Biological reagent filling equipment

Abstract

The utility model provides biological reagent filling equipment. The biological reagent filling equipment comprises a workbench, a conveying frame, a test solution filling mechanism, a paraffin filling mechanism and an enzyme reagent filling mechanism, the conveying frame is installed on the workbench, the conveying frame is provided with a conveying belt, the test solution filling mechanism is used for filling test tubes on the conveying belt with a test solution, and the paraffin filling mechanism is used for filling the test tubes on the conveying belt with the test solution. The paraffin filling mechanism is used for filling the test tubes on the conveying belt with paraffin, the enzyme reagent filling mechanism comprises a first positioning frame, a first tube pushing assembly and a filling assembly, the first positioning frame is installed on the workbench, and the first positioning frame and the conveying frame jointly form a first moving channel; and the first tube pushing assembly is installed on the workbench and used for pushing test tubes to move in the first moving channel, and the filling assembly is installed on the workbench and used for filling enzyme reagents into the test tubes on the first positioning frame.

Description

Technical Field

[0001] The present disclosure relates to the field of medical biological equipment, and particularly to a biochemical reagent filling device. Background Art

[0002] A biochemical reagent refers to a biological material or organic compound related to life science research, as well as a reagent for clinical diagnosis and medical research. Due to the wide range and rapid development of life science, there is a large variety of such reagents with complex properties.

[0003] For a biochemical reagent that needs to add an enzyme reagent and a test solution, during the production process, after the test solution is filled into a test tube, paraffin needs to be added, and then the enzyme reagent is added. The paraffin separates the test solution from the enzyme reagent to prevent the test solution from reacting with the enzyme reagent, so as to extend the shelf life. In the traditional technology, after the test solution and paraffin are filled into the test tube through a semi-automatic device, the enzyme reagent is manually dropped into the test tube, and finally the cover of the test tube is manually buckled to seal the test tube. However, due to the large number of manual operations, there is a problem of low production efficiency, and there are errors in manual operations. It is difficult to control the amount of enzyme reagent titrated, which further leads to a problem of poor product yield in mass production.

[0004] Therefore, there is an urgent need for a biochemical reagent filling device with high automation and high product yield. Summary of the Utility Model

[0005] The purpose of the present disclosure is to overcome the deficiencies in the prior art and provide a biochemical reagent filling device with high automation and high product yield.

[0006] The purpose of the present disclosure is achieved by the following technical solutions:

[0007] A biochemical reagent filling device includes:

[0008] A workbench, a conveying rack, a test solution filling mechanism, and a paraffin filling mechanism. The conveying rack is installed on the workbench. The conveying rack is provided with a conveyor belt for conveying test tubes. The test solution filling mechanism and the paraffin filling mechanism are arranged at intervals on the workbench. The test solution filling mechanism is used to fill the test tubes on the conveyor belt with the test solution, and the paraffin filling mechanism is used to fill the test tubes on the conveyor belt with paraffin.

[0009] The biological reagent filling device further includes an enzyme reagent filling mechanism, which is located on the side of the paraffin filling mechanism away from the test solution filling mechanism. The enzyme reagent filling mechanism includes a first positioning frame, a first push tube assembly, and a filling assembly. The first positioning frame is installed on the workbench, and a first moving channel is formed jointly by the first positioning frame and the conveying frame. The first push tube assembly is installed on the workbench and is used to push the test tube to move in the first moving channel. The filling assembly is installed on the workbench and is used to fill the test tube on the first positioning frame with enzyme reagent.

[0010] In one embodiment, the filling assembly includes a first mounting frame, a first horizontal driving member, a first vertical driving member, a connecting plate, and a first dropper. The first mounting frame is installed on the workbench. The first horizontal driving member is connected to the first mounting frame, and the power output end of the first horizontal driving member is connected to the first vertical driving member. The power output end of the first vertical driving member is connected to the connecting plate, and the first dropper is installed on the connecting plate.

[0011] In one embodiment, the number of the first droppers is multiple, and the multiple first droppers are arranged at intervals on the connecting plate.

[0012] In one embodiment, the first push tube assembly includes a second mounting frame, a second horizontal driving member, and a first moving frame. The second mounting frame is installed on the workbench. The second horizontal driving member is connected to the second mounting frame, and the power output end of the second horizontal driving member is connected to the first moving frame. A part of the structure of the first moving frame is located in the first moving channel.

[0013] In one embodiment, the first positioning frame is provided with a positioning groove, and the conveying frame is provided with an avoidance opening. The positioning groove is communicated with the avoidance opening, so that the first moving channel is formed jointly by the first positioning frame and the conveying frame.

[0014] In one embodiment, the test solution filling mechanism includes a third mounting frame, a third horizontal driving member, a second vertical driving member, and a second dropper. The third mounting frame is installed on the workbench. The third horizontal driving member is installed on the third mounting frame, and the power output end of the third horizontal driving member is connected to the second vertical driving member. The power output end of the second vertical driving member is connected to the second dropper.

[0015] In one embodiment, the paraffin filling mechanism includes a fourth mounting bracket, a fourth horizontal driving member, a third vertical driving member, and a third dropper. The fourth mounting bracket is mounted on the workbench. The fourth horizontal driving member is mounted on the fourth mounting bracket. The power output end of the fourth horizontal driving member is connected to the third vertical driving member. The power output end of the third vertical driving member is connected to the third dropper.

[0016] In one embodiment, the biological reagent filling device further includes a capping mechanism. The capping mechanism is located on a side of the enzyme reagent filling mechanism away from the paraffin filling mechanism. The capping mechanism includes a second push tube assembly, a second positioning bracket, and a capping assembly. The second positioning bracket is mounted on the workbench. The second positioning bracket and the conveying bracket together form a second moving channel. The second push tube assembly is mounted on the conveying bracket. The second push tube assembly is configured to push a test tube to move within the second moving channel.

[0017] The capping assembly includes a fourth vertical driving member, a fifth horizontal driving member, a first push plate, and a second push plate. The fourth vertical driving member is mounted on the second positioning bracket. The power output end of the fourth vertical driving member is connected to the first push plate. The fifth horizontal driving member is mounted on the first push plate. The power output end of the fifth horizontal driving member is connected to the second push plate.

[0018] In one embodiment, the second push tube assembly includes a fifth mounting bracket, a sixth horizontal driving member, and a second moving bracket. The fifth mounting bracket is mounted on the workbench. The sixth horizontal driving member is mounted on the fifth mounting bracket. The power output end of the sixth horizontal driving member is connected to the second moving bracket. A part of the structure of the second moving bracket is located within the second moving channel.

[0019] In one embodiment, the biological reagent filling device further includes a laminar flow hood, and the laminar flow hood covers the workbench.

[0020] Compared with the prior art, the present disclosure has at least the following advantages:

[0021] The above-mentioned biological reagent filling equipment has a test solution filling mechanism, a paraffin filling mechanism, and an enzyme reagent filling mechanism arranged at intervals in sequence. The conveyor belt is used to transport test tubes. The test tubes are first transported to the test solution filling mechanism for test solution filling. After the test solution filling is completed, the conveyor belt transports the test tubes to the paraffin filling mechanism for paraffin filling to separate the test solution from the enzyme reagent. After the paraffin filling is completed, the conveyor belt transports the test tubes to the enzyme reagent filling mechanism. The first push tube assembly pushes the test tubes to move in the first moving channel, so that the test tubes on the conveyor belt are pushed into the first positioning frame. After the filling assembly fills the test tubes on the first positioning frame with enzyme reagent, the first push tube assembly pushes the test tubes back to the conveyor belt. In this way, through the mutual cooperation of multiple mechanisms, the function of filling multiple processes of the equipment is realized, the automation degree of the equipment is improved, the error caused by manual operation is greatly reduced, and the product yield is thus improved. Brief Description of the Drawings

[0022] To more clearly illustrate the technical solutions of the embodiments of the present disclosure, the accompanying drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present disclosure and should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can be obtained based on these drawings without creative efforts.

[0023] Figure 1 Structural schematic diagram of the biological reagent filling equipment of an embodiment;

[0024] Figure 2 is Figure 1 Another structural schematic diagram of the biological reagent filling equipment shown;

[0025] Figure 3 is Figure 1 Structural schematic diagram of the enzyme reagent filling mechanism of the biological reagent filling equipment shown;

[0026] Figure 4 is Figure 1 Structural schematic diagram of the test solution filling mechanism of the biological reagent filling equipment shown;

[0027] Figure 5 is Figure 1 Structural schematic diagram of the paraffin filling mechanism of the biological reagent filling equipment shown;

[0028] Figure 6 is Figure 1 Structural schematic diagram of the capping mechanism of the biological reagent filling equipment shown;

[0029] Figure 7 is Figure 1 Structural schematic diagram of the height detection mechanism of the biological reagent filling equipment shown;

[0030] Figure 8 is Figure 1 a schematic structural view of the clamping mechanism of the biological reagent filling device shown in Specific embodiments

[0031] To facilitate the understanding of the present disclosure, the present disclosure will be described more comprehensively below with reference to the relevant drawings. Preferred embodiments of the present disclosure are shown in the drawings. However, the present disclosure can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided so that the understanding of the disclosure content of the present disclosure is more thorough and comprehensive.

[0032] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there may also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and do not represent the only embodiments.

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which this disclosure belongs. The terms used in the description of the present disclosure in this specification are only for the purpose of describing specific embodiments and are not intended to limit the present disclosure. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0034] The present disclosure provides a biological reagent filling device, including a workbench, a conveying rack, a test solution filling mechanism, a paraffin filling mechanism and an enzyme reagent filling mechanism. The conveying rack is installed on the workbench. The conveying rack is provided with a conveyor belt for conveying test tubes. The test solution filling mechanism and the paraffin filling mechanism are arranged at intervals on the workbench. The test solution filling mechanism is used to fill the test tubes on the conveyor belt with test solution. The paraffin filling mechanism is used to fill the test tubes on the conveyor belt with paraffin. The enzyme reagent filling mechanism is located on the side of the paraffin filling mechanism away from the test solution filling mechanism. The enzyme reagent filling mechanism includes a first positioning rack, a first pushing tube assembly and a filling assembly. The first positioning rack is installed on the workbench. The first positioning rack and the conveying rack together form a first moving channel. The first pushing tube assembly is installed on the workbench. The first pushing tube assembly is used to push the test tube to move in the first moving channel. The filling assembly is installed on the workbench. The filling assembly is used to fill the test tubes on the first positioning rack with enzyme reagent.

[0035] The above-mentioned biological reagent filling equipment has a test solution filling mechanism, a paraffin filling mechanism, and an enzyme reagent filling mechanism arranged at intervals in sequence. The conveyor belt is used to convey test tubes. The test tubes are first conveyed to the test solution filling mechanism to fill the test tubes with test solution. After the test solution filling is completed, the conveyor belt conveys the test tubes to the paraffin filling mechanism to fill the test tubes with paraffin, so as to separate the test solution from the enzyme reagent. After the paraffin filling is completed, the conveyor belt conveys the test tubes to the enzyme reagent filling mechanism. The first push tube assembly pushes the test tubes to move in the first moving channel, so that the test tubes on the conveyor belt are pushed into the first positioning frame. After the filling assembly fills the test tubes on the first positioning frame with enzyme reagent, the first push tube assembly pushes the test tubes back to the conveyor belt. In this way, through the mutual cooperation of multiple mechanisms, the function of filling multiple processes of the equipment is realized, the automation degree of the equipment is improved, the error caused by manual operation is greatly reduced, and the product yield is thus improved.

[0036] To better understand the technical solutions and beneficial effects of the present disclosure, the following further describes the present disclosure in detail with specific embodiments:

[0037] As Figures 1 to 3 shown, a biological reagent filling equipment 10 of an embodiment includes a workbench 100, a conveying frame 200, a test solution filling mechanism 300, a paraffin filling mechanism 400, and an enzyme reagent filling mechanism 500. The conveying frame 200 is installed on the workbench 100. The conveying frame 200 is provided with a conveyor belt for conveying test tubes. The test solution filling mechanism 300 and the paraffin filling mechanism 400 are arranged at intervals on the workbench 100. The test solution filling mechanism 300 is used to fill the test tubes on the conveyor belt with test solution, and the paraffin filling mechanism 400 is used to fill the test tubes on the conveyor belt with paraffin.

[0038] Furthermore, the enzyme reagent filling mechanism 500 is located on the side of the paraffin filling mechanism 400 away from the test solution filling mechanism 300. The enzyme reagent filling mechanism 500 includes a first positioning frame 510, a first push tube assembly 520, and a filling assembly 530. The first positioning frame 510 is installed on the workbench 100. The first positioning frame 510 and the conveying frame 200 jointly form a first moving channel. The first push tube assembly 520 is installed on the workbench 100. The first push tube assembly 520 is used to push the test tubes to move in the first moving channel. The filling assembly 530 is installed on the workbench 100. The filling assembly 530 is used to fill the test tubes on the first positioning frame 510 with enzyme reagent.

[0039] In this embodiment, the test tube is fixed in the jig, the conveyor belt conveys the jig, the first positioning frame 510 is installed on the workbench 100 and located on one side of the conveyor belt. The first positioning frame 510 and the conveying frame 200 jointly form a first moving channel, so that the jig can move in the first moving channel. The conveyor belt conveys the jig to sequentially pass through the test solution filling mechanism 300 and the paraffin filling mechanism 400, so that the test tube is filled with the test solution and paraffin in sequence. Then, when the conveyor belt conveys the jig to the enzyme reagent filling mechanism 500, the first push tube assembly 520 pushes the jig to move in the first moving channel, so that the jig enters the first positioning frame 510 from the conveyor belt. At this time, the filling assembly 530 works to fill the test tube on the first positioning frame 510 with the enzyme reagent. After the filling is completed, the first push tube assembly 520 pushes the jig back to the conveyor belt, and the conveyor belt conveys the jig to the next station. In this way, through the mutual cooperation of each mechanism in the equipment, the automated operation of filling the test tube with the test solution, paraffin and enzyme reagent is realized, and the manual operation process is reduced.

[0040] For the above-mentioned biological reagent filling equipment 10, the test solution filling mechanism 300, the paraffin filling mechanism 400 and the enzyme reagent filling mechanism 500 are arranged at intervals in sequence. The conveyor belt is used to convey the test tube. The test tube is first conveyed to the test solution filling mechanism 300 to fill the test tube with the test solution. After the test solution filling is completed, the conveyor belt conveys the test tube to the paraffin filling mechanism 400 to fill the test tube with paraffin to separate the test solution from the enzyme reagent. After the paraffin filling is completed, the conveyor belt conveys the test tube to the enzyme reagent filling mechanism 500. The first push tube assembly 520 pushes the test tube to move in the first moving channel, so that the test tube on the conveyor belt is pushed into the first positioning frame 510. After the filling assembly 530 fills the test tube on the first positioning frame 510 with the enzyme reagent, the first push tube assembly 520 pushes the test tube back to the conveyor belt. In this way, through the mutual cooperation of multiple mechanisms, the function of filling the equipment in multiple processes is realized, the automation degree of the equipment is improved, the error caused by manual operation is greatly reduced, and the product yield is further improved.

[0041] As Figure 3As shown, in one embodiment, the filling assembly 530 includes a first mounting bracket 531, a first horizontal driving member 532, a first vertical driving member 533, a connecting plate 534, and a first dropper 535. The first mounting bracket 531 is mounted on the workbench 100. The first horizontal driving member 532 is connected to the first mounting bracket 531. The power output end of the first horizontal driving member 532 is connected to the first vertical driving member 533. The power output end of the first vertical driving member 533 is connected to the connecting plate 534. The first dropper 535 is mounted on the connecting plate 534. In this embodiment, the first mounting bracket 531 is disposed adjacent to the first positioning bracket 510. The first dropper 535 is mounted on the connecting plate 534. The first horizontal driving member 532 drives the first dropper 535 to move in the horizontal direction, and the first vertical driving member 533 drives the first dropper 535 to move in the vertical direction, so that the first dropper 535 moves in multiple dimensions. Moreover, the first dropper 535 is communicated with the air pump to realize filling the enzyme reagent into the test tubes in the first positioning bracket 510. Further, the first horizontal driving member 532 and the first vertical driving member 533 are motors or cylinders.

[0042] As Figure 3 shown, in one embodiment, the number of the first droppers 535 is multiple, and the multiple first droppers 535 are spaced apart on the connecting plate 534. It can be understood that the number of test tubes in the jig is multiple. By setting the number of the first droppers 535 to be multiple and arranging the multiple first droppers 535 on the connecting plate 534, when the connecting plate 534 moves, it drives the multiple first droppers 535 to move, so that the multiple first droppers 535 are correspondingly arranged with the corresponding test tubes, that is, multiple test tubes can be filled with the enzyme reagent simultaneously in one operation, further improving the production efficiency.

[0043] As Figure 3 shown, in one embodiment, the first pushing tube assembly 520 includes a second mounting bracket 521, a second horizontal driving member 522, and a first moving bracket 523. The second mounting bracket 521 is mounted on the workbench 100. The second horizontal driving member 522 is connected to the second mounting bracket 521. The power output end of the second horizontal driving member 522 is connected to the first moving bracket 523. A part of the structure of the first moving bracket 523 is located in the first moving channel. In this embodiment, the second mounting bracket 521 is located on the side of the first positioning bracket 510 away from the first mounting bracket 531. The second horizontal driving member 522 drives the first moving bracket 523 to move. Two clamping columns are provided at the end of the first moving bracket 523. The two clamping columns are located in the first moving channel. When the conveyor belt transports the jig to a predetermined position, the two clamping columns clamp the jig, so that when the first moving bracket 523 moves, it drives the jig to move. Further, the second horizontal driving member 522 is a motor or a cylinder.

[0044] As Figure 3 shown, in one embodiment, the first positioning frame 510 is provided with a positioning groove 511, and the conveying frame 200 is provided with an avoidance opening (not shown in the figure). The positioning groove 511 communicates with the avoidance opening, so that the first positioning frame 510 and the conveying frame 200 jointly form the first moving channel. In this embodiment, the number of avoidance openings is two, and the two avoidance openings are respectively arranged on both sides of the conveying frame 200. The two clamping columns of the first moving frame 523 are respectively located in the avoidance openings. When the conveyor belt conveys the fixture to the avoidance opening, the two clamping columns clamp the fixture. When the second horizontal driving member 522 drives the two clamping columns to move, the two clamping columns drive the fixture to enter or leave the positioning groove 511.

[0045] As Figure 4 shown, in one embodiment, the test solution filling mechanism 300 includes a third mounting frame 310, a third horizontal driving member 320, a second vertical driving member 330, and a second dropper 340. The third mounting frame 310 is mounted on the workbench 100. The third horizontal driving member 320 is mounted on the third mounting frame 310. The power output end of the third horizontal driving member 320 is connected to the second vertical driving member 330. The power output end of the second vertical driving member 330 is connected to the second dropper 340. It can be understood that the third horizontal driving member 320 drives the second dropper 340 to move in the horizontal direction, and the second vertical driving member 330 drives the second dropper 340 to move in the vertical direction, so that the second dropper 340 moves in multiple dimensions. And the second dropper 340 is communicated with an air pump, so as to realize that the second dropper 340 fills the test solution into the test tube. In this embodiment, the third horizontal driving member 320 and the second vertical driving member 330 are motors or cylinders.

[0046] As Figure 5 shown, in one embodiment, the paraffin filling mechanism 400 includes a fourth mounting frame 410, a fourth horizontal driving member 420, a third vertical driving member 430, and a third dropper 440. The fourth mounting frame 410 is mounted on the workbench 100. The fourth horizontal driving member 420 is mounted on the fourth mounting frame 410. The power output end of the fourth horizontal driving member 420 is connected to the third vertical driving member 430. The power output end of the third vertical driving member 430 is connected to the third dropper 440. It can be understood that the fourth horizontal driving member 420 drives the third dropper 440 to move in the horizontal direction, and the third vertical driving member 430 drives the third dropper 440 to move in the vertical direction, so that the third dropper 440 moves in multiple dimensions. And the third dropper 440 is communicated with an air pump, so that the third dropper 440 can fill the paraffin into the test tube. In this embodiment, the fourth horizontal driving member 420 and the third vertical driving member 430 are motors or cylinders.

[0047] As Figure 5 shown, further, paraffin is prone to condense into a solid state at normal temperature. Therefore, paraffin needs to be heated before pouring to make it in a liquid state at high temperature. In one embodiment, the paraffin filling mechanism 400 further includes a heating box 450. The heating box 450 is disposed adjacent to the fourth mounting bracket 410. The heating box 450 is used for heating and containing paraffin. It can be understood that the heating box 450 continuously heats the paraffin to make it in a liquid state. When filling paraffin, the third dropper 440 adsorbs the paraffin in the heating box 450 under the drive of the third vertical driving member 430 and the fourth horizontal driving member 420. Then, the third dropper 440 pours the paraffin into the test tube, so that the liquid paraffin floats on the surface of the test solution.

[0048] As Figure 2 shown, further, the liquid paraffin floating on the surface of the test solution needs to be cooled to make the liquid paraffin cool to form solid paraffin, thereby separating the test solution from the enzyme reagent. In order to improve the cooling efficiency of the paraffin, in one embodiment, the paraffin filling mechanism 400 further includes a refrigerator 460. The refrigerator 460 is installed on the conveyor rack 200. The air outlet of the refrigerator 460 faces the conveyor belt. In this embodiment, the refrigerator 460 is located on one side of the fourth mounting bracket 410 close to the enzyme reagent filling mechanism 500, so that after the test tube is filled with paraffin, it is conveyed to the position of the refrigerator 460 by the conveyor belt. The air outlet of the refrigerator 460 faces the conveyor belt. Under the action of the low-temperature air, the liquid paraffin is quickly cooled, so that the paraffin in the test tube cools to a solid state when it reaches the enzyme reagent filling mechanism 500.

[0049] As Figure 6 shown, in one embodiment, the biological reagent filling device 10 further includes a capping mechanism 600. The capping mechanism 600 is located on the side of the enzyme reagent filling mechanism 500 away from the paraffin filling mechanism 400. The capping mechanism 600 includes a second push tube assembly 610, a second positioning bracket 620 and a capping assembly 630. The second positioning bracket 620 is installed on the workbench 100. The second positioning bracket 620 and the conveyor rack 200 jointly form a second moving channel. The second push tube assembly 610 is installed on the conveyor rack 200. The second push tube assembly 610 is used to push the test tube to move in the second moving channel;

[0050] The capping assembly 630 includes a fourth vertical driving member 631, a fifth horizontal driving member 632, a first push plate 633 and a second push plate 634. The fourth vertical driving member 631 is installed on the second positioning bracket 620. The power output end of the fourth vertical driving member 631 is connected to the first push plate 633. The fifth horizontal driving member 632 is installed on the first push plate 633. The power output end of the fifth horizontal driving member 632 is connected to the second push plate 634.

[0051] In this embodiment, the second positioning frame 620 is provided with a fixing groove, and the conveying frame 200 is provided with a port, and the fixing groove communicates with the port, so that the second positioning frame 620 and the conveying frame 200 jointly form a second moving channel, and the second push tube assembly 610 pushes the test tube to move in the second moving channel. Further, the fourth vertical driving member 631 and the fifth horizontal driving member 632 are motors or cylinders. The fourth vertical driving member 631 drives the first push plate 633 to move in the vertical direction, and the fifth horizontal driving member 632 drives the second push plate 634 to move in the horizontal direction, so that the first push plate 633 and the second push plate 634 jointly buckle the lid of the test tube. The working process of the lid buckling mechanism 600 is as follows: when the test tube in the fixture is conveyed to the lid buckling mechanism 600, the second push tube assembly 610 pushes the fixture into the second positioning frame 620. At this time, the fourth vertical driving member 631 drives the first push plate 633 to move upward, so that the first push plate 633 bends the lid of the test tube in the clockwise direction. Then, the fifth horizontal driving member 632 drives the second push plate 634 to move, so that the second push plate 634 continues to bend the lid in the clockwise direction and makes the lid parallel to the test tube mouth. Under the joint action of the first push plate 633 and the second push plate 634, the lid is flipped 180°. At this time, the fourth vertical driving member 631 drives the first push plate 633 to move downward to drive the second push plate 634 to move downward together, so that the second push plate 634 presses the lid against the test tube mouth, thereby completing the lid buckling operation. Finally, the second push tube assembly 610 pushes the test tube and the fixture with the lid buckled back to the conveyor belt to enter the next working station.

[0052] As Figure 6 shown, in one of the embodiments, the second push tube assembly 610 includes a fifth mounting frame 611, a sixth horizontal driving member 612 and a second moving frame 613. The fifth mounting frame 611 is mounted on the workbench 100, the sixth horizontal driving member 612 is mounted on the fifth mounting frame 611, the power output end of the sixth horizontal driving member 612 is connected to the second moving frame 613, and a part of the structure of the second moving frame 613 is located in the second moving channel. It can be understood that two clamping columns are provided at the end of the second moving frame 613, and the two clamping columns are jointly used to clamp the fixture. When the conveyor belt conveys the fixture to the port of the second positioning frame 620, the fixture is just located between the two clamping columns. At this time, the sixth horizontal driving member 612 drives the second moving frame 613 to move in the horizontal direction, thereby driving the fixture to enter or leave the fixing groove of the second positioning frame 620. In this embodiment, the sixth horizontal driving member 612 is a motor or a cylinder.

[0053] As Figure 1As shown, in one embodiment, the biological reagent filling device 10 further includes a laminar flow hood 700, and the laminar flow hood 700 covers the workbench 100. It can be understood that the laminar flow hood 700 covers the workbench 100 and is connected to the ventilation system, so that the laminar flow hood 700 sends the highly filtered air into the area of the workbench 100 at a constant speed and direction, forming a uniform and stable air flow, effectively removing pollutants such as dust and microorganisms in the area of the workbench 100, and maintaining the cleanliness of the area of the workbench 100, thereby avoiding the contamination of the test solution or enzyme reagent during the filling process.

[0054] It can be understood that due to the high viscosity of the enzyme reagent, the enzyme reagent extruded by the air pump through the first dropper 535 cannot completely drop into the test tube. That is, there may still be residual enzyme reagent sticking to the nozzle of the first dropper 535, resulting in deviation in the product ratio concentration and reducing the product yield. Therefore, in order to improve the product yield, as Figure 3 As shown, in one embodiment, the filling assembly 530 further includes a fixing plate 535 and a swing driving member 536. The fixing plate 535 is connected to the power output end of the first vertical driving member 533. The fixing plate 535 is rotatably connected to the connecting plate 534. The swing driving member 536 is installed on the fixing plate 535, and the power output end of the swing driving member 536 is connected to the connecting plate 534. In this embodiment, the swing driving member 536 is a motor or a cylinder. The fixing plate 535 is installed at the power output end of the first vertical driving member 533, and the first vertical driving member 533 is installed at the power output end of the first horizontal driving member 532. Thus, the fixing plate 535 can move in the horizontal direction or the vertical direction. Since the connecting plate 534 is connected to the fixing plate 535 and the first dropper 535 is installed on the connecting plate 534, when the fixing plate 535 moves, the first dropper 535 is driven to move together. Further, both the connecting plate 534 and the fixing plate 535 are provided with rotating holes, and the rotating shaft passes through the rotating holes so that the connecting plate 534 is rotatably connected to the fixing plate 535, and the swing driving member 536 drives the connecting plate 534 to rotate. The working process of the filling assembly 530 is as follows: The conveyor belt transports the test tube to the position of the first moving channel, and the first pushing tube assembly 520 pushes the test tube into the first positioning frame 510. The first vertical driving member 533 and the first horizontal driving member 532 drive the first dropper 535 to move so that the first dropper 535 moves above the test tube. The air pump is started to fill the enzyme reagent in the first dropper 535 into the test tube. At this time, the swing driving member 536 drives the first dropper 535 to swing, so that the nozzle of the first dropper 535 abuts against the tube wall of the test tube. When the nozzle of the first dropper 535 slides out of the tube wall of the test tube, the enzyme reagent sticking to the nozzle of the first dropper 535 is scraped on the tube wall of the test tube, so that the content accuracy of the enzyme reagent in the test tube is higher, and thus the product yield is improved.

[0055] Further, in order to enable the swing driving member 536 to better drive the connection plate 534 to swing, as Figure 3 shown, in one embodiment, the swing driving member 536 is installed on the fixed plate 535, and there is a preset angle between the swing driving member 536 and the fixed plate 535. In this embodiment, the swing driving member 536 is inclined on the fixed plate 535. For example, the preset angle can be 45°, that is, the inclination angle between the fixed plate 535 and the swing driving member 536 is 45°, so that there is also an angle between the output shaft of the swing driving member 536 and the connection plate 534. The top of the connection plate 534 is rotatably connected to the fixed plate 535 through a rotating shaft. When the swing driving member 536 is started, the output shaft of the swing driving member 536 performs a telescopic movement to make the first dropper 535 rotate clockwise or counterclockwise. And because the output shaft of the swing driving member 536 is inclined and connected to the bottom of the connection plate 534, the swing driving member 536 can drive the connection plate 534 to rotate with less force, that is, the swing driving member 536 can better drive the connection plate 534 to swing, which is more conducive to the miniaturized design of the swing driving member 536.

[0056] It can be understood that when the paraffin filling mechanism 400 fills paraffin into the test tube, there may be a situation where the device fails to fill the test tube or the paraffin has not completely cooled into a solid state before reaching the enzyme reagent filling mechanism 500, resulting in the contact and mixing of the enzyme reagent and the test solution, thus causing the product to be scrapped. Therefore, it is necessary to detect the test tube after filling paraffin. As Figure 2 shown, in one embodiment, the biological reagent filling device 10 further includes a first detection mechanism 800. The first detection mechanism 800 includes a first bracket 810 and a first vision detection member 820. The first bracket 810 is installed on the workbench 100. The first bracket 810 is located between the paraffin filling mechanism 400 and the enzyme reagent filling mechanism 500. The first vision detection member 820 is installed on the first bracket 810, and the first vision detection member 820 faces the conveyor belt. In this embodiment, the first vision detection member 820 uses a high-precision CCD camera. The first vision detection member 820 is electrically connected to the background control system. The first vision detection member 820 is located between the paraffin filling mechanism 400 and the enzyme reagent filling mechanism 500, and the first vision detection member 820 faces the conveyor belt. When the test tube is filled by the paraffin filling mechanism 400, the conveyor belt transports the test tube to the first vision detection member 820. At this time, the first vision detection member 820 takes a photo of the test tube on the conveyor belt and uploads the photo to the background control system for matching. If it is detected that the test tube is not filled with paraffin or the paraffin in the test tube has not completely solidified, the background control system issues an alarm signal and stops the conveyor belt, so that the staff can take out the defective products and reprocess them, thus improving the product yield.

[0057] Further, to ensure that the enzyme reagent is filled into the corresponding test tube and prevent leakage of the enzyme reagent, as Figure 2 shown, in one embodiment, the biological reagent filling device 10 further includes a second detection mechanism 900. The second detection mechanism 900 further includes a second bracket 910 and a second vision detection component 920. The second bracket 910 is installed on the workbench 100. The second bracket 910 is located on a side of the enzyme reagent filling mechanism 500 away from the paraffin filling mechanism 400. The second vision detection component 920 is installed on the second bracket 910, and the second vision detection component 920 faces the conveyor belt. In this embodiment, the second vision detection component 920 uses a high-precision CCD camera. The second vision detection component 920 is electrically connected to the background control system. When the second vision detection component 920 detects that the test tube on the conveyor belt is filled with the enzyme reagent leaking, the second vision detection component 920 outputs a signal to the background control system, so that the background control system issues an alarm signal and stops the conveyor belt from operating, so as to facilitate the staff to take out the defective products and reprocess them, thus improving the product yield.

[0058] It can be understood that after the test tube and the connected lid pass through the capping mechanism 600, the capping mechanism 600 covers the lid on the test tube mouth. However, when the capping mechanism 600 works, there are cases of poor capping or missed capping of the test tube and the lid, such as covering half of the lid on the test tube mouth, that is, the lid is tilted and covered on the test tube mouth, so that the sealing performance is poor, resulting in easy leakage of the reagent during transportation. Therefore, after capping, the test tube needs to be detected. As Figure 7As shown, in one of the embodiments, the biological reagent filling device 10 further includes a height detection mechanism 1000. The height detection mechanism 1000 includes a third bracket 1010, a seventh horizontal driving member 1020, and a distance detection member 1030. The third bracket 1010 is installed on the workbench 100. The seventh horizontal driving member 1020 is installed on the third bracket 1010. The power output end of the seventh horizontal driving member 1020 is connected to the distance detection member 1030. The distance detection member 1030 is used to detect the height of the test tube. In this embodiment, the third bracket 1010 is located on the side of the capping mechanism 600 away from the enzyme reagent filling mechanism 500. The seventh horizontal driving member 1020 is installed on the third bracket 1010. The seventh horizontal driving member 1020 drives the distance detection member 1030 to move in the horizontal direction so that the distance detection member 1030 passes through the test tubes in the fixture in sequence and detects the test tubes in the fixture one by one. Further, the distance detection member 1030 is a height sensor. When the seventh horizontal driving member 1020 drives the distance detection member 1030 to move in the horizontal direction, the distance detection member 1030 detects the height of the test tubes in the fixture. If the detected height of the test tube is greater than or less than the preset value, it indicates that there is a problem with the capping of the test tube. For example, if the lid of the test tube is crooked, the detected height at this time is greater than the height of normal capping. If the lid of the test tube is not capped, the detected height at this time is less than the height of normal capping. Thus, the height detection mechanism 1000 detects the capping quality of the test tube lids.

[0059] Further, after detecting the capping quality of the test tube lids, it is necessary to remove the products with poor capping for reprocessing in subsequent processes. As Figure 8As shown, in one embodiment, the biological reagent filling device 10 further includes a clamping mechanism 1100. The clamping mechanism 1100 includes a clamping component 1110, a push plate component 1120, and a collection box 1130. The clamping component 1110 is disposed opposite to the push plate component 1120. The clamping component 1110 includes a fourth bracket 1111, an eighth horizontal driving member 1112, a fifth vertical driving member 1113, a ninth horizontal driving member 1114, and two clamping plates 1115. The fourth bracket 1111 is installed on the workbench 100. The eighth horizontal driving member 1112 is installed on the fourth bracket 1111. The power output end of the eighth horizontal driving member 1112 is connected to the fifth vertical driving member 1113. The power output end of the fifth vertical driving member 1113 is connected to the ninth horizontal driving member 1114. The power output ends of the ninth horizontal driving member 1114 are respectively connected to the two clamping plates 1115 to move the two clamping plates 1115 closer to or away from each other. The collection box 1130 is located below the fourth bracket 1111. The push plate component 1120 includes a fifth bracket 1121, a tenth horizontal driving member 1122, and a sliding plate 1123. The fifth bracket 1121 is installed on the workbench 100. The tenth horizontal driving member 1122 is installed on the fifth bracket 1121. The power output end of the tenth horizontal driving member 1122 is connected to the sliding plate 1123.

[0060] In this embodiment, after the height detection mechanism 1000 detects the buckling of the test tube and the lid, it marks the products with poor buckling. When the test tube is conveyed to the clamping mechanism 1100, the clamping assembly 1110 clamps out the product with poor buckling from the jig. The slide plate 1123 is inclinedly arranged on the tenth horizontal driving member 1122, and the tenth horizontal driving member 1122 drives the slide plate 1123 to move, so that the test tube released by the clamping assembly 1110 falls into the lower collection box 1130 through the slide plate 1123. The working process of the clamping mechanism 1100 is as follows: The eighth horizontal driving member 1112 drives the clamping plate 1115 to move in the horizontal direction, and the fifth vertical driving member 1113 drives the clamping plate 1115 to move in the vertical direction, so that the two clamping plates 1115 correspond to the test tube in the jig. The ninth driving member drives the two clamping plates 1115 to approach each other to clamp out the test tube with poor buckling in the jig. The eighth horizontal driving member 1112 drives the clamping plate 1115 to move so that the test tube is located above the collection box 1130. The tenth horizontal driving member 1122 drives the slide plate 1123 to extend, so that the slide plate 1123 is located below the two clamping plates 1115. At this time, the ninth horizontal driving member 1114 drives the two clamping plates 1115 to move away from each other, and the test tube falls on the slide plate 1123. Since the slide plate 1123 is inclinedly arranged, the test tube falls into the lower collection box 1130 through the slide plate 1123, completing the clamping operation. The clamping mechanism 1100 clamps the test tube with poor buckling and places the test tube in the collection box 1130, facilitating subsequent reprocessing of the test tube with poor buckling, and thus avoiding the leakage of reagents.

[0061] Compared with the prior art, the present disclosure has at least the following advantages:

[0062] In the above-mentioned biological reagent filling device 10, the test solution filling mechanism 300, the paraffin filling mechanism 400, and the enzyme reagent filling mechanism 500 are sequentially arranged at intervals. The conveyor belt is used to convey the test tubes. The test tubes are first conveyed to the test solution filling mechanism 300 to fill the test tubes with the test solution. After the test solution filling is completed, the conveyor belt conveys the test tubes to the paraffin filling mechanism 400 to fill the test tubes with paraffin to separate the test solution from the enzyme reagent. After the paraffin filling is completed, the conveyor belt conveys the test tubes to the enzyme reagent filling mechanism 500. The first pushing tube assembly 520 pushes the test tubes to move in the first moving channel, so that the test tubes on the conveyor belt are pushed into the first positioning frame 510. After the filling assembly 530 fills the test tubes on the first positioning frame 510 with enzyme reagents, the first pushing tube assembly 520 pushes the test tubes back to the conveyor belt. In this way, through the mutual cooperation of multiple mechanisms, the function of filling multiple processes of the device is realized, the automation degree of the device is improved, the error caused by manual operation is greatly reduced, and the product yield is thus improved.

[0063] The above-described embodiments merely represent several implementation manners of the present disclosure. The description thereof is relatively specific and detailed, but it should not be construed as a limitation on the scope of the utility model patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present disclosure, several modifications and improvements can still be made, and these all fall within the protection scope of the present disclosure. Therefore, the protection scope of the present disclosure patent shall be subject to the appended claims.

Claims

1. A biological reagent filling device, comprising a workbench, a conveying rack, a test solution filling mechanism and a paraffin filling mechanism. The conveying rack is installed on the workbench. The conveying rack is provided with a conveyor belt for conveying test tubes. The test solution filling mechanism and the paraffin filling mechanism are arranged at intervals on the workbench. The test solution filling mechanism is used for filling test tubes on the conveyor belt with test solution, and the paraffin filling mechanism is used for filling test tubes on the conveyor belt with paraffin. It is characterized in that, the biological reagent filling device further comprises an enzyme reagent filling mechanism. The enzyme reagent filling mechanism is located on the side of the paraffin filling mechanism away from the test solution filling mechanism. The enzyme reagent filling mechanism includes a first positioning rack, a first pushing tube assembly and a filling assembly. The first positioning rack is installed on the workbench. The first positioning rack and the conveying rack jointly form a first moving channel. The first pushing tube assembly is installed on the workbench and is used for pushing the test tube to move in the first moving channel. The filling assembly is installed on the workbench and is used for filling the test tube on the first positioning rack with enzyme reagent.

2. The biological reagent filling device according to claim 1, wherein, The filling assembly includes a first mounting rack, a first horizontal driving member, a first vertical driving member, a connecting plate and a first dropper. The first mounting rack is installed on the workbench. The first horizontal driving member is connected to the first mounting rack. The power output end of the first horizontal driving member is connected to the first vertical driving member. The power output end of the first vertical driving member is connected to the connecting plate. The first dropper is installed on the connecting plate.

3. The biological reagent filling equipment according to claim 2, characterized in that, The number of the first droppers is multiple, and the multiple first droppers are arranged at intervals on the connecting plate.

4. The biological reagent filling device according to claim 1, characterized in that, The first pushing tube assembly includes a second mounting rack, a second horizontal driving member and a first moving rack. The second mounting rack is installed on the workbench. The second horizontal driving member is connected to the second mounting rack. The power output end of the second horizontal driving member is connected to the first moving rack. A part of the structure of the first moving rack is located in the first moving channel.

5. The biological reagent filling equipment according to claim 1, characterized in that The first positioning rack is provided with a positioning groove, and the conveying rack is provided with an avoidance opening. The positioning groove is communicated with the avoidance opening, so that the first positioning rack and the conveying rack jointly form the first moving channel.

6. The biological reagent filling device according to claim 1, characterized in that The test solution filling mechanism includes a third mounting rack, a third horizontal driving member, a second vertical driving member and a second dropper. The third mounting rack is installed on the workbench. The third horizontal driving member is installed on the third mounting rack. The power output end of the third horizontal driving member is connected to the second vertical driving member. The power output end of the second vertical driving member is connected to the second dropper.

7. The biological reagent filling device according to claim 1, characterized in that, The paraffin filling mechanism includes a fourth mounting rack, a fourth horizontal driving member, a third vertical driving member and a third dropper. The fourth mounting rack is installed on the workbench. The fourth horizontal driving member is installed on the fourth mounting rack. The power output end of the fourth horizontal driving member is connected to the third vertical driving member. The power output end of the third vertical driving member is connected to the third dropper.

8. The biological reagent filling device according to claim 1, wherein, The biological reagent filling device further includes a cap-pressing mechanism, which is located on the side of the enzyme reagent filling mechanism away from the paraffin filling mechanism. The cap-pressing mechanism includes a second push tube assembly, a second positioning frame and a cap-pressing assembly. The second positioning frame is installed on the workbench. The second positioning frame and the conveying frame jointly form a second moving channel. The second push tube assembly is installed on the conveying frame and is used to push the test tube to move in the second moving channel; The cap-pressing assembly includes a fourth vertical driving member, a fifth horizontal driving member, a first push plate and a second push plate. The fourth vertical driving member is installed on the second positioning frame, and the power output end of the fourth vertical driving member is connected to the first push plate. The fifth horizontal driving member is installed on the first push plate, and the power output end of the fifth horizontal driving member is connected to the second push plate.

9. The biological reagent filling device according to claim 8, characterized in that, The second push tube assembly includes a fifth mounting frame, a sixth horizontal driving member and a second moving frame. The fifth mounting frame is installed on the workbench. The sixth horizontal driving member is installed on the fifth mounting frame, and the power output end of the sixth horizontal driving member is connected to the second moving frame. A part of the structure of the second moving frame is located in the second moving channel.

10. The biological reagent filling equipment according to claim 1, characterized in that, The biological reagent filling device further includes a laminar flow hood, which covers the workbench.

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