Centrifugal tube magnetic separation device

Abstract

The utility model discloses a centrifugal tube magnetic separation device, which relates to the technical field of biological experiment equipment and comprises a centrifugal machine, a transfer mechanism, a magnetic separation structure and a storage tray. A groove is formed in the top of the centrifugal machine, a rotating disc is arranged in the groove, an avoiding groove is formed in the center of the top of the rotating disc, and a plurality of inserting grooves are evenly formed in the rotating disc. The storage disc is placed at the top of the rotary disc, a circular ring is arranged in the center of the storage disc and located in the avoiding groove, a plurality of through holes are evenly formed in the storage disc and used for allowing centrifugal tubes to be inserted, and the through holes correspond to the inserting grooves in position; the magnetic separation structure comprises a chassis, a circular groove is formed in the top of the chassis, a plurality of mounting blocks are uniformly distributed in the circular groove, and magnets are arranged on the sides, facing the center of the circular groove, of the mounting blocks; the transferring mechanism is used for transferring the storage disc between the magnetic separation structure and the centrifugal machine, and when the storage disc is located in the circular groove, the centrifugal tube corresponds to the magnet in position. According to the scheme, all centrifugal tubes can be taken out of a centrifugal machine at a time and placed into a magnetic separation structure.

Description

Technical Field

[0001] The utility model relates to the technical field of biological experimental equipment, in particular to a centrifuge tube magnetic separation device. Background Art

[0002] The magnetic separation device is also called a magnetic separation rack, a magnetic separation rack, a magnetic bead separation rack or a magnetic rack. It is mainly used for the rapid solid-liquid separation of magnetic particles. It is an essential device for experiments such as nucleic acid extraction or purification, antibody or protein purification, and immunoprecipitation based on the magnetic bead method.

[0003] The magnetic separation device is equipped with a row of circular holes. After centrifugation, the centrifuge tube is inserted into the corresponding circular hole. The magnetic block on the magnetic separation device can be used to concentrate the magnetic beads in the centrifuge tube on the tube wall, and then the pipette tip can be used to suck up the liquid in the tube. The problem is that after the centrifuge tube is centrifuged, the staff needs to take out the centrifuge tubes in the centrifuge one by one, and then insert the centrifuge tubes into the circular holes of the magnetic separation device one by one. This process takes a lot of time and affects the efficiency of the experiment. Utility Model Content

[0004] In order to solve the deficiencies of the prior art, the utility model provides a centrifuge tube magnetic separation device, which can take out all centrifuge tubes from a centrifuge at one time and put them into a magnetic separation structure.

[0005] In order to achieve the purpose of this utility model, the following scheme is proposed:

[0006] A centrifuge tube magnetic separation device comprises a centrifuge, a transfer mechanism, a magnetic separation structure and a storage tray.

[0007] A groove is provided on the top of the centrifuge, a turntable is provided in the groove, an avoidance groove is provided at the center of the top of the turntable, and a plurality of slots are evenly provided on the turntable;

[0008] The storage tray is placed on the top of the turntable, with a ring at the center, which is located in the avoidance groove. A plurality of through holes are evenly arranged on the storage tray for inserting centrifuge tubes, and the through holes correspond to the slot positions;

[0009] The magnetic separation structure includes a chassis, a circular groove is provided on the top of the chassis, a plurality of mounting blocks are evenly distributed in the circular groove, and a magnet is provided on one side of the mounting block facing the center of the circular groove;

[0010] The transfer mechanism is used to transfer the placement plate between the magnetic separation structure and the centrifuge. When the placement plate is located in the circular groove, the centrifuge tube corresponds to the position of the magnet.

[0011] Furthermore, the transfer mechanism includes a motor, a screw, an inverted U-shaped plate, a lifting block, an adjusting plate and an inner clamping assembly. The inverted U-shaped plate is mounted above the motor, the motor output shaft is connected to the screw, the top of the screw is rotatably connected to the inverted U-shaped plate, the lifting block is threadedly engaged with the screw and slidably engaged with the inner wall of the inverted U-shaped plate, an annular groove is provided at the bottom of the lifting block, one end of the adjusting plate is rotatably connected to the annular groove, the inner clamping assembly is provided at the bottom of the other end of the adjusting plate, the inner clamping assembly is used to clamp the ring, and a notch is provided on one side wall of the inverted U-shaped plate. When the adjusting plate rotates around the annular groove, the notch is used to avoid the adjusting plate.

[0012] Furthermore, the height of the lifting block is greater than the height of the notch.

[0013] Furthermore, the center of the circular groove and the center of the turntable are symmetrical about the axis of the screw rod.

[0014] Furthermore, the magnetic separation structure is arranged on the top of the inverted L-shaped plate, and the centrifuge, the transfer mechanism and the inverted L-shaped plate are all arranged on the platform.

[0015] The beneficial effect of the utility model is that after centrifugation, the placement plate can be directly taken out of the centrifuge by using the transfer mechanism and placed in the magnetic separation structure for magnetic separation. Compared with the prior art, the utility model does not need to insert the centrifuge tubes after centrifugation into the magnetic separation structure one by one, thereby improving the experimental efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Shown is a structural diagram of a centrifuge tube magnetic separation device;

[0017] Figure 2 A diagram showing the structure of the storage tray is shown;

[0018] Figure 3 A front view of a centrifuge tube magnetic separation device is shown;

[0019] Figure 4 A top view of a centrifuge tube magnetic separation device is shown;

[0020] Figure 5 A structural diagram showing a storage tray located above the magnetic separation structure;

[0021] Figure 6 A plan view of the lifting block and the lead screw is shown. DETAILED DESCRIPTION

[0022] like Figure 1 As shown, this embodiment provides a centrifuge tube magnetic separation device, including a centrifuge 1, a transfer mechanism 2, a magnetic separation structure 3, and a placement tray 4.

[0023] The centrifuge 1, the transfer mechanism 2, and the magnetic separation structure 3 are all arranged on the platform 5. The centrifuge 1 is a prior art, and its structure and principle are not described in detail here. Only the improvements made to the centrifuge 1 in this embodiment are described here: Figure 5 As shown, a groove 11 is provided at the top of the centrifuge 1 , a turntable 12 is provided in the groove 11 , an avoidance groove 121 is provided at the center of the top of the turntable 12 , and 8 slots 122 are evenly provided on the turntable 12 .

[0024] Specifically, Figure 1 , Figure 2 , Figure 5 As shown, the placing tray 4 is placed on the top of the turntable 12, a ring 41 is provided at the center of the placing tray 4, the ring 41 is located in the avoidance groove 121, and 8 through holes 42 are evenly provided on the placing tray 4, the through holes 42 correspond to the positions of the slots 122, and the through holes 42 and the slots 122 are used to insert centrifuge tubes. When in use, the cover of the centrifuge 1 is closed, the power supply of the centrifuge 1 is turned on, and the turntable 12 and the placing tray 4 rotate together, so that the 8 centrifuge tubes are centrifuged.

[0025] Specifically, Figure 1 , Figure 4 As shown, the magnetic separation structure 3 includes a chassis 31, a circular groove 32 is provided on the top of the chassis 31, 8 mounting blocks 33 are evenly distributed in the circular groove 32, a magnet 34 is provided on the side of the mounting block 33 facing the center of the circular groove 32, and the transfer mechanism 2 is located between the magnetic separation structure 3 and the centrifuge 1. The transfer mechanism 2 is used to transfer the placement plate 4 between the magnetic separation structure 3 and the centrifuge 1. When the placement plate 4 is located in the circular groove 32, the centrifuge tube corresponds to the position of the magnet 34, and the magnetic beads in the centrifuge tube can be concentrated on the tube wall through the magnetic block 34.

[0026] The specific implementation method of the transfer mechanism 2 is as follows: Figure 1 , Figure 3 , Figure 6 As shown, it includes a motor 21, a screw rod 22, an inverted U-shaped plate 23, a lifting block 24, an adjusting plate 25 and an inner clamping assembly 26. The motor 21 is arranged on the top of the platform 5, and the inverted U-shaped plate 23 is mounted above the motor 21. The output shaft of the motor 21 is connected to the screw rod 22, and the screw rod 22 is located in the inverted U-shaped plate 23. The top of the screw rod 22 is rotatably connected to the inverted U-shaped plate 23. The lifting block 24 is threadedly engaged with the screw rod 22 and slidably engaged with the inner wall of the inverted U-shaped plate 23. An annular groove 241 is provided at the bottom of the lifting block 24, and one end of the adjusting plate 25 is rotatably connected to the annular groove 241. The inner clamping assembly 26 is arranged at the bottom of the other end of the adjusting plate 25. The inner clamping assembly 26 is a conventional structure, and its structure and principle are not elaborated in detail here. The inner clamping assembly 26 is used to clamp the ring 41, and a notch 231 is provided on one side wall of the inverted U-shaped plate 23.

[0027] When the regulating plate 25 rotates around the annular groove 241, the notch 231 is used to avoid the regulating plate 25. In order to ensure that the placing plate 4 is located directly above the circular groove 32 when the regulating plate 25 rotates 180° around the annular groove 241, the center of the circular groove 32 and the center of the rotating disk 12 are symmetrical about the axis of the screw rod 22 in this embodiment. In order to ensure that the lifting block 24 is always located in the inverted U-shaped plate 23, the height value of the lifting block 24 is greater than the height value of the notch 231.

[0028] The operating principle is as follows: in the perspective of 1, the control plate 25 is exactly located at the notch 231, and the staff rotates the control plate 25 to make the control plate 25 deviate from the centrifuge 1; the cover of the centrifuge 1 is closed, and the centrifuge tube is centrifuged. Here, it is explained that in actual application, the height of the control plate 25 can be set to ensure that the inner clamping assembly 26 does not hinder the cover of the centrifuge 1, so when opening or closing the cover, there is no need to make the control plate 25 deviate from the centrifuge 1; after centrifugation, the cover of the centrifuge 1 is opened, and the control plate 25 is rotated again to make the centrifuge tube The control plate 25 is reset to the top of the centrifuge 1; the motor 21 drives the screw 22 to move the lifting block 24 and the control plate 25 thereon downward until the inner clamping assembly 26 moves down to the ring 41 and stops; the inner clamping assembly 26 clamps the ring 41, and the motor 21 drives the screw 22 in the reverse direction to reset the lifting block 24 upward. When the control plate 25 is located at the notch 231, the placement plate 4 has already separated from the turntable 12; the staff rotates the control plate 25, and when the control plate 25 rotates 180°, the placement plate 4 is located directly above the circular groove 32, and the state is as follows Figure 5 As shown; the motor 21 drives the screw rod 22 to move the lifting block 24 and the regulating plate 25 thereon downward until the placement plate 4 contacts the mounting block 33, and a centrifuge tube corresponds to a magnet 34, and the magnetic beads in the centrifuge tube are concentrated at the tube wall through the magnetic block 34.

[0029] More specifically, when the storage tray 4 is located directly above the circular groove 32 , in order to shorten the downward travel distance of the lifting block 24 , the magnetic separation structure 3 is disposed on the top of the inverted L-shaped plate 35 in this embodiment, and the inverted L-shaped plate 35 is disposed on the platform 5 .

[0030] In summary, after centrifugation, the transfer mechanism 2 can be used to directly remove the placement plate 4 from the centrifuge 1 and place it in the magnetic separation structure 3 for magnetic separation. Compared with the prior art, this embodiment does not need to insert the centrifuge tubes after centrifugation into the magnetic separation structure 3 one by one, thereby improving the experimental efficiency.

[0031] The above embodiments are only used to illustrate the technical ideas and features of the utility model, and are not intended to be the only or limit the utility model. Those skilled in the art should understand that various changes or equivalent replacements made to the utility model without departing from the scope of the utility model are within the scope of protection of the utility model.

Claims

1. A centrifuge tube magnetic separation device, characterized in that: It comprises a centrifuge (1), a transfer mechanism (2), a magnetic separation structure (3), and a storage tray (4); A groove (11) is provided at the top of the centrifuge (1), a turntable (12) is provided in the groove (11), an avoidance groove (121) is provided at the center of the top of the turntable (12), and a plurality of slots (122) are evenly provided on the turntable (12); The storage tray (4) is placed on the top of the rotating disk (12), and a circular ring (41) is provided at the center thereof. The circular ring (41) is located in the avoidance groove (121). A plurality of through holes (42) are evenly provided on the storage tray (4) for inserting centrifuge tubes, and the positions of the through holes (42) and the slots (122) correspond to each other. The magnetic separation structure (3) comprises a chassis (31), a circular groove (32) is provided on the top of the chassis (31), a plurality of mounting blocks (33) are evenly distributed in the circular groove (32), and a magnet (34) is provided on one side of the mounting block (33) facing the center of the circular groove (32); The transfer mechanism (2) is used to transfer the placement plate (4) between the magnetic separation structure (3) and the centrifuge (1); when the placement plate (4) is located in the circular groove (32), the centrifuge tube and the magnet (34) are located in corresponding positions.

2. The centrifuge tube magnetic separation device according to claim 1, characterized in that: The transfer mechanism (2) comprises a motor (21), a screw rod (22), an inverted U-shaped plate (23), a lifting block (24), a regulating plate (25) and an inner clamping assembly (26). The inverted U-shaped plate (23) is mounted above the motor (21). The output shaft of the motor (21) is connected to the screw rod (22). The top of the screw rod (22) is rotatably connected to the inverted U-shaped plate (23). The lifting block (24) is threadedly engaged with the screw rod (22) and is slidably engaged with the inverted U-shaped plate (23). The inner wall and the bottom of the lifting block (24) are provided with an annular groove (241), one end of the regulating plate (25) is rotatably connected to the annular groove (241), an inner clamping assembly (26) is provided at the bottom of the other end of the regulating plate (25), and the inner clamping assembly (26) is used to clamp the ring (41), and a notch (231) is provided on one side wall of the inverted U-shaped plate (23), and when the regulating plate (25) rotates around the annular groove (241), the notch (231) is used to avoid the regulating plate (25).

3. The centrifuge tube magnetic separation device according to claim 2, characterized in that: The height of the lifting block (24) is greater than the height of the notch (231).

4. The centrifuge tube magnetic separation device according to claim 2, characterized in that: The center of the circular groove (32) and the center of the rotating disk (12) are symmetrical about the axis of the screw rod (22).

5. The centrifuge tube magnetic separation device according to claim 1, characterized in that: The magnetic separation structure (3) is arranged on the top of the inverted L-shaped plate (35), and the centrifuge (1), the transfer mechanism (2), and the inverted L-shaped plate (35) are all arranged on the platform (5).

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