Sulbactam sodium mother liquor pH value adjusting device

Abstract

The utility model relates to a sulbactam sodium mother liquor pH value adjusting device, which comprises a reaction tank, an adjusting tank, a stirring mechanism and a pH value detector, when the pH value is adjusted, a part of sulbactam sodium mother liquor enters the reaction tank through a feed port of the sulbactam sodium mother liquor; the other part of sulbactam sodium mother liquor is conveyed to a vertical liquid conveying pipeline through a first bypass pipeline under the action of a first lifting pump, meanwhile, alkali liquor for adjustment is conveyed into the vertical liquid conveying pipeline through a discharging opening of an adjusting tank, and the alkali liquor and the sulbactam sodium mother liquor are mixed and then enter a reaction tank through the lower end of the vertical liquid conveying pipeline and an adjusting opening; the alkali liquor is mixed with more sulbactam sodium mother liquor after entering the reaction tank, on one hand, the stirring paddle assembly is used for stirring, and on the other hand, the mixed liquid is led out from the bottom of the reaction tank through the second lifting pump and then flows back into the reaction tank through the second bypass pipeline and the annular liquid separation pipe. According to the utility model, the adjusting time is shortened, and the pH value adjusting efficiency is obviously improved.

Description

Technical Field

[0001] The utility model relates to the technical field of sulbactam sodium production equipment, in particular to a sulbactam sodium mother liquor pH value regulating device. Background Art

[0002] Sulbactam sodium is an artificially synthesized irreversible competitive β-lactamase inhibitor, usually used in combination with penicillins and cephalosporins to prevent them from being destroyed by β-lactamase and enhance their antibacterial activity. It is suitable for respiratory system infections. At present, a large amount of ethanol mother liquor is produced in the common production process of sulbactam sodium, and recycling ethanol for recycling is a common practice in the industry. When recycling sulbactam sodium mother liquor to prepare pharmaceutical-grade anhydrous ethanol, the pH value of sulbactam sodium mother liquor is first adjusted to 7-9, and then distillation, oxidation and impurity removal, decolorization, osmotic membrane dehydration and vacuum distillation are carried out in sequence to obtain anhydrous ethanol. When adjusting the pH value of sulbactam sodium mother liquor, a reaction tank pH adjustment device is required.

[0003] CN 219647496 U discloses a pH value regulating device for a reaction tank, comprising a tank body, a top cover fixedly mounted on the top of the tank body, a titration device arranged on the top cover, a cap fixedly mounted on the top cover and an extrusion cylinder arranged on one side of the cap, the cap is connected to the inside of the tank body, a storage cylinder is fixedly mounted on the top of the cap, a valve is fixedly mounted on the bottom cylinder of the storage cylinder, a sealing cover is threadedly connected on the top cylinder of the storage cylinder, the extrusion cylinder and the storage cylinder are connected through an inclined tube, an electric push rod is fixedly mounted on the top surface of the extrusion cylinder, a piston slidably connected to the extrusion cylinder is arranged on the telescopic shaft of the electric push rod, an external through pipe arranged at an upward inclination of 45° to 60° is fixedly mounted on the side of the tank body, and a pH value detector is fixedly mounted on the external through pipe. The device is convenient for adding acid and alkali solutions to adjust the pH value, and is convenient to use. However, there are still the following problems during use: when the alkali solution or acid solution used to adjust the pH value is mixed with the main raw material in the reaction tank, in order to ensure the accurate detection of the pH value in order to mix evenly, the stirring time is too long, and the adjustment efficiency is low. Utility Model Content

[0004] The purpose of the utility model is to provide a device for adjusting the pH value of sulbactam sodium mother solution with reasonable structure and reliable use to solve the above problems, thereby significantly improving the adjustment efficiency.

[0005] The technical solution of the utility model is:

[0006] A sulbactam sodium mother liquor pH value regulating device comprises a reaction tank, a regulating tank, a stirring mechanism and a pH value detector, wherein the regulating tank is arranged above the reaction tank, a vertical liquid feeding pipeline is arranged between the discharge port of the regulating tank and the regulating port at the top of the reaction tank, a sulbactam sodium mother liquor feed port is arranged at the top of the reaction tank, the stirring mechanism comprises a stirring motor arranged at the center of the top of the reaction tank, and a stirring paddle assembly connected to the stirring motor, and the technical key points are: the sulbactam sodium mother liquor feed port is provided with a first bypass pipeline, the end of the first bypass pipeline is connected to the upper part of the vertical liquid feeding pipeline, the first bypass pipeline is provided with a first lifting pump, and the inlet of the first lifting pump is connected to the vertical liquid feeding pipeline. A first control valve is provided on the side, a first flowmeter is provided on the outlet side, a second flowmeter and a second control valve are provided at the regulating port, a third flowmeter and a third control valve are provided at the sulbactam sodium mother liquor feed port, an annular liquid separatory pipe is provided on the upper part of the outer wall of the reaction tank, a second bypass pipeline is provided at the liquid discharge port at the bottom of the reaction tank, the end of the second bypass pipeline is connected with the annular liquid separatory pipe, a plurality of inclined connecting pipelines are provided between the annular liquid separatory pipe and the reaction tank, a second lift pump is provided on the second bypass pipeline, a fourth control valve is provided at the starting end of the second bypass pipeline and a one-way valve is provided at the end, and a fifth control valve is fixed at the lower end of the liquid discharge port at the bottom of the reaction tank.

[0007] In the above-mentioned sulbactam sodium mother solution pH value regulating device, the top of the regulating tank is connected and communicated with the pressurizing device, and a liquid injection port is provided on the upper part of the outer wall of the regulating tank.

[0008] The above-mentioned sulbactam sodium mother liquor pH adjustment device has two inclined mounting tubes symmetrically arranged on the upper parts of both sides of the reaction tank, the number of the pH detectors is two, and they correspond one to one with the inclined mounting tubes, the pH detector is fixed to the top of the corresponding inclined mounting tube and its detection end is inserted into the reaction tank through the inclined mounting tube.

[0009] The beneficial effects of the utility model are:

[0010] 1. When adjusting the pH value, a part of the sulbactam sodium mother liquor enters the reaction tank through its feed port, and the other part of the sulbactam sodium mother liquor is transmitted to the vertical liquid feeding pipeline through the first bypass pipeline under the action of the first lifting pump, and at the same time, the discharge port of the regulating tank feeds the regulating alkali solution into the vertical liquid feeding pipeline. After the alkali solution is mixed with the sulbactam sodium mother liquor, it enters the reaction tank through the lower end of the vertical liquid feeding pipeline and the regulating port to achieve pre-mixing and pre-adjustment. After the alkali solution enters the reaction tank, it is mixed with more sulbactam sodium mother liquor. In order to speed up the mixing and adjustment speed, on the one hand, the stirring paddle assembly is used for stirring, and on the other hand, the mixed liquid is drawn out from the bottom of the reaction tank through the second lifting pump and then refluxed to the reaction tank through the second bypass pipeline and the annular liquid separation pipe. The utility model shortens the adjustment time and significantly improves the pH value adjustment efficiency.

[0011] 2. Use two pH detectors to simultaneously detect the pH value of the liquid in the reaction tank, significantly improving the detection accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a structural schematic diagram of the utility model.

[0013] In the figure: 1. liquid injection port, 2. regulating tank, 3. pressurizing device, 4. sulbactam sodium mother liquor feed port, 5. first control valve, 6. first lifting pump, 7. first flow meter, 8. first bypass pipeline, 9. vertical liquid delivery pipeline, 10. second control valve, 11. second flow meter, 12. stirring motor, 13. third control valve, 14. third flow meter, 15. inclined installation pipe, 16. annular liquid dispensing pipe, 17. pH value detector, 18. reaction tank, 19. inclined connecting pipeline, 20. one-way valve, 21. second bypass pipeline, 22. second lifting pump, 23. fourth control valve, 24. fifth control valve, 25. liquid discharge port. DETAILED DESCRIPTION

[0014] The utility model is described in detail according to the accompanying drawings of the specification.

[0015] like Figure 1 As shown, the sulbactam sodium mother liquor pH value regulating device comprises a reaction tank 18, a regulating tank 2, a stirring mechanism and a pH value detector 17. The regulating tank 2 is arranged above the reaction tank 18, a vertical liquid delivery pipeline 9 is arranged between the discharge port of the regulating tank 2 and the regulating port at the top of the reaction tank 18, and a sulbactam sodium mother liquor feed port 4 is further arranged at the top of the reaction tank 18. The stirring mechanism comprises a stirring motor 12 arranged at the top center of the reaction tank 18, and a stirring paddle assembly connected to the stirring motor 12.

[0016] Wherein: the sulbactam sodium mother liquor feed port 4 is provided with a first bypass pipeline 8, the end of the first bypass pipeline 8 is connected to the upper part of the vertical liquid delivery pipeline 9, the first bypass pipeline 8 is provided with a first lift pump 6, the inlet side of the first lift pump 6 is provided with a first control valve 5, and the outlet side is provided with a first flowmeter 7. The regulating port is provided with a second flowmeter 11 and a second control valve 10. The sulbactam sodium mother liquor feed port 4 is provided with a third flowmeter 14 and a third control valve 13.

[0017] An annular liquid dispensing pipe 16 is provided on the upper portion of the outer wall of the reaction tank 18, a second bypass pipeline 21 is provided at a liquid discharge port 25 at the bottom of the reaction tank 18, the end of the second bypass pipeline 21 is connected to the annular liquid dispensing pipe 16, a plurality of inclined connecting pipelines 19 are provided between the annular liquid dispensing pipe 16 and the reaction tank 18, a second lift pump 22 is provided on the second bypass pipeline 21, a fourth control valve 23 is provided at the starting end of the second bypass pipeline 22 and a one-way valve 20 is provided at the end, and a fifth control valve 24 is fixed to the lower end of the liquid discharge port 25 at the bottom of the reaction tank 18.

[0018] In this embodiment, the top of the regulating tank 2 is connected and communicated with the pressure device 3. When the amount of alkali solution in the regulating tank 2 is small, the pressure device 3 is used to assist the liquid to be discharged. The upper part of the outer wall of the regulating tank 2 is provided with a liquid injection port 1 for replenishing the alkali solution. Two inclined mounting tubes 15 are symmetrically provided on the upper part of both sides of the reaction tank 18. The number of the pH value detectors 17 is two, and they correspond one to one with the inclined mounting tubes 15. The pH value detectors 17 are fixed to the top of the corresponding inclined mounting tubes 15 and their detection ends are inserted into the reaction tank 18 through the inclined mounting tubes 15.

[0019] Working principle:

[0020] 1. First, a portion of the sulbactam sodium mother solution to be adjusted is fed into the reaction tank 18 through the sulbactam sodium mother solution feed port 4, and measured by the third flow meter 14, and then the third control valve 13 is closed.

[0021] 2. Open the first control valve 5 and start the first lift pump 6 to transfer the remaining sulbactam sodium mother liquor to the vertical liquid delivery pipeline 9 through the first bypass pipeline 8 and measure it with the first flowmeter 7.

[0022] 3. Open the second control valve 10 and the discharge port of the regulating tank 2. The regulating tank 2 feeds the regulating alkali solution into the vertical liquid delivery pipeline 9. The alkali solution is mixed with the sulbactam sodium mother liquor and enters the reaction tank 18 through the vertical liquid delivery pipeline 9 and the second control valve 10 to achieve pre-mixing and pre-adjustment.

[0023] 4. When the pre-adjusted mixed liquid falls into the reaction tank 18, the stirring motor 12 drives the stirring paddle assembly to rotate, and at the same time starts the second lifting pump 22 to draw the mixed liquid out from the bottom of the reaction tank 18 and then return it to the reaction tank 18 through the second bypass pipeline 21, the annular liquid separation pipe 16 and each inclined connecting pipeline 19, thereby accelerating the adjustment speed.

[0024] 5. Use two pH detectors 17 to detect the pH value of the mixed liquid in the reaction tank 18 in real time. When all the sulbactam sodium mother liquor is added, use the second flow meter 11 to continue to monitor the injection amount of the alkali solution. When the average value of the detection data of the two pH detectors 17 shows that the preset pH value is reached, close the second control valve 10 and the discharge port of the regulating tank 2.

[0025] The above is a detailed description of the embodiments of the utility model, but the above contents are only preferred embodiments of the utility model and cannot be considered to limit the scope of implementation of the utility model. All equivalent changes and improvements made within the scope of the invention of the utility model should still fall within the scope of this patent.

Claims

1. A sulbactam sodium mother liquor pH value regulating device, comprising a reaction tank, a regulating tank, a stirring mechanism and a pH value detector, wherein the regulating tank is arranged above the reaction tank, a vertical liquid delivery pipeline is arranged between the discharge port of the regulating tank and the regulating port at the top of the reaction tank, and a sulbactam sodium mother liquor feed port is arranged at the top of the reaction tank, the stirring mechanism comprises a stirring motor arranged at the center of the top of the reaction tank, and a stirring paddle assembly connected to the stirring motor, characterized in that: The sulbactam sodium mother liquor feed port is provided with a first bypass pipeline, the end of the first bypass pipeline is connected to the upper part of the vertical liquid delivery pipeline, the first bypass pipeline is provided with a first lift pump, the inlet side of the first lift pump is provided with a first control valve, the outlet side is provided with a first flowmeter, the regulating port is provided with a second flowmeter and a second control valve, the sulbactam sodium mother liquor feed port is provided with a third flowmeter and a third control valve, the upper part of the outer wall of the reaction tank is provided with an annular liquid separation pipe, the liquid discharge port at the bottom of the reaction tank is provided with a second bypass pipeline, the end of the second bypass pipeline is connected to the annular liquid separation pipe, a plurality of inclined connecting pipelines are provided between the annular liquid separation pipe and the reaction tank, the second bypass pipeline is provided with a second lift pump, the starting end of the second bypass pipeline is provided with a fourth control valve and the end is provided with a one-way valve, and the lower end of the liquid discharge port at the bottom of the reaction tank is fixed with a fifth control valve.

2. The pH value regulating device of sulbactam sodium mother solution according to claim 1, characterized in that: The top of the regulating tank is connected and communicated with the pressurizing device, and a liquid injection port is arranged on the upper part of the outer wall of the regulating tank.

3. The pH value regulating device of sulbactam sodium mother solution according to claim 1, characterized in that: Two inclined mounting tubes are symmetrically arranged on the upper parts of both sides of the reaction tank. There are two pH detectors, which correspond one to one with the inclined mounting tubes. The pH detector is fixed to the top of the corresponding inclined mounting tube and its detection end is inserted into the reaction tank through the inclined mounting tube.

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