Rapid magnetic bead uniform mixing device

Abstract

The utility model discloses a quick magnetic bead mixing device, and relates to the technical field of mixers. The upper surface of the bottom plate is connected with a top plate through a stand column; a movable plate A is supported on the upper surface of the bottom plate through a plurality of telescopic pieces A, N rows * M columns of positioning sleeves are arranged on the upper edge surface of the movable plate A, and magnetic bead bottles containing magnetic bead liquid are placed in the positioning sleeves during use; the inner bottom side face of the top plate is connected with a movable plate B through a plurality of telescopic pieces B. The movable plate B is provided with a stirring structure which is inserted into the magnetic bead bottle and conducts stirring along with lifting of the movable plate B. According to the utility model, the plurality of magnetic bead bottles are placed on the movable plate A, and the stirring structure which is inserted into the magnetic bead bottles and is used for stirring along with the lifting of the movable plate B is arranged on the movable plate B, so that the plurality of magnetic bead bottles can be simultaneously stirred and uniformly mixed in a single stirring operation process.

Description

Technical Field

[0001] The utility model belongs to the technical field of mixers, in particular to a quick magnetic bead mixing device. Background Art

[0002] A mixer, as the name suggests, is a tool used for mixing evenly. It is widely used in the field of reagent mixing. In single-cell sequencing technology, magnetic beads are needed to capture RNA sequences in cells. Before this operation, the magnetic beads need to fully react with the reagent. In order to prevent the magnetic beads from sinking to the bottom of the container, a magnetic bead mixer is needed to mix the magnetic beads so that they are always suspended in the reagent.

[0003] Since the magnetic beads will sink to the bottom after the magnetic bead solution has been stationary for a long time, the magnetic bead solution needs to be mixed before use. For example, CN215610825U discloses a stirring magnetic bead solution mixing mechanism, which includes a container with an opening at the top, an impeller arranged in the container, and a container cover that seals and closes the opening at the top of the container, and the magnetic bead solution is fully mixed by stirring the solution with the impeller; however, in this technical solution, only a single magnetic bead bottle can be stirred evenly during one stirring process. Utility Model Content

[0004] The utility model aims to provide a quick magnetic bead mixing device, which solves the problem that only a single magnetic bead bottle can be stirred evenly in one stirring process in the prior art by placing multiple magnetic bead bottles on a movable plate A and arranging a stirring structure on a movable plate B that is inserted into the magnetic bead bottles and stirs as the movable plate B rises and falls.

[0005] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0006] The utility model discloses a quick magnetic bead mixing device, comprising a bottom plate, wherein the upper surface of the bottom plate is connected to a top plate via a column; a movable plate A is supported on the upper surface of the bottom plate via a plurality of telescopic parts A, and positioning sleeves with N rows and M columns are arranged on the upper side of the movable plate A, and a magnetic bead bottle containing magnetic bead liquid is placed in the positioning sleeve when in use; the inner bottom side surface of the top plate is connected to a movable plate B via a plurality of telescopic parts B, and a stirring structure is arranged on the movable plate B, which is inserted into the magnetic bead bottle and stirs the bottle as the movable plate B rises and falls.

[0007] Furthermore, the stirring structure includes a stirring rod and a sphere arranged at the end of the stirring rod.

[0008] Furthermore, a rectangular hole is opened on the movable plate B located directly above any positioning sleeve, and sliding grooves are arranged on the two opposite inner walls of the rectangular hole. A base block is arranged in the rectangular hole, and sliding blocks that slide along the length direction of the sliding groove are arranged on both sides of the base block; the stirring rod is fixed to the bottom side surface of the base block, and a hinge seat A is arranged on the upper surface of the base block, a connecting rod is hinged on the hinge seat A, and a hinge seat B hinged to the end of the connecting rod is arranged on the top side surface of the top plate.

[0009] Furthermore, the telescopic member B and the telescopic member A are both telescopic cylinders.

[0010] Furthermore, a positioning sleeve is provided on the bottom side of the movable plate A and is sleeved on the end of the telescopic cylinder.

[0011] The utility model has the following beneficial effects:

[0012] The utility model places a plurality of magnetic bead bottles on a movable plate A, and provides a stirring structure on a movable plate B which is inserted into the magnetic bead bottles and stirs along with the lifting and lowering of the movable plate B, thereby achieving simultaneous stirring and mixing of the plurality of magnetic bead bottles in a single stirring operation.

[0013] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0015] Figure 1 This is a schematic diagram of the structure of the mixing device of the utility model;

[0016] Figure 2 for Figure 1 The main view;

[0017] Figure 3 for Figure 2 Section view at AA in the middle. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0019] See also Figure 1-3As shown, the utility model is a quick magnetic bead mixing device, including a bottom plate 1 and a top plate 12 connected by a column 11, and the upper surface of the bottom plate 1 is supported by four synchronously retractable telescopic parts A10 with a movable plate A3, the inner bottom side surface of the top plate 12 is installed with four synchronously retractable telescopic parts B13, and the ends of the four telescopic parts B13 are connected to the movable plate B2; at the same time, five rows and five columns totaling twenty-five positioning sleeves 30 are arranged on the upper surface of the movable plate A3, and a stirring structure that is placed in the magnetic bead bottle 4 and stirs with the rise and fall of the movable plate B2 is arranged on the movable plate B2 directly above any positioning sleeve 30.

[0020] Based on this, when in use, first control the telescopic part A10 to retract, then place the magnetic bead bottle 4 containing magnetic bead liquid in the positioning sleeve 30, and then control the telescopic part A10 to extend to the stirring structure and insert it into the magnetic bead bottle 4; control the telescopic part B13 to continuously retract and retract, thereby driving the movable plate B2 to reciprocate and rise and fall, so as to use the stirring structure to mix the magnetic bead liquid in the magnetic bead bottle 4.

[0021] It should be noted that, in a specific embodiment, a rectangular hole 20 is provided on the movable plate B2 located directly above any positioning sleeve 30, and slide grooves 21 are provided on the two opposite inner walls of the rectangular hole 20, and a base block 22 is provided in the rectangular hole 20, and sliders that slide along the length direction of the slide groove 21 are provided on both sides of the base block 22; a stirring rod 25 is fixed to the bottom side surface of the base block 22, and a hinge seat A23 is provided on the upper surface of the base block 22, and a connecting rod 24 is hinged on the hinge seat A23, and a hinge seat B14 hinged to the end of the connecting rod 24 is provided on the inner top side surface of the top plate 12, thereby realizing that in the process of controlling the movable plate B2 to perform reciprocating lifting activities, the stirring structure connected to the bottom of the base block 22 not only accompanies the movable plate B2 to move up and down, but also, under the action of the slide groove 21 and the slider, the stirring structure moves synchronously in the horizontal direction during the reciprocating lifting activities of the movable plate B2.

[0022] The stirring structure includes a stirring rod 25 and a ball 26 disposed at the end of the stirring rod 25 . The ball 26 is used to move up and down and to mix the magnetic bead liquid stored in the magnetic bead bottle 4 .

[0023] Furthermore, the telescopic part B13 and the telescopic part A10 are both telescopic cylinders, and the bottom side surface of the movable plate A3 is provided with a positioning sleeve 31 which is sleeved on the end of the telescopic cylinder. The positioning sleeve 31 is used to facilitate the positioning of the magnetic bead bottle 4 placed on the movable plate A3 to avoid deviation in its placement position. At the same time, after the mixing is completed, the telescopic part B13 and the telescopic part A10 are controlled to complete the contraction. At this time, the movable plate A3 is controlled to move upward to complete the removal of the movable plate A3 as a whole from the ends of the four telescopic parts A10, and then the positioning sleeve 31 is removed from the positioning sleeve 31.

[0024] In the above, in order to prevent the magnetic bead bottle 4 from shaking due to waves generated by the shaking of the liquid in the magnetic bead bottle 4 during the stirring process, a sponge layer or the like is provided on the inner wall of the magnetic bead bottle 4 to clamp a deformable lining layer on the outer wall of the magnetic bead bottle 4, thereby preventing the magnetic bead bottle 4 from shaking.

[0025] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A quick magnetic bead mixing device, characterized in that: It comprises a bottom plate (1), the upper surface of the bottom plate (1) being connected to a top plate (12) via a column (11); The upper surface of the bottom plate (1) supports a movable plate A (3) via a plurality of telescopic parts A (10); the upper surface of the movable plate A (3) is provided with N rows and M columns of positioning sleeves (30); when in use, a magnetic bead bottle (4) containing magnetic bead liquid is placed in the positioning sleeves (30); The inner bottom side surface of the top plate (12) is connected to a movable plate B (2) via a plurality of telescopic parts B (13); the movable plate B (2) is provided with a stirring structure which is inserted into the magnetic bead bottle (4) and stirs as the movable plate B (2) rises and falls.

2. A quick magnetic bead mixing device according to claim 1, characterized in that: The stirring structure comprises a stirring rod (25) and a sphere (26) arranged at the end of the stirring rod (25).

3. A quick magnetic bead mixing device according to claim 2, characterized in that: A rectangular hole (20) is provided on the movable plate B (2) located directly above any positioning sleeve (30), and slide grooves (21) are provided on two opposite inner side walls of the rectangular hole (20). A base block (22) is provided in the rectangular hole (20), and sliders are provided on both sides of the base block (22) for sliding along the length direction of the slide groove (21); The stirring rod (25) is fixed to the bottom side of the base block (22); an articulated seat A (23) is provided on the upper surface of the base block (22); a connecting rod (24) is hingedly connected to the articulated seat A (23); and an articulated seat B (14) is provided on the inner top side of the top plate (12) and is hingedly connected to the end of the connecting rod (24).

4. A quick magnetic bead mixing device according to claim 1, characterized in that: The telescopic member B (13) and the telescopic member A (10) are both telescopic cylinders.

5. A quick magnetic bead mixing device according to claim 4, characterized in that: The bottom side of the movable plate A (3) is provided with a positioning sleeve (31) sleeved on the end of the telescopic cylinder.

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