Electrical stimulation vestibular evoked muscle-derived potential device

Abstract

The device comprises an electrical stimulation controller, the electrical stimulation controller comprises a double-layer insulating outer shell and a conductive inner shell, the conductive inner shell is internally provided with a switching power supply for supplying power, a main control unit, a sound stimulation circuit, a direct current stimulation circuit, a secondary amplifier and an analog-to-digital converter, and the switching power supply and the conductive inner shell are grounded. The preamplifier comprises a differential amplifier; the upper computer is electrically connected with the main control unit, the main control unit is connected with the sound stimulation earphone through the sound stimulation circuit, the main control unit is connected with the direct-current stimulation electrode through the direct-current stimulation circuit, and the anode and the cathode of the direct-current stimulation electrode are attached to the midpoint of a forehead hairline and the mastoid of a human body respectively. The input end of the differential amplifier is connected with the recording electrode, the reference electrode and the grounding electrode, the recording electrode, the reference electrode and the grounding electrode are respectively attached to the midpoint of the sternocleidomastoid muscle, the suprasternal fossa and the nasal root of a human body, and the output end of the differential amplifier is electrically connected with the main control unit through the secondary amplifier and the analog-to-digital converter in sequence.

Description

Technical Field

[0001] The utility model relates to the technical field of vestibular induced myogenic potential, in particular to an electrical vestibular induced myogenic potential device. Background Art

[0002] Vestibular apparatus: It is the body's balance sensor, which includes three pairs of semicircular canals and the utricle and saccule of the vestibule. There are ampulla crests in the semicircular canals, and otolith organs (also known as saccule macules) in the utricle and saccule. They are all vestibular terminal receptors that can sense the stimulation of various specific motion states. Vestibular receptors sense the body's position in space and its position changes, and transmit this information to the central nervous system, which mainly produces two physiological effects: on the one hand, it adjusts the body's changed position and posture to maintain the body's balance; on the other hand, it participates in regulating eye movements to keep the body's vision clear during changes in body position and movement, so it plays an important role in maintaining our posture balance and clear vision. When the function of the vestibular organs is damaged or too sensitive, people often experience dizziness, nystagmus, abnormal posture and balance disorders. Vertigo is mostly caused by vestibular diseases. When patients with vertigo visit doctors, doctors often first ask patients to undergo vestibular function tests in order to analyze and find the cause of the vertigo and the location and degree of the lesions that cause the vertigo, and then take appropriate treatment plans.

[0003] Vestibular-evoked myogenic potentials (VEMP) refer to a myoelectric response recorded on the surface of superficial skeletal muscles of the body through specific conduction pathways when a variety of appropriate stimuli activate the human vestibular otolith organs.

[0004] Galvanic vestibular stimulation-vestibular evoked myogenic potentials (GVS-VEMP): It is an evoked myogenic response recorded in the sternocleidomastoid muscle or inferior oblique muscle by transcutaneous direct current stimulation of the vestibular nerve. GVS-VEMP is a new method for evaluating the vestibular conduction pathway and can be used as an auxiliary examination for a variety of vestibular-related diseases.

[0005] Indications for vestibular evoked myogenic potential: It can be used for clinical testing of patients with dizziness, vertigo, or patients with damage to the vestibular otoliths, vestibular nerves or nerve conduction pathways, or labyrinthine third window diseases (including superior semicircular canal dehiscence syndrome, large vestibular aqueduct syndrome and labyrinthine fistula).

[0006] At present, balance disorders and vertigo related to vestibular function are very common in clinical practice, and the diagnosis of vestibular otoliths is mainly based on vestibular evoked myogenic potential. There is no registered and marketed vestibular evoked potential detection equipment in China. In order to meet the needs of clinical diagnosis, this patent describes an electrical stimulation vestibular evoked myogenic potential device that can be used in clinical practice. Utility Model Content

[0007] The utility model aims at the problems and shortcomings of the prior art and provides a device for electrically stimulating the vestibular system to induce myogenic potentials.

[0008] The utility model solves the above technical problems through the following technical solutions:

[0009] The utility model provides an electrical vestibular stimulation induced myogenic potential device, which is characterized in that it comprises a host computer, an electrical stimulation controller and a preamplifier, the electrical stimulation controller comprises a double-layer insulating outer shell and a conductive inner shell, a switching power supply for powering the device, a main control unit, an acoustic stimulation circuit, a direct current stimulation circuit, a secondary amplifier and an analog-to-digital converter are arranged in the conductive inner shell, the switching power supply and the conductive inner shell are grounded, and the preamplifier comprises a differential amplifier.

[0010] The host computer is electrically connected to the main control unit, the main control unit is connected to the sound stimulation headphones through the sound stimulation circuit, the main control unit is connected to the DC stimulation electrode through the DC stimulation circuit, the anode and cathode of the DC stimulation electrode are respectively attached to the midpoint of the forehead hairline and the mastoid of the human body, the input end of the differential amplifier is connected to the recording electrode, the reference electrode and the ground electrode, the recording electrode, the reference electrode and the ground electrode are respectively attached to the midpoint of the sternocleidomastoid muscle, the suprasternal fossa and the root of the nose of the human body, and the output end of the differential amplifier is electrically connected to the main control unit through a secondary amplifier and an analog-to-digital converter in sequence.

[0011] The electrical vestibular evoked myogenic potential device proposed in the utility model has the functions of acoustic vestibular evoked myogenic potential and direct current vestibular evoked myogenic potential, and can be applied to the detection of a variety of different vestibular diseases. During the detection process of the traditional acoustic vestibular evoked myogenic potential, the vestibular myogenic potential cannot be elicited when using acoustic stimulation due to the abnormality of the vestibular receptors, and thus the functional status of the vestibular nerve and the central nervous system cannot be evaluated. However, the use of electrical vestibular evoked myogenic potential can directly excite the vestibular nerve, and even when the vestibular receptor function is abnormal, the vestibular nerve and the central nervous system can be evaluated, and the vestibular receptor function can also be further differentiated and diagnosed. This provides a further evaluation method for the current clinical evaluation of the vestibular nerve function and vestibular receptors. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1This is a principle block diagram of a device for electrically stimulating the vestibular system to induce myogenic potentials according to a preferred embodiment of the utility model.

[0013] Figure 2 This is a main control principle block diagram of the electrical vestibular stimulation evoked myogenic potential device of a preferred embodiment of the utility model.

[0014] Figure 3 This is a principle block diagram of a DC stimulation circuit according to a preferred embodiment of the utility model. DETAILED DESCRIPTION

[0015] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0016] like Figure 1-3 As shown, this embodiment provides an electrical stimulation vestibular evoked myogenic potential device, which includes a host computer, an electrical stimulation controller and a preamplifier. The electrical stimulation controller includes a double-layer insulating outer shell and a conductive inner shell. The conductive inner shell is provided with a switching power supply for powering the device, a main control unit, an acoustic stimulation circuit, a DC stimulation circuit, a secondary amplifier and an analog-to-digital converter. The switching power supply and the conductive inner shell are grounded, and the preamplifier includes a differential amplifier.

[0017] The host computer is electrically connected to the main control unit, the main control unit is connected to the sound stimulation headset through the sound stimulation circuit, the main control unit is connected to the DC stimulation electrode through the DC stimulation circuit, the anode and cathode of the DC stimulation electrode are respectively attached to the midpoint of the forehead hairline and the mastoid of the human body, the main control unit is electrically connected to the secondary amplifier and the differential amplifier, the input end of the differential amplifier is connected to the recording electrode, the reference electrode and the grounding electrode, the recording electrode is attached to the midpoint of the sternocleidomastoid muscle of the human body, the reference electrode is attached to the suprasternal fossa of the human body, the grounding electrode is attached to the root of the nose of the human body, and the output end of the differential amplifier is electrically connected to the main control unit through the secondary amplifier and the analog-to-digital converter in turn.

[0018] The main control unit adopts an MCU chip. According to the functions of each port pin of the MCU chip, it is a routine setting for technicians in this field to determine which specific port pin of the MCU chip each electronic device (host computer, switching power supply, sound stimulation circuit, DC stimulation circuit, analog-to-digital converter, secondary amplifier, differential amplifier) ​​is electrically connected to. This is the prior art.

[0019] The host computer, switching power supply, sound stimulation circuit, analog-to-digital converter, secondary amplifier, differential amplifier and MCU chip selected in this embodiment according to actual needs are all existing commercial products, and their structures have not been improved. They are all existing structures. The specific structures, circuit designs and working principles of the host computer, switching power supply, sound stimulation circuit, analog-to-digital converter, secondary amplifier, differential amplifier and MCU chip are all publicly available prior arts. The specification only uses these electronic devices to achieve certain functions, and there is no need to describe in detail the specific structures, circuit designs and working principles of these existing electronic devices. The entire solution is also clear.

[0020] The main control unit is used to control the filtering parameters and amplification factor of the secondary amplifier and the filtering parameters and amplification factor of the differential amplifier.

[0021] The host computer is used to send a direct current stimulation instruction containing a target stimulation intensity, a target stimulation width, a target stimulation frequency, and a target stimulation waveform to the main control unit, or send an acoustic stimulation instruction containing a target stimulation intensity, a target stimulation type, and a target stimulation frequency to the main control unit.

[0022] Main performance of vestibular electrical stimulation evoked myogenic potential:

[0023] 1) DC stimulation performance:

[0024] a) Stimulation intensity range: 0-100mApp;

[0025] b) Stimulus width range: 0.1ms-1ms;

[0026] c) Maximum stimulation frequency: 100 Hz;

[0027] d) Stimulation waveform: unidirectional rectangular constant current pulse, bidirectional rectangular constant current pulse.

[0028] 2) Acoustic stimulation performance:

[0029] Stimulation intensity range: 25-135db (SPL peak);

[0030] Stimulus type: short pure tone, sparse wave, dense wave, sparse and dense alternating wave;

[0031] Stimulation frequencies include: 250Hz, 500Hz, 750Hz, 1kHz, 1.5kHz, 2kHz, 2.5kHz, 3Hz, 3.5kHz, 4kHz, 5kHz, 6kHz, 7kHz, 8kHz.

[0032] 3) Collection performance:

[0033] 1) Sampling channels: 2 channels;

[0034] 2) Collection voltage sensitivity: 0.05μV / div—10mV / div;

[0035] 3) Frequency range: 0.5Hz~10KHz;

[0036] 4) Scanning speed: 1ms / div—200ms / div;

[0037] 5) Common mode signal suppression capability: ≥100dB (patient cable input, 50Hz);

[0038] 6) Noise voltage: ≤1μV (rms, 1Hz~2KHz).

[0039] The main control unit is used to control the DC stimulation circuit to output a DC stimulation signal corresponding to the target stimulation intensity, target stimulation width, target stimulation frequency, and target stimulation waveform to the DC stimulation electrode when the instruction is a DC stimulation instruction; and to control the sound stimulation circuit to output a sound stimulation signal corresponding to the target stimulation intensity, target stimulation type, and target stimulation frequency to the sound stimulation headphones when the instruction is a sound stimulation instruction.

[0040] The differential amplifier is used to collect the induced vestibular evoked myogenic potential signal, which is transmitted to the secondary amplifier after filtering and amplification. The secondary amplifier is used to perform secondary filtering and amplification and then transmit it to the analog-to-digital converter. The analog-to-digital converter is used to perform analog-to-digital conversion on the amplified vestibular evoked myogenic potential signal and then transmit it to the main control unit. The main control unit is used to upload the received vestibular evoked myogenic potential signal to the host computer, which is displayed on the display of the host computer.

[0041] The DC power supply isolation module, the first digital optocoupler, the second digital optocoupler, the current control chip, the constant current source control circuit, the boost module and the power stimulation output circuit are all existing and belong to the prior art.

[0042] The main control unit is electrically connected to the DC-DC power isolation module, a capacitor is electrically connected between the first output terminal and the second output terminal of the DC-DC power isolation module, the first output terminal is electrically connected to the input terminal of the boost module, and the second output terminal is grounded.

[0043] The main control unit is electrically connected to the current control chip through a first digital optocoupler, the main control unit is electrically connected to the current control chip through a second digital optocoupler, and the current control chip is electrically connected to the constant current source control circuit.

[0044] The output end of the constant current source control circuit is electrically connected to the anode of the DC stimulation electrode through the resistor R1 and the first magnetic bead, the resistor R1 and the first magnetic bead are electrically connected to the output end of the boost module, the output end of the constant current source control circuit is electrically connected to the cathode of the DC stimulation electrode through the second magnetic bead, and the output end of the second magnetic bead is electrically connected to the output end of the first magnetic bead to the Zener diode.

[0045] The sound stimulation circuit is an existing circuit, and the specific circuit will not be given here.

[0046] The main control unit is used to output a power supply voltage when the instruction is a direct current stimulation instruction, and then transmit it to the boost module for boosting after power isolation by the DC-DC power isolation module, and the boosted voltage is provided to the electrical stimulation output circuit.

[0047] At the same time, the main control unit is used to output a stimulation current intensity control signal, which is output to the current control chip after signal isolation by the first digital optocoupler. The current control chip performs current intensity control to output a current intensity signal to the constant current source control circuit.

[0048] At the same time, the main control unit is used to output a stimulation current waveform control signal, which is output to the current control chip after signal isolation through the second digital optocoupler. The current control chip performs current pulse width control to output a current pulse width signal to the constant current source control circuit.

[0049] The constant current source control circuit is used to control the electrical stimulation output circuit to output a DC stimulation signal with a certain stimulation intensity, stimulation width, stimulation frequency and stimulation waveform to the DC stimulation electrode based on the current intensity signal and the current pulse width signal.

[0050] Although the specific embodiments of the present invention are described above, those skilled in the art should understand that these are only examples, and the protection scope of the present invention is defined by the appended claims. Those skilled in the art may make various changes or modifications to these embodiments without departing from the principle and essence of the present invention, but these changes and modifications fall within the protection scope of the present invention.

Claims

1. A device for electrically stimulating the vestibular system to induce myogenic potentials, characterized in that: It includes a host computer, an electrical stimulation controller and a preamplifier. The electrical stimulation controller includes a double-layer insulating outer shell and a conductive inner shell. A switching power supply for powering the device, a main control unit, an acoustic stimulation circuit, a direct current stimulation circuit, a secondary amplifier and an analog-to-digital converter are arranged in the conductive inner shell. The switching power supply and the conductive inner shell are grounded. The preamplifier includes a differential amplifier. The host computer is electrically connected to the main control unit, the main control unit is connected to the sound stimulation headphones through the sound stimulation circuit, the main control unit is connected to the DC stimulation electrode through the DC stimulation circuit, the anode and cathode of the DC stimulation electrode are respectively attached to the midpoint of the forehead hairline and the mastoid of the human body, the input end of the differential amplifier is connected to the recording electrode, the reference electrode and the ground electrode, the recording electrode, the reference electrode and the ground electrode are respectively attached to the midpoint of the sternocleidomastoid muscle, the suprasternal fossa and the root of the nose of the human body, and the output end of the differential amplifier is electrically connected to the main control unit through a secondary amplifier and an analog-to-digital converter in sequence.

2. The device for electrically stimulating vestibular evoked myogenic potentials according to claim 1, characterized in that: The direct current stimulation circuit includes a DC-DC power isolation module, a first digital optocoupler, a second digital optocoupler, a current control chip, a constant current source control circuit, a boost module and an electrical stimulation output circuit, and the electrical stimulation output circuit includes a resistor, a first magnetic bead, a second magnetic bead and a voltage regulator tube; The main control unit is electrically connected to the DC-DC power isolation module, a capacitor is electrically connected between the first output terminal and the second output terminal of the DC-DC power isolation module, the first output terminal is electrically connected to the input terminal of the boost module, and the second output terminal is grounded; The main control unit is electrically connected to the current control chip through a first digital optocoupler, the main control unit is electrically connected to the current control chip through a second digital optocoupler, and the current control chip is electrically connected to the constant current source control circuit; The output end of the constant current source control circuit is electrically connected to the anode of the DC stimulation electrode through a resistor and a first magnetic bead, the output end of the boost module is electrically connected between the resistor and the first magnetic bead, the output end of the constant current source control circuit is electrically connected to the cathode of the DC stimulation electrode through a second magnetic bead, and the output end of the second magnetic bead is electrically connected to the output end of the first magnetic bead through a voltage regulator.

3. The electrical vestibular stimulation evoked myogenic potential device according to claim 1, characterized in that: The main control unit is electrically connected to the secondary amplifier to control the filtering parameters and amplification factor of the secondary amplifier, and the main control unit is electrically connected to the differential amplifier to control the filtering parameters and amplification factor of the differential amplifier.

4. The device for electrically stimulating vestibular evoked myogenic potentials according to claim 1, characterized in that: The main control unit adopts an MCU chip.

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