Wet granulation and drying all-in-one machine

Abstract

The utility model discloses a wet granulation and drying all-in-one machine which comprises a granulation and drying bin, the granulation and drying bin comprises a material bin, a movable bin and a dust collecting chamber which are butted from bottom to top through cylinder buckling and pressing and inflation sealing strips to form a closed granulation and drying space, a rotatable paddle is arranged in the material bin and close to the bin bottom, a sintering net is arranged on the lower portion of the rotatable paddle, and the lower portion of the sintering net is connected with the movable bin. The sintering net and the rotatable blade are spaced, an air chamber is arranged at the lower part of the sintering net, a rotating shaft of the rotatable blade penetrates through the air chamber and is in transmission connection with a speed reducer, the rotating speed of the rotatable blade is adjustable, the air chamber is communicated with a purification air supply system on one side, and a discharge pipe is arranged on one side outside the stock bin and is positioned on the upper edge of the rotatable blade; the movable bin is located on the upper portion of the stock bin and provided with an atomizing spray gun entering the movable bin. The wet granulation and drying all-in-one machine is simple in structure, materials cannot be bonded at the bin bottom, low-temperature drying is achieved, heat-sensitive components are prevented from being damaged, operation procedures are few, efficiency is high, and the wet granulation and drying all-in-one machine has very high practical value and popularization value.

Description

Technical Field

[0001] The utility model relates to the technical field of wet granulation and drying integrated machines, in particular to a wet granulation and drying integrated machine. Background Art

[0002] "Granulation" is an important process before drug molding. For example, for tablets and capsules, the materials must be made into granules before tablet compression and capsule filling to ensure that the tablet weight and filling volume differences meet the standards. Dried granules are also a "granular dosage form" that can be directly taken orally, such as "Ganmao Qingre Granules" and so on.

[0003] At present, there are two methods to make granules of Chinese medicine formula granules:

[0004] 1. The Chinese medicine extract fluid extract + auxiliary materials are spray dried in a spray drying tower, and the powder obtained by spray drying is then made into granules by a dry granulator;

[0005] 2. The Chinese medicine extract is dried and crushed by vacuum drying equipment, added with auxiliary materials, and then made into granules by dry granulation machine;

[0006] Usually it requires 1 spray drying tower, 1 air purification unit, 1 fin steam heater, 1 electric heater, 1 cyclone separator, 1 water foam dust collector, 1 insulation batching tank, and 1 pump. The heating temperature exceeds 300°C. There are some disadvantages, such as the equipment takes up too much space, there are many processes, the drying temperature is high, and the heat-sensitive components are destroyed. Utility Model Content

[0007] The technical problem to be solved by the utility model is to overcome the defects of the above-mentioned technology and provide a wet granulation and drying integrated machine.

[0008] In order to solve the above technical problems, the technical solution provided by the utility model is a wet granulation and drying integrated machine: comprising a granulation and drying bin, the granulation and drying bin comprising a silo, a mobile bin, and a dust-fighting chamber connected from bottom to top by cylinder buckling and an inflatable sealing strip, forming a closed granulation and drying space, a rotatable paddle is provided near the bottom of the bin in the silo, a sintered mesh is provided at the lower part of the rotatable paddle, there is a gap between the sintered mesh and the rotatable paddle, the lower part of the sintered mesh is an air chamber, the rotating shaft of the rotatable paddle passes through the air chamber and is transmission-connected to a reducer, the speed of the rotatable paddle is adjustable, the air chamber is connected to a purification air supply system on one side, the reducer is transmission-connected to a motor, a discharge pipe is provided on one side of the outside of the silo, and the discharge pipe is located at the upper edge of the rotatable paddle;

[0009] The mobile bin is located at the upper part of the silo, and is provided with an atomizing spray gun entering the interior of the mobile bin, and the atomizing spray gun is externally connected to a peristaltic pump.

[0010] As an improvement, the purified air supply system includes a booster fan, a primary filter, a heater, hot and cold air valves, a high-efficiency filter and an air supply pipe. The air supply pipe enters the air chamber tangentially and is provided with an air volume regulating valve.

[0011] As an improvement, a plurality of dust-fighting titanium rods are provided in the dust-fighting chamber, a high-pressure gas pulse back-blowing device is provided at the outlet of the dust-fighting titanium rods, and the dust-fighting chamber is provided with an air outlet pipe leading to the outside.

[0012] Compared with the prior art, the utility model has the following advantages: open the mobile bin, pour the solid material into the bin, reset it, start the rotatable blade (0--200 / min) to rotate, so that the material rotates and quickly moves upward to the center, and then flows downward to the bottom of the bin. The peristaltic pump sends the fluid extract of the adhesive or Chinese medicine into the atomizing spray gun and sprays it into the bin, attaches it to the surface of the dynamic material powder particles, and the adjacent powder particles are bonded into particles. After a few minutes, start the booster fan to send hot air (temperature ≤80℃, controllable wind speed), and enter the synchronous operation of granulation and drying. The airflow in the bin passes through the titanium rod to extinguish the dust and is discharged from the air outlet pipe.

[0013] When the utility model is implemented, the purification air supply system can be not started at the initial granulation, the material movement and bonding granulation is not carried out synchronously with the air flow drying, and the purification air supply system is started again after a few minutes to send hot air and granulation and drying synchronously, so that the material of extremely fine particle size can be avoided from running. For example, celecoxib.

[0014] Since the paddles rotate continuously, the materials are kept moving, which can avoid the phenomenon of materials sticking to the bottom of the silo (commonly known as the nesting phenomenon in the industry).

[0015] Since the temperature is adjustable and controllable, and it can be operated even at room temperature, this machine is suitable for drying materials containing volatile substances, such as the drying of compound Danshen granules with borneol.

[0016] This wet granulation and drying all-in-one machine has a simple structure and occupies a small space. The material will not stick to the bottom of the silo. It dries at low temperature to avoid damage to heat-sensitive components. It has fewer operating procedures, high efficiency, and low energy consumption. It has high practical value and promotion value. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the structure of a wet granulation and drying integrated machine of the utility model. Figure 1 .

[0018] Figure 2 This is a schematic diagram of the structure of a wet granulation and drying integrated machine of the utility model. Figure 2 .

[0019] Figure 3 The utility model is a schematic diagram of the structure of a rotatable blade of a wet granulation and drying integrated machine.

[0020] Figure 4 The utility model is a schematic diagram of the structure of a dust suppression chamber of a wet granulation and drying integrated machine.

[0021] As shown in the figure: 1. Air supply pipe, 2. Discharge pipe, 3. Sight glass, light mirror, 4. Dust-fighting titanium rod, 5. Air outlet pipe, 6. Air volume regulating valve, 7. HEPA filter, 8. Dust-fighting chamber, 9. Mobile bin, 10. Bin, 11. Atomizing spray gun, 12. Rotatable blades, 13. Sintered mesh, 14. Air chamber, 15. Rotating shaft, 16. Booster fan, 17. Primary filter, 18. Heater, 19. Hot and cold air valves, 20. Motor, 21. Reducer, 22. Cylinder, 23. Inflatable sealing strip, 24. High-pressure gas pulse backblowing device. DETAILED DESCRIPTION

[0022] The wet granulation and drying integrated machine of the utility model is further described in detail below in conjunction with the accompanying drawings.

[0023] Combined with Figures 1 to 4 , a wet granulation and drying integrated machine, including a granulation and drying bin, the granulation and drying bin includes a bin 10, a mobile bin 9, and a dust-fighting chamber 8 which are connected from bottom to top by a cylinder 22 and an inflatable sealing strip 23, forming a closed granulation and drying space, a rotatable blade 12 is provided near the bottom of the bin in the bin 10, a sintered mesh 13 is provided at the lower part of the rotatable blade 12, a gap is provided between the sintered mesh 13 and the rotatable blade 12, an air chamber 14 is provided at the lower part of the sintered mesh 13, a rotating shaft 15 of the rotatable blade 12 passes through the air chamber 14 and is transmission-connected to a reducer 21, the speed of the rotatable blade 12 is adjustable, the air chamber 14 is communicated with a purification air supply system on one side, the reducer 21 is transmission-connected to a motor 20, a discharge pipe 2 is provided on one side of the outside of the bin 10, and the discharge pipe 2 is located at the upper edge of the rotatable blade 12;

[0024] The mobile bin 9 is located on the upper part of the silo 10 , and the mobile bin 9 is provided with an atomizing spray gun 11 entering the interior, and the atomizing spray gun 11 is externally connected to a peristaltic pump.

[0025] The purification air supply system includes a booster fan 16, a primary filter 17, a heater 18, a hot and cold air valve 19, a high-efficiency filter 7 and an air supply pipe 1. The air supply pipe 1 enters the air chamber 14 tangentially, and the air supply pipe 1 is provided with an air volume regulating valve 6.

[0026] A plurality of dust-fighting titanium rods 4 are arranged in the dust-fighting chamber 8, a high-pressure gas pulse back-blowing device 24 is arranged at the outlet of the dust-fighting titanium rods 4, and the dust-fighting chamber 8 is provided with an air outlet pipe 5 leading to the outside.

[0027] The mobile warehouse 9 is provided with a viewing mirror and a light mirror 3 around it.

[0028] During the specific implementation of the utility model, the mobile bin 9 is opened, and the solid material is poured into the bin 10. After resetting, the rotatable blade 12 is started (0--200 / min) to rotate, so that the material rotates and quickly moves upward to the center, and then flows downward to the bottom of the bin. The peristaltic pump sends the fluid extract of the adhesive or Chinese medicine into the atomizing spray gun 11 and sprays it into the bin 10, attached to the surface of the dynamic material powder particles, and the adjacent powder particles are bonded into particles. After a few minutes, the booster fan 16 is started to deliver hot air (temperature ≤80℃, wind speed controllable), and the granulation and drying are synchronized. The airflow in the bin passes through the titanium rod 4 to extinguish the dust and is discharged from the air outlet pipe 5.

[0029] When the utility model is implemented, during the initial granulation, the material movement and bonding granulation can be performed synchronously with the airflow drying, and the purification air supply system can be started after a few minutes to supply hot air and granulation and drying synchronously, so that the material of extremely fine particle size can be avoided from running. For example, celecoxib.

[0030] Since the blades rotate continuously, the materials move continuously, which can avoid the phenomenon of the materials sticking to the bottom of the silo 10 (commonly known as the nesting phenomenon in the industry).

[0031] Since the temperature is adjustable and controllable, and it can be operated even at room temperature, this machine is suitable for drying materials containing volatile substances, such as the drying of compound Danshen granules with borneol.

[0032] The above describes the utility model and its implementation methods, which is not restrictive. The drawings show only one implementation method of the utility model, and the actual structure is not limited thereto. In short, if ordinary technicians in this field are inspired by it and design structural methods and embodiments similar to the technical solution without creative design without departing from the purpose of the invention of the utility model, they should all fall within the protection scope of the utility model.

Claims

1. A wet granulation and drying integrated machine, characterized in that: The invention comprises a granulation drying bin, wherein the granulation drying bin comprises a silo (10), a mobile bin (9), and a dust suppression chamber (8) which are connected from bottom to top by pressing with a cylinder (22) and an inflatable sealing strip (23), so as to form a closed granulation drying space. A rotatable blade (12) is arranged near the bottom of the silo (10), a sintered net (13) is arranged below the rotatable blade (12), and a gap is formed between the sintered net (13) and the rotatable blade (12). (13) The lower part is an air chamber (14), the rotating shaft (15) of the rotatable blade (12) passes through the air chamber (14) and is connected to the reducer (21) in a transmission manner, the rotation speed of the rotatable blade (12) is adjustable, the air chamber (14) is connected to a purification air supply system on one side, the reducer (21) is connected to the motor (20) in a transmission manner, and a discharge pipe (2) is provided on one side of the outside of the silo (10), and the discharge pipe (2) is located at the upper edge of the rotatable blade (12); The mobile bin (9) is located on the upper part of the material bin (10), and the mobile bin (9) is provided with an atomizing spray gun (11) that enters the interior, and the atomizing spray gun (11) is externally connected to a peristaltic pump.

2. The wet granulation and drying integrated machine according to claim 1, characterized in that: The purification air supply system comprises a booster fan (16), a primary filter (17), a heater (18), a hot and cold air valve (19), a high-efficiency filter (7) and an air supply pipe (1); the air supply pipe (1) enters the air chamber (14) tangentially, and the air supply pipe (1) is provided with an air volume regulating valve (6).

3. The wet granulation and drying integrated machine according to claim 1, characterized in that: A plurality of dust-fighting titanium rods (4) are arranged in the dust-fighting chamber (8), a high-pressure gas pulse back-blowing device (24) is arranged at the outlet of the dust-fighting titanium rods (4), and the dust-fighting chamber (8) is provided with an air outlet pipe (5) leading to the outside.

4. The wet granulation and drying integrated machine according to claim 1, characterized in that: The movable bin (9) is provided with a viewing mirror and a light mirror (3) around it.

5. The wet granulation and drying integrated machine according to claim 1, characterized in that: The purification and air supply system can be disabled during the initial granulation, so that the material movement and adhesion granulation are not carried out synchronously with the air flow drying. After a few minutes, the purification and air supply system can be started to supply hot air and granulation drying synchronously, so as to avoid the escape of extremely fine particles.

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