An enzymatic hydrolysis device for producing highly water-soluble heparin sodium

Abstract

The utility model discloses an enzymatic hydrolysis device for producing sodium heparin with high water solubility. The utility model relates to the technical field of sodium heparin production devices. The enzymatic hydrolysis device for producing sodium heparin with high water solubility drives a transmission shaft and a stirring blade to perform stirring operation through a motor, cooperates with an intelligent temperature control box and a liquid pump to drive a heat energy medium into a heat exchange tube, so that the heat energy medium is heated in a spiral distribution around an inner stirring tube, which is convenient for realizing uniform heating, and uses a heat preservation layer made of polyurethane foam material to prevent heat loss, which is beneficial to improving the production quality of sodium heparin. The temperature inside the device is monitored at all times through a temperature sensor, and the temperature sensor is electrically connected to the intelligent temperature control box, so that the intelligent temperature control box can control the temperature change in the processing process in real time, thereby making timely adjustments, which is beneficial to improving the accuracy of temperature control of the enzymatic hydrolysis device for producing sodium heparin with high water solubility.

Description

Technical Field

[0001] The utility model relates to the technical field of heparin sodium production equipment, in particular to enzymatic hydrolysis equipment for producing heparin sodium with strong water solubility. Background Art

[0002] Heparin sodium is an anticoagulant that can interfere with many aspects of the blood coagulation process. It has anticoagulant effects both in vivo and in vitro. Its mechanism of action is relatively complex. It mainly binds to antithrombin III and enhances the latter's inhibitory effect on activated coagulation factors II, IX, X, XI and XII. Its consequences involve preventing platelet aggregation and destruction, hindering the formation of coagulation activating enzymes, preventing prothrombin from turning into thrombin, inhibiting thrombin, and thus hindering fibrinogen from turning into fibrin, thereby exerting an anticoagulant effect. In the production process of heparin sodium, an enzymatic hydrolysis equipment for the production of heparin sodium with strong water solubility is used.

[0003] For example, publication number CN212388039U, the utility model discloses a fast stirring type sodium heparin production enzymolysis tank, belonging to the technical field of sodium heparin production equipment, the fast stirring type sodium heparin production enzymolysis tank, including a tank body and a stirring shaft, the surface of the stirring shaft is movably sleeved with a sleeve, the inner wall of the sleeve is provided with a sealing ring, the inner wall of the sealing ring is movably connected with the surface of the stirring shaft, the inner wall of the sleeve is fixedly connected with a slider, the surface of the stirring shaft is provided with a chute, the surface of the slider is movably connected with the inner wall of the chute, the top of the inner wall of the chute and the top of the slider are respectively fixedly connected with the top and bottom of the spring, and the surface of the sleeve is fixedly sleeved with a stirring blade. The utility model is provided with a sleeve, a spring, a stirring blade and a stirring rod to solve the problem in the prior art that the currently common sodium heparin production enzymolysis tank needs a long time to fully mix the intestinal mucosal fluid with the enzymolysis agent when in use, thereby reducing the production efficiency of the enzymolysis solution.

[0004] Existing enzymatic hydrolysis equipment for the production of highly water-soluble sodium heparin usually needs to be equipped with a temperature adjustment tube during operation, but most temperature control structures have certain limitations, are prone to uneven heating, and are affected by heat loss, which is not conducive to improving the production quality of sodium heparin. Utility Model Content

[0005] In view of the shortcomings of the prior art, the utility model provides an enzymatic hydrolysis device for producing sodium heparin with high water solubility, so as to solve the problem in the above background technology that the existing enzymatic hydrolysis device for producing sodium heparin with high water solubility usually needs to be equipped with an adjustment tube temperature during operation, but most of the temperature control structures have certain limitations, and are prone to uneven heating, and are affected by heat loss, which is not conducive to improving the production quality of sodium heparin.

[0006] To achieve the above purpose, the utility model is implemented by the following technical scheme: an enzymatic hydrolysis device for producing heparin sodium with strong water solubility, comprising a support frame, a protective outer tank is fixedly installed on the upper end of the support frame, a stirring inner tube is fixedly installed inside the protective outer tank, a heat exchange tube is arranged between the protective outer tank and the stirring inner tube, one end of the heat exchange tube is fixedly connected to a water inlet pipe, and the other end of the heat exchange tube is fixedly connected to a water outlet pipe, an intelligent temperature control box is fixedly installed on the right side of the upper end of the support frame, a thermal insulation layer is fixedly connected to the surface of the protective outer tank, and a protective layer is fixedly connected to the surface of the thermal insulation layer, a telescopic cylinder is fixedly installed on the upper end of the support frame at the side of the protective outer tank, a sealing cover plate is fixedly installed on the output end of the telescopic cylinder, a motor is fixedly installed on the upper end of the sealing cover plate, the output end of the motor extends to the inside of the stirring inner tube and a transmission shaft is fixedly installed, a stirring blade is fixedly installed on the surface of the transmission shaft, a temperature sensor is fixedly installed on the left side of the upper end of the sealing cover plate, and an enzymolytic agent inlet is arranged on the left side of the upper end of the sealing cover plate.

[0007] Preferably, the ends of the water inlet pipe and the water outlet pipe away from the heat exchange pipe extend to the outside of the protective outer tank and are connected to the intelligent temperature control box, and a liquid pump is fixedly installed on the lower side of the surface of the water inlet pipe.

[0008] Preferably, the thermal insulation layer is made of the same polyurethane foam material, and the protective layer is made of polyurethane rubber material.

[0009] Preferably, the telescopic cylinders are distributed in a ring array, and the protective outer tank and the stirring inner tube are both compatible with the sealing cover plate.

[0010] Preferably, the output end of the motor is rotatably connected to the sealing cover plate, and the stirring blade is designed in a spiral structure.

[0011] Preferably, the temperature sensor is electrically connected to the intelligent temperature control box, and a pH value detector is provided at the upper end of the sealing cover plate, located on the side of the temperature sensor.

[0012] Preferably, a feed port is provided at the lower end of the inner stirring tube, and a feed port is provided at the upper end of the sealing cover plate, located on the side of the enzymolysis agent inlet. Beneficial Effects

[0013] The utility model provides an enzymatic hydrolysis device for producing heparin sodium with strong water solubility. Compared with the prior art, it has the following beneficial effects:

[0014] 1. The enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium uses a motor to drive the transmission shaft and stirring blades to perform stirring operations, and cooperates with an intelligent temperature control box and a liquid pump to drive the thermal energy medium into the heat exchange tube, so that the thermal energy medium is heated in a spiral distribution around the stirring inner tube, which is convenient for achieving uniform heating, and uses a thermal insulation layer made of polyurethane foam material to prevent heat loss, which is beneficial to improving the production quality of heparin sodium.

[0015] 2. The enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium is designed with a spiral structure of stirring blades. When rotating, it is easy to drive the heparin sodium raw material to move upward, realize the anti-precipitation function, and is conducive to improving the uniformity of processing and stirring.

[0016] 3. The enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium monitors the internal temperature of the equipment at all times through a temperature sensor, and is electrically connected to an intelligent temperature control box in conjunction with the temperature sensor, so that the intelligent temperature control box can real-time control the temperature changes during the processing process, thereby making timely adjustments, which is beneficial to improving the accuracy of temperature control of the enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium.

[0017] 4. When the enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium needs to be cleaned or overhauled, the sealing cover plate is driven upward by the telescopic cylinder to move the transmission shaft and the stirring blade away from the stirring inner tube, which is beneficial to improving the convenience of overhaul or cleaning of the enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 The three-dimensional structure of the utility model is shown in FIG. Figure 1 .

[0019] Figure 2 The three-dimensional structure of the utility model is shown in FIG. Figure 2 .

[0020] Figure 3 The structure of the utility model is shown in FIG. Figure 1 .

[0021] Figure 4 The structure of the utility model is shown in FIG. Figure 2 .

[0022] In the figure: 1. Support frame; 2. Protective outer tank; 3. Stirring inner tube; 4. Heat exchange tube; 5. Water inlet pipe; 6. Water outlet pipe; 7. Intelligent temperature control box; 8. Insulation layer; 9. Protective layer; 10. Telescopic cylinder; 11. Sealing cover plate; 12. Motor; 13. Drive shaft; 14. Stirring blade; 15. Temperature sensor; 16. Enzyme inlet; 17. Liquid pump; 18. pH value detector; 19. Unloading port; 20. Loading port. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-4 The utility model provides a technical solution: an enzymatic hydrolysis device for producing heparin sodium with strong water solubility, comprising a support frame 1, a protective outer tank 2 is fixedly installed on the upper end of the support frame 1, a stirring inner tube 3 is fixedly installed inside the protective outer tank 2, a heat exchange tube 4 is arranged between the protective outer tank 2 and the stirring inner tube 3, one end of the heat exchange tube 4 is fixedly connected to a water inlet pipe 5, and the other end of the heat exchange tube 4 is fixedly connected to a water outlet pipe 6, an intelligent temperature control box 7 is fixedly installed on the right side of the upper end of the support frame 1, a heat preservation layer 8 is fixedly connected to the surface of the protective outer tank 2, and a protective layer 9 is fixedly connected to the surface of the heat preservation layer 8, and the ends of the water inlet pipe 5 and the water outlet pipe 6 away from the heat exchange tube 4 are extended to the protective outer tank 2 The outer side is connected to the intelligent temperature control box 7, and a liquid pump 17 is fixedly installed on the lower side of the surface of the water inlet pipe 5. The insulation layer 8 is made of the same polyurethane foam material, and the protective layer 9 is made of polyurethane rubber. The heparin sodium raw material is added through the feeding port 20, and the enzymolysis agent is added from the enzymolysis agent inlet 16. The motor 12 is turned on to drive the transmission shaft 13 and the stirring blade 14 to perform stirring operations. The intelligent temperature control box 7 and the liquid pump 17 drive the thermal energy medium to enter the heat exchange tube 4, so that the thermal energy medium is heated in a spiral distribution around the stirring inner tube 3, which is convenient for achieving uniform heating, and the insulation layer 8 is made of polyurethane foam material to prevent heat loss, which is beneficial to improving the production quality of heparin sodium;

[0025] The upper end of the support frame 1 is located on the side of the protective outer tank 2 and is fixedly installed with a telescopic cylinder 10. The output end of the telescopic cylinder 10 is fixedly installed with a sealing cover plate 11. The telescopic cylinders 10 are distributed in a ring array. The protective outer tank 2 and the stirring inner tube 3 are both adapted to the sealing cover plate 11. When the equipment needs to be cleaned or repaired, the sealing cover plate 11 is driven by the telescopic cylinder 10 to move upward, so that the transmission shaft 13 and the stirring blade 14 are away from the stirring inner tube 3, which is conducive to improving the convenience of maintenance or cleaning of the enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium;

[0026] A motor 12 is fixedly installed on the upper end of the sealing cover plate 11, and a transmission shaft 13 is fixedly installed on the output end of the motor 12 extending to the inside of the stirring inner tube 3, and a stirring blade 14 is fixedly installed on the surface of the transmission shaft 13. The output end of the motor 12 is rotatably connected to the sealing cover plate 11, and the stirring blade 14 is designed in a spiral structure. The stirring blade 14 is designed in a spiral structure, which is convenient for driving the heparin sodium raw material to move upward during rotation, realizing the anti-precipitation function, which is conducive to improving the uniformity of processing and stirring;

[0027] A temperature sensor 15 is fixedly installed on the left side of the upper end of the sealing cover plate 11, and an enzymolysis agent liquid inlet 16 is arranged on the left side of the upper end of the sealing cover plate 11. The temperature sensor 15 is electrically connected to the intelligent temperature control box 7, and a pH value detector 18 is arranged on the side of the temperature sensor 15 at the upper end of the sealing cover plate 11, a discharge port 19 is arranged on the lower end of the stirring inner tube 3, and a loading port 20 is arranged on the side of the enzymolysis agent liquid inlet 16 at the upper end of the sealing cover plate 11. The internal temperature of the equipment is monitored at all times by the temperature sensor 15, and the temperature sensor 15 is electrically connected to the intelligent temperature control box 7, so that the intelligent temperature control box 7 can control the temperature changes in the processing process in real time, so as to make timely adjustments, which is beneficial to improving the accuracy of temperature control of the enzymatic hydrolysis equipment for the production of highly water-soluble heparin sodium.

[0028] During operation, the heparin sodium raw material is added through the feed port 20, and the enzymolysis agent is added from the enzymolysis agent inlet 16, the motor 12 is turned on to drive the transmission shaft 13 and the stirring blade 14 to perform stirring operation, and the intelligent temperature control box 7 and the liquid pump 17 are used to drive the thermal energy medium to enter the heat exchange tube 4, so that the thermal energy medium is heated in a spiral distribution around the stirring inner tube 3, which is convenient for achieving uniform heating, and the thermal insulation layer 8 is made of polyurethane foam material to prevent heat loss. The stirring blade 14 is designed with a spiral structure, which is convenient for driving the heparin sodium raw material to move upward when rotating, so as to achieve the anti-precipitation function, and the temperature sensor 15 is used to monitor the internal temperature of the equipment at all times, and the temperature sensor 15 is electrically connected to the intelligent temperature control box 7, so that the intelligent temperature control box 7 can control the temperature changes in the processing process in real time, so as to make timely adjustments. When the equipment needs to be cleaned or repaired, the telescopic cylinder 10 drives the sealing cover plate 11 to move upward, so that the transmission shaft 13 and the stirring blade 14 are away from the stirring inner tube 3.

[0029] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

Claims

1. An enzymatic hydrolysis device for producing highly water-soluble heparin sodium, comprising a support frame (1), characterized in that: The upper end of the support frame (1) is fixedly mounted with a protective outer tank (2), the interior of the protective outer tank (2) is fixedly mounted with a stirring inner tube (3), a heat exchange tube (4) is arranged between the protective outer tank (2) and the stirring inner tube (3), one end of the heat exchange tube (4) is fixedly connected to a water inlet pipe (5), and the other end of the heat exchange tube (4) is fixedly connected to a water outlet pipe (6), an intelligent temperature control box (7) is fixedly mounted on the right side of the upper end of the support frame (1), a thermal insulation layer (8) is fixedly connected to the surface of the protective outer tank (2), and a protective layer (9) is fixedly connected to the surface of the thermal insulation layer (8), and the support frame (1) is fixedly mounted with a protective layer (9) on the surface of the protective outer tank (2). ) is fixedly mounted on the side of the protective outer tank (2) at its upper end, a telescopic cylinder (10) is fixedly mounted on the output end of the telescopic cylinder (10) to a sealing cover plate (11), a motor (12) is fixedly mounted on the upper end of the sealing cover plate (11), the output end of the motor (12) extends to the inside of the stirring inner tube (3) to be fixedly mounted with a transmission shaft (13), a stirring blade (14) is fixedly mounted on the surface of the transmission shaft (13), a temperature sensor (15) is fixedly mounted on the left side of the upper end of the sealing cover plate (11), and an enzymatic agent liquid inlet (16) is provided on the left side of the upper end of the sealing cover plate (11).

2. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 1, characterized in that: The ends of the water inlet pipe (5) and the water outlet pipe (6) away from the heat exchange pipe (4) extend to the outside of the protective outer tank (2) and are connected to the intelligent temperature control box (7), and a liquid pump (17) is fixedly installed on the lower side of the surface of the water inlet pipe (5).

3. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 1, characterized in that: The thermal insulation layer (8) is made of the same polyurethane foam material, and the protective layer (9) is made of polyurethane rubber material.

4. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 1, characterized in that: The telescopic cylinders (10) are distributed in a ring array, and the protective outer tank (2) and the stirring inner tube (3) are both mutually compatible with the sealing cover plate (11).

5. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 4, characterized in that: The output end of the motor (12) is rotatably connected to the sealing cover plate (11), and the stirring blade (14) is designed to have a spiral structure.

6. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 5, characterized in that: The temperature sensor (15) is electrically connected to the intelligent temperature control box (7), and a pH value detector (18) is provided at the upper end of the sealing cover plate (11) and located on the side of the temperature sensor (15).

7. The enzymatic hydrolysis equipment for producing highly water-soluble heparin sodium according to claim 6, characterized in that: The lower end of the inner stirring tube (3) is provided with a feed opening (19), and the upper end of the sealing cover plate (11) is provided with a feed opening (20) located on the side of the enzymolysis agent inlet (16).

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