Mouse experiment fixing device

Abstract

The utility model relates to the field of experiment devices, in particular to a mouse experiment fixing device which comprises a shell and a bottom plate, a fixing mechanism used for fixing a mouse body is arranged on the shell, one end of the shell is a closed end, and the other end of the shell is an open end. The head fixing block is opposite to the closed end, and a head groove is formed in the side face, opposite to the closed end, of the head fixing block; and a clamp avoiding hole is formed in the side wall of the head fixing block. By means of the scheme, in the ear vagus nerve stimulation experiment, the head of a mouse is fixed, and electric stimulation can be conveniently conducted on the ears of the mouse.

Description

Technical Field

[0001] The utility model relates to the field of experimental devices, in particular to a mouse experimental fixing device. Background Art

[0002] Auricular vagus nerve stimulation is a technique used in mouse experiments. In the experiment, researchers use a clip connected to a wire to clamp the mouse's ear to electrically stimulate the auricular vagus nerve. By stimulating the auricular vagus nerve, researchers can explore its effects on cardiovascular function, respiratory control, etc., and gain deeper knowledge of physiology and pathophysiology.

[0003] When conducting experiments on mice, a fixing device is needed to fix the mice. However, the current fixing device can only fix the body of the mouse (mainly the back and abdomen of the body), but cannot fix the head of the mouse. However, since the clip is clamped on the mouse's ear, the mouse's head will still shake left and right, making it easy for the clip to fall off the ear, affecting the stability of the clip's clamping of the ear and affecting the progress of the experiment. Utility Model Content

[0004] The utility model aims to provide a mouse experiment fixing device, which is used to fix the mouse head in an ear vagus nerve stimulation experiment.

[0005] To achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a mouse experimental fixing device, comprising a shell and a bottom plate, the shell is provided with a fixing mechanism for fixing the mouse body, one end of the shell is a closed end, and the other end of the shell is an open end;

[0006] It also includes a head fixing block, which is opposite to the closed end and has a head groove on the side of the head fixing block relative to the closed end; a clip avoidance hole connected to the head groove is provided on the side wall of the head fixing block.

[0007] The principle and advantage of this scheme are: when conducting an ear vagus nerve stimulation experiment on mice, the mice are placed between the shell and the bottom plate, and then the body of the mice is pressed against the bottom plate using a fixing mechanism, so that the body of the mice does not move, thereby achieving fixation of the body of the mice. At the same time, the head of the mouse is inserted into the head groove of the head fixing block, so that the head fixing block limits the head of the mouse, and the head of the mouse cannot shake left and right, so that the clip is clamped on the ear of the mouse more stably, and the normal conduct of the experiment can be ensured. The setting of the clip avoidance hole can prevent the head fixing block from obstructing the clip from clamping on the ear, and can make the mouse's ears exposed without being blocked by the head fixing block, thereby facilitating the clip to be clamped on the ear.

[0008] When conducting experiments on mice, the mouse's head is against the head fixing block, and the mouse's tail is against the closed end, so that the mouse is caught in a dilemma, thereby achieving stable fixation of the mouse.

[0009] Preferably, as an improvement, the distance between the head fixing block and the closed end is adjustable.

[0010] When testing a mouse, the tail of the mouse is against the closed end, and the head of the mouse enters the head slot, so the distance between the head fixing block and the closed end is the length of the mouse. In this solution, by adjusting the distance between the head fixing block and the closed end, it is suitable for fixing and testing mice of different lengths, thereby improving the applicability of the device.

[0011] Preferably, as an improvement, a slide plate is transversely slidably connected to the bottom plate, and the head fixing block is fixedly located on the slide plate.

[0012] Therefore, by sliding the slide plate, the slide plate moves relative to the bottom plate, thereby realizing the movement of the head fixing block and the adjustment of the distance between the head fixing block and the closed end.

[0013] Preferably, as an improvement, a transverse plate groove is provided on the bottom plate, the end of the bottom plate away from the closed end is an opening of the plate groove, the slide plate is laterally inserted into the plate groove from the opening of the plate groove, a strip groove connected to the plate groove is provided on the top of the bottom plate, a connecting block is fixedly connected between the bottom of the head fixing block and the top of the slide plate, there is a gap between the bottom of the head fixing block and the top of the slide plate, and the connecting block is slidably located in the strip groove.

[0014] Therefore, in this solution, the skateboard slides in the board groove, and the skateboard is not slidably located on the top of the bottom plate, so that the mouse is still located on the top of the bottom plate. When the skateboard slides, the mouse will not directly contact the skateboard, and the mouse will not hinder the movement of the skateboard. At the same time, the sliding of the skateboard will not affect the mouse.

[0015] The strip groove is used to allow the connection block to pass through, so that the connection between the head fixing block and the top of the slide plate is realized. When the slide plate moves, the connection block moves in the strip groove, and the slide plate drives the head fixing block to move through the connection block. The gap between the bottom of the head fixing block and the slide plate is used to accommodate and avoid the top of the bottom plate. When the slide plate slides into the plate groove, the top of the bottom plate is located between the head fixing block and the slide plate.

[0016] Preferably, as an improvement, a locking mechanism is connected between the bottom plate and the slide plate. Thus, the bottom plate and the slide plate are locked by the locking mechanism, so that when conducting an experiment, the slide plate will not move away from the closed end to release the fixation of the mouse head, thereby ensuring the stability of the head fixation block on the mouse head.

[0017] Preferably, as an improvement, the locking mechanism includes a locking rod located on the base plate and a plurality of locking holes located on the slide plate, the plurality of locking holes are distributed laterally along the sliding direction of the slide plate, and the locking rod is inserted into the locking holes.

[0018] Thus, the base plate and the slide plate are fixed by inserting the locking rod into the locking hole. Since the slide plate can slide laterally on the base plate, multiple locking holes are provided. When the slide plate slides to different positions, there can be corresponding locking holes facing the locking rod, so that the locking rod can be inserted into the corresponding locking hole, thereby locking the slide plate.

[0019] Preferably, as an improvement, the locking mechanism includes a locking tooth, a plurality of one-way teeth are provided on the surface of the skateboard, the plurality of one-way teeth are laterally distributed along the sliding direction of the skateboard, the locking tooth and the one-way teeth cooperate, and a pressing member is connected to the locking tooth for pressing the locking tooth against the one-way teeth; the inclined surface of the locking tooth slidably cooperates with the inclined surface of the one-way tooth, and the plane of the locking tooth is pressed against the plane of the one-way tooth.

[0020] Therefore, by using the locking mechanism in this solution, the slide plate is pushed toward the closed end, the inclined surface of the one-way tooth and the inclined surface of the locking tooth slide relative to each other, the one-way tooth repeatedly presses the pressing member, the one-way tooth can automatically retreat, and the one-way tooth and the locking tooth will not be locked. When the slide plate moves away from the closed end, the plane of the locking tooth and the plane of the one-way tooth abut against each other, and the locking tooth and the one-way tooth are locked, and the slide plate cannot move away from the closed end, thereby preventing the head fixing block from automatically moving away from the closed end and releasing the fixation of the mouse head.

[0021] Preferably, as an improvement, a notch is provided at the open end of the shell. The notch provides a sufficiently large operating space when the clip is clamped on the mouse ear, thereby reducing the obstruction of the shell to the operation.

[0022] Preferably, as an improvement, the closed end of the shell is movably connected to a door, a rat-tail hole is provided on the door, a limiting member is provided between the door and the end of the bottom plate, and the limiting member is laterally slidably connected to the end of the bottom plate.

[0023] Thus, the mouse tail hole is used to extend the mouse tail, making it easier for the clamp or electric needle to contact the tail, thereby forming a closed current loop.

[0024] The limiter is used to limit the position of the door to prevent it from opening. When the mouse is detected, the limiter is slid, and the limiter no longer limits the door. At this time, the door can be opened, so that the mouse can be quickly released, and the operation is faster.

[0025] Preferably, as an improvement, the housing is provided with data lines and detection lines. Thus, the housing is provided with relevant data lines and detection lines, so that it is convenient to electrically stimulate the mouse, and no additional data lines and detection lines need to be prepared during the experiment, which is simple and convenient to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a three-dimensional diagram of a mouse experimental fixture, mainly showing the open end.

[0027] Figure 2 It is a three-dimensional diagram of a mouse experimental fixation device, mainly illustrating the closed end.

[0028] Figure 3 It is a top view of the locking mechanism (one-way tooth and locking tooth method). DETAILED DESCRIPTION

[0029] The following is further described in detail through specific implementation methods:

[0030] The figure marks in the drawings of the specification include: shell 1, base plate 2, operating handle 3, slide plate 4, lock hole 5, head fixing block 6, connecting block 7, pull rod 8, fixed compression spring 9, arc pressure plate 10, notch 11, clip avoidance hole 12, strip groove 13, data line 14, tail detection line 15, ear detection line 16, rotating part 17, rat tail hole 18, limit piece 19, slide groove 20, positioning block 21, one-way tooth 22, compression spring 23.

[0031] The embodiment is basically as shown in the attached Figure 1-Figure 2 As shown: A mouse experiment fixing device includes a shell 1 and a bottom plate 2. The shell 1 is arc-shaped. The bottom of the shell 1 is fixedly connected to the bottom plate 2. The fixing method can be bolts or screws. The shell 1 is provided with a fixing mechanism for fixing the mouse body. The fixing mechanism includes an arc-shaped pressure plate 10, a fixed compression spring 9 and a pull rod 8. The top of the pull rod 8 is fixedly connected to the top of the arc-shaped pressure plate 10 (for example, bonding, screw connection, etc.). The top of the shell 1 is provided with a pull rod hole. The pull rod 8 passes vertically through the pull rod hole. The two ends of the fixed compression spring 9 are respectively welded or clamped on the shell 1 and the arc-shaped pressure plate 10. In this way, the mouse is placed in the shell 1, and the arc-shaped pressure plate 10 presses the body of the mouse on the bottom plate 2 under the action of the fixed compression spring 9, thereby achieving the fixation of the mouse. By pulling the pull rod 8 upward, the pull rod 8 drives the arc-shaped pressing plate 10 to move upward, and the arc-shaped pressing plate 10 presses the fixed compression spring 9 upward, and the distance between the arc-shaped pressing plate 10 and the bottom plate 2 becomes larger, thereby releasing the fixation of the mouse body.

[0032] Of course, in other embodiments, the fixing mechanism may also adopt other forms. For example, the pull rod 8 is replaced by a vertical threaded adjustment column, the threaded adjustment column and the shell 1 are threadedly connected, and the bottom end of the threaded adjustment column is rotatably connected to the arc pressure plate 10. By rotating the threaded adjustment column, the vertical movement of the arc pressure plate 10 is achieved.

[0033] In this embodiment, the left end of the housing 1 is a closed end, and the right end of the housing 1 is an open end. The specific closing method of the closed end is: Figure 2 As shown, the left end of the housing 1 is rotatably connected to a warehouse door through a rotating part 17 (the rotating part 17 can be a rotating shaft or a hinge). The shape of the warehouse door is semicircular, and the rotating part 17 is located between the top of the warehouse door and the top of the left end of the housing 1. A mouse tail hole 18 is provided on the bottom of the warehouse door, so that the mouse tail can pass through. A limiter 19 is provided between the warehouse door and the end of the bottom plate 2, and the limiter 19 is slidably connected to the end of the bottom plate 2 horizontally. The limiter 19 in this embodiment is an L-shaped rod, and a T-shaped slide groove 20 is provided at the left end of the bottom plate 2. One end of the limiter 19 is adapted to the T-shaped shape of the slide groove 20 and is slidably located in the slide groove 20 horizontally. In this way, the limiter 19 is slid toward the mouse tail hole 18, and the limiter 19 blocks the bottom of the warehouse door, and the warehouse door cannot be opened. By sliding the limiter 19 away from the mouse tail hole 18, the limiter 19 is separated from the bottom of the warehouse door, so that the bottom of the warehouse door is no longer limited, and the warehouse door can be flipped upward and opened.

[0034] Combination Figure 1 As shown, the fixing device of this embodiment also includes a head fixing block 6, which is opposite to the closed end, and a head groove for accommodating the mouse head is provided on the side of the head fixing block 6 relative to the closed end; a clip avoidance hole 12 is provided on the side wall of the head fixing block 6, and the clip avoidance hole 12 is connected to the head groove.

[0035] The distance between the head fixing block 6 and the closed end is adjustable. Specifically, a transverse plate groove is provided inside the bottom plate 2, and the right end of the bottom plate 2 is the opening of the plate groove. A slide plate 4 is inserted into the plate groove, and the slide plate 4 can slide transversely in the plate groove. A strip groove 13 is provided on the top of the bottom plate 2, and the strip groove 13 is connected to the plate groove. The head fixing block 6 is located on the bottom plate 2, and a connecting block 7 vertically passing through the strip groove 13 is fixedly connected between the bottom of the head fixing block 6 and the top of the slide plate 4. There is a gap between the bottom of the head fixing block 6 and the top of the slide plate 4, and the gap is used for the top of the bottom plate 2 to pass transversely, so that when the head fixing block 6 moves transversely, the head fixing block 6 and the top of the bottom plate 2 will not interfere with each other.

[0036] A locking mechanism is connected between the bottom plate 2 and the slide plate 4. The locking mechanism includes a locking rod located on the side of the bottom plate 2 and a plurality of locking holes 5 located on the side of the slide plate 4. The plurality of locking holes 5 are distributed laterally along the sliding direction of the slide plate 4. An operating handle 3 is connected to the end of the locking rod. The locking rod passes through the side of the bottom plate 2 and is inserted into the locking hole 5. In this way, the slide plate 4 and the bottom plate 2 are locked by inserting the locking rod into the locking hole 5, and the slide plate 4 will not slide freely.

[0037] In addition, in order to facilitate operation, a notch 11 is provided at the open end of the shell 1. The notch 11 provides an operating space for clamping the mouse ear.

[0038] Thus, when conducting an ear vagus nerve stimulation experiment on mice, the limiter 19 is slid to both sides of the bottom plate 2, and the limiter 19 does not limit the door, then the door is turned upward, the left closed end of the housing 1 is opened, and the pull rod 8 is pulled upward at the same time, and the pull rod 8 drives the arc-shaped pressing plate 10 to move upward, and the mouse is placed between the arc-shaped pressing plate 10 and the bottom plate 2, and the pull rod 8 is released. The arc-shaped pressing plate 10 moves downward under the action of the fixed compression spring 9 and presses the mouse on the bottom plate 2, so that the body of the mouse does not move, and the body of the mouse is fixed. Then, the door is closed, and the two limiters 19 are brought close to each other, and the limiters 19 limit the door, and the door cannot be opened. The door is against the tail of the mouse. In order to improve the comfort of the arc-shaped pressing plate pressing on the mouse, a flexible layer, such as a rubber layer, can be bonded to one side of the bottom of the arc-shaped pressing plate.

[0039] Then the slide plate 4 is slid into the plate groove, and the slide plate 4 drives the head fixing block 6 to move toward the warehouse door through the connecting block 7, so that the mouse's head is inserted into the head groove of the head fixing block 6. In this way, the head fixing block 6 limits the mouse's head, and the mouse's head cannot shake left and right. The mouse's head is against the head fixing block 6, and at the same time, the mouse's tail is against the warehouse door. In this way, the mouse's tail and head are both limited, and the mouse is in a dilemma, so that the mouse is fixed more stably.

[0040] After the mouse head is fixed, the locking rod is inserted into the corresponding locking hole 5, the bottom plate 2 and the slide plate 4 are fixed, and the slide plate 4 does not slide freely. Then the mouse is tested. During the test, two clips are used to clamp the two ears of the mouse through the clip avoidance hole 12, and then another clip is used to clamp the tail extending from the mouse tail hole 18, or an electric needle is used to pierce the tail of the mouse. The clip or electric needle in this embodiment is transmitted to the detection instrument through the detection line and the data line, thereby realizing the detection.

[0041] After the test is completed, the clamp is removed or the electric needle is removed, and then the door is opened, and the pull rod 8 is pulled upward, so that the arc-shaped pressing plate 10 no longer presses the body of the mouse, and the mouse can be released.

[0042] Of course, in other embodiments, the data line 14 (the data line 14 is used to transmit the detection data to the detection instrument) and the detection line (the detection line is used to directly stimulate and detect the mouse) can be directly fixed (for example, by bonding or by snapping) on ​​the shell 1, and the detection line is divided into an ear detection line 16 (the end of the ear detection line 16 is electrically connected to a clip, which is not shown in the figure, and is used to stimulate and detect the ear) and a tail detection line 15 (the end of the tail detection line 15 is electrically connected to a clip or an electric needle, which is not shown in the figure, and is used to stimulate and detect the tail). The detection line and the data line 14 are electrically connected. In this way, when detecting the mouse, there is no need to additionally look for the detection line and the data line 14, and the data line 14 and the detection line provided on the shell 1 can be directly used.

[0043] This embodiment uses a locking rod and a locking hole 5 to achieve the locking of the slide plate 4 and the base plate 2. Of course, in other embodiments, the locking mechanism can also be other structures, such as Figure 3 As shown, the locking mechanism includes a locking tooth, a one-way tooth 22, a compression spring 23 and a positioning block 21. The positioning block 21 is fixed (by screws or welding, or integral connection) on the side of the base plate 2. The locking tooth passes through the positioning block 21 and the side of the base plate 2 transversely. The end of the locking tooth is fixed with an operating handle 3. The compression spring 23 is connected between the operating handle 3 and the positioning block 21. The locking tooth is provided with an inclined surface, which faces the opening of the plate slot. There are multiple one-way teeth 22, which are arranged and fixed on the side surface of the slide plate 4. The inclined surface of the one-way tooth 22 faces the bottom of the plate slot. The inclined surface of the locking tooth and the inclined surface of the one-way tooth 22 are slidably matched, and the plane of the locking tooth and the plane of the one-way tooth 22 are pressed tightly.

[0044] Thus, the slide plate 4 is pushed into the plate groove, the inclined surface of the one-way tooth 22 and the inclined surface of the lock tooth slide relative to each other, and the one-way tooth 22 continuously and repeatedly squeezes the compression spring 23, and the one-way tooth 22 can automatically retreat, and the one-way tooth 22 and the lock tooth will not be locked, so that the slide plate 4 can slide into the plate groove. When the slide plate 4 moves away from the closed end direction, the plane of the lock tooth and the plane of the one-way tooth 22 are against each other, then the lock tooth and the one-way tooth 22 are locked, and the slide plate 4 cannot move away from the closed end direction, thereby avoiding the head fixing block 6 to automatically move away from the closed end direction and release the fixation of the mouse head. When it is necessary to move the slide plate 4 away from the closed end direction, pull the operating handle 3, the operating handle 3 drives the lock tooth to move to the left, and the lock tooth is separated from the one-way tooth 22, and now the one-way tooth 22 and the lock tooth no longer restrict each other, and the slide plate 4 can be pulled out from the plate groove.

[0045] In addition, a friction device (such as a rubber pad with friction patterns) is provided at the bottom of the base plate 2 to increase the friction between the device and the desktop, or a suction cup is added to the bottom of the base plate 2 to fix the device on the desktop to prevent the device from sliding on the desktop.

[0046] The material and size of the fixing device in this embodiment can be set and changed according to actual conditions, and will not be described in detail here.

[0047] The above is only an embodiment of the utility model, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the utility model, several deformations and improvements can be made, which should also be regarded as the protection scope of the utility model, and these will not affect the effect of the implementation of the utility model and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A mouse experimental fixing device, comprising a shell and a bottom plate, wherein the shell is provided with a fixing mechanism for fixing the mouse body, and one end of the shell is a closed end, characterized in that: The other end of the shell is an open end; It also includes a head fixing block, which is opposite to the closed end and has a head groove on the side of the head fixing block relative to the closed end; a clip avoidance hole connected to the head groove is provided on the side wall of the head fixing block.

2. A mouse experimental fixing device according to claim 1, characterized in that: The distance between the head fixing block and the closed end is adjustable.

3. A mouse experimental fixing device according to claim 2, characterized in that: A slide plate is slidably connected to the bottom plate in a transverse direction, and the head fixing block is fixed on the slide plate.

4. A mouse experimental fixing device according to claim 3, characterized in that: The bottom plate is provided with a transverse plate groove, and the end of the bottom plate away from the closed end is the opening of the plate groove. The slide plate is transversely inserted into the plate groove from the opening of the plate groove. The top of the bottom plate is provided with a strip groove connected to the plate groove. A connecting block is fixedly connected between the bottom of the head fixing block and the top of the slide plate. There is a gap between the bottom of the head fixing block and the top of the slide plate, and the connecting block is slidably located in the strip groove.

5. A mouse experiment fixing device according to claim 3, characterized in that: A locking mechanism is connected between the bottom plate and the slide plate.

6. A mouse experiment fixing device according to claim 5, characterized in that: The locking mechanism comprises a locking rod located on the bottom plate and a plurality of locking holes located on the slide plate. The plurality of locking holes are distributed laterally along the sliding direction of the slide plate, and the locking rod is inserted into the locking holes.

7. A mouse experiment fixing device according to claim 5, characterized in that: The locking mechanism includes a locking tooth. A plurality of one-way teeth are arranged on the surface of the skateboard. The plurality of one-way teeth are laterally distributed along the sliding direction of the skateboard. The locking tooth cooperates with the one-way teeth. A pressing member is connected to the locking tooth for pressing the locking tooth against the one-way teeth. The inclined surface of the locking tooth cooperates with the inclined surface of the one-way teeth in a sliding manner, and the plane of the locking tooth is pressed against the plane of the one-way teeth.

8. A mouse experiment fixing device according to claim 1, characterized in that: The open end of the shell is provided with a notch.

9. A mouse experiment fixing device according to claim 1, characterized in that: The closed end of the shell is movably connected with a warehouse door, a rat-tail hole is arranged on the warehouse door, a limiting piece is arranged between the warehouse door and the end of the bottom plate, and the limiting piece is laterally slidably connected to the end of the bottom plate.

10. A mouse experiment fixing device according to claim 1, characterized in that: The housing is provided with a data line and a detection line.

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