Extracorporeal circulation connecting pipe for hemodialysis

Abstract

The utility model provides an extracorporeal circulation connecting tube for hemodialysis, which comprises a connecting tube body, the front end of the connecting tube body is communicated with a joint, the connecting tube body comprises a substrate layer, a first functional layer and a second functional layer, and the first functional layer comprising a polydimethylsiloxane coating and a heparin coating is arranged, so that the heparin coating is coated on the first functional layer, and the heparin coating is coated on the second functional layer. Wherein the polydimethylsiloxane coating reduces the interaction between the surface and blood components through the unique non-polarity and low surface energy characteristics of the polydimethylsiloxane coating, and can significantly reduce protein adsorption and platelet adhesion, so that the risk of thrombosis is reduced, the hemodialysis effect is improved, the blood vessel health of a long-term dialysis patient is maintained, and the treatment effect is improved. The heparin coating heparin is a substance with an anticoagulation function, the coating of the heparin coating forms an interface capable of active anticoagulation on the surface of the extracorporeal circulation connecting pipe, and the heparin coating not only reduces platelet aggregation and thrombin generation by being combined with antithrombin III (ATIII) in blood.

Description

Technical Field

[0001] The utility model relates to an extracorporeal circulation connecting tube, in particular to an extracorporeal circulation connecting tube for hemodialysis, belonging to the technical field of hemodialysis. Background Art

[0002] Hemodialysis is one of the renal replacement therapies for patients with acute and chronic renal failure. It drains blood from the body to the outside of the body and passes it through a dialyzer composed of countless hollow fibers. The blood and an electrolyte solution (dialysate) containing electrolytes at concentrations similar to those in the body are exchanged inside and outside the hollow fibers through the principles of diffusion, ultrafiltration, adsorption and convection, thereby removing metabolic waste from the body, maintaining electrolyte and acid-base balance, and removing excess water from the body. The entire process of returning the purified blood is called hemodialysis.

[0003] During hemodialysis, the use of extracorporeal circulation connecting tubes is crucial because they are part of the extracorporeal blood purification system and are responsible for guiding the patient's blood out of the body, cleaning it through the dialysis machine, and then returning it to the patient. In this process, the extracorporeal circulation connecting tubes act as a bridge, allowing the blood to leave and return to the patient's body.

[0004] However, the surface affinity of existing extracorporeal circulation connecting tubes may be insufficient, making it easier for proteins and other blood cells in the blood to be adsorbed and aggregated on the surface of the connecting tube, thereby activating the blood coagulation system. In this case, blood clots may form in the connecting tube, affecting blood flow, reducing dialysis efficiency, and increasing the risk of complications such as thrombosis and embolism in patients. In addition, blood cell damage may increase, leading to vascular inflammatory reactions, increasing patient discomfort and dialysis-related complications, and in severe cases may even threaten the patient's life safety;

[0005] Therefore, an extracorporeal circulation connecting tube for hemodialysis is proposed. Utility Model Content

[0006] In view of this, the utility model provides an extracorporeal circulation connecting tube for hemodialysis to solve or alleviate the technical problems existing in the prior art and at least provide a beneficial choice.

[0007] The technical solution of the utility model is implemented as follows: it includes a connecting tube body, the front end of which is connected to a joint, the connecting tube body includes a base layer, a first functional layer and a second functional layer, the first functional layer includes a polydimethylsiloxane coating and a heparin coating, and the second functional layer includes a polyvinyl alcohol coating and a phosphatidylcholine coating.

[0008] Further preferably, the first functional layer is arranged on the inner side of the base layer, and the second functional layer is arranged on the inner side of the first functional layer.

[0009] Further preferably, the polydimethylsiloxane coating is disposed on the inner side of the base layer, and the heparin coating is disposed on the inner side of the polydimethylsiloxane coating.

[0010] Further preferably, the polyvinyl alcohol coating is disposed on the inner side of the heparin coating, and the phosphatidylcholine coating is disposed on the inner side of the polyvinyl alcohol coating.

[0011] Further preferably, the thickness of the polydimethylsiloxane coating and the heparin coating are consistent, and are both 1 μm-2 μm.

[0012] Further preferably, the thickness of the polyvinyl alcohol coating and the phosphatidylcholine coating are consistent, and are both 1 μm-3 μm.

[0013] The embodiment of the utility model has the following advantages due to the adoption of the above technical solution:

[0014] The utility model is provided with a first functional layer including a polydimethylsiloxane coating and a heparin coating, wherein the polydimethylsiloxane coating reduces the interaction between the surface and the blood components through its unique non-polar and low surface energy characteristics, can significantly reduce protein adsorption and platelet adhesion, thereby reducing the risk of thrombosis, improving the hemodialysis effect, and maintaining the vascular health of long-term dialysis patients. The heparin coating heparin is a substance with anticoagulant function, and its coating forms an interface capable of active anticoagulation on the surface of the extracorporeal circulation connecting tube, and combines with antithrombin III (ATIII) in the blood. The heparin coating not only reduces platelet aggregation and thrombin generation, but also reduces the adsorption of blood components. A second functional layer including a polyvinyl alcohol coating and a phosphatidylcholine coating is provided, wherein the polyvinyl alcohol coating provides a highly hydrophilic surface, which reduces the adsorption of proteins and platelets on the surface of the connecting tube through the formation of a hydration layer. The hydrophilic nature of the polyvinyl alcohol coating mimics the surface characteristics of the natural blood vessel wall, thereby significantly reducing the interaction between blood components and the tube wall and reducing the risk of thrombosis, which is crucial to improving the quality of dialysis. The phosphatidylcholine coating improves surface affinity by mimicking the outer layer of the cell membrane. This coating can effectively reduce the adsorption of proteins and platelets on the surface of the material. Because of its good biocompatibility and simulation of the characteristics of the natural cell membrane, it reduces immune response and blood damage. The phosphatidylcholine coating shows excellent performance in reducing thrombosis and inflammatory response, which is of significant significance for improving the safety and comfort of long-term hemodialysis patients.

[0015] The above summary is for the purpose of description only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the utility model will be readily apparent by reference to the accompanying drawings and the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 This is a front view of the main structure of the utility model;

[0018] Figure 2 This is a structural diagram of the connecting pipe body in the utility model;

[0019] Figure 3 This is the structural diagram of the first functional layer in the utility model;

[0020] Figure 4 This is a structural diagram of the second functional layer in the utility model.

[0021] Reference numerals: 1. connecting tube body; 101. base layer; 102. first functional layer; 1021. polydimethylsiloxane coating; 1022. heparin coating; 103. second functional layer; 1031. polyvinyl alcohol coating; 1032. phosphatidylcholine coating; 2. connector; DETAILED DESCRIPTION

[0022] In the following, only some exemplary embodiments are briefly described. As those skilled in the art will appreciate, the described embodiments may be modified in various ways without departing from the spirit or scope of the present invention. Therefore, the drawings and descriptions are considered to be exemplary and non-restrictive in nature.

[0023] The embodiments of the present utility model are described in detail below with reference to the accompanying drawings.

[0024] Example 1

[0025] like Figure 1-4As shown, the embodiment of the utility model provides a connecting tube body 1, the front end of the connecting tube body 1 is connected to the joint 2, the connecting tube body 1 includes a base layer 101, a first functional layer 102 and a second functional layer 103, the first functional layer 102 includes a polydimethylsiloxane coating 1021 and a heparin coating 1022, the second functional layer 103 includes a polyvinyl alcohol coating 1031 and a phosphatidylcholine coating 1032, the first functional layer 102 is arranged on the inner side of the base layer 101, the second functional layer 103 is arranged on the inner side of the first functional layer 102, and the polydimethylsiloxane coating 1021 and the heparin coating 1022 are arranged on the inner side of the first functional layer 102. The dimethylsiloxane coating 1021 is arranged on the inner side of the base layer 101, the heparin coating 1022 is arranged on the inner side of the polydimethylsiloxane coating 1021, the polyvinyl alcohol coating 1031 is arranged on the inner side of the heparin coating 1022, and the phosphatidylcholine coating 1032 is arranged on the inner side of the polyvinyl alcohol coating 1031. The thickness of the polydimethylsiloxane coating 1021 and the heparin coating 1022 is consistent, and both are 1μm-2μm, and the thickness of the polyvinyl alcohol coating 1031 and the phosphatidylcholine coating 1032 is consistent, and both are 1μm-3μm.

[0026] When the utility model is working, the first functional layer 102 including the polydimethylsiloxane coating 1021 and the heparin coating 1022 is provided, wherein the polydimethylsiloxane coating 1021 reduces the interaction between the surface and the blood components through its unique non-polarity and low surface energy characteristics, can significantly reduce protein adsorption and platelet adhesion, thereby reducing the risk of thrombosis, improving the hemodialysis effect, and maintaining the vascular health of long-term dialysis patients, and the heparin coating 1022 heparin is a substance with anticoagulant function, and its coating forms an interface capable of active anticoagulation on the surface of the extracorporeal circulation connecting tube, and binds to antithrombin III (ATIII) in the blood. In summary, the heparin coating not only reduces platelet aggregation and thrombin generation, but also reduces the adsorption of blood components. A second functional layer 103 including a polyvinyl alcohol coating 1031 and a phosphatidylcholine coating 1032 is provided, wherein the polyvinyl alcohol coating 1031 provides a highly hydrophilic surface, which reduces the adsorption of proteins and platelets on the surface of the connecting tube through the formation of a hydration layer. The hydrophilic nature of the polyvinyl alcohol coating 1031 mimics the surface characteristics of the natural blood vessel wall, thereby significantly reducing the interaction between blood components and the tube wall, reducing the risk of thrombosis, which is crucial to improving the quality of dialysis. The phosphatidylcholine coating 1032 improves surface affinity by mimicking the outer layer of the cell membrane. This coating can effectively reduce the adsorption of proteins and platelets on the surface of the material, because of its good biocompatibility and simulation of the characteristics of the natural cell membrane, reducing immune response and blood damage, and the phosphatidylcholine coating 1032 shows excellent performance in reducing thrombosis and inflammatory response, which is of great significance to improving the safety and comfort of long-term hemodialysis patients.

[0027] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any technician familiar with the technical field can easily think of various changes or substitutions within the technical scope disclosed by the utility model, which should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. An extracorporeal circulation connecting tube for hemodialysis, characterized in that: The invention comprises a connecting tube body (1), the front end of the connecting tube body (1) being connected to a joint (2), the connecting tube body (1) comprising a base layer (101), a first functional layer (102) and a second functional layer (103), the first functional layer (102) comprising a polydimethylsiloxane coating (1021) and a heparin coating (1022), and the second functional layer (103) comprising a polyvinyl alcohol coating (1031) and a phosphatidylcholine coating (1032).

2. The extracorporeal circulation connecting tube for hemodialysis according to claim 1, characterized in that: The first functional layer (102) is arranged on the inner side of the base layer (101), and the second functional layer (103) is arranged on the inner side of the first functional layer (102).

3. The extracorporeal circulation connecting tube for hemodialysis according to claim 1, characterized in that: The polydimethylsiloxane coating (1021) is disposed on the inner side of the base layer (101), and the heparin coating (1022) is disposed on the inner side of the polydimethylsiloxane coating (1021).

4. The extracorporeal circulation connecting tube for hemodialysis according to claim 1, characterized in that: The polyvinyl alcohol coating (1031) is disposed on the inner side of the heparin coating (1022), and the phosphatidylcholine coating (1032) is disposed on the inner side of the polyvinyl alcohol coating (1031).

5. The extracorporeal circulation connecting tube for hemodialysis according to claim 1, characterized in that: The thickness of the polydimethylsiloxane coating (1021) and the heparin coating (1022) are consistent, and are both 1 μm-2 μm.

6. The extracorporeal circulation connecting tube for hemodialysis according to claim 1, characterized in that: The thickness of the polyvinyl alcohol coating (1031) and the phosphatidylcholine coating (1032) are consistent, and are both 1 μm-3 μm.

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