Plasma separating device

Abstract

The plasma separating device comprises a blood collecting cylinder, a plasma collecting box and a collecting needle assembly, a pre-filtering film and a blood filtering film are sequentially fixed in an opening in the lower end of the blood collecting cylinder from top to bottom, and the plasma collecting box is made of elastic materials. The plasma collecting box can be detachably connected with the blood collecting cylinder and the collecting needle assembly. A water absorbing block is arranged in the plasma collecting box, and when the plasma collecting box is connected with the blood collecting cylinder, the upper surface of the water absorbing block is in direct contact with the blood filtering film. By utilizing the physical form difference between blood visible components and plasma components, the blood collecting cylinder is connected with the plasma collecting box, the upper surface of the water absorbing block is in direct contact with the blood filtering film, and the water absorbing block provides strong capillary force, so that the plasma filtering efficiency is improved; then the plasma collecting box is fixedly connected with the collecting needle assembly, plasma can be separated from the water absorbing block and flows out of the collecting needle assembly by extruding the plasma collecting box through external force, and operation is convenient and fast.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection, in particular to a plasma separation device. Background Art

[0002] When conducting in vitro diagnostic tests (such as biochemical and immunological tests), the test samples may be whole blood, serum or plasma, depending on the test items and the requirements of the test reagents. Some projects specify that the samples must be serum or plasma due to the influence of blood cells, which requires the whole blood collected to be separated before the test to produce plasma or serum that meets the test requirements. The blood components mainly include blood cells, various proteins, water, ions, etc. When no anticoagulant is added, the whole blood coagulates and is divided into a blood cell layer and serum. Serum and blood cells can be separated by high-speed centrifugation; when an anticoagulant is added, blood cells and plasma can be separated by centrifugation. In the testing laboratory, a high-speed centrifuge is required to separate serum or plasma from whole blood, and the amount of blood centrifuged is also above the mL level. Vacuum blood collection tubes are often used for centrifugation to obtain serum or plasma. The disadvantage of this separation method is that it requires a special centrifuge, a large amount of blood is collected, special operators are required, and the turnover cycle is extended.

[0003] In order to solve the above problems, the Chinese patent with publication number CN207613776U provides a blood collection tube capable of separating plasma, including a collection tube body, a top tube cover, a bottom rubber sleeve, a cell screen, a multi-layer filter membrane, a bracket and a one-way baffle. The top of the collection tube body is provided with a top tube cover, and the bottom is provided with a bottom rubber sleeve; the top tube cover is embedded with a rubber sleeve matching the collection tube body; the inside of the collection tube is divided into two spaces, upper and lower, by the one-way baffle, the lower part close to the bottom rubber sleeve is a blood collection chamber, and the upper part close to the top tube cover is a plasma collection chamber; the inner wall of the blood collection chamber is provided with a bracket, a multi-layer filter membrane and a cell screen in sequence near the one-way baffle; a layer of anticoagulant is provided on the inner wall of the collection tube body. Through the cell screen and the multi-layer filter membrane built into the inner wall of the collection tube body, the formed components of the blood are retained in the blood collection chamber, while the plasma components can smoothly pass through the cell screen and the multi-layer filter membrane into the lower part of the blood collection tube, i.e., the plasma collection chamber, so as to separate the formed components of the plasma from the blood. However, the filtration efficiency of the above blood collection tube is low.

[0004] Therefore, the prior art has a large room for improvement. Utility Model Content

[0005] The purpose of the utility model is to make up for the deficiencies of the prior art and to propose a plasma separation device. A second connecting component that can be detachably connected to a first connecting component on a plasma collection box is provided on a blood collection tube. When the first connecting component is connected to the second connecting component, the upper surface of the water absorbent block is in direct contact with the blood filter membrane, so that the water absorbent block provides a strong capillary force, which is beneficial to improving the filtering efficiency of plasma.

[0006] In order to achieve the above object, the utility model is implemented through the following technical solutions:

[0007] The utility model provides a plasma separation device, comprising a blood collection tube, a plasma collection box and a collecting needle assembly, wherein a pre-filter membrane and a blood filter membrane are fixed in sequence from top to bottom in the lower end opening of the blood collection tube, and the upper surface of the blood filter membrane is directly in contact with the lower surface of the pre-filter membrane; the plasma collection box is made of elastic material, a first connecting component is provided on the plasma collection box, and a second connecting component that can be detachably connected to the first connecting component is provided on the blood collection tube; a water absorbent block is provided in the plasma collection box, and when the first connecting component is connected to the second connecting component, the upper surface of the water absorbent block is in direct contact with the blood filter membrane; the collecting needle assembly comprises a connecting seat and a collecting needle that are interconnected, the collecting needle is arranged at the upper end of the connecting seat, and a third connecting component that can be detachably connected to the first connecting component is provided on the connecting seat.

[0008] The plasma collection box can be connected to the blood collection tube or the collection needle assembly by connecting the first connection component with the second connection component or the third connection component. First, the first connection component is connected with the second connection component, so that the blood collection tube is fixed on the plasma collection box, and the upper surface of the water absorption block is in direct contact with the blood filter membrane. After the whole blood mixed with the anticoagulant is added to the blood collection tube, it passes through the pre-filter membrane and the blood filter membrane in turn to filter out the plasma. The water absorption block absorbs the filtered plasma, and the water absorption block provides a strong capillary force, which is conducive to improving the filtration efficiency of the plasma on the pre-filter membrane and the blood filter membrane; after the water absorption block is completed, the first connection component is disconnected from the second connection component, and the first connection component is connected to the third connection component, so that the collection needle assembly is fixed on the plasma collection box, and a force is applied to the plasma collection box from the outside, so that the plasma collection box is deformed, thereby producing an effect of squeezing the water absorption block without contacting the water absorption block, and the plasma is separated from the water absorption block and flows out through the connection seat and the collection needle in turn.

[0009] The function of the pre-filter membrane is to intercept some blood cells, reduce the clogging effect of blood cells on the subsequent blood filter membrane, and increase the filtration efficiency. The material can be fiber membrane, polyester mesh, glass fiber, etc., preferably fiber membrane. The function of the blood filter membrane is to intercept blood cells in the blood and filter out plasma. The material can be polyethersulfone, polyester fiber, mixed fiber, etc., preferably polyethersulfone. The absorbent block has strong water absorption, and the material can be cellulose, polyester and rayon / polypropylene blend material, preferably rayon / polypropylene blend. The plasma collection box is made of elastic materials such as rubber and plastic, which do not deform under normal circumstances, thereby supporting the absorbent block.

[0010] According to the above solution, the first connecting component is a buckle part, and the second connecting component is a first convex ring. The buckle part is rotatably arranged on the outer wall of the plasma collection box, and the first convex ring is arranged on the outer wall of the blood collection tube. Through the cooperation between the first convex ring and the buckle part, the plasma collection box can be detachably fixed on the blood collection tube, thereby improving the convenience of disassembly and assembly.

[0011] According to the above solution, the third connecting component is a second convex ring, and the second convex ring is arranged on the outer wall of the connecting seat. Through the cooperation between the second convex ring and the buckle part, the plasma collection box can be detachably fixed on the connecting seat, thereby improving the convenience of disassembly and assembly.

[0012] According to the above solution, the first connecting component is an external thread, which is arranged on the outer wall of the plasma collection box, and the second connecting component is a first internal thread, which is arranged on the inner wall of the lower end opening of the blood collection tube.

[0013] According to the above solution, the third connecting component is a second internal thread, and the second internal thread is arranged on the inner wall of the connecting seat.

[0014] The utility model adopts the buckle part to cooperate with the first convex ring and the second convex ring, and the external thread to cooperate with the first internal thread and the second internal thread to achieve a detachable connection; it is understandable that those skilled in the art can also choose other detachable connection structures as a substitute. According to the above scheme, the connecting seat is funnel-shaped. Through the above structural setting, the connecting seat plays a drainage role, increasing the speed of plasma flowing into the collection needle.

[0015] According to the above solution, a sealing ring is provided at the connection between the connection seat and the plasma collection box. By providing the sealing ring, the sealing performance of the connection between the connection seat and the plasma collection box is improved, and plasma is prevented from flowing out from the connection between the connection seat and the plasma collection box when the water absorption block is squeezed.

[0016] According to the above solution, the connection seat is funnel-shaped. Through the above structural arrangement, the connection seat plays a drainage role and increases the speed at which plasma flows into the collection needle.

[0017] According to the above solution, a vacuum blood collection tube is also included, the vacuum blood collection tube includes a tube body and a rubber plug, the rubber plug seals the tube opening of the tube body. The rubber plug can seal the tube body.

[0018] According to the above scheme, a puncture groove is provided on the upper surface of the rubber plug. Through the above structural setting, the rubber plug corresponding to the puncture groove is thinner, and the collecting needle is inserted into the rubber plug from the puncture groove, and it is easier to pierce into the tube body. The collecting needle pierces the rubber plug from the puncture groove and communicates with the tube body. Under the negative pressure of the vacuum blood collection tube, the plasma in the connecting seat quickly flows into the tube body through the collecting needle.

[0019] The beneficial effects of the utility model are:

[0020] The utility model provides a plasma separation device, which utilizes the physical form difference between formed elements of blood and plasma components, firstly fixes a blood collection tube with a plasma collection box so that the upper surface of a water absorbent block is in direct contact with a blood filter membrane, and the blood in the blood collection tube passes through a pre-filter membrane and a blood filter membrane to separate plasma from whole blood, and the water absorbent block provides a strong capillary force, thereby facilitating improving the filtration efficiency of plasma on the pre-filter membrane and the blood filter membrane; then, the plasma collection box is fixedly connected with a collection needle assembly, and the plasma collection box can be separated from the water absorbent block and flows out of the collection needle assembly by squeezing the plasma collection box with an external force, and the operation is convenient and quick. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the structure of the blood collection tube described in Example 1 of the utility model;

[0022] Figure 2 This is a schematic diagram of the structure of the plasma collection box described in Example 1 of the utility model;

[0023] Figure 3 It is a structural schematic diagram of the collecting needle assembly described in Example 1 of the utility model;

[0024] Figure 4 It is a schematic diagram of the structure of the vacuum blood collection tube described in Example 1 of the utility model;

[0025] Figure 5 This is the usage state of the utility model embodiment 1 Figure 1 ;

[0026] Figure 6 This is the usage state of the utility model embodiment 1 Figure 2 ;

[0027] Figure 7 This is the usage state of the utility model embodiment 1 Figure 3 ;

[0028] Figure 8This is a schematic diagram of the connection between the plasma collection box and the blood collection tube in Example 2 of the utility model;

[0029] Fig. 9 It is a schematic diagram of the connection between the plasma collection box and the collection needle assembly of Example 2 of the utility model.

[0030] In the figure: 1. blood collection tube; 11. pre-filter membrane; 12. blood filter membrane; 13. first convex ring; 14. first internal thread; 2. plasma collection box; 21. buckle part; 22. external thread; 3. water absorbent block; 4. connecting seat; 41. collecting needle; 42. second convex ring; 43. second internal thread; 5. tube body; 51. rubber plug; 511. puncture groove. DETAILED DESCRIPTION

[0031] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0032] Example 1

[0033] like Figure 1-7 As shown, the utility model provides a plasma separation device, including a blood collection tube 1, a plasma collection box 2 and a collecting needle assembly, wherein a pre-filter membrane 11 and a blood filter membrane 12 are fixed in sequence from top to bottom in the lower end opening of the blood collection tube 1, and the upper surface of the blood filter membrane 12 is directly in contact with the lower surface of the pre-filter membrane 12; the plasma collection box 2 is made of elastic material, and a first connecting component is provided on the plasma collection box 2, and a second connecting component that can be detachably connected to the first connecting component is provided on the blood collection tube 1; a water absorbent block 3 is provided in the plasma collection box 2, and when the first connecting component is connected to the second connecting component, the upper surface of the water absorbent block 3 is in direct contact with the blood filter membrane 12; the collecting needle assembly includes a connecting seat 4 and a collecting needle 41 that are interconnected, and the collecting needle 41 is arranged at the upper end of the connecting seat 4, and a third connecting component that can be detachably connected to the first connecting component is provided on the connecting seat 4.

[0034] The plasma collection box 2 can be connected to the blood collection tube 1 or the collection needle assembly by connecting the first connection component with the second connection component or the third connection component. First, the first connection component is connected with the second connection component, so that the blood collection tube 1 is fixed on the plasma collection box 2, and the upper surface of the water absorption block 3 is in direct contact with the blood filter membrane 12. After the whole blood mixed with the anticoagulant is added to the blood collection tube 1, it passes through the pre-filter membrane 11 and the blood filter membrane 12 in sequence to filter out the plasma. The water absorption block 3 absorbs the filtered plasma, and the water absorption block 3 provides a strong capillary force, which is conducive to improving the filtration efficiency of the plasma on the pre-filter membrane 11 and the blood filter membrane 12; after the water absorption block 3 completes the absorption, the first connection component is disconnected from the second connection component, and the first connection component is connected to the third connection component, so that the collection needle assembly is fixed on the plasma collection box 2, and a force is applied to the plasma collection box 2 from the outside, so that the plasma collection box 2 is deformed, thereby producing an effect of squeezing the water absorption block 3 without contacting the water absorption block 3, and the plasma is separated from the water absorption block 3 and flows out through the connection seat 4 and the collection needle 41 in sequence.

[0035] Furthermore, the pre-filter membrane 11 is a fiber membrane, and the blood filter membrane 12 is a polyethersulfone membrane. The function of the pre-filter membrane 11 is to intercept some blood cells, reduce the clogging effect of blood cells on the subsequent blood filter membrane 12, and increase the filtering efficiency. The function of the blood filter membrane 12 is to intercept blood cells in the blood and filter out plasma. The water absorbent block 3 has strong water absorption and is made of a rayon / polypropylene blend. The plasma collection box 2 is made of an elastic material such as rubber, plastic, etc., which does not deform under normal circumstances, thereby supporting the water absorbent block 3.

[0036] Specifically, the first connecting component is a buckle portion 21, and the second connecting component is a first convex ring 13. The buckle portion 21 is rotatably disposed on the outer wall of the plasma collection box 2, and the first convex ring 13 is disposed on the outer wall of the blood collection tube 1. The third connecting component is a second convex ring 42, and the second convex ring 42 is disposed on the outer wall of the connecting seat 4.

[0037] The first convex ring 13 cooperates with the buckle part 21, so that the plasma collection box 2 can be detachably fixed under the blood collection tube 1, thereby improving the convenience of disassembly and assembly. The second convex ring 42 cooperates with the buckle part 21, so that the plasma collection box 2 can be detachably fixed on the connecting seat 4, thereby improving the convenience of disassembly and assembly.

[0038] Furthermore, a sealing ring is provided at the connection between the connection seat 4 and the plasma collection box 2. By providing the sealing ring, the sealing performance of the connection between the connection seat 4 and the plasma collection box 2 is improved, and the plasma is prevented from flowing out from the connection between the connection seat 4 and the plasma collection box 2 when the water absorption block 3 is squeezed.

[0039] Furthermore, the connection seat 4 is funnel-shaped. Through the above-mentioned structural arrangement, the connection seat 4 plays a drainage role, thereby increasing the speed at which plasma flows into the collection needle 41.

[0040] Furthermore, a vacuum blood collection tube is also included, and the vacuum blood collection tube includes a tube body 5 and a rubber plug 51, and the rubber plug 51 blocks the tube opening of the tube body 5. The rubber plug 51 can seal the tube body 5.

[0041] Furthermore, a puncture groove 511 is provided on the upper surface of the rubber plug 51. Through the above-mentioned structural setting, the position of the rubber plug 51 corresponding to the puncture groove 511 is relatively thin, and the collecting needle 41 is inserted into the rubber plug 51 from the puncture groove 511, and it is easier to pierce into the tube body 5. The collecting needle 41 pierces the rubber plug 51 from the puncture groove 511 and communicates with the tube body 5. Under the negative pressure of the vacuum blood collection tube, the plasma in the connecting seat 4 quickly flows into the tube body 5 through the collecting needle 41.

[0042] When the plasma separation device of the utility model is used, Figure 5 As shown, first, the buckle portion 21 of the plasma collection box 2 is buckled with the first convex ring 13 of the blood collection tube 1, so that the plasma collection box 2 is fixed below the blood collection tube 1, and the upper surface of the water absorbent block 3 is in direct contact with the blood filter membrane 12, and then the whole blood mixed with the anticoagulant is added to the blood collection tube 1, and the blood passes through the pre-filter membrane 11 and the blood filter membrane 12 to filter out the plasma, and the water absorbent block 3 absorbs the filtered plasma. After the water absorbent block 3 completes the absorption, the buckle portion 21 is brought into contact and connection with the first convex ring 13 so that the plasma collection box 2 is brought into contact and connection with the blood collection tube 1; as shown in FIG. Figure 6 As shown, the buckle portion 21 of the plasma collection box 2 is buckled with the second convex ring 42 on the connecting seat 4, so that the lower end of the connecting seat 4 is fixed to the plasma collection box 2, and the plasma collection box 2 is squeezed by hand or mechanical force to deform the water absorption block 3, so that the plasma is squeezed out of the water absorption block 3 and the squeezed state is maintained; Figure 7 As shown, the collecting needle 41 is inserted into the rubber plug 51 from the puncture groove 511 and connected with the tube body 5. Under the negative pressure of the vacuum blood collection tube, the squeezed plasma quickly flows into the tube body 5 through the collecting needle 41. During this period, the squeezing can be continued to ensure that all the plasma is transferred to the tube body 5.

[0043] Example 2

[0044] like Figure 8-9As shown, this embodiment provides a plasma separation device, whose structure is basically the same as that of Example 1, except that: the first connecting component is an external thread 22, and the external thread 22 is arranged on the outer wall of the plasma collection box 2; the second connecting component is a first internal thread 14, and the first internal thread 14 is arranged on the inner wall of the lower end opening of the blood collection tube 1; the third connecting component is a second internal thread 43, and the second internal thread 43 is arranged on the inner wall of the connecting seat 4.

[0045] The above description is only a preferred embodiment of the present utility model, so all equivalent changes or modifications made according to the structure, features and principles described in the scope of the present utility model patent application are included in the scope of the present utility model patent application.

Claims

1. A plasma separation device, characterized in that: The invention comprises a blood collection tube (1), a plasma collection box (2) and a collection needle assembly, wherein a pre-filter membrane (11) and a blood filter membrane (12) are fixed in sequence from top to bottom in the lower end opening of the blood collection tube (1), and the upper surface of the blood filter membrane (12) is directly in contact with the lower surface of the pre-filter membrane (11); The plasma collection box (2) is made of an elastic material, the plasma collection box (2) is provided with a first connecting component, and the blood collection tube (1) is provided with a second connecting component that can be detachably connected to the first connecting component; The plasma collection box (2) is provided with a water absorbent block (3), and when the first connecting component is connected to the second connecting component, the upper surface of the water absorbent block (3) is in direct contact with the blood filter membrane (12); The collecting needle assembly comprises a connecting seat (4) and a collecting needle (41) which are interconnected, wherein the collecting needle (41) is arranged at the upper end of the connecting seat (4), and the connecting seat (4) is provided with a third connecting component which can be detachably connected to the first connecting component.

2. The plasma separation device according to claim 1, characterized in that: The pre-filtration membrane (11) is a fiber membrane, and the blood filter membrane (12) is a polyethersulfone membrane.

3. The plasma separation device according to claim 1, characterized in that: The first connecting component is a buckle portion (21), and the second connecting component is a first convex ring (13). The buckle portion (21) is rotatably arranged on the outer wall of the plasma collection box (2), and the first convex ring (13) is arranged on the outer wall of the blood collection tube (1).

4. The plasma separation device according to claim 3, characterized in that: The third connecting component is a second convex ring (42), and the second convex ring (42) is arranged on the outer wall of the connecting seat (4).

5. The plasma separation device according to claim 1, characterized in that: The first connecting component is an external thread (22), and the external thread (22) is arranged on the outer wall of the plasma collection box (2). The second connecting component is a first internal thread (14), and the first internal thread (14) is arranged on the inner wall of the lower end opening of the blood collection tube (1).

6. The plasma separation device according to claim 5, characterized in that: The third connecting component is a second internal thread (43), and the second internal thread (43) is arranged on the inner wall of the connecting seat (4).

7. The plasma separation device according to claim 1, characterized in that: A sealing ring is provided at the connection between the connection seat (4) and the plasma collection box (2).

8. The plasma separation device according to claim 1, characterized in that: The connecting seat (4) is funnel-shaped.

9. The plasma separation device according to claim 1, characterized in that: It also comprises a vacuum blood collection tube, which comprises a tube body (5) and a rubber plug (51), wherein the rubber plug (51) blocks the tube opening of the tube body (5).

10. The plasma separation device according to claim 9, characterized in that: The upper surface of the rubber plug (51) is provided with a puncture groove (511).

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