Reaction tank of iodine-125 sealed seed source core and preparation device of iodine-125 sealed seed source core

Abstract

The utility model relates to the technical field of medical preparations, and provides a reaction tank of an iodine-125 sealed seed source core and a preparation device of the iodine-125 sealed seed source core, the reaction tank comprises a tank body and a reaction container, a sealing cover is arranged at a tank opening of the tank body, and a pipeline feeding hole is formed in the sealing cover; a discharge port is formed in the bottom of the tank body, and a sealing structure is arranged in the discharge port; the reaction container is arranged in the tank body, and a plurality of leaking holes are formed in the bottom of the reaction container; the pipeline feed port is communicated with the reaction container, the leak hole is located in the discharge port, and the discharge port is selectively communicated with the reaction container through a sealing structure. The clamping groove is formed in the tank body, so that the clamping groove can provide a clamping position for an external transfer mechanism, clamping of the reaction tank is achieved, the discharging opening can be selectively opened through the arrangement of the sealing structure, waste liquid in the reaction tank can be conveniently discharged in the automatic preparation process, full-automatic operation is achieved, and the production efficiency is improved. And a reliable scheme is provided for automatic operation.

Description

Technical Field

[0001] The utility model relates to the technical field of medical preparations containing radioactive substances, in particular to a reaction tank for an iodine-125 sealed seed source core and a preparation device thereof. Background Technique

[0002] As a radioactive medical product, the iodine-125 sealed seed source has achieved remarkable results in the treatment of malignant tumors by brachytherapy in recent years. Briefly, the iodine [125I] sealed seed source is a product formed by placing a silver wire (source core) adsorbed with 125I isotope ions in a hollow titanium tube and sealing both ends of the titanium tube by welding.

[0003] Among them, the preparation of the source core is the first process in the production of the seed source. The preparation of the source core is to mix silver wire with three reagents for reaction. After the reaction is completed, the silver wire (source core) adsorbed with iodine-125 isotope ions is washed, dried, collected and bottled. In the related technology, the reaction tank usually realizes the transfer and subsequent processing manually or semi-automatically, and it is difficult to realize the automated and batch preparation operations. Summary of the Utility Model

[0004] The utility model provides a reaction tank for an iodine-125 sealed seed source core and a preparation device thereof, so as to solve the defect that it is difficult to realize automated and batch operations in the prior art.

[0005] In the first aspect of the utility model, a reaction tank for an iodine-125 sealed seed source core is provided, including: a tank body and a reaction container. A sealing cover is detachably arranged at the tank mouth of the tank body, and a pipeline feed port is arranged on the sealing cover; a discharge port is arranged at the bottom of the tank body, and a sealing structure is arranged in the discharge port; the reaction container is arranged in the tank body, and a plurality of leakage holes are arranged at the bottom of the reaction container; wherein, a clamping groove is formed in a circle on the outer wall of the tank body near the tank mouth, the pipeline feed port is communicated with the reaction container, the leakage holes are located in the discharge port, and the discharge port can be selectively communicated with the reaction container through the sealing structure.

[0006] According to the reaction tank for an iodine-125 sealed seed source core provided by the utility model, a limiting step is arranged in the discharge port, the sealing structure is arranged in the discharge port, and the sealing structure includes: a main body column, one end of the main body column has a sealing plug and is located above the limiting step, the other end of the main body column is provided with a spring fixing plate and is located below the limiting step, and a spring is sleeved between the spring fixing plate and the limiting step; a sealing ring is arranged on the limiting step so that when the discharge port is closed, the sealing plug is in butt joint with the sealing ring for sealing, and when the discharge port is opened, the sealing plug is separated from the sealing ring.

[0007] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, a mating hole is provided on the main body column at one end of the spring fixing plate, and the mating hole is arranged along the axial direction of the main body column.

[0008] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, a buffer layer is provided between the tank body and the reaction container.

[0009] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, the buffer layer is filled with a flexible buffer material.

[0010] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, the tank body includes a base, a tank body and a tank mouth part, the tank body is connected to the base, and the tank mouth part is connected to the tank body.

[0011] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, a clamping groove is provided on the outer wall of one end where the tank mouth part is connected to the tank body in a circumferential manner.

[0012] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, the tank mouth part is provided with a first magnetic attraction part, and a second magnetic attraction part is correspondingly provided on the sealing cover.

[0013] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, the reaction container is of a rectangular barrel-shaped structure, a limiting groove is provided on the base, and the reaction container is installed in the limiting groove.

[0014] According to the reaction tank of the iodine-125 sealed seed source core provided by the present utility model, the pipeline feed port is located in the middle of the sealing cover, and the caliber of the pipeline feed port gradually decreases from top to bottom to form a funnel-shaped reduced opening structure.

[0015] The second aspect of the present utility model provides an iodine-125 sealed seed source core preparation device, including: a device main body having a plurality of stations and the reaction tank of the iodine-125 sealed seed source core according to any one of the above; the device main body includes: a transfer mechanism, and the transfer mechanism is used to grab the reaction tank to move between different stations in the device main body.

[0016] A reaction tank for an iodine-125 sealed seed source core provided by the utility model realizes the clamping of the reaction tank by arranging a reaction container inside the tank body and providing a clamping groove on the tank body, so that the clamping groove can provide a clamping position for an external transfer mechanism, providing a reliable and effective solution for automated preparation. Through the setting of the sealing structure, the discharge port can be selectively opened, which facilitates the discharge of the waste liquid in the reaction tank during the automated preparation process and realizes fully automated operation, providing a reliable solution for fully automated operation.

[0017] Additional aspects and advantages of the utility model will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the utility model. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0019] Figure 1 is a schematic three-dimensional structure diagram of the reaction tank provided by the present utility model.

[0020] Figure 2 is a schematic cross-sectional structure diagram of the reaction tank provided by the present utility model.

[0021] Figure 3 is provided by the present utility model Figure 2 is an enlarged structure diagram at A.

[0022] Reference numerals:

[0023] 10, tank body; 11, base; 111, discharge port; 112, sealing ring; 113, limiting step; 12, tank body; 13, tank opening part; 131, clamping groove; 132, first magnetic attraction part; 20, reaction container; 21, leakage hole; 30, sealing cover; 31, pipeline feed port; 32, second magnetic attraction part; 40, sealing structure; 41, main body column; 411, mating hole; 412, spring fixing plate; 413, sealing plug; 42, spring; 50, buffer layer. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] To make the objectives, technical solutions and advantages of the present utility model clearer, the technical solutions in the present utility model will be clearly and completely described below with reference to the accompanying drawings in the present utility model. Obviously, the described embodiments are some, but not all, of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present utility model without making creative efforts shall fall within the protection scope of the present utility model.

[0025] In the description of the embodiments of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the embodiments of the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the embodiments of the present utility model. In addition, the terms "first", "second", and "third" are only used for descriptive purposes and should not be construed as indicating or implying relative importance.

[0026] In the description of the embodiments of the present utility model, it should be noted that unless otherwise clearly specified and defined, the terms "connected" and "coupled" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present utility model can be understood according to specific circumstances.

[0027] In the embodiments of the present utility model, unless otherwise clearly specified and defined, the first feature being "on" or "under" the second feature may be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature may be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" and "underneath" the second feature may be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0028] In the description of this specification, the descriptions referring to terms such as "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc., mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the embodiments of the present utility model. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0029] The following will describe in conjunction with Figure 1 , Figure 2 A reaction tank for an iodine-125 sealed seed source core provided by the present utility model is described. It includes a tank body 10 and a reaction vessel 20. A sealing cover 30 is detachably provided at the tank opening of the tank body 10, and a pipeline feed port 31 is provided on the sealing cover 30. A discharge port 111 is provided at the bottom of the tank body 10, and a sealing structure 40 is provided in the discharge port 111. The reaction vessel 20 is arranged in the tank body 10, and a plurality of leakage holes 21 are provided at the bottom of the reaction vessel 20. Among them, a clamping groove 131 is formed in a circle on the outer wall of the tank body 10 near the tank opening. The pipeline feed port 31 is communicated with the reaction vessel 20. The leakage holes 21 are located in the discharge port 111, and the discharge port 111 is selectively communicated with the reaction vessel 20 through the sealing structure 40. The reaction vessel 20 is used to load reaction materials (silver wires and three reaction reagents). In this embodiment, when loading the silver wires, it is realized by opening the sealing cover 30. The detachable connection method is convenient for opening and closing. The reagent can be input into the reaction vessel 20 through the pipeline feed port 31. During the reaction process, it is necessary to keep the reaction reagent at the bottom of the reaction vessel 20 from flowing out. This is realized by the sealing structure 40 for the reagent at the bottom of the reaction vessel 20. After the reaction is completed, it is necessary to discharge the waste liquid. In this embodiment, the communication between the discharge port 111 and the reaction vessel 20 is realized by opening the sealing structure 40, so as to enable the discharge of the waste liquid. Overall, it is beneficial for the automatic addition of materials and the automatic discharge of waste liquid.

[0030] It can be understood that the detachable connection of the sealing cover 30 is beneficial for placing the silver wires. Subsequently, when adding the reaction reagent, the pipeline can be inserted into the pipeline feed port 31 to realize the automatic addition of the reagent. The upper part of the tank body 10 is provided with a clamping groove 131, which can cooperate with an automated transfer mechanism to realize the transfer of the tank body 10. For the waste liquid in the tank body 10 after the reaction is completed, it is discharged through the sealing structure 40, so as to realize the full-automatic operation of feeding, reacting, and discharging.

[0031] For example, a liquid adding station can be provided, and a liquid adding pipeline can be arranged above the liquid adding station. A perfusion head is provided at the output port of the liquid adding pipeline. The perfusion head extends into the reaction reagent through the pipeline feed port 31 to input the reaction reagent into the reaction vessel 20, realizing automatic liquid addition. After the liquid addition is completed, the claw clamp on the displacement mechanism cooperates with the clamping groove 131, and the displacement mechanism moves it to the reaction station to realize the reaction. After the reaction is completed, the waste liquid in the reaction tank needs to be discharged, and then it is transferred to the suction filtration station through the transfer mechanism. A convex part matching with the sealing structure 40 is provided on the suction filtration station, so that the convex part cooperates with the sealing structure 40 to connect the discharge port 111 with the reaction vessel 20, thereby realizing the discharge of the waste liquid in the reaction tank. It can be understood that the transfer mechanism can realize the transfer and switching of different stations, and the sealing structure 40 can realize the automatic discharge of the waste liquid in the reaction tank, thus realizing the automatic operation of the whole preparation process, which is beneficial to batch preparation and automatic operation.

[0032] Among them, in the above embodiment, the sealing structure 40 can be a valve core structure or other elastic sealing structures, which can realize sealing through this structure and can be quickly opened when needed.

[0033] According to an embodiment provided by the present invention, as Figure 2 , Figure 3 shown, a limiting step 113 is arranged in the discharge port 111, the sealing structure 40 is arranged in the discharge port 111, the sealing structure 40 includes a main body column 41, one end of the main body column 41 has a sealing plug 413 and is located above the limiting step 113, the other end of the main body column 41 is provided with a spring 42 fixing plate 412 and is located below the limiting step 113, and a spring 42 is sleeved between the spring 42 fixing plate 412 and the limiting step 113; a sealing ring 112 is arranged on the limiting step 113, so that when the discharge port 111 is closed, the sealing plug 413 abuts and cooperates with the sealing ring 112 for sealing, and when the discharge port 111 is opened, the sealing plug 413 is separated from the sealing ring 112. One end of the spring 42 abuts against the limiting step 113, and the other end of the spring 42 abuts against the spring 42 fixing plate 412, so that in the normal state, the sealing plug 413 cooperates with the sealing ring 112 under the action of the spring 42 to realize sealing, so that the waste liquid will not be discharged from the discharge port 111. When the discharge port 111 needs to be opened, by driving the main body column 41 to move upward, the sealing plug 413 is separated from the sealing ring 112, so that the discharge port 111 can be opened.

[0034] During specific setting, a mating hole 411 is formed in the main body column 41 at one end of the spring 42 fixing plate 412, and the mating hole 411 is arranged along the axial direction of the main body column 41. By mating the mating hole 411 with the protruding portion in the middle of the liquid extraction station, the main body column 41 moves upward, so that the sealing plug 413 disengages from the sealing ring 112 to form a communication gap, and the discharge port 111 is opened.

[0035] It can be understood that the sealing structure 40 is simple and effective as a whole, capable of sealing the reaction vessel 20 in the required sealed state, and realizing the communication between the discharge port 111 and the reaction vessel 20 when the waste liquid needs to be discharged, which is convenient for automated operation.

[0036] According to an embodiment provided by the present utility model, a buffer layer 50 is provided between the tank body 10 and the reaction vessel 20. Through the setting of the buffer layer 50, the stability of the reaction vessel 20 can be further realized, so that the reaction vessel 20 has a stable position state during the transfer process, and the overall stability is improved.

[0037] During specific setting, the buffer layer 50 is filled with a flexible buffer material. The filled flexible buffer material can keep the reaction vessel 20 relatively stable during the movement of the transfer mechanism, ensuring the stability during the automation process.

[0038] During specific application, the flexible buffer material can be selected from silica gel, polyurethane foam, etc. Filling the flexible buffer material can also have a certain protective effect on the reaction vessel 20.

[0039] According to an embodiment provided by the present utility model, the tank body 10 includes a base 11, a tank body 12 and a tank mouth part 13. The tank body 12 is connected to the base 11, and the tank mouth part 13 is connected to the tank body 12. The whole adopts a split connection method, which is convenient for the preparation of the tank body 10 and reduces the preparation difficulty.

[0040] It can be understood that the base 11, as the bottom of the tank body 10, forms the main structure when connected to the tank body 12. The setting of the tank mouth part 13 can facilitate the installation of the sealing cover 30 and the opening of the clamping groove 131.

[0041] During specific setting, a clamping groove 131 is formed in a circle on the outer wall of one end of the tank mouth part 13 connected to the tank body 12. By adopting a split connection and assembly method for the tank mouth part 13, it is convenient for the processing and forming of the clamping groove 131 and reduces the overall preparation difficulty.

[0042] In some embodiments, the tank mouth part 13 is provided with a first magnetic attraction part 132, and a second magnetic attraction part 32 is provided corresponding to the sealing cover 30. Both the first magnetic attraction part 132 and the second magnetic attraction part 32 are magnets, and the detachable connection of the sealing cover 30 is realized through the setting of the magnets.

[0043] It is understandable that the magnetic attraction part facilitates installation and disassembly, reducing the difficulty of assembly and disassembly.

[0044] In a specific example, the pipeline feed inlet 31 is located in the middle of the sealing cover 30, and the diameter of the pipeline feed inlet 31 gradually decreases from top to bottom to form a funnel-shaped reduced opening structure. This method facilitates the connection of the pipeline. That is, when the pipeline extends into the interior of the reaction vessel 20, the guiding effect can be achieved through the pipeline feed inlet 31, facilitating the extension of the material pipeline.

[0045] According to an embodiment provided by the present utility model, the reaction vessel 20 is of a rectangular barrel-shaped structure, and a limiting groove is provided on the base 11. The reaction vessel 20 is installed in the limiting groove. The limiting groove is of a rectangular structure and cooperates with the bottom of the reaction vessel 20. The cooperation between the reaction vessel 20 and the limiting groove enables the leakage holes 21 at the bottom of the reaction vessel 20 to be only connected to the discharge port 111, and will not penetrate into the tank body 10 through the leakage holes 21.

[0046] The present utility model also provides an iodine-125 sealed seed source core preparation device, including: a device main body with multiple stations and a reaction tank for the iodine-125 sealed seed source core as provided in any of the above embodiments; the device main body includes: a transfer mechanism, and the transfer mechanism is used to grab the reaction tank to move between different stations in the device main body.

[0047] Specifically, the transfer mechanism is provided with a claw clip, and the claw clip cooperates with the clamping groove 131 to realize the clamping of the reaction tank. The multiple stations on the device main body (not shown) at least include a liquid addition station, a reaction station, a suction filtration station, and a drying station. Among them, the liquid addition station is used to add reaction reagents, the reaction station is used to realize the reaction between the reagents and the silver wire, the suction filtration station is used to discharge the waste liquid in the reaction tank, and the drying station is used to dry the silver wire in the reaction tank.

[0048] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present utility model, rather than to limit it; although the present utility model has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present utility model.

Claims

1. A reaction tank for sealing iodine-125 seed source core, characterized in that: include: A tank body, wherein a sealing cover is detachably provided at the tank opening of the tank body, and a pipeline feed port is provided on the sealing cover; a discharge port is provided at the bottom of the tank body, and a sealing structure is provided in the discharge port; A reaction container, the reaction container is arranged in the tank body, and a plurality of leakage holes are arranged at the bottom of the reaction container; Among them, a clamping groove is opened around the outer wall of the tank body near the tank mouth, the pipeline feed port is connected with the reaction container, the leakage hole is located in the discharge port, and the discharge port can be selectively connected with the reaction container through the sealing structure.

2. The reaction tank of the iodine-125 sealed seed source core according to claim 1, characterized in that: A limiting step is provided in the discharge port, and the sealing structure is provided in the discharge port. The sealing structure comprises: A main column, one end of which has a sealing plug and is located above the limiting step, the other end of which is provided with a spring fixing plate and is located below the limiting step, and a spring is sleeved between the spring fixing plate and the limiting step; The sealing ring is arranged on the limiting step so that the sealing plug and the sealing ring abut and cooperate to seal when the discharge port is closed, and the sealing plug and the sealing ring are separated when the discharge port is opened.

3. The reaction tank of the iodine-125 sealed seed source core according to claim 2, characterized in that: A matching hole is provided on the main body column at one end of the spring fixing plate, and the matching hole is arranged along the axial direction of the main body column.

4. The reaction tank of the iodine-125 sealed seed source core according to claim 1, characterized in that: A buffer layer is provided between the tank body and the reaction container.

5. The reaction tank of the iodine-125 sealed seed source core according to claim 4, characterized in that: The buffer layer is filled with flexible buffer material.

6. The reaction tank of the iodine-125 sealed seed source core according to claim 1, characterized in that: The tank body comprises a base, a tank body and a tank mouth, wherein the tank body is connected to the base, and the tank mouth is connected to the tank body.

7. The reaction tank of the iodine-125 sealed seed source core according to claim 6, characterized in that: The clamping groove is arranged on a circle of the outer wall of one end of the can mouth portion connected with the can body.

8. The reaction tank of the iodine-125 sealed seed source core according to claim 6, characterized in that: The tank mouth is provided with a first magnetic attraction portion, and the corresponding sealing cover is provided with a second magnetic attraction portion.

9. The reaction tank of the iodine-125 sealed seed source core according to claim 6, characterized in that: The reaction container is a rectangular barrel structure, the base is provided with a limiting groove, and the reaction container is installed in the limiting groove.

10. An iodine-125 sealed seed source core preparation device, characterized in that: include: A device body having multiple workstations and a reaction tank having an iodine-125 sealed seed source core as described in any one of claims 1 to 9; The device body comprises: A transfer mechanism is used to grab the reaction tank to move between different stations in the device body.

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