A rapid detection device for microsphere particle size

Abstract

The utility model provides a device for rapid detection of microsphere particle size, so as to detect the proportion of sustained-release microspheres that meet the particle size requirements, comprising: a sample box to be tested, which is also connected to an ultrasonic dispersion device on the outside and is provided with a temperature and humidity sensor inside; a humidity adjustment device for adjusting the humidity inside the sample box to be tested; a fixed shell, which is respectively provided with a feed port and a discharge port at the upper and lower ends, and is provided with a temperature sensor inside; a vibrating screen device, which is arranged inside the fixed shell and comprises a first vibrating screen and a second vibrating screen that are spaced apart from each other in the upper and lower parts; a weighing device, comprising a first weighing component, a second weighing component and a third weighing component that are respectively arranged below the first vibrating screen and the second vibrating screen; a heat exchange device that is arranged on the sample box to be tested and the outer wall of the fixed shell; the device can detect the proportion of qualified particle sizes of microsphere samples in batches, reduce the influence of static electricity between microspheres and the detection environment on the detection results, and improve the detection accuracy.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a microsphere particle diameter rapid detection device. Background Art

[0002] Sustained-release microspheres are microcarriers used in drug delivery systems. The particle size has a key influence on the release rate, biodistribution and therapeutic effect of the drug:

[0003] 1. Drug release rate: The particle size of microspheres directly affects the release rate of drugs. Generally speaking, microspheres with smaller particle sizes have larger specific surface areas and may therefore have faster release rates.

[0004] 2. Distribution in the body: Microspheres of different particle sizes have different distribution patterns in the body. For example, larger microspheres may be retained in specific organs (such as the liver or spleen), while smaller microspheres may more easily penetrate the blood vessel wall and enter the tissue space;

[0005] 3. Targeting: By precisely controlling the particle size of microspheres, the targeted therapeutic effect of certain diseases can be improved and the side effects on normal tissues can be reduced;

[0006] In the prior art, dynamic light scattering (DLS), laser diffraction (LLD) and AFM are generally used to detect the particle size and particle size distribution of microspheres. The above detection equipment is expensive and the detection operation is relatively complicated.

[0007] In the actual detection process, the presence of static electricity will cause adsorption and adhesion between microspheres. The generation of static electricity is mainly due to the unbalanced distribution of charge on the surface of the material, which is more likely to occur in a dry, high-resistance environment. Sustained-release microspheres are usually made of polymer materials. During processing, transportation and storage, these materials may accumulate static electricity due to friction, contact separation and other reasons. Static electricity may affect the physical and chemical properties of the microspheres, causing the microspheres to aggregate and adhere, thereby affecting the detection of the particle size of the microspheres. Therefore, too low humidity may cause static electricity problems or cause material embrittlement, and too high humidity may cause the material to absorb moisture and expand or undergo hydrolysis reactions. In addition, changes in temperature will cause the polymer material on the surface of the microspheres to expand and contract, resulting in changes in its size, thereby affecting the particle size measurement results. Utility Model Content

[0008] The utility model provides a device for rapid detection of microsphere particle size, so as to realize rapid detection of the proportion of sustained-release microspheres that meet the particle size requirements, and to serve as a basis for modifying preparation parameters. In order to achieve the above purpose, the technical scheme adopted is as follows:

[0009] A microsphere particle size rapid detection device, characterized in that it comprises:

[0010] The sample box to be tested is fixedly connected to the top of the bracket, and a feed pipe and a discharge pipe are respectively provided at the upper and lower ends. The discharge pipe is provided with a discharge switch valve, and an ultrasonic dispersion device is also connected to the outside of the sample box to be tested, and a temperature and humidity sensor is provided inside;

[0011] A humidity regulating device, connected to the interior of the sample box to be tested, and used to regulate the humidity of the sample to be tested inside the sample box to be tested;

[0012] The fixed shell is arranged below the sample box to be tested, and the upper and lower ends thereof are respectively provided with a feed port and a discharge port, and a temperature sensor is arranged inside the fixed shell;

[0013] A vibrating screen device, comprising a first vibrating screen and a second vibrating screen fixedly connected to the inner wall of the housing and spaced apart from each other, wherein the aperture of the first vibrating screen is equal to the maximum value of the allowable particle size range, and the aperture of the second vibrating screen is equal to the minimum value of the allowable particle size range;

[0014] The weighing device comprises a first weighing assembly, a second weighing assembly and a third weighing assembly respectively arranged below the first vibrating screen and the second vibrating screen, wherein the first weighing assembly is arranged above the fixed housing and below the discharge pipe, and is used to measure the total weight of the sample to be measured, and the second weighing assembly and the third weighing assembly are respectively arranged below the first vibrating screen and the second vibrating screen, and are used to weigh the sample to be measured after being screened by the first vibrating screen and the second vibrating screen respectively;

[0015] The heat exchange device comprises a first heat exchanger and a second heat exchanger, which are respectively used for exchanging heat between the sample box to be tested and the sample to be tested inside the fixed shell.

[0016] Furthermore, the first weighing assembly includes a feed hopper, a first weighing sensor arranged between the feed hopper and the upper end of the shell, a discharge pipe corresponding to and connected to the position of the feed port is arranged at the lower end of the feed hopper, and a discharge switch valve is arranged on the discharge pipe. The second weighing assembly and the third weighing assembly are both composed of a receiving hopper, a support plate and a weighing sensor, the support plate is fixedly connected to the side wall of the shell, the receiving hopper is arranged above the support plate, the weighing sensor is arranged between the receiving hopper and the support plate, and a discharge pipe is connected below the receiving hopper, and a discharge switch valve is arranged on the discharge pipe.

[0017] Furthermore, a shield is disposed above the first vibrating screen and the second vibrating screen, and the shield is provided with through holes distributed corresponding to the positions of the discharge pipes of the respective weighing components.

[0018] Furthermore, the first vibrating screen and the second vibrating screen are fixedly connected to the inner wall of the fixed shell through a support frame respectively.

[0019] Furthermore, the humidity regulating device includes a humidifier and a dehumidifier, both of which are connected to the inside of the sample box to be tested.

[0020] Furthermore, it also includes a control system, which is composed of a controller and a qualified particle size specific gravity calculation module. The weighing sensors on the first weighing component, the second weighing component and the third weighing component are all connected to the signal input end of the controller. The qualified particle size specific gravity calculation module is connected to the signal output end of the controller and is used to calculate the ratio of the microsphere particle size on the second vibrating screen to the total weight of the microsphere sample to be tested. The discharge switch valve and the discharge switch valve are both connected to the signal output end of the controller.

[0021] Furthermore, the qualified particle size specific gravity calculation module is also connected to a display module for displaying the qualified particle size specific gravity result.

[0022] Furthermore, the temperature and humidity sensor and the temperature sensor are connected to the signal input end of the controller, and the humidity regulating device, the ultrasonic dispersion device, the heat exchange device and the discharge switch valve are all connected to the signal output end of the controller.

[0023] Furthermore, the vibration components on the first vibration screen and the second vibration screen are connected to the signal output end of the controller.

[0024] Furthermore, the ultrasonic dispersion device includes an ultrasonic generator and a transducer, and the transducer is fixedly connected to the outer side wall of the sample box to be tested.

[0025] The beneficial effects of the utility model are:

[0026] 1. Before the particle size test, the humidity of the microspheres to be tested is adjusted through a humidity adjustment device to avoid water swelling or decomposition due to excessive humidity and electrostatic adsorption and aggregation between microspheres due to low humidity, which may affect the subsequent particle size test. In addition, a heat exchange device is used to keep the microspheres at a suitable temperature to ensure the stability of the particle size and improve the accuracy of the particle size test results.

[0027] 2. Use the ultrasonic dispersion device to disperse the sample box to be tested by ultrasonic vibration, which can overcome the van der Waals force and electrostatic attraction between the microspheres, so that the microspheres can enter the subsequent screening and weighing device after dispersion, further reduce the electrostatic influence between the microspheres to be tested, and reduce the adsorption and adhesion between the microspheres caused by static electricity;

[0028] 3. The total weight of the sample entering the fixed housing is measured by the first weighing component, and the microsphere samples meeting the particle size requirements can be screened out by the first vibrating screen and the second vibrating screen. The weight is detected by the second weighing component and the third weighing component, and the specific gravity of the microspheres to be tested meeting the particle size requirements can be calculated, so as to quickly evaluate and judge whether the sample particle size meets the requirements, which can serve as a basis for modifying the subsequent preparation parameters;

[0029] 4. The setting of the control system can realize the control of each switch valve and vibration screen, so as to realize the automatic screening, weighing and calculation of the qualified particle size ratio of the microsphere samples to be tested. The operation is simple and the detection efficiency is effectively improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is a schematic diagram of the structure of the first embodiment of the utility model

[0031] Figure 2 This is a schematic diagram of the distribution structure of the weighing component and the screen component in the first embodiment of the utility model

[0032] Figure 3 This is a schematic diagram of the structure of the second embodiment of the utility model

[0033] Figure 4 This is a schematic diagram of the distribution structure of the weighing component and the screen component in the second embodiment of the utility model

[0034] Figure 5 This is a logic diagram of the control system in the third embodiment of the utility model

[0035] Figure 6 This is a logic diagram of the control system in the fourth embodiment of the utility model

[0036] in:

[0037] 1-test sample box, 101-feed pipe, 102-discharge pipe, 103-discharge switch valve; 2-humidifier, 3-dehumidifier, 4-first heat exchanger, 5-temperature and humidity sensor, 6-ultrasonic generator, 7-transducer, 8-bracket, 9-fixed shell, 901-feed port, 902-discharge port, 10-feed hopper, 1001-discharge pipe, 1002-discharge switch valve, 11-first weighing sensor, 12-first vibrating screen, 13-first receiving hopper, 1301-first discharge pipe, 130 2-first discharge switch valve, 14-second weighing sensor, 15-first support plate, 16-second vibrating screen, 17-second receiving hopper, 1701-second discharge pipe, 1702-second discharge switch valve, 18-third weighing sensor, 19-second support plate, 20-first protective cover, 21-second protective cover, 22-second heat exchanger, 23-temperature sensor, 24-fixing frame, 25-screen body, 26-support frame, 27-controller, 28-qualified particle size specific gravity calculation module, 29-display module. DETAILED DESCRIPTION

[0038] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0039] In the description of the utility model, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the viewing direction or position relationship, and are only for the convenience of describing the utility model, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0040] First embodiment

[0041] like Figure 1-Figure 2 The device for rapid detection of microsphere particle size shown in the figure comprises a sample box 1 to be tested, a humidity regulating device, an ultrasonic dispersion device, a fixed shell 9, a weighing device, a vibrating screen device and a heat exchange device.

[0042] Specifically, the sample box 1 to be tested is fixedly connected to the top of the bracket 8, and its interior is used to accommodate the microsphere samples to be tested. The upper and lower ends of the sample box 1 to be tested are respectively provided with a feed pipe 101 and a discharge pipe 102, and the discharge pipe 102 is provided with a discharge switch valve 103, and a temperature and humidity sensor 5 is also provided inside for detecting the internal temperature and humidity.

[0043] The humidity regulating device includes a humidifier 2 and a dehumidifier 3. The humidifier 2 adopts an ultrasonic humidifier. The air outlet pipe of the humidifier 2 is connected to the inside of the sample box 1 to be tested for precise humidity control. The dehumidifier 3 adopts an adsorption dehumidifier (such as silica gel, molecular sieve), and its air inlet pipe is connected to the inside of the sample box 1 to be tested. In this embodiment, the relative humidity (RH) inside the sample box 1 to be tested is set to 40% to 60%. When the temperature and humidity sensor 5 detects that the humidity is lower than the lower limit of the preset value, the inside of the sample box 1 is humidified by the humidifier 2, thereby avoiding the sample box to be tested from 1 The internal drying causes static electricity between the microsphere samples to be tested, which affects the subsequent screening. When the humidity measured by the temperature and humidity sensor 5 is higher than the upper limit of the preset value, the dehumidifier 3 is used to dehumidify the inside until the humidity meets the preset value requirement, so as to avoid the microsphere material to be tested from hygroscopic expansion or hydrolysis reaction due to excessive humidity; Of course, if the external environmental humidity is too high, the humidity regulating device may also only use the dehumidifier 3, and if the external environmental humidity is far below the preset requirement, the humidity regulating device may also only use the humidifier 2. The selection of the humidity regulating device can be determined according to the actual situation.

[0044] The ultrasonic dispersion device includes an ultrasonic generator 6 and a transducer 7. The ultrasonic generator 6 is fixedly connected to a bracket 8 and electrically connected to the transducer 7. The transducer 7 is fixedly connected to the outer wall of the sample box 1 to be tested. The ultrasonic dispersion device can be used to vibrate and disperse the microsphere sample to be tested inside the sample box 1 to overcome the van der Waals force and electrostatic attraction between the microspheres, ensuring that the microspheres are fully dispersed before entering the vibration screen device below.

[0045] The fixed shell 9 is located below the sample box 1 to be tested, with legs at the lower end, and a feed port 901 and a discharge port 902 at the upper and lower ends of the fixed shell 9, respectively. A temperature sensor 23 is also provided inside to detect the internal temperature.

[0046] The vibrating screen device includes a first vibrating screen 12 and a second vibrating screen 16 which are spaced apart from each other and fixedly connected to the inner wall of the fixed shell 9. The first vibrating screen 12 and the second vibrating screen 16 are both composed of a fixed frame 24, a screen body 25 and a vibration component. The screen body 25 is fixedly connected to the fixed frame 24, and the fixed frame 24 is fixedly connected to the inner wall of the fixed shell 9 through a support frame 26. In this embodiment, the vibration component adopts a vibration rod (not shown in the figure) and is placed inside the fixed frame 24. The vibration rod can drive the fixed frame 24 and the screen body 25 to vibrate, thereby screening the microspheres. It should be noted that the vibration component can also use a vibration motor to be set in the fixed frame 24, and the structure of the vibrating screen is not limited to the above structure, and other conventional vibrating screen structures in the prior art are acceptable.

[0047] In addition, the aperture of the screen body of the first vibrating screen 12 is set to the maximum value of the allowable particle size range, and the aperture of the screen body of the second vibrating screen 16 is set to the minimum value of the allowable particle size range. In the present embodiment, taking leuprorelin acetate microspheres for injection as an example, the target design microsphere particle size is 20 μm, and the allowable particle size error range is set to ±10% to ±20% of the average particle size, that is, the allowable particle size range is 16 to 24 μm, that is, the aperture of the screen body of the first vibrating screen 12 is set to 24 μm, and the aperture of the screen body of the second vibrating screen 16 is set to 16 μm.

[0048] The weighing device includes a first weighing component, a second weighing component and a third weighing component. The first weighing component is arranged above the fixed shell 9, and includes a feed hopper 10 and a first weighing sensor 11. A discharge pipe 1001 is arranged at the lower end of the feed hopper 10. The discharge pipe 1001 extends from the feed port 901 on the fixed shell 9 into the interior of the fixed shell 9, and a discharge switch valve 1002 is arranged on the discharge pipe 1001. The first weighing sensor 11 is connected between the feed hopper 10 and the upper end surface of the fixed shell 9. The microspheres to be tested inside the sample box 1 to be tested enter the feed hopper 10 through the discharge pipe 102. The total weight M of the microspheres to be tested in the feed hopper 10 can be detected by the first weighing sensor 11; the second weighing component is arranged below the first vibrating screen 12, and includes a first receiving hopper 13, a second weighing sensor 14 and a first support plate 15. The first receiving hopper 13 is fixed below the first vibrating screen 12 through the first support plate 15. The lower end of the first receiving hopper 13 is connected to There is a first discharge pipe 1301, on which a first discharge switch valve 1302 is arranged. A second weighing sensor 14 is connected between the first receiving hopper 13 and the first support plate 15, and is used to detect the weight M1 of the microspheres to be measured that fall into the first receiving hopper 13 after being screened by the first vibrating screen 12; a third weighing assembly is arranged below the second vibrating screen 16, and includes a second receiving hopper 17, a third weighing sensor 18 and a second support plate 19. The second receiving hopper 17 is connected to the inner wall of the fixed shell 9 through the second support plate 19. A second discharge pipe 1701 is arranged below the second receiving hopper 17, and the second discharge pipe 1701 extends downward through the discharge port 902 to below the fixed shell 9, and a second discharge switch valve 1702 is arranged on the second discharge pipe 1701. The third weighing sensor 18 is connected between the second receiving hopper 17 and the second support plate 19, and is used to detect the weight M2 of the microspheres to be measured after being screened by the second vibrating screen 16.

[0049] The heat exchange device includes a first heat exchanger 4 and a second heat exchanger 22. In the present embodiment, both are jacketed heat exchangers and are respectively fixedly connected to the outer wall of the sample box 1 to be tested and the fixed shell 9. In the present embodiment, the preset temperature range is 20°C to 30°C (68°F to 86°F). The first heat exchanger 4 and the second heat exchanger 22 ensure that the microsphere sample to be tested is in a suitable temperature range during the detection process, thereby avoiding thermal expansion and contraction of the microspheres due to excessively high or low temperature, thereby affecting the final detection result.

[0050] The working principle of this device is as follows:

[0051] First, the temperature and humidity inside the sample box 1 to be tested are adjusted by the humidity regulating device and the first heat exchanger 4 until they meet the preset requirements, so as to reduce the electrostatic influence between the microspheres and the stability of the particle size of the microsphere sample to be tested, and the sample box 1 to be tested is driven to vibrate by the ultrasonic dispersion device to further reduce the van der Waals force and electrostatic attraction between the microspheres, and reduce the adsorption and adhesion between the microspheres; then the discharge switch valve 103 is opened, and the microsphere sample to be tested enters the feed hopper 10, and the weight can be detected by the first weighing sensor 11. When the preset weight M is reached, the discharge switch valve 103 is closed and the discharge switch valve 1002 is opened; at the same time, the vibration component on the first vibrating screen 12 is turned on, and the microsphere sample to be tested is screened by the first vibrating screen 12. The particles with a particle size greater than 24 μm are retained on the first vibrating screen 12, and the particles with a particle size less than 24 μm enter the first receiving hopper 13. After the screening is completed, in order to improve the measurement result of the second weighing sensor 14, the first vibrating screen can be temporarily closed. The vibration assembly on 12 is used to obtain the weight M1 of the microspheres to be tested in the first receiving hopper 13; then the first discharge switch valve 1302 is opened, and the vibration assembly on the second vibration screen 16 works at the same time, and the microsphere sample to be tested in the first receiving hopper 13 enters the second vibration screen 16 and is screened by the second vibration screen 16. At this time, the microspheres with a particle size between 16 and 24 μm are retained on the second vibration screen 16, and the microspheres smaller than 16 μm enter the second receiving hopper 17, and then the vibration assembly on the second vibration screen 16 is closed, and the microspheres in the second receiving hopper 17 are weighed by the third weighing sensor 18 to obtain the weight M2. At this time, the weight of the microspheres with a particle size range of 16 to 24 μm can be obtained by subtracting M1 from M2, and then the weight proportion of the microspheres within the allowable particle size range can be calculated by (M1-M2) / M, so that the proportion that meets the particle size requirements can be preliminarily evaluated. If the weight proportion of microspheres with the allowable particle size is too low, the preparation parameters can be adjusted in time.

[0052] Second embodiment

[0053] This embodiment adds a protective cover on the basis of the first embodiment to avoid the problem that the microspheres fall into the lower screen due to excessive bounce when screening the microspheres and cause damage to the microspheres.

[0054] Specifically, Figure 3 and Figure 4 As shown, a first protective cover 20 and a second protective cover 21 are respectively provided on the first vibrating screen 12 and the second vibrating screen 16. Both protective covers are fixedly connected to the top of the fixing frame 24. Of course, the height of the protective covers can be selected according to actual conditions.

[0055] A through hole is provided in the middle of the shield. The through hole on the first shield 20 is larger than the discharge pipe 1001, and the discharge pipe 1001 extends into the first shield 20. The through hole on the second shield 21 is larger than the first discharge pipe 1301, and the first discharge pipe 1301 extends into the second shield 21. The through holes cooperate with the respective material pipes to avoid interference between the shields and the material pipes when the vibrating screen is working.

[0056] Third embodiment

[0057] This embodiment further includes a control system based on the first and second embodiments, and the control system is used to calculate the specific gravity of microspheres with qualified particle sizes.

[0058] Specifically, Figure 5 As shown, the control system includes a controller 27, a qualified particle size ratio calculation module 28 and a display module 29. The first weighing sensor 11, the second weighing sensor 14 and the third weighing sensor 18 are all connected to the signal input end of the controller 27, and the discharge switch valve 1002, the first discharge switch valve 1302, the second discharge switch valve 1702 and the qualified particle size ratio calculation module 28 are all connected to the signal output end of the controller 27. The controller 27 receives the initial weight M of the microsphere sample to be measured, the weight M1 of the microspheres in the first receiving hopper 13 and the weight M2 of the microspheres in the second receiving hopper 17 measured by the first weighing sensor 11, the second weighing sensor 14 and the third weighing sensor 18, and inputs the above detection signals into the qualified particle size ratio calculation module 28. (M1-M2) / M can obtain the weight ratio of microspheres that meet the required particle size, and the signal output end of the qualified particle size ratio calculation module 28 is also connected to the display module 29 for displaying the calculation results.

[0059] Fourth embodiment

[0060] In order to improve the degree of automation of measurement, this embodiment is based on the third embodiment. Figure 6 As shown, the temperature and humidity sensor 5 and the temperature sensor 23 are connected to the signal input end of the controller 27, and the humidifier 2, the dehumidifier 3, the ultrasonic generator 6, the first heat exchanger 4, the second heat exchanger 22, and the discharge switch valve 103 are connected to the signal output end of the controller 27. The humidity regulating device, the ultrasonic dispersion device and the heat exchange device are automatically controlled by the controller 27 to work automatically, and the discharge switch valve 103 and the first weighing sensor 11 are controlled by the controller 27 to discharge the material accurately.

[0061] Of course, the vibration motors or vibration rods on the first vibrating screen 12 and the second vibrating screen 16 can also be connected to the signal output end of the controller 27 (not shown in the figure), and the controller 27 is used to control the on and off or working of each vibration component. The controller 27 is also connected to a timing module, and the action of the first vibrating screen 12 and the second vibrating screen 16 is controlled by the controller 27, and the vibration time of each vibrating screen is controlled by the timing module. When the vibrating screen stops working, the measurement results of each weighing sensor after stabilization are counted to avoid inaccurate measurement results of the weighing sensor due to vibration, thereby improving the accuracy of detection.

[0062] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements can be made without departing from the principle of the present invention, and these improvements should also be regarded as the protection scope of the present invention.

Claims

1. A rapid detection device for microsphere particle size, characterized in that: include: The sample box to be tested is fixedly connected to the top of the bracket, and a feed pipe and a discharge pipe are respectively provided at the upper and lower ends. The discharge pipe is provided with a discharge switch valve, and an ultrasonic dispersion device is also connected to the outside of the sample box to be tested, and a temperature and humidity sensor is provided inside; A humidity regulating device, connected to the interior of the sample box to be tested, and used to regulate the humidity of the sample to be tested inside the sample box to be tested; The fixed shell is arranged below the sample box to be tested, and the upper and lower ends thereof are respectively provided with a feed port and a discharge port, and a temperature sensor is arranged inside the fixed shell; A vibrating screen device, comprising a first vibrating screen and a second vibrating screen fixedly connected to the inner wall of the housing and spaced apart from each other, wherein the aperture of the first vibrating screen is equal to the maximum value of the allowable particle size range, and the aperture of the second vibrating screen is equal to the minimum value of the allowable particle size range; The weighing device comprises a first weighing assembly, a second weighing assembly and a third weighing assembly respectively arranged below the first vibrating screen and the second vibrating screen, wherein the first weighing assembly is arranged above the fixed housing and below the discharge pipe, and is used to measure the total weight of the sample to be measured, and the second weighing assembly and the third weighing assembly are respectively arranged below the first vibrating screen and the second vibrating screen, and are used to weigh the sample to be measured after being screened by the first vibrating screen and the second vibrating screen respectively; The heat exchange device comprises a first heat exchanger and a second heat exchanger, which are respectively used for exchanging heat between the sample box to be tested and the sample to be tested inside the fixed shell.

2. The microsphere particle size rapid detection device according to claim 1, characterized in that: The first weighing assembly includes a feed hopper, a first weighing sensor arranged between the feed hopper and the upper end of the shell body, a discharge pipe corresponding to and connected to the position of the feed port is arranged at the lower end of the feed hopper, and a discharge switch valve is arranged on the discharge pipe. The second weighing assembly and the third weighing assembly are both composed of a receiving hopper, a support plate and a weighing sensor. The support plate is fixedly connected to the side wall of the shell, the receiving hopper is arranged above the support plate, the weighing sensor is arranged between the receiving hopper and the support plate, and a discharge pipe is connected below the receiving hopper, and a discharge switch valve is arranged on the discharge pipe.

3. The microsphere particle size rapid detection device according to claim 2, characterized in that: A shield is disposed above the first vibrating screen and the second vibrating screen, and the shield is provided with through holes distributed corresponding to the positions of the discharge pipes of the respective weighing components.

4. The microsphere particle size rapid detection device according to claim 1 or 3, characterized in that: The first vibrating screen and the second vibrating screen are respectively fixedly connected to the inner wall of the fixed shell through a support frame.

5. The microsphere particle size rapid detection device according to claim 1, characterized in that: The humidity regulating device comprises a humidifier and a dehumidifier, both of which are connected to the inside of the sample box to be tested.

6. The microsphere particle size rapid detection device according to claim 2, characterized in that: It also includes a control system, which is composed of a controller and a qualified particle size specific gravity calculation module. The weighing sensors on the first weighing component, the second weighing component and the third weighing component are all connected to the signal input end of the controller. The qualified particle size specific gravity calculation module is connected to the signal output end of the controller and is used to calculate the proportion of the microsphere particle size on the second vibrating screen to the total weight of the microsphere sample to be tested. The discharge switch valve and the discharge switch valve are both connected to the signal output end of the controller.

7. The microsphere particle size rapid detection device according to claim 6, characterized in that: The qualified particle size specific gravity calculation module is also connected to a display module for displaying the qualified particle size specific gravity result.

8. The microsphere particle size rapid detection device according to claim 6, characterized in that: The temperature and humidity sensor and the temperature sensor are all connected to the signal input end of the controller, and the humidity adjustment device, the ultrasonic dispersion device, the heat exchange device and the discharge switch valve are all connected to the signal output end of the controller.

9. The microsphere particle size rapid detection device according to claim 6, characterized in that: The vibration components on the first vibration screen and the second vibration screen are connected to the signal output end of the controller.

10. The microsphere particle size rapid detection device according to claim 1, characterized in that: The ultrasonic dispersion device comprises an ultrasonic generator and a transducer, and the transducer is fixedly connected to the outer side wall of the sample box to be tested.

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