Mouse limb fixing device

Abstract

The utility model discloses a mouse limb fixing device, which relates to the technical field of small animal experiment equipment and comprises a U-shaped groove, a head fixing band, a tail fixing band and four limb fixing bands. The head fixing band and the tail fixing band are both located at the bottom of the U-shaped groove. The four limb fixing bands are distributed on the side wall of the U-shaped groove; the shape of the U-shaped groove is matched with that of a placing groove in the PET / CT tester, and the radial height of the U-shaped groove is not higher than that of the placing groove; a bolt hole is formed in the side wall of the top of the U-shaped groove, and a fixing bolt used for abutting against the containing groove is arranged in the bolt hole. Through the combination of the U-shaped groove and the elastic fixing band, the four limbs, the head and the tail of the mouse can be accurately and quickly fixed, and it is ensured that the needed symmetrical and consistent body position is kept in the PET / CT imaging process; the device can be perfectly matched with a PET / CT scanner through a U-shaped groove and a fixing bolt, so that the imaging quality is remarkably improved, the operation time is shortened, and the experiment efficiency and the data accuracy are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of small animal experimental equipment, in particular to a mouse limb fixing device. Background Art

[0002] In modern biomedical research, small animal models, especially mouse models, play an indispensable role. PET / CT scans performed using mouse models provide important physiological, pathological, and drug dynamic distribution information for disease mechanism research and new drug development. However, in actual operations, mice need to be anesthetized and placed in the PET / CT placement slot. Ensuring that mice maintain a correct and consistent position during PET / CT scanning becomes a challenge, especially when performing dynamic scanning at multiple time points to observe the distribution and metabolic processes of radionuclides in the body. Inconsistent body positions not only affect imaging quality, but may also lead to deviations in data interpretation, thereby affecting the accuracy and reliability of research results.

[0003] The current methods for fixing the mouse position on the market usually use tape or homemade fixators, which are cumbersome to operate and difficult to ensure the consistency and repeatability of the position. In addition, traditional fixation methods may cause unnecessary pressure or discomfort to the mice, affecting the effectiveness of the experiment and the reliability of the results.

[0004] To address these issues, a device that can quickly, accurately, and humanely fix the body position of mice is needed to improve the efficiency and quality of PET / CT imaging and ensure the consistency of body position during dynamic scanning, thereby optimizing data accuracy and experimental repeatability. Utility Model Content

[0005] The purpose of the utility model is to provide a mouse limb fixing device to solve the problems existing in the prior art. By combining a U-shaped groove with an elastic fixing belt, not only can the limbs, head and tail of the mouse be fixed accurately and quickly, ensuring that the required symmetry and consistent body position are maintained during PET / CT imaging; the U-shaped groove and the fixing bolts can also be perfectly matched with the PET / CT scanner, thereby significantly improving the imaging quality, reducing the operation time, and improving the experimental efficiency and data accuracy.

[0006] To achieve the above-mentioned purpose, the utility model provides the following scheme: the utility model provides a mouse limb fixing device, comprising a U-shaped groove and a head fixing belt, a tail fixing belt and four limb fixing belts, all made of elastic materials, which are located on the inner surface of the U-shaped groove; the head fixing belt and the tail fixing belt are both located at the bottom of the U-shaped groove and are arranged perpendicular to the axial direction of the U-shaped groove; the four limb fixing belts are distributed on the side walls of the U-shaped groove, corresponding to the positions of the limbs of the mouse, and the four limb fixing belts are arranged in groups of two symmetrically relative to the mid-vertical plane of the U-shaped groove; the shape of the U-shaped groove is adapted to the shape of the placement groove on the PET / CT examination instrument, and the radial height of the U-shaped groove is not higher than the radial height of the placement groove; a bolt hole is arranged on the top side wall of the U-shaped groove, and a fixing bolt for tightening the placement groove is arranged in the bolt hole.

[0007] Preferably, a transparent baffle is provided at the end of the U-shaped groove, and an exposure hole for exposing the tail of the mouse is opened on the baffle.

[0008] Preferably, a fixing hole is provided at the bottom of the U-shaped groove, and the fixing hole can be aligned with the platform hole on the tail vein injection instrument, and a detachable fixing part is inserted into the fixing hole and the platform hole to fix the U-shaped groove.

[0009] Preferably, the fixing member is a screw.

[0010] Preferably, along the axial direction of the U-shaped groove, the fixing hole is located between the tail fixing belt and the end of the U-shaped groove.

[0011] Preferably, a pulling rope is fixed to the middle part of the head fixing belt, the middle part of the tail fixing belt and the middle part of the limb fixing belt.

[0012] Preferably, the ends of the head fixing belt, the tail fixing belt and the limb fixing belts are all located inside the U-shaped groove.

[0013] Preferably, the head fixing strap, the tail fixing strap and the four limb fixing straps are all made of rubber bands.

[0014] Preferably, the top edge of the U-shaped groove is provided with scale lines.

[0015] Preferably, the U-shaped groove is made of transparent plastic material.

[0016] Compared with the prior art, the utility model has achieved the following technical effects:

[0017] The utility model adopts the combination of a U-shaped groove and an elastic fixing belt, so that the staff can put the mouse into the U-shaped groove, and fix the mouse's limbs by simply pulling up and releasing the elastic fixing belt, which significantly reduces the operation time of fixing the mouse's limbs and ensures that the required symmetry and consistent posture are maintained during the PET / CT imaging process; at the same time, the utility model can perfectly adapt to the PET / CT scanner through the U-shaped groove and the fixing bolts, avoiding the mouse from moving in the PET / CT scanner, thereby significantly improving the imaging quality and data accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0019] Figure 1 This is a schematic diagram of the overall structure of the mouse limb fixing device without a transparent baffle in the utility model;

[0020] Figure 2 The figure is a schematic diagram of the overall structure of a mouse limb fixing device with a transparent baffle;

[0021] Figure 3 This is a schematic diagram of the coordination between the mouse limb fixation device and the PET / CT examination apparatus;

[0022] Figure 4 is a top view of the mouse limb fixation device after the mouse is fixed;

[0023] Figure 5 This is a schematic diagram of the coordination between the mouse limb fixation device and the tail vein injection instrument;

[0024] Among them, 1. U-shaped groove; 2. Head fixing strap; 3. Tail fixing strap; 4. Limb fixing strap; 5. Placement slot; 6. Fixing bolt; 7. Bolt hole; 8. Fixing hole; 9. Fixing piece; 10. Tail intravenous injection device; 11. Pull rope; 12. Transparent baffle; 13. Exposure hole. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] The purpose of the utility model is to provide a mouse limb fixing device to solve the problems existing in the prior art. By combining a U-shaped groove with an elastic fixing belt, not only can the limbs, head and tail of the mouse be fixed accurately and quickly, ensuring that the required symmetry and consistent body position are maintained during PET / CT imaging; the U-shaped groove and the fixing bolts can also be perfectly matched with the PET / CT scanner, thereby significantly improving the imaging quality, reducing the operation time, and improving the experimental efficiency and data accuracy.

[0027] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0028] like Figure 1 to Figure 5 As shown, this embodiment provides a mouse limb fixing device, including a U-shaped groove 1 and a head fixing belt 2, a tail fixing belt 3 and four limb fixing belts 4, all made of elastic materials, located on the inner surface of the U-shaped groove 1; the head fixing belt 2 and the tail fixing belt 3 are both located at the bottom of the U-shaped groove 1 and are arranged perpendicular to the axial direction of the U-shaped groove 1; the four limb fixing belts 4 are distributed on the side walls of the U-shaped groove 1, corresponding to the positions of the mouse's limbs, and the four limb fixing belts 4 are arranged symmetrically in groups of two relative to the mid-vertical plane of the U-shaped groove 1. In order to adapt to the position of the mouse's limbs, in the axial direction, the four limb fixing belts 4 are all located between the head fixing belt 2 and the tail fixing belt 3. And in order to adapt to the size of the mouse's limbs, the length of the head fixing belt 2 is longer and has a larger gap with the bottom of the U-shaped groove 1, while the length of the tail fixing belt 3 and the four limb fixing belts 4 is shorter, and the gap with the bottom or side wall of the U-shaped groove 1 is smaller. Those skilled in the art can reasonably set the length of each fixing belt. The shape of the U-shaped groove 1 is adapted to the shape of the placement groove 5 on the PET / CT inspection instrument, and the radial height of the U-shaped groove 1 is not higher than the radial height of the placement groove 5; a bolt hole 7 is provided on the top side wall of the U-shaped groove 1, and a fixing bolt 6 for tightening the placement groove 5 is provided in the bolt hole 7.

[0029] When used, anesthetized mice ( Figure 3The mouse is placed inside the U-shaped groove 1 (the middle dotted line part), and the staff pulls up the head fixing belt 2, and stuffs the mouse's head into the gap between the head fixing belt 2 and the U-shaped groove 1. After releasing the head fixing belt 2, the head fixing belt 2 tightens and fixes the mouse's head. According to the above method, the mouse's limbs and tail are fixed in turn. When fixing the mouse's tail, the middle part of the mouse's tail is fixed to ensure that its tail extends in a fixed direction; at the same time, the staff should design the length of each fixing belt in advance to avoid the fixing belt being too loose to fix the mouse's limbs, or the fixing belt being too tight to cause damage to the mouse's limbs. After the mouse is fixed, the staff puts the U-shaped groove 1 into the placement groove 5 of the PET / CT detector, and then screws the fixing bolt 6 into the bolt hole 7, and presses the inner wall of the placement groove 5 to prevent the U-shaped groove 1 from moving, so as to achieve the positioning of the U-shaped groove 1. Finally, the mouse is photographed and tested using the PET / CT detector.

[0030] Therefore, in this embodiment, by adopting the combination of the U-shaped groove 1 and the elastic fixing belt, the staff can put the mouse into the U-shaped groove 1, and fix the mouse's limbs by simply pulling up and releasing the elastic fixing belt, which significantly reduces the operation time of fixing the mouse's limbs and ensures that the required symmetry and consistent posture are maintained during the PET / CT imaging process; at the same time, this embodiment can perfectly adapt to the PET / CT scanner through the U-shaped groove 1 and the fixing bolt 6, avoiding the mouse from moving in the PET / CT scanner, thereby significantly improving the imaging quality and data accuracy.

[0031] In this embodiment, the head fixing belt 2, the tail fixing belt 3 and the four limb fixing belts 4 are all made of rubber bands.

[0032] like Figure 2 As shown, in this embodiment, a transparent baffle 12 is provided at the end of the U-shaped groove 1, and an exposure hole 13 for exposing the mouse's tail is opened on the baffle. By providing the transparent baffle 12, not only the overall strength and deformation resistance of the U-shaped groove 1 can be improved, but also the mouse's tail can be further positioned through the exposure hole 13, thereby improving the position accuracy of the mouse's tail.

[0033] Furthermore, in this embodiment, a fixing hole 8 is provided at the bottom of the U-shaped groove 1, and the fixing hole 8 can be aligned with the platform hole on the tail vein injection instrument 10, and a detachable fixing member 9 is inserted into the fixing hole 8 and the platform hole to fix the U-shaped groove 1. Thus, the U-shaped groove 1 can be fixed to the tail vein injection instrument 10 through the fixing member 9, which makes it easier for the U-shaped groove 1 to adapt to it, thereby improving the efficiency of tail vein injection for mice.

[0034] Furthermore, in this embodiment, the fixing member 9 may be a pin or the like; threads may also be provided inside the fixing hole 8, in which case the fixing member 9 may be a screw.

[0035] In order to prevent the fixing hole 8 from being blocked by the body of the mouse, in this embodiment, the fixing hole 8 is located between the tail fixing belt 3 and the end of the U-shaped groove 1 along the axial direction of the U-shaped groove 1 .

[0036] Furthermore, in this embodiment, a pulling rope 11 is fixed to the middle of the head fixing belt 2, the middle of the tail fixing belt 3, and the middle of the limb fixing belt 4. The staff can pull up each fixing belt by pulling the pulling rope 11 to put the mouse limbs. The pulling rope 11 can be a rubber band, which is integrally formed with the corresponding fixing belt.

[0037] Furthermore, the U-shaped groove 1 is made of a transparent plastic material. The ends of the head fixing belt 2, the tail fixing belt 3 and the limb fixing belt 4 are all located inside the U-shaped groove 1. The U-shaped groove 1 can be formed by an injection molding process, and the ends of each fixing belt are fixed inside the U-shaped groove 1 during the injection molding process. At the same time, the ends of the head fixing belt 2, the tail fixing belt 3 and the limb fixing belt 4 will not leak out of the outer surface of the U-shaped groove 1, and will not affect the fit between the U-shaped groove 1 and the placement groove 5.

[0038] Furthermore, in this embodiment, the top edge of the U-shaped groove 1 is provided with scale lines to facilitate accurate fixing of the U-shaped groove 1 in the placement groove 5 .

[0039] Adaptive changes made according to actual needs are all within the protection scope of this utility model.

[0040] It should be noted that it is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any reference numerals in the claims should not be regarded as limiting the claims involved.

[0041] The present invention uses specific examples to illustrate the principle and implementation of the present invention. The above examples are only used to help understand the method and core idea of ​​the present invention. At the same time, for those skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A mouse limb fixing device, characterized in that: It comprises a U-shaped groove and a head fixing strap, a tail fixing strap and four limb fixing straps which are all made of elastic materials and are located on the inner surface of the U-shaped groove; the head fixing strap and the tail fixing strap are both located at the bottom of the U-shaped groove and are arranged perpendicular to the axial direction of the U-shaped groove; the four limb fixing straps are distributed on the side walls of the U-shaped groove, corresponding to the positions of the limbs of the mouse, and the four limb fixing straps are arranged in groups of two symmetrically relative to the mid-vertical plane of the U-shaped groove; the shape of the U-shaped groove is adapted to the shape of the placement groove on the PET / CT inspection instrument, and the radial height of the U-shaped groove is not higher than the radial height of the placement groove; a bolt hole is arranged on the top side wall of the U-shaped groove, and a fixing bolt for tightening the placement groove is arranged in the bolt hole.

2. The mouse limb fixing device according to claim 1, characterized in that: A transparent baffle is provided at the end of the U-shaped groove, and an exposure hole for exposing the tail of the mouse is opened on the baffle.

3. The mouse limb fixing device according to claim 1 or 2, characterized in that: A fixing hole is arranged at the bottom of the U-shaped groove, and the fixing hole can be aligned with the platform hole on the tail vein injection instrument. A detachable fixing part is inserted into the fixing hole and the platform hole to fix the U-shaped groove.

4. The mouse limb fixing device according to claim 3, characterized in that: The fixing member is a screw.

5. The mouse limb fixing device according to claim 3, characterized in that: Along the axial direction of the U-shaped groove, the fixing hole is located between the tail fixing belt and the end of the U-shaped groove.

6. The mouse limb fixing device according to claim 3, characterized in that: Pull ropes are fixed to the middle of the head fixing belt, the middle of the tail fixing belt and the middle of the limb fixing belts.

7. The mouse limb fixing device according to claim 6, characterized in that: The ends of the head fixing belt, the tail fixing belt and the limb fixing belts are all located inside the U-shaped groove.

8. The mouse limb fixing device according to claim 7, characterized in that: The head fixing belt, the tail fixing belt and the four limb fixing belts are all made of rubber bands.

9. The mouse limb fixing device according to claim 8, characterized in that: The top edge of the U-shaped groove is provided with scale lines.

10. The mouse limb fixing device according to claim 9, characterized in that: The U-shaped groove is made of transparent plastic material.

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