Low-temperature trapezoidal antibody reagent storage device

Abstract

The utility model discloses a low-temperature trapezoidal antibody reagent storage device, which relates to a reagent shelf and comprises a reagent shelf internally provided with a plurality of rows of storage cabins arranged in a stepped manner, the base is clamped at the bottom opening of the reagent shelf and is used for sealing the opening; an evaporation guide pipe and a semiconductor chilling plate of which the cold surface is in contact with the evaporation guide pipe are arranged on the base; the connecting part is detachably arranged on the end face of the reagent shelf, and an upper cover is arranged in the connecting part in a sliding manner. The low-temperature trapezoidal antibody reagent storage device is simple in structure and convenient and fast to operate, low-temperature and constant-temperature storage and timing of stored antibody reagents can be achieved, the whole device adopts a detachable design, and the follow-up reagent shelf disinfection requirement is greatly met.

Description

Technical Field

[0001] The utility model relates to a reagent rack, in particular to a low-temperature ladder-shaped antibody reagent storage device. Background Art

[0002] Antibodies are a type of immunoglobulin that can specifically bind to antigens and are widely used in the diagnosis and treatment of diseases. With the development of medicine, precision diagnosis and treatment are increasingly needed by doctors and patients in clinical practice, and precise diagnosis and treatment are inseparable from accurate pathological diagnosis. Pathological diagnosis has always been called the doctor's doctor, which is enough to illustrate the importance of pathological diagnosis, especially in the differentiation of benign and malignant tumors, prognosis indications, and targeted medication guidance. Immunohistochemical staining technology is one of the prerequisites for supporting accurate pathological diagnosis, and the accuracy of its results directly affects the accuracy of pathological diagnosis. The core of immunohistochemical staining technology is antibodies. The quality of antibodies directly affects the accuracy of test results, because erroneous results caused by the decline in antibody quality (decreased titer) during use also occur from time to time in the pathology department.

[0003] Antibody reagents are prepared through hybridoma technology, recombinant DNA or protein engineering. Because they are immunoglobulins, they have certain requirements for storage temperature. Due to the complex production process, the price of antibodies is relatively high, ranging from several hundred to several thousand yuan. In work, it is often the case that the antibody titer decreases due to the inability to maintain a relatively constant storage temperature during use, especially for some antibodies with relatively low stability. Antibodies with decreased titer are usually discarded by clinicians and replaced with new antibodies. This situation leads to a large waste of clinical resources.

[0004] How to make antibodies retain their potency longer during frequent use, so as to ensure the accuracy of the results, is a problem we need to solve. The low-temperature ladder-shaped antibody storage device will provide clinical workers with a relatively stable temporary storage space for antibodies, which largely solves the problem of antibody titer decline caused by unstable laboratory antibody storage temperature, thereby increasing the storage time of antibodies.

[0005] At present, most of the reagent racks sold on the market have several rows of holes for storing reagents. Reagents are placed in multiple rows on one layer, which is not conducive to the search of reagents in clinical work. To solve this problem, I designed the reagent rack as a single-layer trapezoid, with a height difference on each layer, and the diameter of each hole is designed to be the width commonly used for clinical reagents, such as 1.5cm, 2cm, 3cm, etc. The reagent storage rack is made of transparent hard plastic, which is convenient for the search of reagents. The trapezoidal design can save space relatively and is convenient for storing more antibody reagents.

[0006] At the same time, antibodies and related laboratory reagents need to be stored in a low-temperature environment. During use, the staff will operate the antibodies at room temperature (about 24°C), and each antibody reagent will be frequently taken out of the 4°C refrigerator for use. The surrounding environment where the antibodies are placed will rise and fall between 4°C and 24°C due to the use of antibody reagents. Because many antibodies (other reagents used clinically) reagents are composed of proteins or small molecules, temperature instability will cause the potency (function) of the reagents to decrease, thereby affecting the test results. To solve this problem, the plastic sheet of the trapezoidal reagent rack can be made hollow in the middle, and a refrigerated substance can be placed in the hollow part, and a power supply device (with a storage battery) and a micro-electronic refrigeration device can be provided under the storage device or on the back wall, so that the antibody storage device can always maintain the set temperature during use. Because it is equipped with a battery, it can be moved and used, which makes it convenient to use. It can maintain a constant temperature for a relatively long time and can be used for temporary storage, reducing the time for clinical workers to repeatedly store and retrieve reagents. The trapezoidal storage device is equipped with an openable insulation cover to facilitate constant temperature. The temperature of the device can be displayed on one side of the storage device, which is convenient for the operator to master the antibody storage conditions. The ladder-shaped antibody storage device has the features of small size, portability, and convenient operation. At the same time, the device can also be used in scientific research experiments to store reagents that need to be stored at low temperatures.

[0007] The ladder-shaped antibody storage device reduces the occurrence of reagent titer reduction caused by large temperature differences during the use of antibodies (reagents). Utility Model Content

[0008] The utility model aims to provide a low-temperature ladder-shaped antibody reagent storage device for solving the above-mentioned problems.

[0009] In order to achieve the above-mentioned purpose, the utility model provides the following technical solutions: a low-temperature ladder-shaped antibody reagent storage device, comprising:

[0010] A reagent rack having multiple rows of storage compartments arranged in a stepped manner;

[0011] A base is clamped to the bottom opening of the reagent rack to seal the opening, on which an evaporation conduit and a semiconductor refrigeration sheet with a cold surface in contact with the evaporation conduit are arranged;

[0012] The connecting part is detachable from the end surface of the reagent rack, and an upper cover is slidably arranged in the connecting part. Preferably, multiple rows of hatch covers arranged in a ladder shape are arranged in the upper cover, and the hatch covers correspond to the storage compartments one by one.

[0013] Preferably, the storage compartment is a rectangular structure, including at least three specifications of 1.5 cm, 2 cm, and 3 cm.

[0014] Preferably, the contact surface between the connecting portion and the end surface of the reagent rack is provided with high temperature resistant medical silica gel, and the contact surface is provided with a plurality of borings arranged according to predetermined specifications and connected with the end surface.

[0015] Preferably, the base has symmetrically arranged clamping feet, and the reagent rack is provided with a clamping groove for clamping with the clamping feet;

[0016] The bottom opening of the reagent rack is provided with high temperature resistant medical silica gel.

[0017] Preferably, the base is also provided with a rechargeable battery and a TP-C interface for supplementing the power supply of the rechargeable battery;

[0018] A notch is provided on the reagent rack, and a silicone jacket covering the TP-C interface is provided on the base, and the silicone jacket and the notch are inlaid and assembled.

[0019] Preferably, the hot surface of the semiconductor cooling plate extends into a rectangular heat dissipation hole opened at the bottom of the base.

[0020] Preferably, a vertical portion is provided on one side of the base, a touch display screen is provided on the vertical portion, and the vertical portion is plug-fitted with a groove provided on the front side of the reagent rack.

[0021] Preferably, the reagent rack, the connecting part and the upper cover are all made of transparent plastic parts.

[0022] In the above technical scheme, the utility model provides a low-temperature ladder-shaped antibody reagent storage device, which has the following beneficial effects: the cold source made by the semiconductor refrigeration sheet is diffused into the sealed opening by using the evaporation conduit, so that the storage compartment is cooled, and then the antibody reagent tube inserted in the storage compartment is covered by the connecting part and the upper cover, so that the antibody reagent is placed in a low-temperature environment;

[0023] Moreover, the cold source and power supply in the embodiment are both assembled on the base, and the base and the reagent rack are designed for quick disassembly, which greatly facilitates the subsequent disinfection of the reagent rack. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present utility model. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0025] Figure 1 The overall structural diagram provided for the embodiment of the utility model;

[0026] Figure 2A schematic diagram of an explosion structure provided for an embodiment of the utility model;

[0027] Figure 3 A schematic diagram of the structure of the TP-C interface and reagent rack provided in an embodiment of the utility model;

[0028] Figure 4 A schematic diagram of the structure of a base provided in an embodiment of the utility model;

[0029] Figure 5 A schematic diagram of the cross-sectional structure of a base provided in an embodiment of the utility model.

[0030] Description of reference numerals:

[0031] 1. Reagent rack; 11. Storage compartment; 2. Base; 21. Evaporation duct; 22. Semiconductor cooling plate; 23. Rechargeable battery; 24. TP-C interface; 3. Connecting part; 4. Upper cover; 5. Vertical part; 51. Touch screen. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0033] like Figure 1-5 As shown, a low-temperature ladder-shaped antibody reagent storage device comprises:

[0034] A reagent rack 1 having multiple rows of storage compartments 11 arranged in a stepped manner is provided therein (the multiple rows of storage compartments 11 arranged in a stepped manner shown in the figure are for reference only, and there are visual differences. The detailed height difference should be that the height difference between each two adjacent rows of storage compartments 11 is equal to the height of the antibody reagent tubes inserted into the storage compartments 11);

[0035] A base 2 is clamped to the bottom opening of the reagent rack 1 and used to seal the opening, on which an evaporation conduit 21 and a semiconductor cooling sheet 22 whose cold surface contacts the evaporation conduit 21 are arranged;

[0036] The connecting part 3 is detachably mounted on the end surface of the reagent rack 1 , and an upper cover 4 is slidably arranged inside the connecting part 3 .

[0037] Specifically, the upper cover 4 in the above embodiment is provided with multiple rows of hatch covers arranged in a ladder shape, and the hatch covers correspond one to one with the storage compartments 11. By pulling the upper cover 4, the length of the upper cover 4 and the connecting portion 3 changes, thereby meeting the storage requirements of antibody reagent tubes of different heights.

[0038] Secondly, according to the storage requirements of antibody reagent tubes in the above embodiment, the reagent rack 1 has at least three types, corresponding to storage compartments 11 of 1.5 cm, 2 cm, and 3 cm respectively. The storage compartment 11 is a rectangular structure, such as 1.5 cm including length, width, and height.

[0039] Further, combined with Figure 1 and Figure 2 It can be seen that the base 2 has symmetrically arranged card feet, and the reagent rack 1 is provided with card slots that are engaged with the card feet, thereby forming a quick-release design. Secondly, high-temperature resistant medical silicone is provided at the bottom opening of the reagent rack 1 to ensure the sealing of the opening after installation.

[0040] Furthermore, the contact surface between the connecting part 3 and the end surface of the reagent rack 1 is provided with high temperature resistant medical silica gel, and the contact surface is provided with a plurality of bores arranged according to predetermined specifications and inserted into the end surface, thereby ensuring the sealing of the connecting part 3 and the reagent rack 1 .

[0041] It should be noted that the reagent rack 1, the connecting portion 3 and the upper cover 4 are all made of transparent plastic parts, so that medical staff can directly observe the antibody reagent with naked eyes.

[0042] In the above technology, the cold source produced by the semiconductor refrigeration sheet 22 is diffused into the sealed opening by the evaporation conduit 21, so that the storage compartment 11 is cooled, and then the antibody reagent tube inserted in the storage compartment 11 is covered by the connecting portion 3 and the upper cover 4, so that the antibody reagent is placed in a low temperature environment;

[0043] In addition, the cold source and the power supply in the embodiment are both assembled on the base 2 , and the base 2 and the reagent rack 1 are designed for quick release, which greatly facilitates the subsequent disinfection of the reagent rack 1 .

[0044] As an embodiment further provided by the present utility model, the base 2 is further provided with a rechargeable battery 23 and a tp-c interface 24 for supplementing the power supply of the rechargeable battery 23;

[0045] A notch is provided on the reagent rack 1, and a silicone jacket covering the TP-C interface 24 is provided on the base 2, and the silicone jacket and the notch are inlaid and assembled.

[0046] Specifically, the combination of the embodiments Figure 2 It can be seen that a vertical portion 5 is provided on one side of the base 2, and a touch screen 51 is provided on the vertical portion 5, and the vertical portion 5 is plugged into the groove provided on the front of the reagent rack 1. A circuit board is provided on the back of the vertical portion 5, and the touch screen 51 is data-connected with the circuit board, and a power switch is provided on the touch screen 51 for starting the circuit board.

[0047] Secondly, a temperature sensor is also provided on the base 2, which is used to detect the temperature of the opening in a sealed state, so as to ensure that the storage compartment 11 is at a reasonable temperature. If it is lower than the storage compartment 11, the operation of the semiconductor refrigeration plate 22 is stopped; if it is higher, the semiconductor refrigeration plate 22 is operated.

[0048] Furthermore, when the circuit board is running, the touch screen 51 will display the temperature and power, as well as the virtual bins corresponding to the number of storage compartments 11. When placing an antibody reagent, just touch the corresponding virtual bin, and the calculation time will appear below the virtual bin. Touching it again will turn off the timing.

[0049] It should be noted that the temperature sensor, TP-C interface 24, rechargeable battery 23 and touch display screen 51 in the above-mentioned embodiment are all connected to the circuit board, and there are well-known electronic components such as processing unit and storage unit on the above-mentioned circuit board, which are used to realize the above-mentioned functions. Since it belongs to the prior art, no further explanation will be given again.

[0050] As another embodiment further provided by the present invention, the hot surface of the semiconductor cooling plate 22 extends to the rectangular heat dissipation hole opened at the bottom of the base 2.

[0051] Specific, combined Figure 5 It can be seen that the base 2 in the embodiment is provided with legs at the bottom, so as to lift the base 2 so that the heat generated by the operation of the semiconductor cooling sheet 22 can be discharged from the rectangular heat dissipation holes.

[0052] The above only describes some exemplary embodiments of the present invention by way of illustration. It is undoubted that those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A low-temperature ladder-shaped antibody reagent storage device, characterized in that: include: A reagent rack (1) having a plurality of rows of storage compartments (11) arranged in a stepped manner; A base (2) is clamped to the bottom opening of the reagent rack (1) and used to seal the opening, on which an evaporation conduit (21) and a semiconductor cooling sheet (22) whose cold surface contacts the evaporation conduit (21) are arranged; A connecting portion (3) is detachably mounted on the end surface of the reagent rack (1), and an upper cover (4) is slidably disposed inside the connecting portion (3).

2. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: A plurality of rows of hatch covers arranged in a stepped manner are arranged inside the upper cover (4), and the hatch covers correspond one to one with the storage compartments (11).

3. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The storage compartment (11) is a rectangular structure, and includes at least three specifications: 1.5 cm, 2 cm, and 3 cm.

4. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The contact surface between the connecting portion (3) and the end surface of the reagent rack (1) is provided with high temperature resistant medical silica gel, and the contact surface is provided with a plurality of boring holes arranged according to predetermined specifications and plugged into the end surface.

5. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The base (2) has symmetrically arranged clamping feet, and the reagent rack (1) is provided with a clamping groove for clamping with the clamping feet; The bottom of the reagent rack (1) is open and is provided with high-temperature resistant medical silica gel.

6. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The base (2) is also provided with a rechargeable battery (23) and a TP-C interface (24) for supplementing power to the rechargeable battery (23); The reagent rack (1) is provided with a notch, and the base (2) is provided with a silicone jacket wrapping the TP-C interface (24), and the silicone jacket and the notch are inlaid and assembled.

7. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The hot surface of the semiconductor cooling sheet (22) extends into a rectangular heat dissipation hole opened at the bottom of the base (2).

8. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: A vertical portion (5) is provided on one side of the base (2), a touch display screen (51) is provided on the vertical portion (5), and the vertical portion (5) is plug-fitted with a groove provided on the front of the reagent rack (1).

9. The low-temperature ladder-shaped antibody reagent storage device according to claim 1, characterized in that: The reagent rack (1), the connecting portion (3) and the upper cover (4) are all transparent plastic parts.

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