Temporary storage device for sampling bottle of bioreactor

Abstract

The utility model provides a temporary storage device for a sampling bottle of a bioreactor. The temporary storage device comprises a table top and table legs, the table top is fixed on the table legs; a plurality of sampling bottle temporary storage inner grooves are formed in the table top and are used for storing sampling bottles; sampling bottle inner groove covers are arranged at groove openings of the sampling bottle temporary storage inner grooves, and the sampling bottle inner groove covers are used for conducting heat preservation on samples and protecting the samples in the moving process. According to the temporary storage device for the bioreactor sampling bottle, the problem that related articles such as the bioreactor sampling bottle cannot meet the GMP regulation when being placed on the ground is solved, and the related problems that facilities and articles used in a clean workshop need to be free of dead angles, easy to clean, free of cross contamination risks and the like according to the GMP regulation are achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of placement racks, in particular to a temporary storage device for sampling bottles of bioreactors. Background Art

[0002] Usually, bioreactors need to meet the requirements of continuous aseptic sampling, which is mainly connected to the sampling valve through the sampling bottle hose and thermoplastic tube. After taking the sample, the sampling bottle is welded down by the aseptic pipe welding machine, which can achieve multiple continuous aseptic sampling, greatly improving the work efficiency. However, it is not in compliance with GMP regulations to place the sampling bottle connected by the hose on the ground or in a simple sampling tray. In addition, the stress of the sampling hose will cause the sampling bottle to fall and spill. The culture materials of the bioreactor are mainly suspended cells or suspended venom. The spillage of samples causes the loss of samples and the hidden danger of biosafety. In addition, the suspended venom samples need to be temporarily stored in a low temperature environment to avoid the loss of antigen expression. By adopting a bioreactor sampling bottle temporary storage device, a series of technical problems such as the need for low-temperature storage of bioreactor sampling samples, the placement of sampling bottles on the ground does not comply with GMP regulations, and the sampling bottles fall and spill due to the stress of the sampling hose are solved.

[0003] The sampling bottle temporary storage method in the prior art cannot guarantee the sampling and transportation of samples that require temperature control; at the same time, no relevant emergency preventive measures are taken during the sampling and transportation of samples that require biosafety.

[0004] Patent document CN216987764U (application number: 202220701342.6) discloses a sampling bottle placement rack that is easy to clamp, including a placement rack main body, a universal wheel is fixedly installed on the bottom of the placement rack main body, and multiple layers of placement plates for clamping sampling bottles are placed in the placement rack main body. The upper surface of the placement plate is provided with a plurality of placement grooves, and the placement grooves are provided with clamping components for clamping the sampling bottles; a pressure plate is correspondingly provided above each placement plate, and a pressure groove is provided on the lower surface of the pressure plate for use with the placement groove, and a driving component for driving the pressure plate to move up and down is installed on the placement rack main body. Utility Model Content

[0005] In view of the defects in the prior art, the utility model aims to provide a bioreactor sampling bottle temporary storage device.

[0006] According to the utility model, a bioreactor sampling bottle temporary storage device is provided, comprising: a table top 3 and table legs;

[0007] The table top 3 is fixed on the table legs;

[0008] The table top 3 is provided with a plurality of temporary inner grooves for sampling bottles, and the temporary inner grooves for sampling bottles are used for storing sampling bottles;

[0009] A sampling bottle inner tank cover 4 is provided at the notch of the plurality of sampling bottle temporary storage inner tanks, and the sampling bottle inner tank cover 4 is used to keep the sampled samples warm and protect the samples during the moving process.

[0010] Preferably, a retractable spring 17 and a retractable spring clip 18 are provided in the sampling bottle temporary storage inner groove, and the retractable spring clip 18 is connected to the sampling bottle temporary storage inner groove through the retractable spring 17; sampling bottles of different shapes or sizes are matched through the retractable spring 17 and the retractable spring clip 18, and the sampling bottles are fixed at the same time.

[0011] Preferably, table top cabins are provided on multiple sides of the table top 3 and are equipped with corresponding cabin doors; the table top cabins are used to place ice packs to ensure a low temperature environment for temporary storage of samples.

[0012] Preferably, an inner tank 6 is provided on the table 3, and a thermometer is placed in the inner tank 6 after adding a proper amount of purified water; the thermometer is used for real-time process temperature monitoring.

[0013] Preferably, the table leg is a liftable adjustable rod 14 and is provided with a fixing buckle 13 , and the height of the table top can be adjusted by using the liftable adjustable rod 14 and the fixing buckle 13 .

[0014] Preferably, movable universal wheels 15 are disposed at the bottom of the table legs, and flexible movement can be achieved by utilizing the movable universal wheels 15 .

[0015] Preferably, an in-situ disinfectant placement position 2 is provided on any side of the table top 3, and the in-situ disinfectant placement position 2 is used for placing an in-situ disinfectant.

[0016] Preferably, a hanging rod 1 is provided on any side of the table top 3, and the hanging rod 1 is used for storing sterilized towels.

[0017] Preferably, the table top 3 is a smooth table top in a cube shape.

[0018] Compared with the prior art, the utility model has the following beneficial effects:

[0019] 1. The present invention adopts a bioreactor sampling bottle temporary storage device to solve the problem that the bioreactor sampling bottles and other related items are placed on the ground and do not comply with the GMP regulations, and achieves the GMP regulations that the facilities and items used in the clean workshop must meet the requirements of no dead angles, easy cleaning, no cross contamination risks, etc.

[0020] 2. The present invention adopts a sampling bottle temporary storage inner groove, a retractable spring and a spring fixing clip, so as to be applicable to sampling bottles of various shapes and sizes matched with different bioreactors, thereby avoiding the singleness of the device being limited to sampling of the same bioreactor, and increasing the wide applicability of the device;

[0021] 3. The present invention can effectively control the activity of suspended cells and suspended venom during bioreactor sampling and sample transfer by using a device table and placing a thermometer in the inner tank, thereby ensuring the activity of suspended cells and the antigen stability of suspended venom, and ensuring the accuracy of the samples taken;

[0022] 4. The present invention adopts an in-situ disinfectant and an in-situ disinfection towel for biosafety emergency. When the sample taken from the bioreactor is a suspended venom, if an unexpected emergency such as venom spillage occurs during sampling or sample transfer, relevant in-situ disinfection measures can be taken in time to avoid the occurrence of biosafety accidents. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0024] Figure 1 This is a schematic diagram of the structure of the temporary storage device for bioreactor sampling bottles.

[0025] Figure 2 This is a schematic diagram of the internal tank structure for temporary storage of sampling bottles.

[0026] 1-hanging rod; 2-placement for in-situ disinfectant; 3-table; 4-sampling bottle inner tank cover; 5-temporary storage inner tank for sampling bottles; 6-inner tank; 7-temporary storage inner tank for sampling bottles; 8-installation of switchable hatch; 9-installation of hatch door switch; 10-installation of switchable hatch; 11-installation of switchable hatch; 12-installation of switchable hatch; 13-fixed buckle; 14-liftable adjustment rod; 15-movable universal wheel; 16-temporary storage inner tank for sampling bottles; 17-retractable spring; 18-sampling bottle fixing clip. DETAILED DESCRIPTION

[0027] The utility model is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be pointed out that for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the utility model. These all belong to the protection scope of the utility model.

[0028] Example 1

[0029] According to a bioreactor sampling bottle temporary storage device provided in this embodiment, Figures 1 to 2 As shown, the table 3 is a smooth cube-shaped table, on which there are two cylindrical sampling bottle temporary storage inner grooves 5 and 7. There are retractable spring clips 18 around the inner grooves to match sampling bottles of different shapes or sizes. The spring clips 18 can also fix the sampling bottles. There are switchable sampling bottle inner groove covers 4 at the notches of the inner grooves 5 and 7 to keep the sample warm and protect the sample during movement. There is a thermometer placement inner groove 6 in the middle of the table. Before use, an appropriate amount of purified water needs to be added to this inner groove, and a qualified glass thermometer calibrated at 0-100°C is placed, so that the device can monitor and control the real-time temperature.

[0030] At the same time, a bioreactor sampling bottle temporary storage device must meet the use requirements of the clean workshop stipulated by GMP, and be made of stainless steel, smooth, without dead corners, and easy to clean.

[0031] Taking conventional animal cell suspension culture as an example, the temperature of the bioreactor is controlled at 37°C during the culture of suspended cells and suspended venom. In order to ensure the accuracy of the sampled samples, the sampled samples need to be temporarily stored in a low-temperature environment, which can inhibit the activity of cells and viruses to the maximum extent. Therefore, there are four switchable hatches 8, 10, 11, and 12 on the side of the device table 3. The hatch can be opened to put the ice pack prepared in advance into the table cabin. After closing the hatch switch 9, the process temperature can be monitored in real time through the glass thermometer placed in the inner tank 6. In this way, the suspended cells and suspended venom samples can be stored at low temperatures, which can effectively ensure the activity of the suspended cells and the antigenic stability of the suspended venom.

[0032] On the other side of the table, there is a placement position 2 for in-situ disinfectant and a hanging rod 1 for placing in-situ disinfectant and in-situ disinfection towels for biosafety emergencies, to ensure biosafety emergency measures in case of accidental spillage during the sampling of suspended venom.

[0033] A liftable adjustment rod 14 is arranged under the table of the bioreactor sampling bottle temporary storage device. The device can be adjusted to the required height at any time according to the height of the sampling port of the bioreactor of different specifications and sizes, so as to facilitate convenient, fast and efficient sampling of the bioreactor. The liftable adjustment rod needs to be equipped with an adjustment rod fixing buckle 13 to fix the position of the device after the height is adjusted to avoid the occurrence of instability of the table during the sampling process.

[0034] The bottom of the adjusting rod of the bioreactor sampling bottle temporary storage device is respectively equipped with a flexibly movable universal wheel 15 to facilitate the position movement of the device.

[0035] In the description of the present application, it should be understood that the terms "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0036] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. In the absence of conflict, the embodiments of the present application and the features in the embodiments can be combined with each other at will.

Claims

1. A bioreactor sampling bottle temporary storage device, characterized in that: include: Table top (3) and table legs; The table top (3) is fixed on the table legs; The table top (3) is provided with a plurality of temporary inner grooves for sampling bottles, and the temporary inner grooves for sampling bottles are used for storing sampling bottles; A sampling bottle inner tank cover (4) is provided at the notch of the plurality of sampling bottle temporary storage inner tanks, and the sampling bottle inner tank cover (4) is used to keep the sampled samples warm and protect the samples during movement.

2. The bioreactor sampling bottle temporary storage device according to claim 1, characterized in that: A retractable spring (17) and a retractable spring clip (18) are provided in the temporary storage inner groove of the sampling bottle. The retractable spring clip (18) is connected to the temporary storage inner groove of the sampling bottle via the retractable spring (17). The retractable spring (17) and the retractable spring clip (18) are used to match sampling bottles of different shapes or sizes and fix the sampling bottles at the same time.

3. The bioreactor sampling bottle temporary storage device according to claim 2, characterized in that: Table cabins are provided on multiple sides of the table (3) and are equipped with corresponding cabin doors; the table cabins are used to place ice packs to ensure a low-temperature environment for temporary storage of samples.

4. The bioreactor sampling bottle temporary storage device according to claim 3, characterized in that: An inner tank (6) is arranged on the table (3), and a thermometer is placed in the inner tank (6) after adding an appropriate amount of purified water; the thermometer is used for real-time process temperature monitoring.

5. The bioreactor sampling bottle temporary storage device according to claim 4, characterized in that: The table leg is a liftable adjustment rod (14) and is provided with a fixed buckle (13). The height of the table top can be adjusted by utilizing the liftable adjustment rod (14) and the fixed buckle (13).

6. The bioreactor sampling bottle temporary storage device according to claim 5, characterized in that: The bottom of the table leg is provided with a movable universal wheel (15), and the movable universal wheel (15) is used to realize flexible movement.

7. The bioreactor sampling bottle temporary storage device according to claim 1, characterized in that: An in-situ disinfectant placement position (2) is arranged on any side of the table top (3), and the in-situ disinfectant placement position (2) is used to place the in-situ disinfectant.

8. The bioreactor sampling bottle temporary storage device according to claim 7, characterized in that: A hanging rod (1) is arranged on any side of the table top (3), and the hanging rod (1) is used for storing sterilized towels.

9. The bioreactor sampling bottle temporary storage device according to claim 1, characterized in that: The table top (3) is a smooth table top in a cube shape.

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