Bagged preparation split charging consumable and system

Abstract

According to the bagged preparation split charging consumable and system, the split charging pipe set and the flow detection pipe set are connected to one end of the main pipeline in parallel, the average flow value of a peristaltic pump at the split charging rotating speed is calculated through the flow detection pipe set, then liquid is filled with the same average flow, and therefore the filling time is more accurately controlled, and the filling efficiency is improved. The flow value error caused by equal-ratio calculation of the flow at different rotating speeds through the rotating speed ratio in a traditional method is eliminated; besides, the split charging pipe group and the flow detection pipe group are connected with the main pipeline in parallel, and the liquid in the pipeline is pumped back to the mother liquid bag, so that the residue of the cell liquid in the pipeline can be reduced; the sub-packaging system adopts specially designed disposable sterile closed consumables, and a peristaltic pump, a flow detection tube module and a sub-packaging tube group are uniformly controlled through a controller, so that the risk that the cell liquid is polluted is reduced while mechanical sub-packaging and exhaust are realized.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, and in particular to a bagged preparation packaging consumable material and a system. Background Art

[0002] Preparation packaging technology is an important part of the field of biopharmaceutical technology, especially for preparation products such as cell therapy and gene therapy. However, there are still the following problems in the packaging of preparations in this field: First, since biologically active preparations cannot be sterilized during the production process, in order to avoid possible cross-contamination in various production links, pharmaceutical companies are increasingly inclined to use disposable sterile and closed consumables for production and packaging. However, many of them currently rely on manually controlled packaging and exhaust, which makes the packaging and exhaust process have certain risks, and can only rely on a very high background clean environment to reduce the risk.

[0003] Second, the current production cost of cell drugs is still very high, especially for cell drugs for personalized treatment. The entire production process, including the packaging process, must minimize the waste of cell fluid. The existing technology for preparation packaging still has shortcomings in residual liquid control: the quantitative module and method used in the utility model patent with application number CN202320554893.9 are connected in series in the main pipeline. The use of a series connection will lead to an increase in residual liquid. To reduce the residual liquid, the quantitative device can only be reversed at the end of the packaging. If this action is done manually, it will become difficult for users to accept. If an automated mechanism is used to do this action, the cost will increase, and the length of the pipeline needs to be increased to have free space for the inversion action. The increase in the length of the pipeline will also increase the amount of residual liquid.

[0004] Third, the preparation packaging bags and tube sets are disposable consumables and will be discarded after packaging a batch of liquid medicine. When packaging other batches of liquid medicine, new packaging bags and tube sets must be used. The volume stability of the dosing device is an important factor in the stability of the packaging accuracy. The gross error of the dosing device processing will lead to unacceptable packaging accuracy. If strict processing accuracy standards are used to control, the cost will also be greatly increased. In real applications, relying entirely on the volume accuracy of the dosing device makes the packaging accuracy of different batches unreliable.

[0005] Therefore, it is urgent to invent a bagged preparation packaging consumables and system to effectively solve at least one of the above-mentioned technical problems. Utility Model Content

[0006] The purpose of the utility model is to provide a bagged preparation packaging consumable and system to effectively solve at least one problem in the aseptic packaging exhaust operation of biological preparations, cell fluid waste, and accurate measurement.

[0007] In order to achieve the above-mentioned purpose, the utility model provides a bagged preparation packaging consumable material, comprising:

[0008] Mother solution bag;

[0009] A main pipeline, one end of which is connected to the mother liquid bag and the other end of which has at least one branch pipeline;

[0010] A flow detection tube group connected to the main pipe; the flow detection tube group includes a dosator and a first air discharge device, and the dosator is located between the first air discharge device and the main pipe;

[0011] At least one group of sub-packaging tube groups, each of which is arranged in one-to-one correspondence with the branch pipelines of the main pipeline and connected to the corresponding branch pipelines; each group of the sub-packaging tube groups includes a multi-component bagging pipeline and a second air exhaust device; the multi-component bagging pipeline is connected in parallel to the corresponding branch pipeline and is located between the second air exhaust device and the flow detection tube group.

[0012] Furthermore, the dosing device includes a cylindrical body and a conical tip, and the conical tip is arranged at two opposite ends of the cylindrical body.

[0013] Furthermore, the quantitative device is provided with a barcode, a two-dimensional code or an RFID chip, and the volume value of the quantitative device is built into the barcode, the two-dimensional code or the RFID chip.

[0014] Furthermore, the first air discharge device comprises:

[0015] A first dripping funnel, one end of which is connected to the outlet of the dosing device;

[0016] The first air filter is connected to the other end of the first drip bucket.

[0017] Furthermore, a filter membrane is provided in the first air filter, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm.

[0018] Furthermore, the second air discharge device comprises:

[0019] A second drip bucket, one end of which is connected to the pipeline;

[0020] The second air filter is connected to the other end of the second drip bucket.

[0021] Furthermore, a filter membrane is provided in the second air filter, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm.

[0022] The first air discharge device and the second air discharge device are both gas collection bags.

[0023] Furthermore, the sub-packaging pipe groups are provided in multiple groups, and the multiple groups of sub-packaging pipe groups are connected in parallel to the main pipe.

[0024] Furthermore, the dispensing bag pipeline includes: a dispensing bag, a dispensing bag pinch valve and a dispensing bag liquid level sensor;

[0025] The sub-packaging bag is connected to the main pipeline through a branch pipeline, the sub-packaging bag liquid level sensor and the sub-packaging bag clamping valve are both arranged on the branch pipeline, and the sub-packaging bag liquid level sensor is located between the sub-packaging bag clamping valve and the sub-packaging bag.

[0026] The utility model also provides a bagged preparation dispensing system, comprising the bagged preparation dispensing consumables as described above, and further comprising:

[0027] A peristaltic pump is arranged on the main pipe and is used to pump the liquid in the mother liquid bag to the flow detection module and the sub-filling tube group, or to pump the liquid in the flow detection module and the sub-filling tube group back to the mother liquid bag;

[0028] A flow detection module, disposed between the doser and the first air discharge device and between the doser and the main line, for detecting an average flow value of the peristaltic pump at a filling speed;

[0029] The controller is signal-connected to the peristaltic pump, the flow detection tube group and the dispensing tube group.

[0030] Furthermore, the flow detection tube set also includes:

[0031] A flow detection lower pipeline is connected to the doser and the main pipeline; a flow detection bypass pinch valve and a lower liquid level sensor are provided on the flow detection lower pipeline, and the flow detection bypass pinch valve is arranged between the lower liquid level sensor and the main pipeline;

[0032] A flow detection upper pipeline, connecting the doser and the first air discharge device;

[0033] An upper liquid level sensor is arranged at the outlet of the dosing device; a lower liquid level sensor is arranged at the inlet of the dosing device;

[0034] A flow detection bypass pinch valve, arranged between the lower liquid level sensor and the main pipe;

[0035] A reading device is used to read the barcode, QR code or RFID signal on the quantitative device to obtain the volume value V of the quantitative device. 定 .

[0036] Furthermore, the packaging tube group also includes:

[0037] A subpackaging pinch tube valve, arranged on the main pipeline and located between the flow detection tube set and the multi-component bagging pipeline;

[0038] The filling liquid level sensor is arranged on the main pipeline and is located between the multi-component bagging pipeline and the second air exhaust device.

[0039] Furthermore, the second air discharge device comprises:

[0040] A second drip bucket, one end of which is connected to the liquid filling level sensor;

[0041] a terminal pinch valve, one end of which is connected to the other end of the second dripping funnel;

[0042] The second air filter is connected to the other end of the terminal pinch valve.

[0043] Furthermore, the second air discharge device comprises:

[0044] An end pinch valve, one end of which is connected to the filling liquid level sensor;

[0045] The second gas collection bag is connected to the other end of the terminal pinch valve.

[0046] Compared with the prior art, the beneficial effects of the present invention are mainly reflected in the following aspects:

[0047] 1. Provide a bagged preparation filling system, wherein a filling pipeline and a flow detection tube group are connected in parallel to one end of a main pipeline, rather than being connected in series in the pipeline. In the distance arrangement relative to the mother liquid bag, the position of the connection point between the flow detection tube group and the main pipeline is located before the connection point between the filling tube group and the main pipeline. The above arrangement reduces the residual cell liquid in the pipeline, thereby saving production costs.

[0048] 2. Provide a bagged preparation filling system, which uses specially designed disposable sterile closed consumables, and uses a controller to uniformly control the peristaltic pump, flow detection module and filling module, thereby realizing mechanized filling and exhaust while reducing the risk of cell liquid contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 A schematic diagram of a bagged preparation dispensing system according to a third embodiment of the present invention;

[0050] Figure 2 A schematic diagram of a bagged preparation dispensing system according to a fourth embodiment of the present invention;

[0051] Figure 3 This is a schematic diagram of the structure of a quantitative device in one embodiment of the utility model;

[0052] Figure 4 It is a schematic diagram of a quantitative device and a flow detection module in one embodiment of the utility model.

[0053] In the figure, 100, the sub-packaging tube group; 200, the flow detection tube group; 300, the sub-packaging bag pipeline; 1, the mother liquid bag; 2, the first gas collection bag; 3, the main pipeline; 4, the second gas collection bag; 5, the controller; 6, the peristaltic pump; 7, the flow detection bypass clamp valve; 8, the lower liquid level sensor; 9, the flow detection lower pipeline; 10, the doser; 11, the container label; 12, the upper liquid level sensor; 13, the flow detection upper pipeline; 14, the first drip bucket; 15, the first air filter; 16, the reading device; 17, the sub-packaging clamp valve; 18, the filling liquid level sensor; 19, the second drip bucket; 20, the end clamp valve; 21, the second air filter; 22, the sub-packaging bag clamp valve; 23, the sub-packaging bag liquid level sensor; 24, the sub-packaging bag; 101, the doser outlet; 102, the doser inlet; 103, the doser outlet; 104, the doser inlet. DETAILED DESCRIPTION

[0054] The following is a more detailed description of a bagged preparation dispensing consumable and system of the utility model in conjunction with the accompanying drawings, wherein preferred embodiments of the utility model are shown. It should be understood that those skilled in the art can modify the utility model described herein and still achieve the beneficial effects of the utility model. Therefore, the following description should be understood as being widely known to those skilled in the art and not as a limitation to the utility model.

[0055] The present invention is described in more detail in the following paragraphs by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the accompanying drawings are in very simplified form and in non-precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0056] Embodiment 1

[0057] The present embodiment proposes a bagged preparation packaging consumable, comprising: a mother liquid bag 1; a main line 3, connected to the mother liquid bag 1; a flow detection tube group 200, connected to the main line 3; the flow detection tube group 200 comprises a doser 10 and a first air discharge device, the doser 10 is located between the first air discharge device and the main line 3; at least one group of packaging tube groups, the packaging tube group 100 comprises a multi-component bagging pipeline 300 and a second air discharge device; the multi-component bagging pipeline 300 is connected in parallel to the main line 3, and is located between the second air discharge device and the flow detection tube group 200.

[0058] Preferably, the quantitative device 10 is provided with a container identification 11, and the actual content volume V of the quantitative device 10 for packaging consumables of the bagged preparations of different batches and individuals is 定During the production process, the internal volume of the dosing device 10 is unknown, which makes the bagged preparation packaging system have no requirements on the volume consistency of different dosing devices 10, and only requires the volume of a single individual to be accurate.

[0059] The bagged preparation dispensing consumables or packaging should have the container identification 11, and the container identification 11 includes the unique serial number of the quantitative device 10 and the actual content volume V 定 The information medium may be a combination of one or more of a QR code, a bar code, an RFID chip, directly engraved or printed characters and / or numbers, etc.

[0060] Preferably, a container identification 11 in the form of a QR code and / or an RFID tag is attached to the dosing device 10, and characters and / or numbers that can be directly read by humans are printed on the container identification 11, and the content includes the brand / manufacturer, the unique serial number of the dosing device 10 and the actual content volume. 定 And other content.

[0061] When filling the sub-packaging bag with liquid, for example, when it is necessary to fill the sub-packaging bag with cell liquid in a sterile environment, the liquid in the mother liquid bag is first transported to the doser 10 in the flow detection tube group 200 until the doser 10 is filled. Since the actual volume in the doser 10 can be obtained by scanning the code, the average flow value of the peristaltic pump 6 can be calculated by recording the time t1 passing through the doser 10.

[0062] According to the volume V required for the filling bag f Calculate the time t required to dispense the liquid f The consumables can be packaged with higher precision, and the actual average flow value of the peristaltic pump 6 can be obtained.

[0063] In order to save cell liquid, after calculating the average flow value of the peristaltic pump 6 , the cell liquid in the flow detection tube set 200 is pumped back into the mother liquid bag 1 .

[0064] In this embodiment, please refer to Figure 4 The dosing device 10 includes a cylindrical body and a conical tip, and the conical tip is disposed at two opposite ends of the cylindrical body.

[0065] In a specific example, the first air discharge device includes: a first drip bucket 14, one end of which is connected to the outlet of the metering device 10; and a first air filter 15, which is connected to the other end of the first drip bucket 14. When the liquid passes through the flow detection tube set 200, the gas in the pipeline of the flow detection tube set 200 is located above the liquid, and at this time, the gas can be discharged from the flow detection tube set 200 through the first air filter 15.

[0066] Preferably, a filter membrane is provided in the first air filter 15, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm to achieve cleaner filtration.

[0067] Since the second air discharge device has the same exhaust function, the second air discharge device can adopt the same or similar structure as the first air discharge device. Specifically, the second air discharge device includes: a second drip bucket 19, one end of which is connected to the pipeline; and a second air filter 21, which is connected to the other end of the second drip bucket 19. When the liquid passes through the multi-component packaging tube group 100, the gas in the sub-packaging tube group 100 and the main pipeline 3 can be discharged to the outside of the consumables through the second air filter 21.

[0068] Similarly, the second air filter 21 is also provided with a filter membrane, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm, so as to achieve the same purpose as the first air filter 15.

[0069] Specifically, the sub-packaging tube groups 100 are provided in multiple groups, and the multiple groups of sub-packaging tube groups 100 are connected in parallel to the main pipe.

[0070] Furthermore, the sub-packaging bag pipeline 300 includes: a sub-packaging bag 24, a sub-packaging bag pinch valve 22 and a sub-packaging bag liquid level sensor 23;

[0071] The sub-packaging bag 24 is connected to the main pipeline 3 through a branch pipeline, the sub-packaging bag liquid level sensor 23 and the sub-packaging bag clamping valve 22 are both arranged on the branch pipeline, and the sub-packaging bag liquid level sensor 23 is located between the sub-packaging bag clamping valve 22 and the sub-packaging bag 24.

[0072] Based on the needs of the actual scenario, the target packaging volume V of each packaging bag 24 in the same component packaging pipeline 300 is f They can be the same or different. If the target dispensing volume is different, the average flow value of the peristaltic pump can be adjusted.

[0073] In summary, this embodiment provides a bagged preparation dispensing consumables, in which the dispensing tube set 100 and the flow detection tube set 200 are connected in parallel at one end of the main line 3, rather than being connected in series in the main line 3. After the flow detection, the liquid in the flow detection tube can be pumped back into the mother liquid bag, and then the dispensing tube set can be directly filled, reducing the liquid remaining in the pipeline of the flow detection tube set, thereby saving production costs. The bagged preparation dispensing consumables proposed in this embodiment can realize mechanized dispensing and reduce the risk of liquid contamination.

[0074] Embodiment 2

[0075] Most of the components in this embodiment are the same as those in the first embodiment, except that in the flow detection tube set 200, the first air discharge device is a first gas collection bag 2. Since the liquid separation is operated in a sealed environment, if there is a gas or liquid leakage in some pipes during the operation, the integrity of the entire consumables will be destroyed; by setting the first gas collection bag 2, if the gas can be squeezed into the bag normally, it means that the consumables can work normally, otherwise, the consumables need to be replaced.

[0076] Similarly, in the multi-component tube assembly 200, the second air exhaust device can also be set as a second gas collection bag 4. Since the liquid separation is operated in a sealed environment, if there is a gas or liquid leakage in some pipelines during the operation, the integrity of the entire consumables will be destroyed; by setting the second gas collection bag 4, if the gas can be squeezed into the bag normally, it means that the consumables can work normally, otherwise, the consumables need to be replaced.

[0077] The remaining structures and working principles are the same as those of the first embodiment. For details, please refer to the description in the first embodiment and will not be repeated here.

[0078] Embodiment 3

[0079] like Figure 1 As shown, this embodiment proposes a bagged preparation dispensing system, including the bagged preparation dispensing consumables as described in Example 1. The specific structure can refer to Example 1 and will not be described in detail here. In addition, the dispensing tube group 100 also includes: a peristaltic pump 6, which is arranged on the main line 3, and is used to pump the liquid in the mother liquid bag 1 to the flow detection module and the dispensing tube group, or to pump the liquid in the flow detection module and the dispensing tube group back to the mother liquid bag 1; a flow detection module, which is arranged between the doser 10 and the first air exhaust device and between the doser 10 and the main line 3, and is used to detect the average flow value of the peristaltic pump 6 at the dispensing speed; a controller 5, which is signal-connected to the peristaltic pump 100, the flow detection tube group 200 and the multi-group dispensing tube group 100.

[0080] In this embodiment, there may be a plurality of main pipes 3 , each of which is independently connected to the mother liquid bag 1 and at least one group of packaging tube groups 100 .

[0081] The peristaltic pump 6 is used to drive the flow direction and flow rate of the liquid and gas inside the bagged preparation dispensing consumables of this embodiment. A section of pipeline suitable for the peristaltic pump 6 is provided on the main pipeline 3, and the material of the section of pipeline can be silica gel.

[0082] In this embodiment, the main line 3 may be composed of one or more sections of pipes and joints of different materials and specifications connected together due to the need to install the peristaltic pump 6, the clamping valve, the fusion seal, the sterile connection pipe and other functions. It may include but not be limited to silicone tubes, PVC hoses, EVA hoses, TPE hoses, etc.

[0083] In a specific example, the flow detection tube group 200 also includes: a flow detection lower pipeline 9, connecting the dosing device 10 and the main pipeline 3; a flow detection bypass pinch valve 7 and a lower liquid level sensor 8 are provided on the flow detection lower pipeline 9, and the flow detection bypass pinch valve 7 is arranged between the lower liquid level sensor 8 and the main pipeline 3; a flow detection upper pipeline 13, connecting the dosing device 10 and the first air exhaust device; an upper liquid level sensor 12, arranged at the outlet of the dosing device 10; a lower liquid level sensor 8, arranged at the inlet of the dosing device 10; a flow detection bypass pinch valve 7, arranged between the lower liquid level sensor 8 and the main pipeline 3; a reading device 16, used to read the bar code, QR code or RFID signal on the dosing device 10 to obtain the volume value V of the dosing device 定 .

[0084] The actual content volume V of the dosing device 10 for packaging consumables of the bagged preparations of different batches and individuals 定 During the production process, the internal volume of the dosing device 10 is unknown, which makes the bagged preparation packaging system have no requirements on the volume consistency of different dosing devices 10, and only requires the volume of a single individual to be accurate.

[0085] The bagged preparation dispensing consumables or packaging should have the container identification 11, which contains the unique serial number of the quantitative device 10 and the information medium of the actual content volume. The information medium can be a combination of one or more of a QR code, a bar code, an RFID chip, directly engraved or printed characters and / or numbers, etc.

[0086] Preferably, a container identification in the form of a QR code and / or an RFID tag is attached to the dosing device 10, and characters and / or numbers that can be directly read by humans are printed on the container identification 11, and the content includes the brand / manufacturer, the unique serial number of the dosing device and the actual content volume. 定 And other content.

[0087] Furthermore, the controller 5 can read the medium information on the doser 10 through the reading device 16 and has the function of automatically modifying the internal volume or related settings of the doser 10 in the controller.

[0088] Preferably, the controller 5 supports modifying the internal volume of the doser 102 or related settings in the controller 5 according to the internal volume value of the doser 10 manually read.

[0089] Obtain the filling time t2 of the liquid filling the volume between the lower liquid level sensor 8 and the upper liquid level sensor 121, and obtain the volume value V of the dosing device 10 定 , a first volume value V of the flow detection lower pipeline 9 between the lower liquid level sensor 8 and the dosing device 10 1、 and the second volume value V2 of the flow detection upper pipeline 13 between the upper liquid level sensor 12 and the doser 10; the total volume V passing through the flow detection tube set 200 is obtained. 总 =V 定 +V1+V2; then the average flow value of the peristaltic pump 6 is obtained.

[0090] In this embodiment, the dosing device 10 has sufficient rigidity, and is generally made of a material such as PC, PP, PE, glass, stainless steel, etc., which has a smooth surface and is not prone to adhesion and residual liquid.

[0091] In a specific example, the sub-packaging tube group 100 also includes: a sub-packaging tube clamping valve 17, which is arranged on the main line and located between the flow detection tube group 200 and the multi-component bagging pipeline 300; a filling level sensor 18, which is arranged on the main line and located between the multi-component bagging pipeline 300 and the second air exhaust device.

[0092] In a specific example, the second air discharge device includes:

[0093] A second drip bucket 19, one end of which is connected to the liquid filling level sensor 18;

[0094] A terminal pinch valve 20, one end of which is connected to the other end of the second drip funnel 19;

[0095] The second air filter 21 is connected to the other end of the terminal pinch valve 20 .

[0096] In a specific example, the sub-packaging bag pipeline 300 includes: a sub-packaging bag 24, a sub-packaging bag clamping valve 22 and a sub-packaging bag liquid level sensor 23; the sub-packaging bag 24 is connected to the main pipeline 3 through the sub-packaging bag liquid level sensor 23 and the sub-packaging bag clamping valve 22 in sequence.

[0097] Among them, the length of each packaging bag pipeline should be consistent.

[0098] Before packaging the liquid, it is necessary to first vent the packaging pipeline and the main pipeline, open the packaging clamp valve 17, and when the peristaltic pump 6 transports the liquid in the mother liquid bag 1 to the liquid filling level sensor 18 through the main pipeline 3, the air in the main pipeline 3 is discharged through the second air discharge device.

[0099] Start to pack the liquid, and obtain the target packing volume V required to be packed in the single or multiple packing bags 24. f , according to the target packaging volume V f and the average flow value of peristaltic pump 6 to calculate the filling time t f =V f ×t2 / (V 定 +V1+V2), start the peristaltic pump 6, and start timing when the liquid is transported to the bag-filling pipeline 300. When the time is t f Stop filling.

[0100] In order to avoid liquid waste, the liquid in the sub-packaging tube set 100 needs to be pumped back: the sub-packaging bag tube clamp valve 17 is closed, and the liquid in the main line 3 is pumped back into the mother liquid bag 1 through the peristaltic pump 6 .

[0101] It should be noted that the bagged preparation dispensing system of the present embodiment is used for filling liquid and serving as a flow path for liquid flow, so that the liquid is aseptically isolated from the external environment. Generally, after dispensing a batch of liquid, it is no longer used for other batches of liquid to avoid cross contamination. However, the flow detection bypass clamp valve 7, the lower liquid level sensor 8, the upper liquid level sensor 12, the dispensing clamp valve 17, the filling liquid level sensor 18, the end clamp valve 20, the dispensing bag clamp valve 22 and the dispensing bag liquid level sensor 23 do not directly contact the inner wall of the pipeline in the bagged preparation dispensing consumables, and are not connected to the pipeline in the bagged preparation dispensing consumables. The sensor used in the present embodiment is generally a non-contact sensor made of ultrasonic, photoelectric, optical fiber, capacitance and other principles. Therefore, it does not contact the fluid in the bagged preparation dispensing consumables during operation and can be used repeatedly.

[0102] Preferably, all the pinch valves in the bag dispensing pipeline 300 are normally closed, that is, the flow path can be cut off when the power is turned off, and the flow path can be connected when the power is turned on.

[0103] In order to facilitate the understanding of the specific structure of the quantitative device, such as Figure 4 As shown, the quantitative device 10 mainly includes the following components: a quantitative device outlet 103 , a quantitative device inlet 104 , a quantitative device outlet end 101 and a quantitative device inlet end 102 , and the container identification label 11 is on the quantitative device 10 .

[0104] In summary, this embodiment provides a bagged preparation filling system, which first calculates the average flow value of the peristaltic pump 6 through the flow detection tube group 200, and then drives the peristaltic pump 6 to fill the single or multiple filling bags 24 with liquid at the same average flow value, thereby accurately controlling the filling time.

[0105] Embodiment 4

[0106] like Figure 2 As shown, most of the components in this embodiment are the same as those in the third embodiment, except that: in the flow detection tube group 200, the first air discharge device is a first gas collection bag 2, and its material is a flexible plastic film material. The first gas collection bag 2 can not only achieve the same effect as the combination of the first drip bucket 14 and the first air filter 15, but also because the entire system operates in a sealed environment, if there are air leakage or liquid leakage problems in some pipelines during operation, it will also destroy the integrity of the entire system; by setting the first gas collection bag 2, if the gas can be squeezed into the bag normally, it means that the system can work normally, otherwise, the system needs to be replaced.

[0107] Furthermore, the second air discharge device includes: an end clamping valve 20, one end of which is connected to the liquid filling level sensor 18; a second gas collection bag 4, which is connected to the end clamping valve 20. The above combination can achieve the same effect as the combination of Example 1. Moreover, since the entire system operates in a sealed environment, if there are air or liquid leakage problems in some pipelines during operation, the integrity of the entire system will be destroyed; by setting the second gas collection bag 4, if the gas can be squeezed into the bag normally, it means that the system can work normally, otherwise, the system needs to be replaced.

[0108] Embodiment 5

[0109] In this embodiment, a method for using a bagged preparation dispensing system is proposed, comprising the following steps:

[0110] The liquid in the mother liquid bag is pumped into the dosing device 10 in the flow detection tube group 200 through the main pipe 3 by the peristaltic pump 6 until the liquid reaches the upper liquid level sensor 12, so that the air in the dosing device 10 is discharged through the first air discharge device;

[0111] Obtain the filling time t2 of the volume between the lower liquid level sensor 8 and the upper liquid level sensor 121, and the volume value V of the quantitative device 10 定 , a first volume value V1 between the lower liquid level sensor 8 and the dosing device 10 and a second volume value V2 between the upper liquid level sensor 12 and the dosing device 10;

[0112] According to the filling time t2、 The volume value V of the dosing device 10 定 , the first volume value V1 and the second volume value V2 are used to calculate the average flow value of the current peristaltic pump 6 at the filling speed;

[0113] According to the packaging volume V required to be packaged in a single or multiple packaging bags 24 f , calculate the filling time t required to complete the filling f ;

[0114] Start filling. When the liquid flows through the sub-packaging bag liquid level sensor 23, start timing until the filling time t is reached. f Stop filling.

[0115] Specifically, the flow detection tube group 200 is firstly vented: when the liquid reaches the upper liquid level sensor 12 of the flow detection tube group 200, the peristaltic pump 6 pumps the liquid in the flow detection tube group 200 back to the mother liquid bag 1.

[0116] Next, if Figure 3 As shown, the filling time t is obtained f The calculation formula is: f =V f ×t2 / (V 定 +V1+V2), where V f is the target packaging volume of a single or multiple packaging bags 24, V 定 is the volume value of the dosing device, V1 is the first volume value between the lower liquid level sensor 8 and the dosing device 10, and V2 is the second volume value between the upper liquid level sensor 12 and the dosing device 10. Get the volume value V 定 The controller 5 may read the actual volume data of the doser 10 in the container identification 11 through a reading device (e.g., a barcode scanner); the first volume value V1 and the second volume value V2 are obtained by ordinary technicians through existing technology and knowledge. The lengths L1 and L2 of the pipeline are known, and the radius r of the pipeline is also known. The calculation formula of the pipeline volume is: πr 2 *length.

[0117] Specifically, before starting filling, the main line 3 is vented, and when the peristaltic pump 6 transports the liquid in the mother liquid bag 1 to the filling level sensor 18 through the main line 3, the air in the main line 3 is discharged through the second air exhaust device.

[0118] Furthermore, after the main pipe 3 is exhausted, the terminal pinch valve 20 is closed, and one or more pinch valves 17 of the sub-packaging bag are opened to start filling.

[0119] Furthermore, after filling is completed, in order to reduce waste of liquid, the sub-filling bag clamp valve 17 is closed, and the liquid in the main line 3 is pumped back into the mother liquid bag 1 through the peristaltic pump 6 .

[0120] Specifically, after the liquid in the main line 3 is pumped back to the mother liquid bag 1, the sub-packaging bag clamp valve 22 is opened, and the peristaltic pump 6 pumps back the liquid in the sub-packaging bag 1 until the liquid is transported to the sub-packaging bag liquid level sensor 23 and stops pumping back. The purpose of this step is to exhaust the sub-packaging bag 24.

[0121] It should be noted that, based on the needs of the actual scenario, the packaging volume V of each packaging bag 24 in the same group packaging pipeline 300 is f The same group of packaging tubes 100 may have different packaging volumes V. f The packing bag 24 is prepared and the above steps are repeated to achieve packing.

[0122] If there are multiple groups of packaging tube groups 100 that need to be packaged, switch to the next group and repeat the above steps until all the packaging bags 24 are filled.

[0123] In summary, this embodiment provides a method for using a bagged preparation dispensing system, by reading and calculating the volume V of a dosing device. 定 , the theoretical volume of the pipeline V1 and V2, and then the filling volume V of different filling bags f Cooperate with the peristaltic pump to transport the cell liquid at the corresponding speed, and record the time t2 required for the dosing device to be filled with liquid through the lower liquid level sensor and the upper liquid level sensor in the flow detection module. Finally, the time formula required for the actual packaging to be completed is obtained: t f =V f ×t2 / (V 定 +V1+V2) to eliminate the flow value error caused by the traditional method of using the speed ratio to proportionally estimate the flow rate at different speeds.

[0124] In addition, the method performs multiple exhaust treatments on the cell liquid in each step in the disposable sterile sealed consumables, which can further improve the accuracy of packaging.

[0125] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A bagged preparation packaging consumable, characterized in that: include: Mother solution bag; A main pipeline, one end of which is connected to the mother liquid bag and the other end of which has at least one branch pipeline; A flow detection tube group connected to the main pipe; The flow detection tube set includes a dosator and a first air discharge device, wherein the dosator is located between the first air discharge device and the main pipe; At least one group of sub-packaging tube groups, each of which is arranged in one-to-one correspondence with the branch pipelines of the main pipeline and connected to the corresponding branch pipelines; each group of the sub-packaging tube groups includes a multi-component bagging pipeline and a second air exhaust device; the multi-component bagging pipeline is connected in parallel to the corresponding branch pipeline and is located between the second air exhaust device and the flow detection tube group.

2. The bagged preparation packaging consumable according to claim 1, characterized in that: The dosing device includes a cylindrical body and a conical tip, wherein the conical tip is disposed at two opposite ends of the cylindrical body.

3. The bagged preparation packaging consumable according to claim 1, characterized in that: The quantitative device is provided with a barcode, a two-dimensional code or an RFID chip, and the volume value of the quantitative device is built into the barcode, the two-dimensional code or the RFID chip.

4. The bagged preparation packaging consumable according to claim 1, characterized in that: The first air discharge device comprises: A first dripping funnel, one end of which is connected to the outlet of the dosing device; The first air filter is connected to the other end of the first drip bucket.

5. The bagged preparation packaging consumable according to claim 4, characterized in that: The first air filter is provided with a filter membrane, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm.

6. The bagged preparation packaging consumable according to claim 1, characterized in that: The second air discharge device comprises: A second drip bucket, one end of which is connected to the pipeline; The second air filter is connected to the other end of the second drip bucket.

7. The bagged preparation packaging consumable according to claim 6, characterized in that: The second air filter is provided with a filter membrane, and the filtering accuracy of the filter membrane is less than or equal to 0.2 μm.

8. The bagged preparation packaging consumable according to claim 1, characterized in that: The first air discharge device and the second air discharge device are both gas collection bags.

9. The bagged preparation packaging consumable according to claim 1, characterized in that: The sub-packaging pipe groups are provided with a plurality of groups, and the plurality of sub-packaging pipe groups are connected in parallel to the main pipe.

10. The bagged preparation packaging consumable according to claim 1, characterized in that: The dispensing bag pipeline comprises: a dispensing bag, a dispensing bag pinch valve and a dispensing bag liquid level sensor; The sub-packaging bag is connected to the main pipeline through a branch pipeline, the sub-packaging bag liquid level sensor and the sub-packaging bag clamping valve are both arranged on the branch pipeline, and the sub-packaging bag liquid level sensor is located between the sub-packaging bag clamping valve and the sub-packaging bag.

11. A bagged preparation packaging system, characterized in that: The bagged preparation dispensing consumables according to any one of claims 1 to 10 further comprising: A peristaltic pump is arranged on the main pipe and is used to pump the liquid in the mother liquid bag to the flow detection module and the sub-filling tube group, or to pump the liquid in the flow detection module and the sub-filling tube group back to the mother liquid bag; A flow detection module, disposed between the doser and the first air discharge device and between the doser and the main line, for detecting an average flow value of the peristaltic pump at a filling speed; The controller is signal-connected to the peristaltic pump, the flow detection module and the dispensing tube group.

12. The bagged preparation dispensing system according to claim 11, characterized in that: The flow detection module comprises: A flow detection lower pipeline, connecting the doser and the main pipeline; A flow detection upper pipeline, connecting the doser and the first air discharge device; An upper liquid level sensor is arranged at the outlet of the doser; A lower liquid level sensor is arranged at the inlet of the doser; A flow detection bypass pinch valve, arranged between the lower liquid level sensor and the main pipe; A reading device is used to read the barcode, QR code or RFID signal on the quantitative device to obtain the volume value V of the quantitative device. 定 .

13. The bagged preparation dispensing system according to claim 11, characterized in that: The packaging tube group also includes: A subpackaging pinch tube valve, arranged on the main pipeline and located between the flow detection tube set and the multi-component bagging pipeline; The filling liquid level sensor is arranged on the main pipeline and is located between the multi-component bagging pipeline and the second air exhaust device.

14. The bagged preparation dispensing system according to claim 13, characterized in that: The second air discharge device comprises: A second drip bucket, one end of which is connected to the liquid filling level sensor; a terminal pinch valve, one end of which is connected to the other end of the second dripping funnel; The second air filter is connected to the other end of the terminal pinch valve.

15. The bagged preparation dispensing system according to claim 13, characterized in that: The second air discharge device comprises: An end pinch valve, one end of which is connected to the filling liquid level sensor; The second gas collection bag is connected to the other end of the terminal pinch valve.

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