Microfluidic mixer

Abstract

The utility model discloses a microfluidic mixer which comprises a mixing chip and a booster, one side of the mixing chip is provided with a sample groove and at least two reagent grooves, the bottoms of the sample groove and the reagent grooves are respectively provided with an outflow hole and an injection hole, and a liquid flow channel is further arranged in the mixing chip. The liquid flow channel is respectively communicated with the sample groove and the reagent grooves through the outflow hole and the injection hole, the booster is provided with at least two piston bodies, and the at least two piston bodies are respectively and movably arranged in the at least two reagent grooves and are in interference connection with the reagent grooves. According to the micro-flow hole mixer, manual mixing of liquid is achieved through cooperation of the mixing chip and the booster, complex mixing equipment does not need to be used for mixing the liquid, in this way, the micro-flow hole mixer is not limited by sites in actual use and is convenient to assemble, the working convenience is greatly improved, and the equipment cost is also greatly reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidics, in particular to a microfluidics mixer. Background Art

[0002] Microfluidic mixing equipment is mainly used to achieve mixing in microfluidic technology. It achieves rapid mixing and reaction of different reagents by precisely controlling the flow rate and mixing degree of different components in the microfluidic.

[0003] In the prior art, microfluidic mixing devices are usually semi-automatic or fully automatic devices based on the principle of microfluidic technology. Such devices usually use motors and screw modules to drive injection pumps to generate power, thereby driving multiphase liquids to mix in microfluidic mixing chips to form nanomedicines.

[0004] However, this type of equipment is not only complex in structure, difficult to assemble and relatively costly, but also occupies a large space and is limited in use by the site, making it inconvenient to use. Utility Model Content

[0005] In view of the deficiencies of the prior art, the utility model provides a microfluidic mixer, comprising:

[0006] A hybrid chip, one side of which has a sample slot and at least two reagent slots, the bottoms of the sample slot and the reagent slot are respectively provided with an outflow hole and an injection hole, and the hybrid chip is also provided with a liquid flow channel, the liquid flow channel is connected to the sample slot and the reagent slot through the outflow hole and the injection hole; and

[0007] The booster has at least two piston bodies, which are movably arranged in at least two reagent tanks respectively and are interference connected with the reagent tanks.

[0008] According to one embodiment of the utility model, the booster also includes a handle, and each piston body includes a connecting rod and a piston head, one end of the connecting rod is fixed to one end of the handle, and the piston head is detachably mounted on the other end of the connecting rod.

[0009] According to one embodiment of the utility model, one end of the connecting rod has a connecting head, and the connecting head includes a connecting column and a limiting column. One end of the connecting column is fixed to one end of the connecting rod, and the limiting column is fixed to the other end of the connecting column. Its outer diameter is smaller than the outer diameter of the connecting rod. There is an installation cavity inside the piston head, and one end of the piston head is provided with a through hole connected to the installation cavity, and the inner diameter of the through hole is larger than the inner diameter of the installation cavity. The outer diameter of the piston head is larger than the inner diameter of the through hole and smaller than the inner diameter of the installation cavity. The installation cavity and the through hole are respectively arranged outside the limiting column and the connecting column.

[0010] According to one embodiment of the present invention, the handle includes a mounting block and a T-shaped handle, at least two sets of connecting rods of the piston bodies are fixed to one side of the mounting block and arranged adjacently, and the T-shaped handle is fixed to the other side of the mounting block.

[0011] According to one embodiment of the utility model, a dust cover is further included. The dust cover is arranged at the notch of the sample slot, and a pressure relief hole is provided at the center of the dust cover. The pressure relief hole is connected to the inside of the sample slot.

[0012] According to one embodiment of the utility model, the hybrid chip includes a chip body and a cover plate, the liquid flow channel is engraved on one side of the chip body, the sample tank and the reagent tank are both arranged on the other side of the chip body, the outflow hole and the injection hole are both arranged through the chip body, the cover plate is covered on one side of the chip body, and the liquid flow channel forms a closed channel.

[0013] According to one embodiment of the utility model, one side of the cover plate has a plurality of fool-proofing posts, and the chip body has a plurality of fool-proofing holes corresponding to the fool-proofing posts. When the cover plate is covered on one side of the chip body, the plurality of fool-proofing posts are respectively inserted into the plurality of fool-proofing holes.

[0014] According to one embodiment of the utility model, the liquid flow channel includes a mixing flow channel and at least two liquid inlet flow channels, one end of the mixing flow channel is connected to the outflow hole, one end of the at least two liquid inlet flow channels is respectively connected to at least two injection holes, and the other end of the mixing flow channel is connected to the other end of the at least two liquid inlet flow channels.

[0015] According to an embodiment of the present invention, along the length direction of the mixing channel, it has a plurality of interconnected mixing grooves, each mixing groove is provided with a liquid blocking block, and the liquid blocking block divides the mixing groove into two liquid separation channels.

[0016] The beneficial effect of the utility model is that manual mixing of liquids is achieved through the cooperation of the mixing chip and the booster, and there is no need to use complex mixing equipment to mix the liquids. In this way, it is not restricted by the site during actual use and is easy to assemble, which greatly improves the convenience of work and greatly reduces the equipment cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0018] Figure 1 Schematic diagram of the structure of the microfluidic mixer in the embodiment;

[0019] Figure 2 Schematic diagram of the explosion structure of the microfluidic mixer in the embodiment;

[0020] Figure 3 This is one of the schematic diagrams of the chip main body structure in the embodiment;

[0021] Figure 4This is a schematic diagram of the booster explosion structure in the embodiment;

[0022] Figure 5 This is a schematic diagram of the longitudinal cross-sectional structure of the piston body in the embodiment;

[0023] Figure 6 This is the second schematic diagram of the chip body structure in the embodiment;

[0024] Figure 7 for Figure 6 Enlarged view of part A in the middle. DETAILED DESCRIPTION

[0025] The following will disclose multiple embodiments of the present invention with drawings. For the purpose of clear description, many practical details will be described together in the following description. However, it should be understood that these practical details should not be used to limit the present invention. In other words, in some embodiments of the present invention, these practical details are not necessary. In addition, in order to simplify the drawings, some conventional structures and components will be depicted in a simple schematic manner in the drawings.

[0026] In addition, in the present utility model, the descriptions of "first", "second", etc. are only used for descriptive purposes, and do not specifically refer to the order or sequence, nor are they used to limit the present utility model. They are only used to distinguish components or operations described with the same technical terms, and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in this field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present utility model.

[0027] See also Figure 1-Figure 3 , Figure 1 is a schematic diagram of the structure of a microfluidic mixer in an embodiment, Figure 2 This is a schematic diagram of the explosion structure of the microfluidic mixer in the embodiment. Figure 31 is one of the schematic diagrams of the chip main structure in the embodiment. A microfluidic mixer in this example includes a mixing chip 1 and a booster 2, wherein one side of the mixing chip 1 has a sample slot 111 and at least two reagent slots 112, and the bottoms of the sample slot 111 and the reagent slot 112 are respectively provided with an outflow hole 1111 and an injection hole 1112, and the inside of the mixing chip 1 is also provided with a liquid flow channel 113, and the liquid flow channel 113 is connected to the sample slot 111 and the reagent slot 112 through the outflow hole 1111 and the injection hole 1112, respectively, and the booster 2 has at least two piston bodies 21, and at least two piston bodies 21 are respectively movably arranged in at least two reagent slots 112, and are interference-connected with the reagent slots 112. In this example, the number of reagent slots 112 is two, and the number of piston bodies 21 is set corresponding to the number of reagent slots 112, that is, the number of piston bodies 21 is also two.

[0028] When in use, the required mixed reagents are loaded into the reagent tanks 112 respectively, and then the two piston bodies 21 of the booster 2 are respectively inserted into the two reagent tanks 112 and the piston bodies 21 are manually squeezed downward. At this time, the reagents in the two reagent tanks 112 are squeezed and flow into the mixed liquid flow channel 113 from the injection hole 1112, and after mixing in the liquid flow channel 113, they flow out from the outflow hole 111 to the sample tank 111, and the mixing of the reagents is completed. That is, in this example, manual mixing of liquids is achieved through the cooperation of the mixing chip 1 and the booster 2, and there is no need to use complex mixing equipment to mix the liquids. In this way, it is not restricted by the site during actual use, and is easy to assemble, which greatly improves the convenience of work and greatly reduces the equipment cost.

[0029] Preferably, during specific implementation, the ratio of the inner diameters of the two reagent tanks 112 can be adjusted according to usage requirements, thereby adjusting the ratio of the injection amounts of different reagents in the two reagent tanks 112 to improve the applicability of the product, wherein the outer diameters of the two piston bodies 21 are adjusted corresponding to the inner diameters of the two reagent tanks 112 respectively.

[0030] See also Figure 4-Figure 5 , review Figure 1-Figure 2 , Figure 4 This is a schematic diagram of the booster explosion structure in the embodiment. Figure 5 Schematic diagram of the longitudinal cross-sectional structure of the piston body in the embodiment. Specifically, the booster 2 also includes a handle 22, and each piston body 21 includes a connecting rod 211 and a piston head 212. One end of the connecting rod 211 is fixed to one end of the handle 22, and the piston head 212 is detachably mounted on the other end of the connecting rod 211. During operation, the two piston bodies 21 can be pushed downward by pressing the handle 22, thereby improving the synchronization of the movement of the two piston bodies 21 and ensuring the consistency of the ratio of the reagents in the two reagent tanks 112 flowing into the liquid flow channel 113.

[0031] Specifically, one end of the connecting rod 211 has a connecting head 2111, and the connecting head 2111 includes a connecting column 21111 and a limiting column 21112. One end of the connecting column 21111 is fixed to one end of the connecting rod 211, and the limiting column 21112 is fixed to the other end of the connecting column 21111, and its outer diameter is smaller than the outer diameter of the connecting rod 211. The piston head 212 has an installation cavity 2121 inside, and one end of the piston head is provided with a through hole 2122 connected to the installation cavity 2121, and the inner diameter of the through hole 2122 is larger than the inner diameter of the installation cavity 2121. The outer diameter of the piston head 212 is larger than the inner diameter of the through hole 2122 and smaller than the inner diameter of the installation cavity 2121. The installation cavity 2121 and the through hole 2122 are respectively sleeved on the outside of the limiting column 21112 and the connecting column 21111. In this example, the piston head 212 is made of elastic silicone material. It can be understood that, in this way, when in use, the outer wall of the piston head 212 can better abut against the inner wall of the reagent tank 112 to ensure the internal sealing effect of the reagent tank 112. At the same time, its elastic recovery ability can also facilitate the installation or removal of the piston head 212 on the connecting head 2111, so as to facilitate the replacement of the piston head 212.

[0032] Preferably, the cross section of the connecting rod 211 is in a cross shape, which ensures the strength of the connecting rod 211 while reducing the friction between the connecting rod 211 and the inner wall of the reagent tank 112, thereby ensuring the uniformity of the operation of the piston body 21.

[0033] Preferably, the handle 22 includes a mounting block 221 and a T-shaped handle 222 , the connecting rods 211 of at least two sets of piston bodies 21 are fixed to one side of the mounting block 221 and are arranged adjacent to each other, and the T-shaped handle 222 is fixed to the other side of the mounting block 221 .

[0034] Review Figure 1-Figure 2 , further, it also includes a dust cover 3, which is arranged at the notch of the sample slot 111, and has a pressure relief hole 31 at the center thereof, and the pressure relief hole 31 is connected to the inside of the sample slot 111. It can be understood that the dust cover 3 can not only prevent dust and other impurities from falling into the sample slot 111 when not in use, but also prevent the mixed sample from splashing out of the sample slot 111 when it flows out of the outflow hole 1111, wherein when the mixed sample flows from the outflow hole 1111 into the sample slot 111, the pressure relief hole 31 can discharge the air in the sample slot 111 to the outside, preventing the dust cover 3 from being ejected due to excessive air pressure in the sample slot 111.

[0035] In specific implementation, a dust cover 3 matching the size of the reagent tank 112 may be used to cover the reagent tank 112 to further prevent dust and other impurities from falling into the reagent tank 112 when the microfluidic mixer is in an idle state.

[0036] See also Figure 6-Figure 7 , review Figure 1-Figure 3 , Figure 6This is the second schematic diagram of the chip body structure in the embodiment. Figure 7 for Figure 6 Further, the hybrid chip 1 includes a chip body 11 and a cover plate 12, a liquid flow channel 113 is engraved on one side of the chip body 11, a sample tank 111 and a reagent tank 112 are both arranged on the other side of the chip body 11, an outflow hole 1111 and an injection hole 1112 are both arranged through the chip body 11, and the cover plate 12 is covered on one side of the chip body 11, and the liquid flow channel 113 forms a closed channel.

[0037] Among them, one side of the cover plate 12 has multiple anti-foolproof columns 121, and the chip body 11 has multiple anti-foolproof holes 114 corresponding to the anti-foolproof columns 121. When the cover plate 12 is covered on one side of the chip body 11, the multiple anti-foolproof columns 121 are respectively inserted into the multiple anti-foolproof holes 114, so as to realize rapid positioning and alignment of the cover plate 12 during installation, thereby facilitating the installation of the cover plate 12.

[0038] Specifically, the liquid flow channel 113 includes a mixing flow channel 1131 and at least two liquid inlet flow channels 1132. One end of the mixing flow channel 1131 is connected to the outflow hole 1111, one end of the at least two liquid inlet flow channels 1132 is respectively connected to at least two injection holes 1112, and the other end of the mixing flow channel 1131 is mutually connected with the other end of the at least two liquid inlet flow channels 1132. When two different reagents enter the injection hole 1121 from the two reagent tanks 112 respectively, they flow along the two liquid inlet flow channels 1132 to the mixing flow channel 1131 to mix, and then flow to the outflow hole 1111 through the mixing flow channel 1131 to flow into the sample tank 111 to complete mixing.

[0039] Among them, along the length direction of the mixing channel 1131, it has a plurality of mixing grooves 11311 that are interconnected, and each mixing groove 11311 is provided with a liquid blocking block 11312, and the liquid blocking block 11312 separates the mixing groove 11311 into two liquid separation channels. After the mixed liquid enters the mixing channel 1131, it passes through each mixing groove 11311 in turn, and is diverted to the two liquid separation channels by the liquid blocking block 11312 in the mixing groove 11311. Before entering the next mixing groove 11311, the mixed liquid in the two liquid separation channels converges again and enters the next mixing groove 11311. The liquid mixed by the plurality of mixing grooves 11311 finally flows out from the outflow hole 1111 to the sample groove 111, thereby effectively improving the liquid mixing effect.

[0040] In summary, in this example, manual mixing of liquids is achieved through the cooperation of the mixing chip and the booster, and there is no need to use complex mixing equipment to mix the liquids. In this way, it is not restricted by the site during actual use and is easy to assemble, which greatly improves the convenience of work and greatly reduces the equipment cost.

[0041] The above is only an embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention shall be included in the scope of the claims of the present invention.

Claims

1. A microfluidic mixer, characterized in that: include: A mixing chip (1) having a sample slot (111) and at least two reagent slots (112) on one side, wherein the sample slot (111) and the reagent slot (112) are respectively provided with an outflow hole (1111) and an injection hole (1112) at the bottom, and a liquid flow channel (113) is further provided inside the mixing chip (1), wherein the liquid flow channel (113) is respectively connected to the sample slot (111) and the reagent slot (112) through the outflow hole (1111) and the injection hole (1112); and The booster (2) has at least two piston bodies (21), and the at least two piston bodies (21) are movably disposed in at least two reagent tanks (112) and are interference-connected with the reagent tanks (112).

2. The microfluidic mixer according to claim 1, characterized in that The booster (2) further comprises a handle (22), and each of the piston bodies (21) comprises a connecting rod (211) and a piston head (212), one end of the connecting rod (211) is fixed to one end of the handle (22), and the piston head (212) is detachably mounted on the other end of the connecting rod (211).

3. The microfluidic mixer according to claim 2, characterized in that: One end of the connecting rod (211) has a connecting head (2111), and the connecting head (2111) includes a connecting column (21111) and a limiting column (21112). One end of the connecting column (21111) is fixed to one end of the connecting rod (211), and the limiting column (21112) is fixed to the other end of the connecting column (21111), and its outer diameter is smaller than the outer diameter of the connecting rod (211). The piston head (212) has an installation cavity (212) inside. 1), one end of which is provided with a through hole (2122) connected to the installation cavity (2121), and the inner diameter of the through hole (2122) is larger than the inner diameter of the installation cavity (2121), the outer diameter of the piston head (212) is larger than the inner diameter of the through hole (2122) and smaller than the inner diameter of the installation cavity (2121), and the installation cavity (2121) and the through hole (2122) are respectively sleeved outside the limiting column (21112) and the connecting column (21111).

4. The microfluidic mixer according to claim 2, characterized in that: The handle (22) comprises a mounting block (221) and a T-shaped handle (222), at least two groups of connecting rods (211) of the piston body (21) are fixed to one side of the mounting block (221) and are arranged adjacent to each other, and the T-shaped handle (222) is fixed to the other side of the mounting block (221).

5. The microfluidic mixer according to claim 1, characterized in that: It also comprises a dust cover (3), which is arranged on the notch of the sample slot (111) and has a pressure relief hole (31) at the center thereof, and the pressure relief hole (31) is connected to the inside of the sample slot (111).

6. The microfluidic mixer according to claim 1, characterized in that: The hybrid chip (1) comprises a chip body (11) and a cover plate (12); the liquid flow channel (113) is engraved on one side of the chip body (11); the sample tank (111) and the reagent tank (112) are both arranged on the other side of the chip body (11); the outflow hole (1111) and the injection hole (1112) are both arranged through the chip body (11); the cover plate (12) is covered on one side of the chip body (11) and forms the liquid flow channel (113) into a closed channel.

7. The microfluidic mixer according to claim 6, characterized in that: One side of the cover plate (12) is provided with a plurality of fool-proofing columns (121), and the chip body (11) is provided with a plurality of fool-proofing holes (114) corresponding to the fool-proofing columns (121). When the cover plate (12) is covered on one side of the chip body (11), the plurality of fool-proofing columns (121) are respectively inserted into the plurality of fool-proofing holes (114).

8. The microfluidic mixer according to claim 6, characterized in that: The liquid flow channel (113) comprises a mixing flow channel (1131) and at least two liquid inlet flow channels (1132), one end of the mixing flow channel (1131) is connected to the outflow hole (1111), one end of the at least two liquid inlet flow channels (1132) are respectively connected to at least two injection holes (1112), and the other end of the mixing flow channel (1131) is connected to the other end of the at least two liquid inlet flow channels (1132).

9. The microfluidic mixer according to claim 8, characterized in that: Along the length direction of the mixing channel (1131), it has a plurality of mixing grooves (11311) that are interconnected, and each of the mixing grooves (11311) is provided with a liquid blocking block (11312), and the liquid blocking block (11312) separates the mixing groove (11311) into two liquid separation channels.

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