Biological detection microneedle sensor

Abstract

The utility model relates to the technical field of microneedles, in particular to a biological detection microneedle sensor which comprises a microneedle array, a microneedle platform and biological detection test paper, the microneedle array comprises a needle membrane and a needle body, a through hole is formed in the needle membrane, a through groove extending in the length direction of the needle body is formed in the side wall of the needle body, and a liquid guide channel is formed by the through hole and an inner cavity of the through groove; the microneedle platform comprises a plug connector and a socket connector, the plug connector and the socket connector are connected in an inserted mode to form a slot for containing biological detection test paper, the microneedle array is fixed to the upper surface of the plug connector, and a through hole communicated with the liquid guide channel is formed in the plug connector; the biological detection test paper is arranged in the slot in a manner of being attached to the through hole. According to the biological detection microneedle sensor, the microneedle platform is formed by inserting and matching the inserting piece and the socket piece, and only the inserting piece for fixing the microneedle array needs to be replaced when the microneedle array is replaced, so that the durability of the biological detection microneedle sensor is improved; after the micro-needle platform is inserted, a slot for placing biological detection test paper is formed, so that the biological detection micro-needle sensor has diversified detection capability.

Description

Technical Field

[0001] The utility model relates to the technical field of microneedles, in particular to a bio-detection microneedle sensor. Background Art

[0002] As classical biomarkers, glucose, uric acid, and pH value play a key role in monitoring chronic diseases. In diabetic patients, hyperuricemia has been associated with microvascular and macrovascular complications. In addition, in the diabetic patient population, the pH value in interstitial fluid is lower, which is one of the reasons for insulin resistance. Therefore, it is crucial to develop a system that can simultaneously detect glucose, uric acid, and pH value in interstitial fluid.

[0003] Microneedle arrays provide a painless way to penetrate the skin to reach interstitial fluid (ISF), making them suitable for drug delivery and monitoring of key biomarkers. In the field of microneedle technology, bio-detection microneedle sensors composed of microneedles and bio-detection test strips are widely used. Although current microneedle sensors integrate sensitive components for detecting specific biomarkers, there are still challenges in their development, especially in terms of diverse detection capabilities and ensuring durability. Summary of the Utility Model

[0004] The technical problem to be solved by the utility model is: in order to overcome the deficiencies existing in the prior art, a bio-detection microneedle sensor is provided to improve the durability of the bio-detection microneedle sensor and endow it with diverse detection capabilities at the same time.

[0005] The technical solution adopted by the utility model to solve its technical problem is: a bio-detection microneedle sensor includes a microneedle array, a microneedle platform for fixing the microneedle array, and a bio-detection test strip.

[0006] The microneedle array includes a needle film and needles located on the front surface of the needle film. The needle film has through holes, and the side wall of the needle has through grooves extending along the length direction of the needle. The inner cavities of the through holes and the through grooves form a liquid guiding channel.

[0007] The microneedle platform includes a plug-in part and a socket part. After the plug-in part and the socket part are plugged together, a slot for placing the bio-detection test strip is formed.

[0008] On both sides of the plug-in part, there are plug-in portions. The microneedle array is fixed on the upper surface of the plug-in part. The plug-in part is provided with a through hole communicated with the liquid guiding channel.

[0009] The socket part is provided with a cavity. One side of the cavity is provided with a lateral opening for the plug-in part to insert. The cavity is provided with an upward opening for the microneedle array to pass through. The two sides of the cavity with the lateral opening are plug-in slots adapted to be plugged with the plug-in portions of the plug-in part.

[0010] The biological detection test paper is placed in the slot in close contact with the through hole.

[0011] Furthermore, a joint exists between the plug-in portion of the plug-in connector and the socket socket of the socket connector when plugged in, and a thin sponge serving as a gasket is pre-filled at the joint.

[0012] Furthermore, a protrusion extending toward the slot is provided at one end of the cavity of the socket away from the upward opening to divide the slot into a plurality of cavities.

[0013] Furthermore, the back surface of the needle film of the microneedle array is bonded to the upper surface of the connector.

[0014] Specifically, the through hole, the bottom surface of the through groove and the through hole are concentrically arranged and adopt a circular structure with the same diameter, and the bottom surface diameter of the through groove is 1 / 2 of the bottom surface diameter of the needle body.

[0015] Furthermore, the biological test strips include glucose test strips, uric acid test strips and pH value test strips.

[0016] The beneficial effects of the utility model are: the microneedle platform formed by the plug-in and socket fittings, when replacing the microneedle array, only the plug-in fixing the microneedle array needs to be replaced, which improves the durability of the biological detection microneedle sensor; after the microneedle platform is plugged in, a slot for placing biological detection test strips is formed, so that the biological detection microneedle sensor has diversified detection capabilities. By pairing with various test strips, the biological detection microneedle sensor can be customized to meet the specific sensing needs of a series of metabolites, which is helpful for disease management and regulation; combined with the flexibility of different test strips, it meets many sensing needs and achieves strong adaptability and multi-dimensional sensing capabilities. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0018] Figure 1 It is a structural schematic diagram of the utility model;

[0019] Figure 2 It is a schematic diagram of the structure of the connector and the microneedle array of the utility model;

[0020] Figure 3 This utility model Figure 2 Schematic cross-sectional view of ;

[0021] Figure 4It is a structural schematic diagram of the socket of the utility model;

[0022] Figure 5 It is a schematic diagram of the structure of the microneedle array of the utility model;

[0023] Figure 6 It is a structural schematic diagram of the needle body of the utility model;

[0024] Figure 7a-7d This is a performance test diagram of the biological detection microneedle sensor of the present utility model.

[0025] Numbers in the figure:

[0026] 1-microneedle array, 11-needle membrane, 111-through hole, 12-needle body, 121-through groove;

[0027] 2-microneedle platform, 21-connector, 211-connector portion, 212-through hole, 22-socket, 221-cavity, 222-socket slot, 223-bump;

[0028] 3-Slots. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0030] Figure 1-Figure 6 A biological detection microneedle sensor shown includes a microneedle array 1, a microneedle platform 2 for fixing the microneedle array 1, and a biological detection test paper.

[0031] The microneedle array 1 includes a needle membrane 11 and a needle body 12 located on the front side of the needle membrane 11.

[0032] The needle membrane 11 has a through hole 111 , and the side wall of the needle body 12 has a through groove 121 extending along the length direction of the needle body 12 . The through hole 111 and the inner cavity of the through groove 121 form a liquid conducting channel.

[0033] The microneedle platform 2 includes a plug-in component 21 and a socket component 22. The plug-in component 21 and the socket component 22 are connected to form a slot 3 for placing a biological test paper. The inserted test paper placement space is convenient for replacing various combinations of test papers.

[0034] The two sides of the plug-in part 21 are provided with plug-in parts 211, and the microneedle array 1 is fixed on the upper surface of the plug-in part 21, that is, the back side of the needle membrane 11 of the microneedle array 1 is bonded to the upper surface of the plug-in part 21, and the microneedle platform formed by plug-in matching only needs to replace the plug-in part fixing the microneedle array when replacing the microneedle array;

[0035] The connector 21 is provided with a through hole 212 communicating with the fluid-conducting channel, forming a flow channel for the interstitial fluid as a whole.

[0036] The socket component 22 is provided with a cavity 221, one side of the cavity 221 is provided with a lateral opening for inserting the connector 21, the cavity 221 is provided with an upward opening for allowing the microneedle array 1 to pass through, and the two sides of the cavity 221 with the lateral opening are socket slots 222 that are plugged and adapted to the plug-in portion 211 of the connector 21.

[0037] The upper end surface of the slot 3 is the lower surface of the connector 21, and the lower end surface of the slot 3 is the lower end surface of the cavity 221. The biological test paper is placed in the slot 3 in a manner fitting the through hole 212, that is, the biological test paper is placed in a manner fitting the upper end surface of the slot 3. When in use, one end of the needle body 12 needs to be inserted downward to slightly penetrate the surface layer of the skin. At this time, the biological test paper fits the through hole 212 under the action of gravity.

[0038] There is a seam between the plug-in portion 211 of the plug-in component 21 and the socket socket 222 of the socket component 22 when they are plugged in. The seam is pre-filled with a thin sponge used as a gasket, so that the plug-in matching structure formed by the plug-in component 21 and the socket component 22 is more stable. At the same time, due to the liquid absorption capacity of the sponge, liquid leakage is effectively reduced.

[0039] Biological test strips include glucose test strips, uric acid test strips and pH test strips.

[0040] The end of the cavity 221 of the socket 22 away from the upward opening is provided with a protrusion 223 extending toward the slot 3 to divide the slot 3 into three cavities, for placing glucose test strips, uric acid test strips and pH test strips respectively. The number of cavities is determined according to the type of biological test strips, so as to facilitate the testing of multiple biomarkers at one time.

[0041] The through hole 111, the bottom surface of the through groove 121 and the through hole 212 are concentrically arranged and adopt a circular structure with the same diameter, and the bottom surface diameter of the through groove 121 is 1 / 2 of the bottom surface diameter of the needle body 12. The larger diameter liquid guide channel ensures that the microneedle array has the ability to absorb liquid and reduces clogging.

[0042] Before use, assemble the biological detection microneedle sensor, specifically: first, insert a thin sponge 4 into the socket slot 222 of the socket 22, and then plug the connector 21 fixed with the microneedle array 1 into the socket 22;

[0043] When in use, one end of the needle body 12 is inserted downward to slightly penetrate the skin surface. Through the action of capillaries, interstitial fluid passes through the through groove 121, the through hole 111 and the through hole 212 to reach the test paper attached to the through hole 212, thereby achieving the purpose of detecting human biomarkers.

[0044] Evaluation tests were conducted on the durability, storage stability, temperature stability, and pH stability of the sensor. The test results are as follows: Figure 7a-7d As shown:

[0045] like Figure 7a As shown, the sensor exhibited a relatively stable response in 50 consecutive tests, indicating that the sensor has certain reliability in continuous use over a short period of time.

[0046] In the storage stability test, the glucose sensing was tested for one week, with the test results on the first day as reference. Figure 7b As shown, the current response reached a maximum on the second day and gradually decreased in subsequent tests.

[0047] In order to further verify its stability, different temperatures ( Figure 7c ) and pH conditions ( Figure 7d ) for temperature and pH stability testing. Our observations showed that the test response was always above 80% over a one-week period. Even under less than ideal conditions (day 7, 15°C and pH 4), the sensor still produced 81.98%, 80.3% and 86% relative current responses, respectively, demonstrating its strong stability.

[0048] These observations suggest that the functionality and stability of the sensor ensure its important application in rapid clinical testing.

[0049] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A biological detection microneedle sensor, characterized in that: It comprises a microneedle array (1), a microneedle platform (2) for fixing the microneedle array (1), and a biological detection test paper. The microneedle array (1) comprises a needle membrane (11) and a needle body (12) located on the front side of the needle membrane (11); the needle membrane (11) has a through hole (111); the side wall of the needle body (12) has a through groove (121) extending along the length direction of the needle body (12); the through hole (111) and the inner cavity of the through groove (121) form a liquid conduction channel. The microneedle platform (2) comprises a plug-in component (21) and a socket component (22), and the plug-in component (21) and the socket component (22) are connected to form a slot (3) for placing a biological test paper; The plug-in part (211) is provided on both sides of the plug-in part (21), the microneedle array (1) is fixed on the upper surface of the plug-in part (21), and a through hole (212) communicating with the liquid guide channel is provided in the plug-in part (21). The socket component (22) is provided with a cavity (221), one side of the cavity (221) is provided with a lateral opening for accommodating the insertion of the plug-in component (21), the cavity (221) is provided with an upward opening for accommodating the passage of the microneedle array (1), and both sides of the cavity (221) with the lateral opening are socket slots (222) adapted to be plugged with the plug-in portion (211) of the plug-in component (21); The biological detection test paper is placed in the slot (3) in a manner conforming to the through hole (212).

2. The bioassay microneedle sensor according to claim 1, characterized in that: When plugged in, a joint exists between the plug-in portion (211) of the plug-in connector (21) and the socket socket (222) of the socket component (22), and the joint is pre-filled with a thin sponge used as a gasket.

3. The bioassay microneedle sensor according to claim 1, characterized in that: The cavity (221) of the socket (22) is provided with a protrusion (223) extending in the direction of the slot (3) at one end away from the upward opening, so as to divide the slot (3) into a plurality of cavities.

4. The bioassay microneedle sensor according to claim 1, characterized in that: The back surface of the needle film (11) of the microneedle array (1) is bonded to the upper surface of the connector (21).

5. The bioassay microneedle sensor according to claim 1, characterized in that: The through hole (111), the bottom surface of the through groove (121) and the through hole (212) are concentrically arranged and have a circular structure with the same diameter. The bottom diameter of the through groove (121) is 1 / 2 of the bottom diameter of the needle body (12).

6. The bioassay microneedle sensor according to claim 1, characterized in that: The biological detection test strips include glucose detection test strips, uric acid detection test strips and pH value detection test strips.

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