Dapagliflozin preparation reaction device with plugging structure

Abstract

The utility model discloses a dapagliflozin preparation reaction device with a plugging structure, which comprises a dapagliflozin preparation reaction kettle, a motor is mounted at the top end of the dapagliflozin preparation reaction kettle, a feeding pipe is mounted on one side of the top end of the dapagliflozin preparation reaction kettle, a mounting seat is mounted in the feeding pipe, and a sealing ring is mounted on the mounting seat. Containing grooves are formed in the two sides of the interior of the mounting base correspondingly, and positioning rods are mounted in the containing grooves correspondingly. According to the dapagliflozin preparation reaction kettle disclosed by the utility model, the anti-scour cover and the diversion pipe are arranged, so that the anti-scour cover can resist and weaken the impact force of most liquid medicine when the liquid medicine in the inner cavity of the dapagliflozin preparation reaction kettle violently reacts to generate material flushing, and meanwhile, the liquid medicine is extruded from the diversion pipe and enters the transition box through the diversion pipe, so that the diversion and pressure relief effects are realized; the safety during use is improved, the control valve can be opened after stabilization, and the dapagliflozin enters the dapagliflozin preparation reaction kettle again through the return pipe for use.

Description

Technical Field

[0001] The utility model relates to the technical field of dapagliflozin preparation, and in particular to a reaction device for preparing dapagliflozin provided with a blocking structure. Background Art

[0002] The chemical name of dapagliflozin (ForxigaTM) is (2S, 3R, 4R, 5S, 6R)-2-[3-(4-ethoxyphenyl)-4-chlorophenyl]-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol. In the preparation process of dapagliflozin, a reaction kettle is required to mix the drug solution;

[0003] Chinese patent authorization announcement number CN 213590462 U discloses a reaction device for preparing dapagliflozin with a protective function, including a reactor; a motor is fixedly installed in the middle of the top of the reactor, a rotating shaft is vertically rotated in the middle of the motor, a feed pipe is welded through the right side of the top of the reactor, a feed hopper is fixedly welded in the middle of the inner cavity of the feed pipe, a limit slide rod is vertically fixedly welded on the top of the feed hopper, a limit plate, a blocking plate and a slip ring are arranged in the inner cavity of the feed pipe, and the limit slide rod slides vertically through the edge of the limit plate. In the actual use of the utility model, the violent reaction of the liquid medicine that causes the material to impact the feed ring, the slip ring and the fixed column, and the fixed column drives the blocking plate to block the bottom of the feed hopper, thereby effectively preventing the liquid medicine that causes the material to be impacted from being sprayed out through the inner cavity of the feed pipe, and avoiding the damage to personnel caused by the violent reaction of the liquid medicine in the inner cavity of the reactor. The above-mentioned existing technical solution has the following shortcomings: the technical solution blocks the bottom of the feed hopper to prevent the liquid medicine from being sprayed out through the inner cavity of the feed pipe. However, when the impact force of the liquid medicine is large during use, it is easy to cause a high pressure inside the reactor. If partial pressure relief operation cannot be performed, it is easy to cause certain safety hazards, and there is room for improvement. Utility Model Content

[0004] The utility model aims to provide a reaction device for preparing dapagliflozin with a blocking structure to solve the problem of inconvenience in pressure relief during drug solution flushing proposed in the above background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a reaction device for preparing dapagliflozin with a blocking structure, comprising a dapagliflozin preparation reactor, a motor is installed at the top of the dapagliflozin preparation reactor, a feed pipe is installed on one side of the top of the dapagliflozin preparation reactor, and a mounting seat is installed inside the feed pipe, both sides of the mounting seat are provided with receiving grooves, and positioning rods are installed inside the receiving grooves, springs are installed on the outside of the positioning rods, a baffle is installed on the top of the positioning rod, and a connecting rod is installed at the bottom end of the baffle, a pull ring is installed on the top of the baffle, and an anti-impact cover is installed at the bottom end of the connecting rod, a shunt pipe is installed at the bottom end of the outer side of the feed pipe, and a guide pipe is installed at one end of the shunt pipe, a transition box is installed on one side of the dapagliflozin preparation reactor, and the top of the transition box is connected to the bottom end of the guide pipe.

[0006] When a reaction device for preparing dapagliflozin provided with a blocking structure according to the technical solution is used, the impact force of most of the drug solution is resisted and weakened by the anti-impact cover, and the shunt pipe is used to achieve the shunt pressure relief effect, thereby improving the safety during use.

[0007] Preferably, a sealing cover is installed on the outer side of the feed pipe, and the outer side of the sealing cover is evenly provided with anti-slip patterns.

[0008] Preferably, a thread groove is provided on the inner side of the sealing cover, and a connecting thread is installed on the outer side of the feed pipe.

[0009] Preferably, the cross-section of the impact shield is set to be trapezoidal, and the interior of the impact shield is a hollow structure.

[0010] Preferably, the cross-section of the positioning rod is T-shaped, and the positioning rod is symmetrically arranged with respect to the central axis of the mounting seat.

[0011] Preferably, a return pipe is installed on the inner side of the transition box, and the return pipe is connected to the motor, and a control valve is installed on the outer side of the return pipe.

[0012] Preferably, a fixing bracket is installed on the inner side of the transition box, and the inner side of the fixing bracket is connected to the motor.

[0013] Compared with the prior art, the utility model has the following beneficial effects: the reaction device for preparing dapagliflozin provided with a blocking structure is convenient for pressure relief protection;

[0014] By providing an anti-impact cover and a diverter pipe, when the drug liquid in the inner cavity of the dapagliflozin preparation reactor reacts violently and causes material impact, the anti-impact cover resists and weakens the impact force of most of the drug liquid. At the same time, the drug liquid is squeezed out of the diverter pipe and enters the transition box through the guide pipe to achieve diversion and pressure relief, thereby improving safety during use. After stabilization, the control valve can be opened and the drug liquid can re-enter the dapagliflozin preparation reactor through the reflux pipe for use.

[0015] By pulling the pull ring to drive the positioning rod to move in the accommodating groove, the positioning rod drives the spring to expand and contract to separate the baffle from the mounting seat, and the medicine liquid can be poured in. When material rushing occurs, release the pull ring to reset the baffle and fit the mounting seat, and the baffle can be pressed against to achieve a blocking effect, thereby preventing the medicine liquid from rushing out and improving safety of use. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 This is a front view structural schematic diagram of the utility model;

[0018] Figure 2 This is a schematic diagram of the front cross-sectional structure of the feed pipe of the utility model;

[0019] Figure 3 This is a schematic diagram of the cross-sectional structure of the feed pipe of the utility model from top view;

[0020] Figure 4 It is a schematic diagram of the three-dimensional structure of the anti-collision cover of the utility model;

[0021] Figure 5 It is a schematic diagram of the three-dimensional structure of the feed pipe of the utility model.

[0022] Explanation of the reference numerals in the figure: 1. Motor; 2. Dapagliflozin preparation reactor; 3. Transition box; 4. Reflux pipe; 5. Control valve; 6. Fixed bracket; 7. Guide pipe; 8. Feed pipe; 9. Sealing cover; 10. Mounting seat; 11. Positioning rod; 12. Diverter pipe; 13. Anti-impact cover; 14. Connecting rod; 15. Spring; 16. Receiving groove; 17. Threaded groove; 18. Connecting thread; 19. Baffle; 20. Pull ring. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-Figure 5 The utility model provides an embodiment: a reaction device for preparing dapagliflozin provided with a blocking structure, comprising a dapagliflozin preparation reactor 2, a motor 1 is installed at the top of the dapagliflozin preparation reactor 2, and a feed pipe 8 is installed at one side of the top of the dapagliflozin preparation reactor 2;

[0025] A sealing cover 9 is installed on the outside of the feed pipe 8, and the outside of the sealing cover 9 is evenly provided with anti-slip patterns, a thread groove 17 is provided on the inside of the sealing cover 9, and a connecting thread 18 is installed on the outside of the feed pipe 8;

[0026] Specifically, Figure 2 As shown, when in use, the sealing cover 9 can be connected to the feed pipe 8 through the connection of the thread groove 17 and the connecting thread 18 to improve the overall sealing performance, and the anti-slip pattern can prevent the hand from slipping;

[0027] A mounting seat 10 is installed inside the feed pipe 8, and receiving grooves 16 are provided on both sides of the mounting seat 10, and positioning rods 11 are installed inside the receiving grooves 16;

[0028] The cross-section of the positioning rod 11 is T-shaped, and the positioning rod 11 is symmetrically arranged with respect to the central axis of the mounting seat 10;

[0029] Specifically, Figure 2 As shown, when in use, the T-shaped cross-section of the positioning rod 11 can play a role in limiting the positioning rod 11;

[0030] The outer side of the positioning rod 11 is equipped with a spring 15, the top of the positioning rod 11 is equipped with a baffle 19, the bottom of the baffle 19 is equipped with a connecting rod 14, the top of the baffle 19 is equipped with a pull ring 20, and the bottom of the connecting rod 14 is equipped with an anti-collision cover 13;

[0031] The cross section of the anti-impact shield 13 is set to be trapezoidal, and the interior of the anti-impact shield 13 is a hollow structure;

[0032] Specifically, Figure 2 As shown, when in use, the cross-section of the anti-impact cover 13 is set to be trapezoidal, and the interior of the anti-impact cover 13 is a hollow structure, which can resist and weaken the impact force of most of the liquid medicine;

[0033] A shunt pipe 12 is installed at the bottom end of the outer side of the feed pipe 8, and a flow guide pipe 7 is installed at one end of the shunt pipe 12. A transition box 3 is installed on one side of the dapagliflozin preparation reactor 2;

[0034] A return pipe 4 is installed inside the transition box 3, and the return pipe 4 is connected to the motor 1, and a control valve 5 is installed outside the return pipe 4;

[0035] Specifically, Figure 1As shown, when in use, the control valve 5 is opened and the reflux pipe 4 re-enters the dapagliflozin preparation reactor 2 for use;

[0036] A fixing frame 6 is installed on the inner side of the transition box 3, and the inner side of the fixing frame 6 is connected to the motor 1;

[0037] Specifically, Figure 1 As shown, when in use, the transition box 3 can be fixedly supported by the fixing frame 6;

[0038] And the top end of the transition box 3 is connected to the bottom end of the flow guide pipe 7 .

[0039] Working principle: When preparing dapagliflozin, the utility model pulls the pull ring 20 to drive the positioning rod 11 to move in the receiving groove 16, and the positioning rod 11 drives the spring 15 to expand and contract to separate the baffle 19 from the mounting seat 10, and the medicine liquid can be poured in. When material rushing occurs, the pull ring 20 is released to reset the baffle 19 to fit the mounting seat 10, and the baffle 19 can be pressed to achieve a blocking effect to prevent the medicine liquid from rushing out. At the same time, the anti-rush cover 13 resists and weakens the impact force of most of the medicine liquid. The medicine liquid is squeezed out of the shunt pipe 12 and enters the transition box 3 through the guide pipe 7 to achieve a shunt pressure relief effect, thereby improving safety during use. After stabilization, the control valve 5 can be opened and the medicine can re-enter the dapagliflozin preparation reactor 2 through the reflux pipe 4 for use.

[0040] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0041] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Ordinary technicians in this field can understand and implement it without paying creative labor.

[0042] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A reaction device for preparing dapagliflozin provided with a blocking structure, comprising a dapagliflozin preparation reaction kettle (2), characterized in that: A motor (1) is installed at the top of the dapagliflozin preparation reactor (2), a feed pipe (8) is installed at one side of the top of the dapagliflozin preparation reactor (2), and a mounting seat (10) is installed inside the feed pipe (8), both sides of the mounting seat (10) are provided with a receiving groove (16), and a positioning rod (11) is installed inside the receiving groove (16), a spring (15) is installed on the outside of the positioning rod (11), and a baffle is installed at the top of the positioning rod (11). (19), and a connecting rod (14) is installed at the bottom end of the baffle (19), a pull ring (20) is installed at the top end of the baffle (19), an anti-impact cover (13) is installed at the bottom end of the connecting rod (14), a shunt pipe (12) is installed at the bottom end of the outer side of the feed pipe (8), and a guide pipe (7) is installed at one end of the shunt pipe (12), and a transition box (3) is installed on one side of the dapagliflozin preparation reactor (2), and the top end of the transition box (3) is connected to the bottom end of the guide pipe (7).

2. A reaction device for preparing dapagliflozin with a blocking structure according to claim 1, characterized in that: A sealing cover (9) is installed on the outer side of the feed pipe (8), and anti-slip patterns are evenly arranged on the outer side of the sealing cover (9).

3. A reaction device for preparing dapagliflozin with a blocking structure according to claim 2, characterized in that: The inner side of the sealing cover (9) is provided with a thread groove (17), and the outer side of the feed pipe (8) is provided with a connecting thread (18).

4. A reaction device for preparing dapagliflozin with a blocking structure according to claim 1, characterized in that: The cross-section of the impact shield (13) is arranged to be trapezoidal, and the interior of the impact shield (13) is a hollow structure.

5. The reaction device for preparing dapagliflozin with a blocking structure according to claim 1, characterized in that: The cross-section of the positioning rod (11) is T-shaped, and the positioning rod (11) is symmetrically arranged with respect to the central axis of the mounting seat (10).

6. The reaction device for preparing dapagliflozin with a blocking structure according to claim 1, characterized in that: A return pipe (4) is installed on the inner side of the transition box (3), and the return pipe (4) is connected to the motor (1). A control valve (5) is installed on the outer side of the return pipe (4).

7. The reaction device for preparing dapagliflozin with a blocking structure according to claim 1, characterized in that: A fixing frame (6) is installed on the inner side of the transition box (3), and the inner side of the fixing frame (6) is connected to the motor (1).

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