Bile acid crystallization and separation integrated device

Abstract

The utility model relates to the technical field of bile separation, and discloses a bile acid crystallization and separation integrated device which comprises a reaction barrel, the top end of the outer wall of the reaction barrel is fixedly connected with a feeding pipe, the top end of the outer wall of the reaction barrel is fixedly connected with a motor, and the output end of the motor is fixedly connected with a rotating shaft. Stirring blades are fixedly connected to the outer wall of the rotating shaft, a cleaning brush is fixedly connected to the outer wall of the rotating shaft, a filter screen is fixedly connected to the interior of the reaction barrel, a fixing plate is fixedly connected to the outer wall of the rotating shaft, a connecting rod is fixedly connected to the outer wall of the fixing plate, and a limiting rod is fixedly connected to the interior of the connecting rod. According to the reaction device disclosed by the utility model, the motor drives the rotating shaft to rotate, so that the stirring blades can preliminarily stir an internal solvent, and meanwhile, the cleaning brush and the second scraping plate are used for cleaning the bottom and the inner wall of the reaction barrel respectively; the problem that most of existing bile acid crystallization and separation integrated devices cannot fully clean the interiors of barrels is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of bile separation, in particular to an integrated device for bile acid crystallization separation. Background Technique

[0002] Bile acid is the main component of bile. Bile acid is an important component of bile and plays an important role in fat metabolism. Bile acid mainly exists in the enterohepatic circulation system and plays a certain protective role through recirculation. Only a small part of bile acid enters the peripheral circulation, etc. During the extraction process of bile acid, reagents such as ethyl acetate are usually used for separation through mixing, cooling crystallization, filtration and drying, etc.

[0003] Existing integrated devices for bile acid crystallization separation are usually used in the fields of medicine, biochemistry or pharmaceutical industry. Such devices are designed to separate bile acid crystals in a mixture from other components for further research or application.

[0004] However, after the reaction barrel in the existing integrated device for bile acid crystallization separation is used, the inside of the barrel body cannot be effectively cleaned, which leads to the residue of bile acid crystals on the inner wall of the kettle body, corrodes the inner wall of the barrel, reduces the service life of the barrel body, and at the same time, bile acid crystals precipitate at the bottom of the barrel body, which easily causes the blockage of the discharge port of the barrel body, resulting in inconvenient use. Content of the Utility Model

[0005] The purpose of the utility model is to solve the deficiencies existing in the prior art, and to propose an integrated device for bile acid crystallization separation, aiming to improve the problem that most of the existing integrated devices for bile acid crystallization separation cannot clean the inside sufficiently after the reaction on bile is completed.

[0006] To achieve the above purpose, the utility model provides the following technical solution: an integrated device for bile acid crystallization separation, including a reaction barrel, the top end of the outer wall of the reaction barrel is fixedly connected with a feed pipe, the top end of the outer wall of the reaction barrel is fixedly connected with a motor, the output end of the motor is fixedly connected with a rotating shaft, the outer wall of the rotating shaft is fixedly connected with stirring blades, the outer wall of the rotating shaft is fixedly connected with a cleaning brush, a filter screen is fixedly connected inside the reaction barrel, a fixing plate is fixedly connected to the outer wall of the rotating shaft, a connecting rod is fixedly connected to the outer wall of the fixing plate, a limiting rod is fixedly connected to the inside of the connecting rod, a fixing rod is slidably connected to the inside of the connecting rod, a second scraper is fixedly connected to the outer wall of the fixing rod, the outer wall of the limiting rod slides inside the fixing rod, a limiting block is fixedly connected to the outer wall of the fixing rod, a first spring is sleeved on the outer wall of the limiting rod, one end of the first spring is fixedly connected to the inside of the connecting rod, and the other end of the first spring is fixedly connected to the outer wall of the fixing rod. A heating component is arranged inside the reaction barrel.

[0007] Furthermore, the heating component includes a heating rod, and the outer wall of the heating rod is fixedly connected to the inside of the reaction barrel.

[0008] Furthermore, a cooling pipe is fixedly connected to the outer wall of the reaction barrel. One end of the cooling pipe is fixedly connected to a water inlet pipe, and the other end of the cooling pipe is fixedly connected to a water outlet pipe.

[0009] Furthermore, a discharge pipe is fixedly connected to the bottom of the outer wall of the reaction barrel, and a fixing seat is fixedly connected to the outer wall of the discharge pipe.

[0010] Furthermore, a cylinder is fixedly connected to the inside of the fixing seat, and a push rod is fixedly connected to the output end of the cylinder.

[0011] Furthermore, one end of the push rod is fixedly connected to a fixing ring, and a first scraper is slidably connected to the inside of the fixing ring.

[0012] Furthermore, a slider is fixedly connected to the outer wall of the first scraper, and the outer wall of the slider is slidably connected to the inside of the fixing ring.

[0013] Furthermore, a second spring is arranged inside the fixing ring, and both ends of the second spring are fixedly connected to the outer wall of the first scraper.

[0014] The utility model has the following beneficial effects:

[0015] 1. In the utility model, first, the motor drives the rotating shaft to rotate, so that the stirring blades can initially stir the internal solvent. At the same time, the cleaning brush and the second scraper respectively clean the bottom and the inner wall of the reaction barrel, thereby achieving the effects of fully mixing the internal solvent of the device and facilitating cleaning. It solves the problem that most of the existing integrated bile acid crystallization separation devices cannot fully clean the inside after the reaction on bile, improves the practicability of the device, and extends the service life of the device.

[0016] 2. In the utility model, the cylinder pushes the push rod to drive the fixing ring to slide on the inner wall of the discharge pipe, and at the same time, the first scraper scrapes the residual solvent on the inner wall of the first scraper, thereby achieving the effect of adjusting the temperature of the internal solvent of the device and preventing the discharge pipe from being blocked. It solves the problem that the crystals generated in the existing integrated bile acid crystallization separation device are easily precipitated at the bottom of the kettle body, which further causes the blockage of the discharge port of the kettle body, improves the adjustability of the device and the reaction rate between solvents. Description of the Drawings

[0017] Figure 1 is a schematic three-dimensional structure diagram of the integrated bile acid crystallization separation device proposed by the utility model;

[0018] Figure 2 It is a cross-sectional view of the internal structure of the reaction barrel of the integrated bile acid crystallization separation device proposed by the present utility model;

[0019] Figure 3 is Figure 2 the enlarged view of part A in

[0020] Figure 4 It is a cross-sectional view of the internal structure of the discharge pipe of the integrated bile acid crystallization separation device proposed by the present utility model.

[0021] Legend:

[0022] 1. Reaction barrel; 2. Feed pipe; 3. Motor; 4. Rotating shaft; 5. Stirring blade; 6. Cleaning brush; 7. Fixed plate; 8. Connecting rod; 9. Limiting rod; 10. Fixed rod; 11. Limiting block; 12. First spring; 13. Cooling pipe; 14. Water inlet pipe; 15. Water outlet pipe; 16. Heating rod; 17. Discharge pipe; 18. Fixed seat; 19. Cylinder; 20. Push rod; 21. Fixed ring; 22. First scraper; 23. Slide block; 24. Second spring; 25. Second scraper; 26. Filter screen. Specific embodiments

[0023] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0024] Referring to Figures 1-3 , an embodiment provided by the present utility model: an integrated bile acid crystallization separation device, including a reaction barrel 1, a feed pipe 2 is fixedly connected to the top end of the outer wall of the reaction barrel 1, a motor 3 is fixedly connected to the top end of the outer wall of the reaction barrel 1, a rotating shaft 4 is fixedly connected to the output end of the motor 3, a stirring blade 5 is fixedly connected to the outer wall of the rotating shaft 4, a cleaning brush 6 is fixedly connected to the outer wall of the rotating shaft 4, a filter screen 26 is fixedly connected inside the reaction barrel 1, a fixed plate 7 is fixedly connected to the outer wall of the rotating shaft 4, a connecting rod 8 is fixedly connected to the outer wall of the fixed plate 7, a limiting rod 9 is fixedly connected to the inside of the connecting rod 8, a fixed rod 10 is slidably connected to the inside of the connecting rod 8, a second scraper 25 is fixedly connected to the outer wall of the fixed rod 10, the outer wall of the limiting rod 9 is slidably connected inside the fixed rod 10, a limiting block 11 is fixedly connected to the outer wall of the fixed rod 10, a first spring 12 is sleeved on the outer wall of the limiting rod 9, one end of the first spring 12 is fixedly connected to the inside of the connecting rod 8, and the other end of the first spring 12 is fixedly connected to the outer wall of the fixed rod 10; a heating assembly is arranged inside the reaction barrel 1;

[0025] Specifically, when it is necessary to thoroughly clean the inside of the reaction barrel 1, the output end of the motor 3 drives the rotating shaft 4 and the stirring blade 5 to rotate, so that the stirring blade 5 can fully stir the solvent in the reaction barrel 1 evenly, ensuring that the reaction substances are fully dissolved or mixed. At the same time, the rotation of the rotating shaft 4 will also drive the cleaning brush 6 to rotate at the bottom of the inner wall of the reaction barrel 1. The cleaning brush 6 can effectively clean and agitate the solid particles or crystals precipitated at the bottom, preventing them from accumulating and affecting the reaction effect. As the rotating shaft 4 rotates, the fixing plate 7 drives the second scraper 25 through the connecting rod 8, and the second scraper 25 cleans the solid residues attached to the inner wall of the reaction barrel 1, keeping the inner wall clean. At the same time, the second scraper 25 can push the fixing rod 10 to slide inside the connecting rod 8, and through the compression of the first spring 12, the second scraper 25 can adapt to different inner wall curved surfaces, ensuring a more thorough cleaning effect. This not only ensures the full mixing of the solvent inside the device but also facilitates the cleaning work of the inside of the reaction barrel 1, improving the operation convenience and service life of the device.

[0026] Refer to Figure 1 、 Figure 2 and Figure 4 , the heating assembly includes a heating rod 16, and the outer wall of the heating rod 16 is fixedly connected inside the reaction barrel 1; the outer wall of the reaction barrel 1 is fixedly connected with a cooling pipe 13, one end of the cooling pipe 13 is fixedly connected with a water inlet pipe 14, and the other end of the cooling pipe 13 is fixedly connected with a water outlet pipe 15; the bottom of the outer wall of the reaction barrel 1 is fixedly connected with a discharge pipe 17, and the outer wall of the discharge pipe 17 is fixedly connected with a fixing seat 18; a cylinder 19 is fixedly connected inside the fixing seat 18, and the output end of the cylinder 19 is fixedly connected with a push rod 20; one end of the push rod 20 is fixedly connected with a fixing ring 21, and a first scraper 22 is slidably connected inside the fixing ring 21; the outer wall of the first scraper 22 is fixedly connected with a slider 23, and the outer wall of the slider 23 is slidably connected inside the fixing ring 21; a second spring 24 is arranged inside the fixing ring 21, and both ends of the second spring 24 are fixedly connected to the outer wall of the first scraper 22;

[0027] Specifically, when it is necessary to dredge the inside of the discharge pipe 17, the solvent in the reaction barrel 1 is heated by the heating rod 16, which can increase the temperature of the solvent, accelerate the chemical reaction rate, thereby shortening the reaction time and improving production efficiency. After the reaction is completed, by injecting coolant into the cooling pipe 13, the solvent temperature can be quickly lowered, the stable storage time of the solvent can be extended, and the quality and stability of the reaction product can be ensured. When it is necessary to clean the inside of the discharge pipe 17, the output end of the cylinder 19 pushes the push rod 20 to move and pulls the fixing ring 21, so that the first scraper 22 scrapes off the attachments on the inner wall of the discharge pipe 17. The slider 23 and the second spring 24 limit the position of the first scraper 22, and the first scraper 22 can adapt to the unevenness of the inner wall of the discharge pipe 17 by compressing the second spring 24 to ensure the cleaning effect. This can not only adjust the temperature of the solvent inside the device and increase the reaction rate, but also prevent the discharge pipe 17 from being blocked, thereby ensuring the stability and reliability of the device.

[0028] Working principle: when it is necessary to fully clean the inside of the reaction barrel 1, the output end of the motor 3 drives the rotating shaft 4 and the stirring blade 5 to rotate, so that the stirring blade 5 can fully stir the solvent inside the reaction barrel 1, and at the same time, the rotating shaft 4 will also drive the cleaning brush 6 to rotate at the bottom of the inner wall of the reaction barrel 1, so that the cleaning brush 6 can clean the crystals deposited at the bottom of the reaction barrel 1, and the fixed plate 7 will rotate with the rotating shaft 4, and drive the second scraper 25 through the connecting rod 8, so that the second scraper 25 can clean the crystals attached to the inner wall of the reaction barrel 1, and the second scraper 25 can push the fixed rod 10 to slide inside the connecting rod 8, and compress the first spring 12, so that the second scraper 25 can adapt to different planes, thereby achieving the effect of fully mixing the solvent inside the device and facilitating cleaning, thereby improving the practicability of the device and extending the service life of the device. When it is necessary to clear the inside of the discharge pipe 17, the solvent inside the reaction barrel 1 can be heated by the heating rod 16 to accelerate the reaction rate of the solvent. After the reaction is completed, the cooling liquid can be injected into the cooling pipe 13 to precipitate bile acid crystals, and then the crystals are filtered and preserved by the filter 26. The push rod 20 is pushed to move by the output end of the cylinder 19, and the fixed ring 21 is pulled at the same time, so that the first scraper 22 can scrape the solvent attached to the inner wall of the discharge pipe 17, wherein the slider 23 and the second spring 24 can limit the position of the first scraper 22, and the first scraper 22 can adapt to the uneven inner wall of the discharge pipe 17 by compressing the second spring 24, so as to achieve the effect of adjusting the temperature of the solvent inside the device, and at the same time prevent the discharge pipe 17 from being blocked, thereby improving the adjustability of the device and the reaction rate between solvents.

[0029] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or perform equivalent replacements on some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An integrated device for separating bile acid crystals, comprising a reaction barrel (1), characterized in that: The outer wall top of the reaction barrel (1) is fixedly connected with a feed pipe (2). The outer wall top of the reaction barrel (1) is fixedly connected with a motor (3). The output end of the motor (3) is fixedly connected with a rotating shaft (4). The outer wall of the rotating shaft (4) is fixedly connected with stirring blades (5). The outer wall of the rotating shaft (4) is fixedly connected with a cleaning brush (6). A filter screen (26) is fixedly connected inside the reaction barrel (1). The outer wall of the rotating shaft (4) is fixedly connected with a fixing plate (7). The outer wall of the fixing plate (7) is fixedly connected with a connecting rod (8). A limiting rod (9) is fixedly connected inside the connecting rod (8). A fixing rod (10) is slidably connected inside the connecting rod (8). The outer wall of the fixing rod (10) is fixedly connected with a second scraping plate (25). The outer wall of the limiting rod (9) is slidably connected inside the fixing rod (10). The outer wall of the fixing rod (10) is fixedly connected with a limiting block (11). A first spring (12) is sleeved on the outer wall of the limiting rod (9). One end of the first spring (12) is fixedly connected inside the connecting rod (8), and the other end of the first spring (12) is fixedly connected to the outer wall of the fixing rod (10). A heating component is arranged inside the reaction barrel (1).

2. The integrated bile acid crystallization separation device according to claim 1, wherein: The heating component includes a heating rod (16), and the outer wall of the heating rod (16) is fixedly connected inside the reaction barrel (1).

3. The integrated bile acid crystallization separation device according to claim 2, wherein: The outer wall of the reaction barrel (1) is fixedly connected with a cooling pipe (13). One end of the cooling pipe (13) is fixedly connected with a water inlet pipe (14), and the other end of the cooling pipe (13) is fixedly connected with a water outlet pipe (15).

4. The integrated bile acid crystallization separation device according to claim 3, characterized in that: The outer wall bottom of the reaction barrel (1) is fixedly connected with a discharge pipe (17), and the outer wall of the discharge pipe (17) is fixedly connected with a fixing seat (18).

5. The integrated bile acid crystallization separation device according to claim 4, characterized in that: A cylinder (19) is fixedly connected inside the fixing seat (18), and the output end of the cylinder (19) is fixedly connected with a push rod (20).

6. The integrated bile acid crystallization separation device according to claim 5, characterized in that: One end of the push rod (20) is fixedly connected with a fixing ring (21), and a first scraping plate (22) is slidably connected inside the fixing ring (21).

7. The integrated bile acid crystallization separation device according to claim 6, characterized in that: The outer wall of the first scraping plate (22) is fixedly connected with a slider (23), and the outer wall of the slider (23) is slidably connected inside the fixing ring (21).

8. The integrated bile acid crystal separation device according to claim 7, wherein: A second spring (24) is arranged inside the fixing ring (21), and both ends of the second spring (24) are fixedly connected to the outer wall of the first scraping plate (22).

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