoustic or ultrasonic signals. In order to successfully reconstruct the image, it is necessary to maintain the shape of the inspected tissue during the detection process and to obtain uniform illumination. Therefore, a unique tissue support device is urgently needed to effectively carry the inspected part to reduce the movement of the inspected tissue and ensure its central positioning. In addition, during the inspection process, the outer surface of the inspected tissue (such as skin), the surface of the tissue support device (such as the curved surface of a transparent cup), the surface of the medium such as the coupling agent, and the reflection or scattering of the photoacoustic signal wave between these contact surfaces will interfere with the detection accuracy. Therefore, it is necessary to meet specific design requirements for the cup shape, thickness and material. And the cup is a container device that allows the ultrasonic coupling agent to flow freely and is easy to replace. Utility Model Content

[0007] The utility model aims at the defects of the prior art and provides a cup device which can support the examined part, circulate ultrasonic coupling agent and perform histological and morphological examination on human tissue.

[0008] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a cup device for performing histological and morphological detection on human tissue, the cup device is in the shape of a cap, and includes a cup body and a connector made of transparent material and connected as one body; the cup body has a semicircular or semi-arc vertical section from the center, and a plurality of flow holes are evenly arranged on the cup body; the connector is annular, and a plurality of connecting grooves are evenly arranged on the connector.

[0009] Furthermore, the cup device has a thickness of 100-200 μm and is made of food-grade or medical-grade plastic material.

[0010] Furthermore, the number of the flow holes is 20 to 60, and the hole diameter is 3 to 5 mm.

[0011] Furthermore, the number of the connecting grooves is at least 4, preferably 4 to 10, and the shapes are circular, hexagonal or other specific shapes.

[0012] Furthermore, when the vertical section of the cup body from the center is semi-arc-shaped, the semi-arc is symmetrical about the central vertical z-axis. The connector of the cup device coincides with the horizontal x-axis. If the center of the semi-arc is located below the x-axis, the arcs of the two ends or edge portions of the semi-arc satisfy the curve simulation formula (1):

[0013] z=c[0]+c[1]×x+c[2]×x 2 +c[3]×x 3 (1)

[0014] The arc in the middle of the semi-arc is a part of the elliptical arc, and this part of the arc satisfies the curve simulation formula (2):

[0015]

[0016] Among them: -1.93×10 -1 ≤c[0]≤-2.50×10 -2 , -4.00≤c[1]≤4.23, -3.33×10 1 ≤c[2]≤8.10×10 1 , -3.88×10 2 ≤c[3]≤9.27×10 2 ; a and b are the major and minor axes of the ellipse, and their value ranges are: 0.060m≤a≤0.092m, 0.025m≤b≤0.088m;

[0017] The value range of the height -h of the middle arc is: 0.007m≤h≤0.049m, and the value range of the corresponding value w of 1 / 2 width of the entire semi-arc on the x-axis is: 0.080m≤w≤0.130m.

[0018] During the human body / breast tissue detection operation, the detected part needs to be kept in a certain stable or concentrated state. In order to enable the ultrasound or light source equipment arranged around the detection space to effectively perform the functions of sending, receiving or scanning, and improve the accuracy of the detection and the clarity of the output image, it is necessary to use a cup device that is easy to replace. The cup device of the present application has the following advantages:

[0019] (1) It can maintain the shape of the human body / breast tissue during the test, support and fix the position of the tissue in the test space, prevent it from shifting during the test, and ensure that the tissue in the cup remains isotropic when receiving the light source or radiating the ultrasonic signal;

[0020] (2) The material and thickness of the cup device can ensure a certain light transmittance and sound transmittance, or minimize the loss of photoacoustic signal propagation, limit signal attenuation, and assist in reducing signal-to-noise interference;

[0021] (3) When the plastic cup is placed in the corresponding detection space, the curved surface or cup surface of the cup device is not parallel to the signal receiving and transmitting end surfaces of the laser, ultrasonic probe and other devices distributed in the surrounding detection space, as well as the surface of the detection space environment, so as to reduce the interference caused by the reflection of the signal wave in the parallel surface interval;

[0022] (4) Multiple size ranges can be set to suit the detection of tissue parts within a certain size range;

[0023] (5) The use process is comfortable and painless; the price is low and can be used once, or the cup device can be guaranteed to be clean before use.

[0024] (6) The porous structure of the cup device is used for the circulation of medium liquid, such as deionized water, so that the medium liquid inside and outside the cup device is kept at the same level. At the same time, if there are bubbles in the medium liquid, this porous structure is conducive to the movement and removal of the bubbles, avoiding the residue of bubbles in the detection space or the medium liquid, and maintaining a good contact state between the tissue and the medium liquid.

[0025] (7) In addition, a connection groove is designed on the edge of the cup device, and the cup device can be fixed to the detection device by matching the connection groove on the edge of the cup with the corresponding connection buckle on the detection device. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a front view of the cup device of the embodiment.

[0027] Figure 2 2 is a side view of the cup device of the embodiment.

[0028] Figure 3 2 is a top view of the cup device of the embodiment.

[0029] Figure 4 4 is a cross-sectional model definition curve diagram of the cup device of the embodiment.

[0030] Figure 5 1 is a diagram showing the corresponding relationship between the cross section of the plastic cup of the embodiment and the definition curve.

[0031] Figure 6 Schematic diagram of plastic cups of different sizes according to the embodiment. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the solution of the present application, the following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of this application.

[0033] It should be noted that the terms "including" and "having" and any variations thereof in the specification and claims of the present application and the above-mentioned drawings are intended to cover non-exclusive inclusions. For example, a process, method, system, product or apparatus comprising a series of steps or units is not necessarily limited to those clearly listed.

[0034] like Figures 1 to 3 The cup device for detecting tumors in human tissues is in the shape of a cap and comprises a cup body and a connector which are made of transparent material and connected in one body.

[0035] The cup body is semi-arc-shaped, with a thickness of 100 to 200 μm, and is made of food-grade or medical-grade PVC to ensure a light transmittance of more than 98% in the wavelength range of 700 to 900 nm, and an attenuation of 0.5 MHz, 1 MHz and 1.5 MHz ultrasonic waves of 9.1 x 10-2 dB, 8.5 x 10-1 dB and 1.2 dB respectively.

[0036] The cross-sectional shape of the cup body consists of three parts: Figure 4 and 5 As shown, there are edge straight segments A and A', curve trajectory segments B and B' defined by polynomials, and elliptic curve segment C.

[0037] In one embodiment, a total of 8 sizes of plastic cups can be designed. Among them, the length of the straight sections A and A' is 22 mm, which is suitable for cup parts of all sizes. The curve definition formula of section B is:

[0038] z=c[0]+c[1]×x+c[2]×x 2 +c[3]×x 3 (1)

[0039] The parameters of the 0th, 1st, 2nd and 3rd order items are c[i], i=0, 1, 2, 3 respectively, and the cup parameters c[i] of different sizes can be taken in the corresponding numerical range:

[0040] -1.93e-01≤c[0]≤-2.50e-02

[0041] -4.00e+00≤c[1]≤4.23e+00

[0042] -3.33e+01≤c[2]≤8.10e+01

[0043] -3.88e+02≤c[3]≤9.27e+01

[0044] Segment B' is symmetrical to segment B about the z-axis.

[0045] The definition formula of elliptic curve segment C is:

[0046]

[0047] The parameters a and b corresponding to cups of different sizes can be taken within the following corresponding numerical ranges (unit: m):

[0048] 0.060≤a≤0.092

[0049] 0.025≤b≤0.088

[0050] in addition, Figure 4 or Figure 5 -h represents the boundary value of the ellipse segment (the middle arc) and the polynomial segment (the two end arcs) on the z-axis, the critical z value, so bh is the height or depth of the middle arc. w represents the boundary value of the polynomial segment on the x-axis, the critical x value, or the 1 / 2 width of the entire half arc on the x-axis. h and w can refer to the following corresponding numerical ranges (unit: m):

[0051] 0.007≤h≤0.049

[0052] 0.095≤w≤0.115.

[0053] Multiple sizes that meet the ranges of formulas (1) and (2) can be set to meet the needs of people of different heights and body shapes or organization sizes, such as Figure 6 shown.

[0054] In one embodiment, 33 circulation holes are evenly arranged on the cup body. Each hole has a diameter of 3 to 5 mm and is used for the circulation of medium liquid such as deionized water to prevent air bubbles from remaining and maintain the contact state between tissue and deionized liquid. The perforation method is from the inside of the arc to the outside, and burrs are avoided as much as possible, or to prevent burrs from causing discomfort to the tissue.

[0055] The connector is annular, and is evenly provided with four, five, six or more connecting grooves. The shape can be hexagonal, circular or other specific shapes. The connecting groove is used to fix the plastic cup at the corresponding position of the detection device.

[0056] The cup device can be manufactured by negative pressure molding, stamping molding, 3D printing and other methods.

[0057] Before use, the cup of appropriate size can be selected according to the shape and size of the tissue to be tested. The buckle structure on the edge of the cup is matched with the corresponding slot on the testing instrument to fix the cup.

[0058] When in use, the subject can adopt a prone position or other body postures so that the cup can effectively accommodate the tissue to be examined.

[0059] After the test, the cup can be removed from the monitoring device and disposed of in accordance with appropriate medical regulations.

[0060] Although the specific implementations of the utility model have been described in detail above in conjunction with the embodiments, it should be pointed out that the protection scope of the utility model is not limited by these specific implementations, but is determined by the claims. Those skilled in the art can make appropriate changes to these implementations without departing from the technical ideas and purposes of the utility model, and these changed implementations are obviously also included in the protection scope of the utility model.

Claims

1. A cup device for performing histological and morphological testing on human tissue, characterized in that: The cup device is in the shape of a cap, and comprises a cup body and a connector which are made of transparent material and connected as one body; the cup body has a semicircular or semi-arc vertical section from the center, and a plurality of flow holes are evenly arranged on the cup body; the connector is in the shape of a ring, and a plurality of connection grooves are evenly arranged on the connector.

2. The cup device for performing histological and morphological testing on human tissue according to claim 1, characterized in that: The cup device has a thickness of 100-200 μm and is made of food-grade or medical-grade plastic material.

3. The cup device for performing histological and morphological testing on human tissue according to claim 1, characterized in that: The number of the flow holes is at least 5.

4. The cup device for performing histological and morphological testing on human tissue according to claim 1, characterized in that: When the vertical section of the cup body from the center is semi-arc-shaped, the semi-arc is symmetrical about the central vertical z-axis; the connector of the cup device coincides with the horizontal x-axis, and if the center of the semi-arc is located below the x-axis, the arcs of the two ends or edge parts of the semi-arc satisfy the curve simulation formula (1): z=c[0]+c[1]×x+c[2]×x 2 +c[3]×x 3 (1) The arc in the middle of the semi-arc is a part of the elliptical arc, and this part of the arc satisfies the curve simulation formula (2): Among them: -1.93×10-1≤c[0]≤-2.50×10-2, -4.00≤c[1]≤4.23, -3.33×101≤c[2]≤8.10×101, -3.88×102≤c[3]≤9.27×102; a and b are the major and minor axes of the ellipse, and the value range is: 0.060m≤a≤0.092m, 0.025m≤b≤0.088m; The value range of the height -h of the middle arc is: 0.007m≤h≤0.049m, and the value range of the corresponding value w of 1 / 2 width of the entire semi-arc on the x-axis is: 0.080m≤w≤0.130m.

5. The cup device for performing histological and morphological testing on human tissue according to claim 1, characterized in that: The number of the connecting slots is at least 4.

6. The cup device for performing histological and morphological testing on human tissue according to claim 1 or 5, characterized in that: The connecting groove realizes the function of fixing the cup device by connecting the buckle at the detection device.

Images