Micro-fluidic chip directly connected with sample extraction tube

Abstract

The utility model discloses a micro-fluidic chip directly connected with a sample extraction tube, and relates to the field of containers or vessels for experiments, and a sample adding opening of a sample adding cavity is matched with a tube opening of the sample extraction tube. A lip edge is fixedly arranged at the inner bottom of the sample adding cavity, a water outlet is formed in the inner side of the lip edge, and a filter element is assembled on the lip edge. And a slot is formed between the outer wall of the lip edge and the inner wall of the sample adding cavity. During use, the sample extraction tube is directly connected with the sample adding cavity, a liquid sample is directly transferred to the micro-fluidic chip from the sample extraction tube, tools such as a dropper are not needed, and the micro-fluidic chip has the advantages that the operation is simple, the liquid sample is not easy to pollute, consumables are reduced, the cost is reduced and the like.

Description

Technical Field

[0001] The utility model relates to the field of containers or utensils for experiments, in particular to a microfluidic chip directly connected to a sample extraction tube. Background Art

[0002] Microfluidic chip technology is known as a laboratory on a chip, which can integrate all aspects of the experiment on a chip. Microfluidic chips have the advantages of high integration, small size, small reagent usage, low cost, and easy operation. The existing microfluidic chip loading method is to transfer the liquid sample from the sample extraction tube to the microfluidic chip through tools such as droppers. The operation is more cumbersome and affects efficiency. In addition, the liquid sample is easily contaminated, which affects the test results. Summary of the invention

[0003] The purpose of the utility model is to provide a microfluidic chip directly connected to a sample extraction tube, and its main purpose is to overcome the problems in the prior art that as the length of the flow channel extends, the resistance of the liquid flow increases, resulting in a slowdown in the flow rate of the liquid sample, and the liquid sample is difficult to fill part of the downstream reaction unit.

[0004] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0005] A microfluidic chip directly connected to a sample extraction tube comprises a chip body, wherein the chip body is provided with a sample adding cavity and a microchannel, the sample adding cavity is provided with a water outlet for connecting to the microchannel, and the sample adding cavity is provided with a sample adding port for plugging the sample extraction tube.

[0006] Furthermore, the sample adding cavity is provided with a threaded section at the sample adding port, and the threaded section is used for threaded connection with the sample extraction tube.

[0007] Furthermore, the threaded section is an internal threaded section.

[0008] Furthermore, the sample adding chamber is provided with a filter element at the water outlet.

[0009] Furthermore, a lip is fixedly provided on the inner bottom of the sample adding cavity, and a slot for inserting the sample extraction tube is formed between the outer wall of the lip and the inner wall of the sample adding cavity.

[0010] Furthermore, the sample adding cavity is provided with the water outlet on the inner side of the lip.

[0011] Furthermore, a filter element is embedded in the lip.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] First, the sample adding port of the sample adding chamber is matched with the tube opening of the sample extraction tube. When in use, the sample extraction tube is directly connected to the sample adding chamber, and the liquid sample is directly transferred from the sample extraction tube to the microfluidic chip without the need for tools such as droppers. It has the advantages of simple operation, low contamination of liquid samples, reduced consumables, and reduced costs.

[0014] Secondly, a lip is fixedly arranged at the inner bottom of the sample adding cavity, and a slot is formed between the outer wall of the lip and the inner wall of the sample adding cavity. After the tube mouth of the sample extraction tube is added to the sample adding cavity, it is inserted into the slot, and the tube mouth is sealed with the lip to improve the stability and sealing of the connection.

[0015] Thirdly, a filter element is provided at the water outlet of the sample adding chamber to prevent large particles of undissolved matter or cotton wool in the sample extraction tube from clogging the microchannel. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a three-dimensional schematic diagram of the chip body in the first embodiment of the present invention.

[0017] Figure 2 It is a cross-sectional view of the first embodiment of the present utility model, wherein the dotted line is the cut contour line of the sample extraction tube.

[0018] Figure 3 It is a three-dimensional schematic diagram of the chip body in the second embodiment of the present invention.

[0019] Figure 4 It is a cross-sectional view of the second embodiment of the present utility model. DETAILED DESCRIPTION

[0020] The specific implementation of the present invention is described below with reference to the accompanying drawings. In order to fully understand the present invention, many details are described below, but for those skilled in the art, the present invention can be implemented without these details.

[0021] Embodiment 1

[0022] like Figure 1 and Figure 2 As shown, a microfluidic chip directly connected to a sample extraction tube comprises a chip body 1 , wherein the chip body 1 is provided with a sample adding chamber 10 and a microfluidic channel 11 , wherein the sample adding chamber 10 is provided with a sample adding port 100 for adding liquid samples and a water outlet 103 for connecting to the microfluidic channel 11 .

[0023] like Figure 1 and Figure 2As shown, the microfluidic chip further includes a sheet 3 and a hydrophobic breathable membrane 4 which are sealed and laid on the microchannel 11, and the sheet 3 includes but is not limited to a pressure-sensitive membrane. Since the improvement of the utility model only involves the chip body 1, and the sheet 3 and the hydrophobic breathable membrane 4 are conventional components of the microfluidic chip and belong to the prior art, the specific structures of the sheet 3 and the hydrophobic breathable membrane 4 are not described here.

[0024] like Figure 1 and Figure 2 As shown, the microfluidic chip is a horizontal microfluidic chip. In other words, the chip body 1 is horizontally extended, the microchannel 11 is arranged on the horizontal end surface of the chip body 1, and the sample chamber 10 is vertically extended, and the upper end is the sample port 100. Of course, the microfluidic chip can also be a vertical microfluidic chip, see Figure 3 and Figure 4 The second embodiment is shown.

[0025] like Figure 1 and Figure 2 As shown, the sample adding port 100 is used to plug the sample extraction tube b, so that the liquid sample in the sample extraction tube b can directly flow into the sample adding chamber 10 and flow into the microchannel 11 through the water outlet 103 .

[0026] like Figure 1 and Figure 2 As shown, the sample adding chamber 10 is provided with a threaded section 101 at the sample adding port 100 , and the threaded section 101 is used for threaded connection with the sample extraction tube b.

[0027] like Figure 1 and Figure 2 As shown, since the tube mouth of the existing sample extraction tube b is usually an external threaded tube mouth, the threaded section 101 is preferably an internal threaded section. Of course, the threaded section 101 can also be an external threaded section to facilitate matching with other sample extraction tubes with internal threaded tube mouths.

[0028] like Figure 1 and Figure 2 As shown, a lip 102 is fixedly provided at the inner bottom of the sample adding chamber 10, and a slot 104 for inserting the sample extraction tube b is formed between the outer wall of the lip 102 and the inner wall of the sample adding chamber 10. The lip 102 is an annular protrusion, and a chamfer is provided at the outer corner of the upper end thereof, so that the tube mouth of the sample extraction tube b can be inserted into the lip 102. The sample adding chamber 10 is provided with a water outlet 103 on the inner side of the lip 102.

[0029] like Figure 1 and Figure 2 As shown, specifically, the mouth of the sample extraction tube b is inserted into the lip 102 by interference fit to achieve a sealing effect. Since the material of the existing sample extraction tube b is usually a soft plastic product, when tightened, the mouth of the sample extraction tube b will be slightly deformed, forming an interference fit with the lip 104 to improve the sealing performance.

[0030] like Figure 1 and Figure 2 As shown, the sample adding chamber 10 is provided with a filter element 2 at the water outlet 103 to prevent large particles of undissolved matter or cotton wool in the sample extraction tube b from clogging the microchannel 11. Specifically, the filter element 2 is embedded in the lip 102. The filter element 2 and the lip 102 are interference fit to fix the filter element 2 and prevent the filter element 2 from falling out of the lip 102. Of course, the filter element 2 can also be fixedly connected to the inner wall of the lip 102 by gluing or other methods.

[0031] like Figure 1 and Figure 2 As shown, when in use, the microfluidic chip is inverted; the sample extraction tube b with the tube mouth facing upward is directly connected to the sample adding chamber 10, so that the tube mouth of the sample extraction tube b is inserted into the lip 104, and the outer wall of the tube mouth is threadedly connected to the threaded section 101; then the sample extraction tube b is squeezed by external force to deform it and reduce its volume, and at the same time, combined with the gravity, the capillary force of the microchannel and the hydrophilic property, the liquid sample is quickly introduced into the microchannel of the horizontal microfluidic chip. The purpose of directly transferring the liquid sample from the sample extraction tube b to the microfluidic chip is achieved without the need for tools such as droppers, and has the advantages of simple operation, liquid sample is not easy to be contaminated, reduced consumables, and reduced costs.

[0032] Embodiment 2

[0033] The difference between the second embodiment and the first embodiment is that the second embodiment is a vertical microfluidic chip. In other words, the chip body 1 is vertically extended, the microchannel 11 is arranged on the vertical end surface of the chip body 1, and the sample chamber 10 is vertically extended, and the upper end is the sample port 100.

[0034] like Figure 3 and Figure 4 As shown, a microfluidic chip directly connected to a sample extraction tube includes a chip body 1, wherein the chip body 1 is provided with a sample loading chamber 10 and a microfluidic channel 11, wherein the sample loading chamber 10 is provided with a sample loading port 100 and a water outlet 103. The microfluidic chip also includes a sheet 3 and a hydrophobic breathable membrane 4 sealed and laid on the microfluidic channel 11, wherein the sheet 3 includes but is not limited to a pressure-sensitive membrane.

[0035] like Figure 3 and Figure 4 As shown, the sample adding port 100 is used to plug in a sample extraction tube (not shown in the figure), so that the liquid sample in the sample extraction tube can directly flow into the sample adding cavity 10 and flow into the microchannel 11 through the water outlet 103 .

[0036] like Figure 3 and Figure 4As shown, the sample loading chamber 10 is provided with a threaded section 101 at the sample loading port 100, and the threaded section 101 is used for threaded connection with the sample extraction tube. Preferably, the threaded section 101 is an internal threaded section.

[0037] like Figure 3 and Figure 4 As shown, a lip 102 is fixedly provided at the inner bottom of the sample adding chamber 10, and a slot 104 for inserting a sample extraction tube is formed between the outer wall of the lip 102 and the inner wall of the sample adding chamber 10. The lip 102 is an annular protrusion.

[0038] like Figure 3 and Figure 4 As shown, the filter element 2 is interference-embedded inside the lip 102 .

[0039] The above is only a specific implementation method of the utility model, but the design concept of the utility model is not limited to this. Any non-substantial changes to the utility model using this concept shall be deemed as an infringement of the protection scope of the utility model.

Claims

1. A microfluidic chip directly connected to a sample extraction tube, comprising a chip body (1), wherein the chip body (1) is provided with a sample addition chamber (10) and a microfluidic channel (11), wherein the sample addition chamber (10) is provided with a water outlet (103) for communicating with the microfluidic channel (11), characterized in that: The sample adding chamber (10) is provided with a sample adding port (100), and the sample adding port (100) is used for plugging in a sample extraction tube (b).

2. A microfluidic chip directly connected to a sample extraction tube according to claim 1, characterized in that: The sample adding chamber (10) is provided with a threaded section (101) at the sample adding port (100) for connecting with a sample extraction tube (b).

3. The microfluidic chip directly connected to the sample extraction tube according to claim 2, characterized in that: The threaded section (101) is an internal threaded section.

4. The microfluidic chip directly connected to the sample extraction tube according to claim 1, characterized in that: The sample adding chamber (10) is provided with a filter element (2) at the water outlet (103).

5. A microfluidic chip directly connected to a sample extraction tube according to any one of claims 1 to 4, characterized in that: The inner bottom of the sample adding chamber (10) is fixedly provided with a lip (102), and a slot (104) for inserting a sample extraction tube (b) is formed between the outer wall of the lip (102) and the inner wall of the sample adding chamber (10).

6. The microfluidic chip directly connected to the sample extraction tube according to claim 5, characterized in that: The sample adding chamber (10) is provided with the water outlet (103) on the inner side of the lip (102).

7. The microfluidic chip directly connected to the sample extraction tube according to claim 6, characterized in that: The lip edge (102) is embedded with a filter element (2).

Images