Internal pipeline of polypeptide synthesis device

Abstract

The utility model belongs to the technical field of polypeptide synthesis, and particularly relates to an internal pipeline of a polypeptide synthesis device, which comprises a pipeline body, and is characterized in that a shell is sleeved on the outer wall of the pipeline body, a heating mechanism is arranged in the shell, and the heating mechanism is used for uniformly heating raw materials conveyed by the pipeline body. And the clamping mechanisms are arranged at the upper end and the lower end of the shell and used for fixing the pipeline body, so that raw materials conveyed in the pipeline body are uniformly heated, the problem of non-uniform heating in the prior art is solved, and the final quality of products is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of polypeptide synthesis, and particularly relates to an internal pipeline of a polypeptide synthesis device. Background Art

[0002] Polypeptide synthesis is a solid-phase synthesis process that generally proceeds from the N-terminus to the C-terminus. In the past, polypeptide synthesis was carried out in solution, which is called the liquid-phase synthesis method. Since the successful development of the solid-phase polypeptide synthesis method, through continuous improvement and perfection, today the solid-phase method has become a commonly used technique in polypeptide and protein synthesis, showing advantages that the classical liquid-phase synthesis method cannot match, thus greatly reducing the difficulty of product purification in each step. Generally speaking, polypeptide synthesis is divided into two types: solid-phase synthesis and liquid-phase polypeptide synthesis. Existing polypeptide synthesis devices use internal pipelines inside.

[0003] Chinese Utility Model Patent CN210103797U discloses an internal pipeline of a polypeptide synthesis device, including: a pipeline body, a fixed shell is sleeved on the surface of the pipeline body, heating pipes are arranged on both sides of the inner cavity of the fixed shell, fixing plates are fixedly connected to both sides of the front and back of the fixed shell, and bolts are arranged on one side of the two fixing plates facing away from each other. By the combined use of the pipeline body, the fixed shell, the heating pipes, the fixing plates, the bolts, the clamping plates, the mounting plates, the mounting holes, the limiting shells, the inserting plates, the limiting plates, the threaded rods, the second bevel gears, the moving plates, the inserting rods, the handwheels, the rotating rods and the first bevel gears.

[0004] In the above technical solution, it is difficult to uniformly heat the raw materials conveyed inside the pipeline body by arranging the heating pipes in the fixed shell, thus affecting the quality of the final product. Summary of the Utility Model

[0005] The purpose of the utility model is to provide an internal pipeline of a polypeptide synthesis device for the above-mentioned existing technical problems, achieving uniform heating of the raw materials conveyed inside the pipeline body, thus solving the problem of uneven heating in the prior art and improving the final quality of the product.

[0006] In view of this, the utility model provides an internal pipeline of a polypeptide synthesis device, including: a pipeline body, characterized in that a shell is sleeved on the outer wall of the pipeline body, a heating mechanism is arranged inside the shell, the heating mechanism is used for uniformly heating the raw materials conveyed by the pipeline body, and clamping mechanisms are arranged at the upper and lower ends of the shell, and the clamping mechanisms are used for fixing the pipeline body.

[0007] In the above technical solution, further, the heating mechanism includes:

[0008] A heating pipe, the heating pipe is spirally wound around the outer wall of the pipe body, one end of the heating pipe is connected with a heat medium inlet pipe, and the other end of the heating pipe is connected with a heat medium outlet;

[0009] A flow guide plate, the flow guide plate is installed in the pipe body and is located between the heating pipes.

[0010] In the above technical solution, further, a plurality of the flow guide plates are longitudinally provided, and a number of flow guide openings are provided on the flow guide plates.

[0011] In this technical solution, before the raw material enters the pipe body, the heat medium is introduced into the heating pipe through the heat medium inlet pipe. The heat medium circulates in the heating pipe, and the heat is transferred to the inside of the pipe through the spirally wound heating pipe on the outer wall of the pipe body, which can heat the raw material in the pipe more evenly, avoid local overheating or insufficiency, and thus ensure the product quality. After the raw material enters the pipe body, under the action of a plurality of flow guide plates, the fluidity of the raw material in the pipe body is improved, thereby assisting the heating pipe to evenly distribute the heat and ensuring that the raw material in the pipe body is evenly heated.

[0012] In the above technical solution, further, the clamping mechanism includes: two fixing plates, the two fixing plates are arranged on both sides of one end surface of the housing, threaded rods are provided on the two fixing plates, one end of the threaded rod penetrates through the fixing plate and is connected with a first clamping plate, and a handle is provided at the end of the threaded rod away from the first clamping plate. Among them, the threaded rod is threadedly connected with the fixing plate.

[0013] In this technical solution, the housing is sleeved on the outer wall of the pipe body, and then the handle is rotated, so that the threaded rod rotates to drive the first clamping plate to gradually approach the outer wall of the pipe body.

[0014] In the above technical solution, further, a chute is provided at one end of the first clamping plate close to the pipe body, springs are fixedly connected to the two end walls of the chute, sliders are connected to the ends of the two springs away from the end walls, and a connecting plate is hinged to one side of the two sliders close to the pipe body, and a second clamping plate is connected to the end of the connecting plate away from the slider.

[0015] In this technical solution, after the first clamping plate gradually approaches the outer wall of the pipe body, the second clamping plate on the first clamping plate is closely attached to the outer wall of the pipe body. When the pipe body conveys the raw material, the raw material falls onto the flow guide plate, so that the pipe body is subjected to an impact force, the pipe body presses against the second clamping plate, and the clamping plate transmits the impact force to the slider, so that the slider moves along the chute for buffering. At the same time, with the cooperation of the spring, part of the impact force of the slider is borne, thereby improving the protection of the pipe body.

[0016] In the above technical solution, further, a rubber pad is fixedly connected to one end of the second clamping plate close to the pipe body.

[0017] In this technical solution, under the action of the rubber pad, the friction force of the second clamping plate on the pipe body is increased, and the shaking of the pipe body is avoided.

[0018] In the above technical solution, further, an installation plate is provided on one side of the housing, a limiting mechanism is installed on the side of the installation plate close to the housing, and the side of the limiting mechanism away from the installation plate is connected to the housing.

[0019] The beneficial effects of the present utility model are as follows:

[0020] 1. Before the raw materials enter the pipe body, the heat medium is introduced into the heating pipe through the heat medium intervention pipe. The heat medium circulates in the heating pipe, and the heat is transferred to the inside of the pipe through the spiral-wound heating pipe on the outer wall of the pipe body, so as to heat the raw materials in the pipe more evenly, avoid local overheating or insufficiency, and thus ensure the product quality. After the raw materials enter the pipe body, under the action of a plurality of flow guiding plates, the fluidity of the raw materials in the pipe body is improved, so as to assist the heating pipe to distribute heat evenly and ensure that the raw materials in the pipe body are heated evenly.

[0021] 2. After the first clamping plate gradually approaches the outer wall of the pipe body, the second clamping plate located on the first clamping plate is closely attached to the outer wall of the pipe body. When the pipe body conveys raw materials, the raw materials fall onto the flow guiding plate, so that the pipe body is subjected to an impact force. The pipe body presses against the second clamping plate, and the clamping plate transmits the impact force to the slider, so that the slider moves along the chute for buffering. At the same time, under the cooperation of the spring, a part of the impact force of the slider is borne, thereby improving the protection of the pipe body. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a schematic structural diagram of the internal pipeline of a polypeptide synthesis device of the present utility model;

[0023] Figure 2 is a schematic diagram of the internal structure of the internal pipeline housing of a polypeptide synthesis device of the present utility model;

[0024] Figure 3 is a cross-sectional view of the internal pipeline of a polypeptide synthesis device of the present utility model;

[0025] Figure 4 is the internal pipeline of a polypeptide synthesis device of the present utility model Figure 1 of the enlarged view at A;

[0026] The reference signs in the figure are shown as:

[0027] 1. Pipe body; 2. Housing; 3. Clamping mechanism; 3.1 Fixed plate; 3.2 Threaded rod; 3.3 Handle; 3.4 First clamping plate; 3.5 Chute; 3.6 Spring; 3.7 Slide block; 3.8 Connecting plate; 3.9 Second clamping plate; 3.10 Rubber pad; 4. Heating mechanism; 4.1 Heating pipe; 4.2 Heat medium inlet; 4.3 Heat medium outlet; 4.4 Deflector; 4.5 Deflection opening; 5. Mounting plate; 6. Limiting mechanism. Detailed implementation manners

[0028] The technical solutions in the embodiments of the present application will be clearly described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art belong to the scope of protection of the present application.

[0029] In the description of the present application, it should be noted that the terms used herein are only for describing specific implementation manners and are not intended to limit the exemplary embodiments according to the present application. For the convenience of description, the dimensions of the various parts shown in the drawings are not drawn in actual proportional relationship. Technologies, methods, and devices known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the technologies, methods, and devices should be regarded as part of the authorization specification. In all the examples shown and discussed here, any specific value should be interpreted as merely exemplary and not as a limitation. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that like reference numerals and letters denote like items in the following drawings, and thus, once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0030] It should be noted that the terms "first", "second", etc. in the description and claims of the present application are used to distinguish similar objects and are not used to describe a specific order or sequence. It should be understood that such data can be interchanged under appropriate circumstances so that the embodiments of the present application can be implemented in an order other than those illustrated or described herein, and the objects distinguished by "first", "second", etc. are generally of the same type and do not limit the number of objects. For example, the first object can be one or more. In addition, "and / or" in the description and claims means at least one of the connected objects, and the character " / " generally means an "or" relationship between the associated objects before and after.

[0031] It should be noted that in the description of the present application, the orientation or positional relationships indicated by the directional terms such as "front, back, top, bottom, left, right", "horizontal, vertical, perpendicular, horizontal" and "top, bottom", etc. are usually based on the orientation or positional relationships shown in the drawings. It is only for the convenience of describing the present application and simplifying the description. Without contrary explanations, these directional terms do not indicate and imply that the devices or components referred to must have a specific orientation or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation on the protection scope of the present application; the directional terms "inside, outside" refer to the inside and outside relative to the contour of each component itself.

[0032] It should be noted that in the present application, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, the element defined by the statement "including one..." does not exclude the existence of additional identical elements in the process, method, article or device including the element. In addition, it should be pointed out that the scope of the methods and devices in the embodiments of the present application is not limited to performing functions in the order shown or discussed, and may also include performing functions in a substantially simultaneous manner or in the reverse order according to the functions involved. For example, the described methods may be performed in a different order than described, and various steps may also be added, omitted, or combined. Additionally, the features described with reference to certain examples may be combined in other examples.

[0033] Example 1:

[0034] As Figures 1-4 shown, the internal pipeline of a polypeptide synthesis device provided in this embodiment includes: a pipeline body 1, a housing 2 is sleeved on the outer wall of the pipeline body 1, a heating mechanism 4 is arranged inside the housing 2, the heating mechanism 4 is used for uniformly heating the raw materials conveyed by the pipeline body 1, clamping mechanisms 3 are arranged at the upper and lower ends of the housing 2, and the clamping mechanisms 3 are used for fixing the pipeline body 1.

[0035] Specifically, the heating mechanism 4 includes: a heating pipeline 4.1, the heating pipeline 4.1 is spirally wound around the outer wall of the pipeline body 1, one end of the heating pipeline 4.1 is connected with a heat medium inlet pipe, and the other end of the heating pipeline 4.1 is connected with a heat medium outlet 4.3; a flow guide plate 4.4, the flow guide plate 4.4 is installed inside the pipeline body 1 and is located between the heating pipelines 4.1.

[0036] Specifically, a plurality of the flow guide plates 4.4 are arranged longitudinally, and a number of flow guide openings 4.5 are arranged on the flow guide plates 4.4.

[0037] Before the raw materials enter the pipe body 1, the heat medium is introduced into the heating pipe 4.1 through the heat medium intervention pipe. The heat medium circulates in the heating pipe 4.1, and the heat is transferred to the inside of the pipe through the helically wound heating pipe 4.1 on the outer wall of the pipe body 1, which can heat the raw materials in the heating pipe 4.1 more evenly, avoid local overheating or insufficiency, and thus ensure the product quality. After the raw materials enter the pipe body 1, under the action of multiple flow guiding plates 4.4, the fluidity of the raw materials in the pipe body 1 is improved, which helps the heating pipe 4.1 to distribute heat evenly and ensures that the raw materials are evenly heated in the pipe body 1.

[0038] Heat medium: A heat medium refers to a medium substance that transfers heat. Such as hot water, steam, and air commonly used now. Thus, it can be divided into a hot water heating system, a steam heating system, and a warm air heating system.

[0039] Embodiment 2:

[0040] As Figures 1-4 shown, this embodiment provides an internal pipe of a polypeptide synthesis device. In addition to including the technical solutions of the above embodiment, it also has the following technical features: The clamping mechanism 3 includes: two fixing plates 3.1, and the two fixing plates 3.1 are arranged on both sides of one end surface of the housing 2. A threaded rod 3.2 is provided on the two fixing plates 3.1. One end of the threaded rod 3.2 passes through the fixing plate 3.1 and is connected to a first clamping plate 3.4. A handle 3.3 is provided at one end of the threaded rod 3.2 away from the first clamping plate 3.4. Among them, the threaded rod 3.2 is threadedly connected to the fixing plate 3.1. The housing 2 is sleeved on the outer wall of the pipe body 1, and then the handle 3.3 is rotated, so that the rotation of the threaded rod 3.2 drives the first clamping plate 3.4 to gradually approach the outer wall of the pipe body 1.

[0041] Specifically, a chute 3.5 is provided at one end of the first clamping plate 3.4 close to the pipe body 1. Springs 3.6 are fixedly connected to the two end walls of the chute 3.5. One end of the two springs 3.6 away from the end wall is connected to a slider 3.7. A connecting plate 3.8 is hinge-connected to one side of the two sliders 3.7 close to the pipe body 1. A second clamping plate 3.9 is connected to one end of the connecting plate 3.8 away from the slider 3.7. After the first clamping plate 3.4 gradually approaches the outer wall of the pipe body 1, the second clamping plate 3.9 on the first clamping plate 3.4 is closely attached to the outer wall of the pipe body 1. When the pipe body 1 conveys raw materials, the raw materials fall onto the flow guiding plate 4.4, causing the pipe body 1 to receive an impact force. The pipe body 1 presses against the second clamping plate 3.9, and the clamping plate transfers the impact force to the slider 3.7, causing the slider 3.7 to move along the chute 3.5 for buffering. At the same time, with the cooperation of the spring 3.6, a part of the impact force of the slider 3.7 is borne, thereby improving the protection of the pipe body 1.

[0042] One end of the second clamping plate 3.9 close to the pipe body 1 is fixedly connected with a rubber pad 3.10. Under the action of the rubber pad 3.10, the friction force of the second clamping plate 3.9 on the pipe body 1 is increased, and the pipe body 1 is prevented from shaking.

[0043] One side of the housing 2 is provided with a mounting plate 5. A limiting mechanism 6 is mounted on the side of the mounting plate 5 close to the housing 2 (the structure and principle of the limiting mechanism 6 have been disclosed in the internal pipeline of a polypeptide synthesis device disclosed in Chinese Patent Publication No. CN210103797U, and will not be described in detail in this technical solution). The side of the limiting mechanism 6 away from the mounting plate 5 is connected to the housing 2.

[0044] The embodiments of the present application have been described above in conjunction with the accompanying drawings. Without conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application is not limited to the above specific embodiments. The above specific embodiments are merely illustrative and not restrictive. Under the inspiration of the present application, those of ordinary skill in the art can also make many forms without departing from the purpose of the present application and the scope protected by the claims, and all of them belong to the protection scope of the present application.

Claims

1. An internal pipeline of a polypeptide synthesis device, comprising: A pipeline body (1), characterized in that a shell (2) is provided on the outer wall of the pipeline body (1), a heating mechanism (4) is provided inside the shell (2), the heating mechanism (4) is used to uniformly heat the raw materials transported by the pipeline body (1), and clamping mechanisms (3) are provided at the upper and lower ends of the shell (2), the clamping mechanisms (3) are used to fix the pipeline body (1); The heating mechanism (4) comprises: A heating pipe (4.1), wherein the heating pipe (4.1) is spirally wound around the outer wall of the pipe body (1), one end of the heating pipe (4.1) is connected to a heat medium inlet pipe, and the other end of the heating pipe (4.1) is connected to a heat medium outlet (4.2); A guide plate (4.4), wherein the guide plate (4.4) is installed in the pipeline body (1) and is located between the heating pipelines (4.1).

2. The internal pipeline of a peptide synthesis device according to claim 1, characterized in that: A plurality of guide plates (4.4) are provided longitudinally, and a plurality of guide ports (4.5) are provided on the guide plates (4.4).

3. The internal pipeline of a peptide synthesis device according to claim 1, characterized in that: The clamping mechanism (3) comprises: two fixing plates (3.1), the two fixing plates (3.1) are arranged on both sides of one end surface of the shell (2), the two fixing plates (3.1) are provided with threaded rods (3.2), one end of the threaded rod (3.2) passes through the fixing plates (3.1) and is connected to a first clamping plate (3.4), and the end of the threaded rod (3.2) away from the first clamping plate (3.4) is provided with a handle (3.3), wherein the threaded rod (3.2) is threadedly connected to the fixing plate (3.1).

4. The internal pipeline of a peptide synthesis device according to claim 3, characterized in that: The first clamping plate (3.4) is provided with a sliding groove (3.5) at one end close to the pipe body (1), and the groove walls at both ends of the sliding groove (3.5) are fixedly connected with springs (3.6), and the ends of the two springs (3.6) away from the groove walls are connected with sliders (3.7), and the two sliders (3.7) are hingedly connected with a connecting plate (3.8) close to one side of the pipe body (1), and the connecting plate (3.8) is connected with a second clamping plate (3.9) at a section away from the sliders (3.7).

5. The internal pipeline of a peptide synthesis device according to claim 4, characterized in that: The second clamping plate (3.9) is fixedly connected to one end close to the pipe body (1) with a rubber pad (3.10).

6. The internal pipeline of a peptide synthesis device according to claim 1, characterized in that: A mounting plate (5) is provided on one side of the housing (2); a limiting mechanism (6) is installed on the side of the mounting plate (5) close to the housing (2); and the limiting mechanism (6) is connected to the housing (2) on the side away from the mounting plate (5).

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