Automatic sampling dissolution instrument

Abstract

The utility model relates to the technical field of dissolution instruments, in particular to an automatic sampling dissolution instrument. Comprising a mounting frame, a plurality of dissolution cups are arranged in the mounting frame, a controller is arranged on the upper surface of the mounting frame, stirring rods are arranged at the positions, corresponding to the dissolution cups, of the surface of the controller, an adjusting device is arranged on the upper surface of the mounting frame and comprises a sliding frame, and the sliding frame is fixedly connected with the surface of the mounting frame; a sliding frame is slidably connected to the arc surface of the sliding frame, the section of the upper surface of the sliding frame is U-shaped, an elastic frame is fixedly connected to the inner wall of the sliding frame, a communicating pipe is clamped to the inner wall of the elastic frame, one end of the communicating pipe is inserted into the inner wall of the dissolution cup, and a sampling cup is fixedly connected to the end, away from the dissolution cup, of the communicating pipe; the arc surface of the communicating pipe is fixedly connected with a one-way air bag valve used for exhausting air in the bearing plate. The automatic sampling dissolution instrument provided by the utility model has the advantage that a solution in the dissolution cup can be conveniently taken out.

Description

Technical Field

[0001] The utility model relates to the technical field of dissolution instruments, in particular to an automatic sampling dissolution instrument. Background Art

[0002] Dissolution apparatus is a dissolution tester. Drug dissolution apparatus is an instrument for conducting drug dissolution experiments. It uses a precision control system composed of a single-chip microcomputer to centrally control each component. Dissolution is the rate and degree of dissolution of a drug under specified conditions. It is an important indicator for evaluating drug quality and is more commonly used in experimental analysis of drugs.

[0003] Prior art includes a utility model with a publication number of CN212722832U, which discloses a dissolution apparatus and a dissolution apparatus with automatic sampling and collection, and includes: a shell; a stirring mechanism, including a power source and a plurality of stirring rods, the stirring rods having a connecting end and a stirring end, the power source being mounted on the shell, and the connecting end being connected to the power source; a lifting column, the lifting column having a telescopic end and a fixed end, the telescopic end being connected to the shell and being located at the center of gravity of the two assemblies of the shell and the stirring mechanism; a base, the fixed end being connected to the base; a plurality of dissolution cups, the dissolution cups being mounted on the base and corresponding to the stirring rods; in a working state, the stirring end is in the dissolution cup, and the power source provides rotational power for the stirring end.

[0004] In the experimental analysis of drugs, it was found that during the operation of the dissolution apparatus, the stirring rod in the dissolution apparatus needs to be used to stir the test object in the dissolution cup during the dissolution experiment. After pouring the test object, the clamping plate needs to be screwed to fix the dissolution cup on the dissolution apparatus through the clamping plate. At this time, it will be inconvenient to extract the solution in the dissolution cup. Utility Model Content

[0005] The utility model aims to solve the problem in the prior art that, during the operation and use of the dissolution apparatus, a stirring rod in the dissolution apparatus needs to be used to stir the object to be tested in the dissolution cup during the dissolution experiment, and after the object to be tested is poured in, a clamping plate needs to be screwed to fix the dissolution cup on the dissolution apparatus through the clamping plate, which makes it inconvenient to extract the solution in the dissolution cup.

[0006] In order to solve the above technical problems, the utility model provides an automatic sampling dissolution instrument, comprising: a mounting frame, a plurality of dissolution cups are arranged inside the mounting frame, a controller is arranged on the upper surface of the mounting frame, stirring rods are arranged at positions corresponding to the dissolution cups on the surface of the controller, an adjustment device is arranged on the upper surface of the mounting frame, the adjustment device comprises a sliding frame, the sliding frame is fixedly connected to the surface of the mounting frame, the arc surface of the sliding frame is slidably connected to the sliding frame, the upper surface cross-section of the sliding frame is "U"-shaped, and the inner wall of the sliding frame is fixedly connected to the sliding frame. An elastic frame is provided, and a connecting tube is clamped on the inner wall of the elastic frame. One end of the connecting tube is plugged into the inner wall of the dissolution cup, and the end of the connecting tube away from the dissolution cup is fixedly connected to the sampling cup, and the arc surface of the connecting tube is fixedly connected to a one-way air bag valve for discharging the air inside the supporting plate, and the arc surface of one end of the connecting tube is fixedly connected to two limiting rings, and the arc surface of the connecting tube slides through a closing plate, and a closing hole is opened on the surface of the closing plate, and the closing hole includes an open end and a contracted end, and the closing plate is located on the side where the two limiting rings are close to each other.

[0007] The effect achieved by the above components is: in the process of operating the dissolution apparatus, in order to facilitate the removal of the sample solution in the dissolution cup of the dissolution apparatus, the connecting tube in the sampling cup is fixed with the help of the sliding rack on the surface of the mounting frame, and then one end of the connecting tube is inserted into the dissolution cup, and then the connecting tube is opened and closed by the closing plate, and then the one-way airbag valve on the surface of the connecting tube is used to extract and pressurize the air in the sampling cup, so that the sample solution in the dissolution cup can enter the sampling cup along the connecting tube conveniently.

[0008] Preferably, a connecting plate is fixedly connected to the surface of one side of the closing plate close to the necking end, a moving rod slides through the surface of the connecting plate, a spring is sleeved on the arc surface of the moving rod, and both ends of the spring are fixedly connected to the connecting plate and the moving rod respectively.

[0009] The effect achieved by the above components is: after the connecting pipe is moved to the constricted end of the closed hole, in order to avoid the position displacement of the connecting pipe, the moving rod is adjusted at this time to block and protect the position of the moving rod and the connecting pipe.

[0010] Preferably, a scale is provided on the arc surface of the carrying plate, and the cross-sectional dimension of the scale is matched with the cross-sectional dimension of the sampling cup.

[0011] The effect achieved by the above components is that the solution can be clearly and quantitatively sampled by utilizing the scale provided on the surface of the sampling cup.

[0012] Preferably, a screw rod is threadedly penetrated through the lower surface of the sliding frame, and one end of the screw rod abuts against the arc surface of the sliding frame.

[0013] The effect achieved by the above components is that when the position of the sliding frame is moved and adjusted, the screw rod on the bottom surface of the sliding frame can be used for extrusion and limiting.

[0014] Preferably, auxiliary devices are provided on the four corner surfaces of the installation frame, and the auxiliary devices include a connecting plate, one end of the connecting plate is fixedly connected to the surface of the installation frame, a driving rod is threaded through the surface of the connecting plate, the bottom end of the driving rod is rotatably connected to a fixing plate, the lower surfaces of both ends of the fixing plate are fixedly connected to fixing columns, and the bottom arc surfaces of the fixing columns are slidably connected to a support frame.

[0015] The effect achieved by the above components is: during the operation and use of the entire dissolution apparatus, since it is necessary to use several stirring rods to stir the dissolution cup, it is easy to cause the entire dissolution apparatus to shake. At this time, in order to better support and limit the dissolution apparatus, the connecting plate fixed on the surface of the installation frame is used to rotate the driving rod on the surface of the connecting plate, and the driving rod is used to drive the movement of the bottom fixed plate, so that the bottom end of the fixed plate can be rotated and limited with the help of the fixed column and the support frame, thereby facilitating better support and protection of the entire installation frame.

[0016] Preferably, a plurality of friction pads are fixedly connected to the bottom surface of the support frame, and the plurality of friction pads are all rubber pads.

[0017] The effect achieved by the above components is that when the support frame is supported and limited, a friction pad made of rubber material fixed on the bottom surface of the support frame can be used for auxiliary protection.

[0018] Preferably, a limiting rod is fixedly connected to one side of the fixing plate, and an upper end of the limiting rod slides through the surface of the connecting plate.

[0019] The effect achieved by the above components is: when the driving rod rotates to drive the support frame at the bottom end of the fixed plate to adjust the position, in order to prevent the position of the fixed plate from deflecting, the limiting rod on the surface of the fixed plate and the connecting plate are used for sliding limitation.

[0020] Compared with the related art, the automatic sampling dissolution instrument provided by the utility model has the following beneficial effects:

[0021] The utility model provides an automatic sampling dissolution instrument. During the operation and use of the dissolution instrument, the object to be tested is first placed in the dissolution cup in the installation frame, and then the control is started to drive the stirring rod to stir the object to be tested in the dissolution cup. In this process, in order to conveniently take out the sample solution in the dissolution cup in the dissolution instrument, the sliding frame on the surface of the installation frame is used to fix the connecting pipe in the sampling cup with the help of the sliding frame, and then one end of the connecting pipe is inserted into the dissolution cup, and then the connecting pipe is opened and closed by the closing plate, and then the one-way air bag valve on the surface of the connecting pipe is used to extract and press the air in the sampling cup, so that the sample solution in the dissolution cup can be conveniently allowed to enter the sampling cup along the connecting pipe. After the connecting pipe is moved to the constricted end of the closing hole, in order to avoid the displacement of the connecting pipe, the moving rod is adjusted at this time, so that the position of the moving rod and the connecting pipe is blocked and protected by operating the adjusting device, so that the solution in the dissolution cup can be conveniently sampled.

[0022] During the operation of the entire dissolution apparatus, since several stirring rods are needed to stir the dissolution cup, the entire dissolution apparatus may be easily caused to shake. At this time, in order to better support and limit the dissolution apparatus, the connecting plates fixed on the surfaces of the surroundings of the installation frame are used to rotate the driving rods on the surface of the connecting plates, and the driving rods are used to drive the movement of the bottom fixed plate, so that the bottom of the fixed plate can be rotated and limited with the help of the fixing columns and the support frame. By operating the auxiliary device, better support and protection of the entire installation frame is achieved to prevent the entire dissolution apparatus from shaking excessively during operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 A schematic diagram of the structure of an automatic sampling dissolution instrument provided by the utility model;

[0024] Figure 2 for Figure 1 The structural schematic diagram of the regulating device shown;

[0025] Figure 3 for Figure 1 A partial structural schematic diagram of the regulating device shown;

[0026] Figure 4 for Figure 3 A schematic diagram of the enlarged structure shown

[0027] Figure 5 for Figure 1 Schematic diagram of the structure of the auxiliary device shown.

[0028] Numbers in the figure: 1. Installation frame; 2. Controller; 3. Dissolution cup; 4. Adjustment device; 401. Sampling cup; 402. One-way airbag valve; 403. Connecting pipe; 404. Sliding frame; 405. Scale; 406. Sliding frame; 407. Elastic frame; 408. Limiting ring; 409. Closing plate; 410. Closing hole; 411. Moving rod; 412. Connecting plate; 413. Spring; 414. Screw; 5. Auxiliary device; 51. Connecting plate; 52. Driving rod; 53. Limiting rod; 54. Fixed plate; 55. Fixed column; 56. Support frame; 57. Friction pad; 6. Stirring rod. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0030] The specific implementation of the present utility model is described in detail below in conjunction with specific embodiments.

[0031] See also Figures 1 to 5 An automatic sampling dissolution instrument provided by an embodiment of the utility model includes: a mounting frame 1, a plurality of dissolution cups 3 are arranged inside the mounting frame 1, a controller 2 is arranged on the upper surface of the mounting frame 1, stirring rods 6 are arranged at positions on the surface of the controller 2 corresponding to the dissolution cups 3, an adjusting device 4 is arranged on the upper surface of the mounting frame 1, and auxiliary devices 5 are arranged on the four corner surfaces of the mounting frame 1.

[0032] In the embodiments of the present invention, please refer to Figure 2 , Figure 3 and Figure 4The adjusting device 4 includes a sliding frame 404, which is fixedly connected to the surface of the mounting frame 1. The sliding frame 406 is slidably connected to the circular arc surface of the sliding frame 404. The upper surface cross-section of the sliding frame 406 is "U"-shaped. The inner wall of the sliding frame 406 is fixedly connected to an elastic frame 407. The inner wall of the elastic frame 407 is clamped with a connecting pipe 403. One end of the connecting pipe 403 is plugged into the inner wall of the dissolution cup 3. The end of the connecting pipe 403 away from the dissolution cup 3 is fixedly connected to the sampling cup 401. The circular arc surface of the connecting pipe 403 is fixedly connected to a one-way airbag valve 402 for discharging the air inside the carrier plate. The circular arc surface of one end of the connecting pipe 403 is fixedly connected to two limit rings 408. The circular arc surface of the connecting pipe 403 slides through the closing plate 40 9. A closing hole 410 is provided on the surface of the closing plate 409. The closing hole 410 includes an open end and a constricted end. The closing plate 409 is located on the side where the two limiting rings 408 are close to each other. A connecting plate 412 is fixedly connected to the surface of the closing plate 409 close to the constricted end. A moving rod 411 is slidably penetrated on the surface of the connecting plate 412. A spring 413 is sleeved on the arc surface of the moving rod 411. Both ends of the spring 413 are respectively fixedly connected to the connecting plate 412 and the moving rod 411. A scale 405 is provided on the arc surface of the bearing plate. The cross-sectional size of the scale 405 is adapted to the cross-sectional size of the sampling cup 401. A screw 414 is threadedly penetrated on the lower surface of the sliding frame 406. One end of the screw 414 abuts against the arc surface of the sliding frame 404.

[0033] In the embodiments of the present invention, please refer to Figure 5 The auxiliary device 5 includes a connecting plate 51, one end of which is fixedly connected to the surface of the installation frame 1, a driving rod 52 is threadedly penetrated through the surface of the connecting plate 51, and a fixing plate 54 is rotatably connected to the bottom end of the driving rod 52, and a fixing column 55 is fixedly connected to the lower surface of both ends of the fixing plate 54, and a supporting frame 56 is slidably connected to the bottom arc surface of the fixing column 55, and a plurality of friction pads 57 are fixedly connected to the bottom surface of the supporting frame 56, and the plurality of friction pads 57 are all rubber pads, and a limiting rod 53 is fixedly connected to one side of the fixing plate 54, and the upper end of the limiting rod 53 slides through the surface of the connecting plate 51;

[0034] The working principle of the automatic sampling dissolution instrument provided by the utility model is as follows: in the process of operating the dissolution instrument, in order to conveniently take out the sample solution in the dissolution cup 3 in the dissolution instrument, at this time, the sliding frame 404 on the surface of the mounting frame 1 is used to fix the connecting tube 403 in the sampling cup 401 with the help of the sliding frame 404, the connecting tube 403 is placed in the sliding frame 406 on the surface of the sliding frame 404, and is clamped by the elastic frame 407, and then one end of the connecting tube 403 is inserted into the dissolution cup 3, and then the closing plate 409 is used to open and close the connecting tube 403, and the connecting tube 403 is moved along the closing hole 410. Slide until the connecting tube 403 and the closing plate 409 are closed at the joint, and then press the one-way airbag valve 402 on the surface of the connecting tube 403 to extract the air in the sampling cup 401, so that the sample solution in the dissolution cup 3 can easily enter the sampling cup 401 along the connecting tube 403. After the connecting tube 403 is moved to the constricted end of the closing hole 410, in order to prevent the connecting tube 403 from shifting in position, the moving rod 411 is adjusted at this time to block and protect the position of the moving rod 411 and the connecting tube 403, so that the solution in the dissolution cup 3 can be sampled conveniently.

[0035] During the operation of the entire dissolution apparatus, since it is necessary to use a plurality of stirring rods 6 to stir the dissolution cup 3, the entire dissolution apparatus is easily caused to shake. At this time, in order to better support and limit the dissolution apparatus, the connecting plate 51 fixed on the surface of the mounting frame 1 is used to rotate the driving rod 52 on the surface of the connecting plate 51, so that the driving rod 52 drives the movement of the position of the bottom fixed plate 54, so that the bottom end of the fixed plate 54 is rotated and limited with the help of the fixing column 55 and the support frame 56, and at the same time, the friction pad 57 made of rubber material on the lower surface of the support frame 56 is used to increase the bottom friction of the support frame 56, so as to facilitate better support and protection of the entire mounting frame 1 and avoid excessive shaking of the entire dissolution apparatus during operation.

[0036] The circuits and controls involved in the present invention are all prior art and will not be described in detail here.

[0037] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. An automatic sampling dissolution instrument, characterized in that: include: A mounting frame (1) is provided, wherein a plurality of dissolution cups (3) are arranged inside the mounting frame (1), a controller (2) is arranged on the upper surface of the mounting frame (1), and stirring rods (6) are arranged at positions on the surface of the controller (2) corresponding to the dissolution cups (3), and an adjustment device (4) is provided on the upper surface of the mounting frame (1), wherein the adjustment device (4) comprises a sliding frame (404), wherein the sliding frame (404) is fixedly connected to the surface of the mounting frame (1), wherein the arc surface of the sliding frame (404) is slidably connected to a sliding frame (406), wherein the upper surface cross-section of the sliding frame (406) is in a "U" shape, wherein the inner wall of the sliding frame (406) is fixedly connected to an elastic frame (407), and the inner wall of the elastic frame (407) is connected to a connecting member. The connecting tube (403) has one end connected to the inner wall of the dissolution cup (3), and the end of the connecting tube (403) away from the dissolution cup (3) is fixedly connected to the sampling cup (401). The arc surface of the connecting tube (403) is fixedly connected to a one-way air bag valve (402) for discharging the air inside the support plate. The arc surface of one end of the connecting tube (403) is fixedly connected to two limit rings (408). The arc surface of the connecting tube (403) is slidably penetrated by a closing plate (409). A closing hole (410) is opened on the surface of the closing plate (409). The closing hole (410) includes an open end and a narrowed end. The closing plate (409) is located on the side where the two limit rings (408) are close to each other.

2. An automatic sampling dissolution apparatus according to claim 1, characterized in that: A connecting plate (412) is fixedly connected to a surface of one side of the closing plate (409) close to the constricted end, a moving rod (411) slidably penetrates the surface of the connecting plate (412), a spring (413) is sleeved on the arc surface of the moving rod (411), and two ends of the spring (413) are fixedly connected to the connecting plate (412) and the moving rod (411), respectively.

3. An automatic sampling dissolution apparatus according to claim 1, characterized in that: A scale (405) is provided on the arc surface of the carrier plate, and the cross-sectional dimensions of the scale (405) are compatible with the cross-sectional dimensions of the sampling cup (401).

4. An automatic sampling dissolution apparatus according to claim 1, characterized in that: A screw rod (414) is threadedly passed through the lower surface of the sliding frame (406), and one end of the screw rod (414) is in contact with the arc surface of the sliding frame (404).

5. An automatic sampling dissolution apparatus according to claim 1, characterized in that: The surfaces of the four corners of the installation frame (1) are provided with auxiliary devices (5), the auxiliary devices (5) comprising a connecting plate (51), one end of the connecting plate (51) being fixedly connected to the surface of the installation frame (1), a driving rod (52) being threadedly penetrated through the surface of the connecting plate (51), the bottom end of the driving rod (52) being rotatably connected to a fixing plate (54), the lower surfaces of both ends of the fixing plate (54) being fixedly connected to fixing columns (55), and the bottom arc surfaces of the fixing columns (55) being slidably connected to a support frame (56).

6. An automatic sampling dissolution apparatus according to claim 5, characterized in that: A plurality of friction pads (57) are fixedly connected to the bottom surface of the support frame (56), and the plurality of friction pads (57) are all rubber pads.

7. An automatic sampling dissolution apparatus according to claim 5, characterized in that: One side of the fixed plate (54) is fixedly connected to a limiting rod (53), and the upper end of the limiting rod (53) slides through the surface of the connecting plate (51).

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