Filtering and washing device for continuous manufacturing of platinum bulk drugs
By designing a platinum raw material filtration and washing device integrating feed, discharge, filtration and stirring functions, the filtration and washing problems in the continuous manufacturing of platinum raw material is solved, and efficient and rapid product filtration and washing are achieved to ensure that Product quality.
Patent Information
- Application Number
- CN202420858705.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-24
- Publication Date
- 2024-12-24
- Estimated Expiration
- 2034-04-24
AI Technical Summary
The existing equipment cannot meet the functions of integrating feeding, discharge, filtration, and stirring in the production process of platinum compounds, making it difficult to achieve continuous manufacturing of platinum raw materials.
A filtering and washing device consisting of two parts is designed, including an open and closed feed port, an air pressure inlet, a stirring paddle, a filter element layer, a metal partition, an air extraction port and a liquid discharge port, and air extraction is evacuated by stirring and vacuum. and air compressor to achieve efficient filtration and washing.
It realizes efficient filtration and washing of platinum products, avoids redissolution and by-product residues, ensures product quality, and is suitable for filtration and washing of "small and fine-grain" products.
Smart Images
Figure CN222220443U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the manufacturing field of platinum raw materials, in particular to a filtering and washing device used for continuous manufacturing of platinum raw materials. Background Art
[0002] Continuous manufacturing is a method of manufacturing products uninterruptedly, which manifests itself in the form of uninterrupted supply of materials and output or removal of products (including by-products) during the production process. The advantages of continuous manufacturing of pharmaceuticals include significantly improving production efficiency, stabilizing product quality, and improving manufacturing flexibility and agility. At the same time, it can effectively reduce costs, reduce the chance of defects and errors, and be environmentally friendly. Therefore, the continuous manufacturing of drugs is an advanced concept and inevitable trend for the current pharmaceutical industry to achieve modern production.
[0003] Nearly half a century has passed since the first generation of platinum drugs were approved for the treatment of human tumor cells. However, the preparation of platinum APIs has not been able to get rid of the problems of small batch size in laboratory production, uneven product quality, and low production efficiency. The main reasons are: ① There has been no obvious innovation in production technology; ② The product has unique performance and large-scale production is difficult; ③ The raw materials are expensive and the cost of technological improvement is high; ④ The early market size was small.
[0004] With the recognition of platinum APIs in the market, the increasing number of cancer patients and the surge in demand for drugs, and in order to improve the competitiveness of enterprises in the industry, it is very necessary to provide a quality-controlled, visualized, batch-continuous manufacturing device and method for producing platinum APIs.
[0005] Another key point in the continuous manufacturing of platinum APIs is the filtration, washing and collection of the products. Among the existing equipment, there is no relevant equipment that can meet the needs of the production process of platinum compounds and integrate the functions of feeding, discharging, filtering, stirring, etc., making it difficult to achieve continuous manufacturing of platinum APIs. Utility Model Content
[0006] In view of the various problems existing in the continuous manufacturing of platinum raw materials mentioned above, the utility model provides a filtering and washing device for the continuous manufacturing of platinum raw materials, the device consists of an upper and lower part, wherein the upper part as a whole consists of a shell, the top of the shell is a box cover 1, the box cover 1 is provided with a stirring paddle 5 extending downward to the bottom of the shell, a feed port 2 that can be opened and closed is provided on one side of the upper half of the shell, and an air pressure inlet 3 that can be opened and closed is provided on the other side; a filter element layer 6 is provided at the bottom of the shell, and a metal partition plate 8 that can be opened and closed is provided below the filter element layer 6, and the metal partition plate 8 separates the upper and lower parts of the device; the lower part consists of a box body, a vacuum port 9 is provided on one side of the top of the box body, and a liquid discharge port 10 is provided on the same side of the bottom of the box body as the vacuum port 9, the vacuum port 9 is connected to the negative pressure device when the product is filtered, and the liquid discharge port 10 is provided with a valve.
[0007] Preferably, a visual window 4 is provided on the housing at a level with the stirring paddle 5 , and the visual window 4 is connected to the housing with a transparent material to form a sealed whole.
[0008] Preferably, the box body is in the shape of a cylinder or a cone.
[0009] Preferably, the box is in the shape of a cube or a cuboid.
[0010] Preferably, a bell-shaped connecting section with an upward opening is provided below the metal partition (8), the diameter of the upper opening of the bell-shaped connecting section is not less than the maximum planar dimension of the metal partition 8, and the diameter of the lower opening of the bell-shaped connecting section is smaller than the upper opening dimension of the box body.
[0011] Preferably, the stirring paddle 5 is driven to rotate by a motor.
[0012] Preferably, the metal partition 8 is driven by a motor to open and close.
[0013] Preferably, the filter element layer 6 completely covers the opening and closing of the metal partition 8 .
[0014] Preferably, the platinum API includes any one of cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin and miplatin.
[0015] The filtering and washing working process of the utility model includes:
[0016] When the filtration system needs to be filtered and washed, close the stirring paddle 5, close the air pressure port 3, close the discharge port 7, open the metal partition 8, and close the liquid discharge port 10. The filtration system enters the device from the feed port 2, closes the metal partition 8, opens the air suction port 9 to evacuate, and the filtrate enters the lower half of the device; closes the air suction port 9, opens the metal partition 8, and the cleaning solvent is added to the device from the feed port 2, opens the stirring paddle 5, and the filtration system is in a washing state; closes the metal partition 8, opens the air suction port 9 to evacuate, and the washing filtrate enters the lower half of the device. Close the stirring paddle 5, close the air suction port 9, open the metal partition 8, close the feed port 2, open the air pressure port 3 to connect to the air pressure, and open the discharge port 7 to collect the washed solid product; when the metal partition 8 is in the open state, the air suction port 9 is not connected to the vacuum device, and the liquid discharge port 10 can be opened to collect the filtrate.
[0017] The beneficial effects of the utility model are:
[0018] The platinum product filtering and washing device of the utility model can filter and wash the product efficiently and quickly, can avoid the phenomenon that the platinum product is redissolved in the solvent due to low filtering efficiency, resulting in a decrease in product yield, and can effectively remove by-products (related substances) and solvent residues in the product to ensure product quality. In addition, the filtering and washing device is not limited to the filtering and washing of platinum products, but can also be applied to "small, fine and advanced" products. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 : A schematic structural diagram of a filtering and washing device for platinum products of the utility model. DETAILED DESCRIPTION
[0020] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention is not limited to the described contents.
[0021] like Figure 1As shown, a filtering and washing device for continuous manufacturing of platinum raw materials is composed of an upper and lower part, wherein the upper part is composed of a cylindrical shell as a whole, the top of the shell is a box cover 1, the box cover 1 is provided with a stirring paddle 5 extending downward close to the bottom of the shell, and a visual window 4 for observing the stirring condition is provided at the level of the stirring paddle 5 of the shell, and the visual window 4 is sealed and connected to the shell with a transparent material to form a whole; a feed port 2 that can be opened and closed is provided on one side of the upper half of the shell, and a feed port 2 that can be opened and closed is provided on the other side. An openable and closed compressed air inlet 3; a filter element layer 6 is arranged at the bottom of the shell, and a metal partition plate 8 driven by a motor is arranged below the filter element layer 6, and the metal partition plate 8 separates the upper and lower parts of the device; the lower half is also composed of an almost closed rectangular box body, a vacuum port 9 is arranged on one side of the top of the box body, and a liquid discharge port 10 is arranged on the same side of the bottom of the box body as the vacuum port 9, the vacuum port 9 is connected to the negative pressure device when the product is filtered, and the liquid discharge port 10 is provided with an openable and closable valve.
[0022] The metal partition 8 is opened or closed by a metal chain driven by a motor, which is specifically implemented as follows: the metal chain is connected to a disc plate. After the motor is started, the disc plate is controlled by the metal chain to rotate clockwise or counterclockwise, thereby realizing the opening or closing of the metal partition 8.
[0023] A bell-shaped connecting section with an upward opening is also provided between the upper and lower parts of the device, the diameter of the upper opening of the bell-shaped connecting section is not less than the maximum size of the metal partition 8, and the diameter of the lower opening of the bell-shaped connecting section is smaller than the opening size of the box body.
Claims
1. A filtering and washing device for continuous production of platinum raw materials, characterized in that: The device is composed of an upper and lower part, wherein the upper part is composed of a shell as a whole, the top of the shell is a box cover (1), the box cover (1) is provided with a stirring paddle (5) extending downward to the bottom of the shell, a feed port (2) that can be opened and closed is provided on one side of the upper part of the shell, and an air pressure inlet (3) that can be opened and closed is provided on the other side; a filter element layer (6) is provided at the bottom of the shell, and a metal partition (8) that can be opened and closed is provided below the filter element layer (6), the metal partition (8) separates the upper and lower parts of the device, and the metal partition (8) is driven by a motor to open or close by a metal chain; the lower part of the device is composed of a box body, a suction port (9) is provided on one side of the top of the box body, and a liquid discharge port (10) is provided on the same side of the bottom of the box body as the suction port (9), the suction port (9) is connected to the negative pressure device when the product is filtered, and the liquid discharge port (10) is provided with a valve.
2. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: A visible window (4) is provided on the shell at a level with the stirring paddle (5), and the visible window (4) is connected to the shell with a transparent material to form a sealed whole.
3. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: The box body is in the shape of a cylinder or a conical cylinder.
4. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: The box body is in the shape of a cube or a cuboid.
5. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: A bell-shaped connecting section with an upward opening is also provided below the metal partition (8), the diameter of the upper opening of the bell-shaped connecting section is not less than the maximum planar dimension of the metal partition (8), and the diameter of the lower opening of the bell-shaped connecting section is less than the upper opening dimension of the box body.
6. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: The stirring paddle (5) is driven to rotate by a motor.
7. A filtering and washing device for continuous production of platinum raw materials as claimed in claim 1, characterized in that: The filter core layer (6) completely covers the opening and closing of the metal partition (8).
8. A filtering and washing device for continuous production of platinum-based bulk drugs according to any one of claims 1 to 7, characterized in that: The platinum API includes any one of cisplatin, carboplatin, nedaplatin, oxaliplatin, lobaplatin and miplatin.