Collection and detection integrated immunoreaction device

Abstract

The utility model belongs to the technical field of medical instruments, and discloses a sampling and detection integrated immunoreaction device which comprises a reaction tube, the reaction tube is provided with a cover, a detection assembly and a bead blasting assembly, a slope is arranged at the bottom end in the reaction tube, and the bead blasting assembly comprises liquid beads arranged on the higher side of the slope. The detection assembly comprises a detection cavity formed in the lower side of the slope, small holes opposite to the liquid beads in position are formed in the side wall of the detection cavity, a sampling swab is arranged at the bottom of the cover, and a sample covering area is arranged at the position, right opposite to the sampling swab, of the surface of the slope. According to the sampling and detection integrated immunoreaction device, the detection component and the bead blasting component are arranged in the reaction tube, so that a patient can operate by himself / herself, sampling and production can be performed immediately, time and labor are saved, the sampling and detection integrated immunoreaction device can be suitable for operation of various reaction test strips, hospital infection can be avoided, and laboratory operation pressure can be relieved.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices and relates to a sampling and testing device, in particular to an immunological reaction device integrating sampling and testing. Background Art

[0002] Taking influenza as an example, in order to confirm whether a patient is infected with the influenza virus, the doctor takes a nasal swab sample. The sampling tube is an ordinary sterilized plastic tube, which is relatively long. When professionals conduct influenza virus testing, they need to take out the swab, wash the specimen with buffer solution, and then put it into the test strip. This not only increases the operation steps, but also increases the chance of infection for medical staff to a certain extent. It is also not conducive to large-scale sample testing.

[0003] Therefore, technicians in this field are in urgent need of designing an immune response device that can achieve integrated sampling and testing. Utility Model Content

[0004] Technical purpose: In response to the above problems, the utility model provides an integrated immune response device for sampling and testing, which can realize integrated test results after nasal swab sampling, save patients' waiting time, and reduce the risk of infection for medical staff. It improves patient satisfaction on the basis of reducing production costs and has good versatility.

[0005] Technical solution: To achieve the above technical objectives, the utility model adopts the following technical solution:

[0006] An integrated sampling and testing immunoreaction device comprises a reaction tube, wherein the top of the reaction tube is provided with an opening and a cover covering the opening, a sampling swab is provided at the bottom center of the cover, and a slope is provided at the inner bottom end of the reaction tube;

[0007] The reaction tube is also provided with a detection component and a bursting bead component, the bursting bead component includes a liquid bead arranged on the higher side of the slope, the liquid bead includes a surface coating film that can be punctured under the action of an external force and a buffer stored in the surface coating film; the detection component includes a detection cavity arranged on the lower side of the slope, a small hole corresponding to the position of the liquid bead is provided on the side wall of the detection cavity, and a reaction test strip is arranged inside the detection cavity;

[0008] The bottom of the sampling swab extends to the slope surface and the total length of the sampling swab is greater than the vertical distance from the tube mouth to the center of the slope surface. The sample covering area is arranged on the surface of the slope facing the sampling swab.

[0009] Preferably, the bead blasting assembly comprises a bead blasting cavity arranged along the slope surface, spikes are arranged on the inner wall of the bead blasting cavity close to the higher side of the slope, liquid beads are placed in the bead blasting cavity below the spikes, and the bead blasting cavity is provided with a buffer solution outlet hole.

[0010] Preferably, the bead blasting assembly comprises a bead blasting cavity arranged on the side wall of the reaction tube close to the higher side of the slope, spikes are arranged on the inner surface wall of the bead blasting cavity close to the lower side of the slope, liquid beads are placed in the bead blasting cavity, and the bead blasting cavity is provided with a buffer outlet hole;

[0011] An elastic film and a roller are arranged on the outer side wall of the bead-blasting chamber, and the elastic film is located between the liquid bead and the roller.

[0012] Preferably, in the sampling tube, the lower end of the detection component is configured as a transparent visual area.

[0013] Preferably, the bursting bead assembly is provided with 1 to 2 liquid beads.

[0014] Preferably, a desiccant storage chamber is provided on the top of the detection chamber for storing desiccant, and the desiccant storage chamber is communicated with the detection chamber.

[0015] Beneficial effects: Compared with the prior art, the utility model has the following beneficial effects:

[0016] The utility model provides an integrated immunological reaction device for sampling and testing, in which a detection component and a bead blasting component are arranged in a reaction tube, which can be operated by patients themselves, and can be tested immediately after sampling, saving time and effort, and avoiding hospital infection. The device can be applied to various reaction test strips, can cope with large-volume sample testing, and can alleviate the operating pressure of secondary laboratories. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the structure of the integrated sampling and testing immunoreaction device provided in Example 1;

[0018] Figure 2 It is a schematic diagram of the structure of the integrated sampling and testing immunoreaction device provided in Example 2;

[0019] Among them, 100-cover, 101-sampling swab; 200-detection component, 201-desiccant storage chamber, 202-reaction test strip, 203-small hole; 300-bursting bead component, 301-roller, 302-elastic film; 400-liquid bead. DETAILED DESCRIPTION

[0020] The embodiments of the present utility model are described in detail below in conjunction with the accompanying drawings.

[0021] Embodiment 1

[0022] The utility model provides an immune response device that integrates sampling and testing. Figure 1The device includes: a cover 100, a sampling swab 101, a detection component 200, and a bead bursting component 300, wherein the cover 100 is connected to the sampling swab 101, and the total length of the sampling swab 101 is greater than the vertical distance from the tube mouth to the middle of the inclined plane, wherein a sample covering area is set on the inclined plane, facing the bottom of the sampling swab 101, with moderate hardness and softness, and the sample covering area can make the liquid after the bead bursting fully elute the sample. The lower end of the detection component 200 is a transparent visual area, which is convenient for quickly viewing the results, and also includes other functional partitions, namely: a desiccant storage chamber 201, which is used to place a trace amount of desiccant to prevent the reaction test strip from being damp and ineffective, and to extend the service life of the device.

[0023] The reaction test strip 202 is provided with a small hole 203 at the bottom of one side of the transparent visible area adjacent to the sampling swab 101, so as to facilitate the liquid to smoothly flow into and contact with the test strip.

[0024] The bursting bead assembly 300 is used to place the buffer solution separately in a spherical device made of special materials (such as polymer film-forming materials, cellulose, etc.) to form liquid beads 400. The buffer solution can be differentiated according to whether it contains inactivating ingredients, that is, it is suitable for influenza virus detection, and it is also suitable for sample detection that needs to be inactivated. Conventional detection buffer solution is placed in a separate bottle, and a few drops need to be checked when taking it to avoid over-diluting the sample. The bottom of this device is set as a slope, and gravity is used to make it easier for the buffer solution to wash the sample and quickly flow into the interior of the detection device.

[0025] In this embodiment, the bursting bead assembly 300 is built along a slope, and the inner wall of the device contains sharp thorns. When the sampling swab moves downward, it passes over the bursting bead assembly 300, bends, and punctures the liquid bead. The liquid quickly washes the swab, and the mixed liquid enters the detection area; it is done immediately after sampling, which is convenient and quick. At this time, the axial length of the cover 100 can be set to a two-stage adjustment structure. The first stage is before sampling, when the cover is installed to the nozzle of the reaction tube, so that the bottom end of the sampling swab just touches the inclined surface. The second stage is after the sampling swab completes sampling and is sent into the sampling tube for detection, the cover is pressed again, so that the bottom end of the sampling swab is bent along the inclined surface, passes over the bursting bead assembly, and then punctures the liquid bead. The end of the swab can be set as a cotton swab head. When squeezing and bursting the liquid bead, it is equivalent to applying a blunt force to the liquid bead.

[0026] Embodiment 2

[0027] like Figure 2 As shown, the difference from the first embodiment is that in this embodiment, the bead blasting device assembly 300 is arranged on the side wall, and is provided with a roller 301 and an elastic film 302 between the liquid bead 400 and the roller 301, so as to prevent the liquid from splashing and contaminating the outside when the roller rolls the bead blasting. Liquid beads of different test items can be placed in the bead blasting assembly as needed, and one more bead can be placed in case of an unexpected test.

[0028] The utility model has made further improvements on the existing technology. On the basis of ordinary sampling tubes, test strips and bead blasting devices can be added to avoid hospital infections, especially to prevent infection with the highly contagious new coronavirus, and the chance of infection for testers can be made negligible. Patients can operate it themselves, and the test can be done immediately after sampling, which saves time and effort and is convenient for promotion to citizens. The test can also be started on demand, which is convenient for batch control. It is especially suitable for times when large-scale testing is required, such as the flu season, and can greatly improve the medical experience and happiness of testers and patients.

[0029] The above description is only a preferred specific implementation manner of the present utility model. It should be pointed out that the protection scope of the present utility model is not limited thereto. Any technician familiar with the technical field within the technical scope disclosed by the present utility model can make equivalent substitutions or changes based on the technical scheme and utility model concept of the present utility model, which should be covered by the protection scope of the present utility model.

Claims

1. An integrated immunoassay device, characterized in that: It comprises a reaction tube, wherein the top of the reaction tube is provided with an opening and a cover (100) covering the opening, a sampling swab (101) is provided at the bottom center of the cover (100), and a slope is provided at the inner bottom end of the reaction tube; The reaction tube is further provided with a detection component (200) and a bead-bursting component (300), wherein the bead-bursting component (300) comprises a liquid bead (400) disposed on the higher side of the slope, wherein the liquid bead (400) comprises a surface coating film that can be punctured by an external force and a buffer solution stored in the surface coating film; the detection component (200) comprises a detection chamber disposed on the lower side of the slope, wherein a small hole (203) opposite to the position of the liquid bead (400) is provided on the side wall of the detection chamber, and a reaction test strip (202) is disposed inside the detection chamber; The bottom of the sampling swab (101) extends to the slope surface and the total length of the sampling swab (101) is greater than the vertical distance from the tube mouth to the center of the slope surface. A sample coverage area is arranged on the surface of the slope directly opposite to the sampling swab (101).

2. The integrated immunoassay device for sampling and testing according to claim 1, characterized in that: The bead blasting assembly (300) comprises a bead blasting cavity arranged along the slope surface, a spike is arranged on the inner surface wall of the bead blasting cavity close to the higher side of the slope, a liquid bead (400) is placed in the bead blasting cavity below the spike, and a buffer outlet is arranged in the bead blasting cavity.

3. The integrated immunoassay device for sampling and testing according to claim 1, characterized in that: The bead blasting assembly (300) comprises a bead blasting cavity arranged on the side wall of the reaction tube close to the higher side of the slope, spikes are arranged on the inner surface wall of the bead blasting cavity close to the lower side of the slope, liquid beads (400) are placed in the bead blasting cavity, and the bead blasting cavity is provided with a buffer outlet hole; An elastic film (302) and a roller (301) are provided on the outer side wall of the bead-bursting chamber, and the elastic film (302) is located between the liquid bead (400) and the roller (301).

4. The integrated immunoassay device for sampling and testing according to claim 1, characterized in that: In the reaction tube, the lower end of the detection component (200) is configured as a transparent visual area.

5. The integrated immunoassay device for sampling and testing according to claim 1, characterized in that: The bursting bead assembly (300) is provided with 1 to 2 liquid beads.

6. The integrated immunoassay device for sampling and testing according to claim 1, characterized in that: A desiccant storage chamber (201) is provided at the top of the detection chamber for storing desiccant, and the desiccant storage chamber (201) is communicated with the detection chamber.

Images