Medical intermediate crystallization device

Abstract

The utility model relates to the technical field of medicine crystallization equipment, and particularly discloses a medicine intermediate crystallization device which comprises a supporting mechanism, a crystallization mechanism is arranged on the inner side of the supporting mechanism, the supporting mechanism comprises two first supports and a supporting plate, the supporting plate is arranged above the first supports, and the crystallization mechanism comprises a crystallization tank. The crystallizing tank comprises a shell and an inner container, the inner container is arranged in the shell, a heating pipe is spirally wound on the outer side of the inner container, and two supporting shafts are arranged on each of the two sides of the shell. Convenience is provided for workers to clean medical intermediate crystals remaining on the inner wall of the inner container and the stirring rod, the situation that the use effect of the stirring shaft is affected by crystal residues is avoided, the heating pipe is arranged on the outer side of the inner container, the influence of medical intermediate precipitation on the heating efficiency of the heating pipe can be reduced, and the heating and crystallizing efficiency of liquid medicine is guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical crystallization equipment, and specifically discloses a crystallization device for pharmaceutical intermediates. Background Art

[0002] Pharmaceutical intermediates are compounds generated as intermediate steps in the process of drug synthesis. They are important raw materials in pharmaceutical production and are used to synthesize the final active drug molecules. During the synthesis of pharmaceutical intermediates, a crystallization device is required to process the solution containing pharmaceutical intermediates in order to crystallize the pharmaceutical intermediates contained therein.

[0003] A Chinese patent with the patent number CN211536605U discloses a crystallization device for pharmaceutical intermediates, which specifically relates to the field of pharmaceutical technology. It includes a box body. Inside the box body, there is a crystallization mechanism. The crystallization mechanism includes a heating box. Inside the heating box, there is a stirring shaft. A plurality of stirring rods are fixedly arranged at the outer end of the stirring shaft. There is a motor at the top of the box body. Inside the heating box, there is a brush plate. A brush is fixedly arranged at the outer end of the brush plate. The brush is in contact with the inner wall of the heating box. An electric push rod and a telescopic rod are arranged at the top of the heating box. The other ends of the electric push rod and the telescopic rod are fixedly connected to the brush plate. Heating rods are arranged inside the heating box. The utility model heats the solution to evaporate the water therein, causing the solution to become supersaturated and crystals to precipitate. Then, the electric push rod is used to push the brush plate, so that the brush on the surface of the brush plate brushes off the solid crystals on the inner wall of the heating box. However, during the use of the above crystallization device, it is not convenient to adjust the angle of the heating box and its connecting components, which is not conducive to cleaning the pharmaceutical intermediates remaining on the inner wall of the heating box, the stirring shaft and the stirring rods, affecting the use effect of the stirring shaft and the output of the pharmaceutical intermediates. The heating rods in the above crystallization device are arranged at the bottom of the heating box. And during the evaporation of the liquid medicine, the pharmaceutical intermediates are likely to precipitate at the bottom of the heating box due to the action of gravity, affecting the heating effect of the heating rods on the liquid medicine above the precipitate, thus affecting the evaporation efficiency of the liquid medicine, and further affecting the crystallization efficiency of the pharmaceutical intermediates. Therefore, in order to solve the above problems, the utility model proposes a crystallization device for pharmaceutical intermediates. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a crystallization device for pharmaceutical intermediates, which is convenient to adjust the inclination angle of the crystallization mechanism during use, providing convenience for workers to clean the pharmaceutical intermediate crystals remaining on the inner wall of the inner tank and the stirring rod, avoiding the influence of the use effect of the stirring shaft due to crystallization residue and the influence of the repeated dissolution and recrystallization of pharmaceutical intermediates on the output of pharmaceutical intermediates. The heating tubes are arranged outside the inner tank, which can reduce the influence of the precipitation of pharmaceutical intermediates on the heating efficiency of the heating tubes and ensure the heating and crystallization efficiency of the liquid medicine.

[0005] The present utility model is realized through the following technical solutions:

[0006] A crystallization device for pharmaceutical intermediates, comprising a support mechanism. Inside the support mechanism is provided a crystallization mechanism. The support mechanism includes two first brackets and a support plate. Above the first brackets is provided a support plate. Inside the support plate are symmetrically provided two arc-shaped holes. The crystallization mechanism includes a crystallization tank. The crystallization tank includes an outer shell and an inner tank. Inside the outer shell is provided the inner tank. The outer side of the inner tank is spirally wound with a heating pipe. On both sides of the outer shell are provided two support shafts. The support shafts penetrate through the inside of the arc-shaped holes and are slidably connected to the arc-shaped holes. The upper and lower ends of the outer shell and the inner tank are respectively connected with a top cover and a bottom cover.

[0007] As a further setting of the above solution, two universal brake wheels are connected below the first brackets, facilitating the adjustment and fixation of the position of the crystallization device. In the middle of the lower end of the first brackets is penetrated and provided with a lead screw. The lead screw is threadedly connected to the first brackets. Below the lead screw is connected with an anti-slip pad, which can make the protective pad contact the ground through the rotation of the lead screw to further fix the crystallization device. Both ends of the support plate are connected with first threaded posts, which are convenient for connecting with a connecting rod.

[0008] As a further setting of the above solution, mounting blocks are provided on both sides of the outer shell. Both ends of the mounting blocks are connected with second threaded posts. Between the second threaded posts and the first threaded posts on the same side is connected a connecting rod. On the outer sides of the second threaded posts and the first threaded posts are threadedly connected first nuts, which can fix the angle of the crystallization mechanism when the crystallization mechanism is in a vertical state, so that the crystallization mechanism remains stable during use. The support shafts are slidably connected to the arc-shaped holes, which can provide support for the crystallization mechanism and limit the position of the crystallization mechanism when it rotates. On the outer side of the support shafts are threadedly connected second nuts, which can tighten the second nuts to fix the angle of the crystallization mechanism after the angle adjustment of the crystallization mechanism is completed, so as to facilitate the cleaning and maintenance of components such as the top cover, bottom cover, scraping ring and stirring rod in the crystallization mechanism by workers.

[0009] As a further setting of the above solution, both ends of the heating pipe penetrate through the inside of the outer shell, which is convenient for connection with control. The heating pipe is detachably connected to the inner shell. The two ends of the outer shell and the inner shell are respectively detachably connected to the top cover and the bottom cover, facilitating the installation and maintenance of the above components and their connecting components. Below the bottom cover is provided a discharge pipe. One end of the discharge pipe is provided with a first solenoid valve, which is convenient for discharging the crystallized liquid medicine intermediate from the crystallization tank.

[0010] As a further setting of the above solution, telescopic rods are provided on both sides above the top cover. The telescopic ends of the two telescopic rods penetrate into the interior of the top cover. The telescopic end of the telescopic rod is connected with a scraping ring, which is convenient to drive the scraping ring to move up and down through the telescopic movement of the telescopic rod, and scrape off the crystals of the pharmaceutical intermediate remaining on the inner wall of the inner tank. A motor is provided in the middle of the top cover. The output end of the motor is connected with a stirring rod. The upper end of the stirring rod is rotatably connected with the top cover, which is convenient to drive the stirring rod to rotate through the motor, so that the liquid medicine in the crystallization tank is evenly heated, and the crystals of the pharmaceutical intermediate are broken up after crystallization is completed, facilitating the discharge of the intermediate crystals.

[0011] As a further setting of the above solution, a second bracket is connected to the outside of the motor. The two ends of the second bracket are respectively connected with the two telescopic rods, and the lower end of the second bracket is connected with the top cover, which can provide stable support for the motor and the telescopic rods, facilitating the installation and maintenance of the second bracket. A feed pipe is provided on one side of the motor. A second solenoid valve is provided at one end of the feed pipe, which is convenient to inject the liquid medicine to be crystallized into the crystallization tank. An exhaust pipe is provided on one side of the feed pipe. A third solenoid valve is provided at one end of the exhaust pipe, which is convenient to discharge the steam generated during the crystallization of the intermediate. A temperature sensor is provided on one side of the exhaust pipe, which is convenient to monitor the temperature in the crystallization tank. A humidity sensor is provided on one side of the temperature sensor, which is convenient to monitor the humidity in the crystallization tank, so that workers can judge the crystallization stage of the pharmaceutical intermediate according to the humidity in the crystallization tank.

[0012] As a further setting of the above solution, a controller is provided on one side of one of the first brackets. Both ends of the heating pipe are connected to the controller through wires. The temperature sensor and the humidity sensor are both connected to the controller through data lines, which is convenient to control the operation of the relevant components in the crystallization device and receive the data transmitted back by the temperature sensor and the humidity sensor.

[0013] The utility model has the following beneficial effects during use:

[0014] The design of the two arc-shaped long holes symmetrically arranged inside the support plate is convenient for connecting with the support shaft and at the same time facilitates the rotation of the support rod inside the long hole during the angle adjustment of the crystallization mechanism to limit the tilting direction of the crystallization mechanism. After the angle adjustment is completed, the angle of the crystallization mechanism is fixed by tightening the two second nuts, so that workers can disassemble the top cover and the bottom cover to clean the crystals of the pharmaceutical intermediate remaining on the stirring rod, avoiding affecting the output of the pharmaceutical intermediate crystals.

[0015] The combination of the connecting rod and the first nut can fix the angle of the crystallization mechanism after it returns to the correct position, keeping the crystallization mechanism stable during use. The heating tube spirally wound around the outer side of the inner tank can heat the liquid medicine to be crystallized inside the inner tank, promoting the evaporation of water in the liquid medicine and reducing the influence of the precipitation of the pharmaceutical intermediate at the bottom of the crystallization tank on the use effect of the heating tube, ensuring the crystallization efficiency of the pharmaceutical intermediate. The temperature sensor and humidity sensor in the crystallization mechanism facilitate monitoring the temperature and humidity conditions in the crystallization tank, so that workers can judge the crystallization process of the pharmaceutical intermediate. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for describing the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0017] Figure 1 Perspective view of the present invention;

[0018] Figure 2 Perspective view of the support mechanism in the present invention;

[0019] Figure 3 Side view of the support mechanism in the present invention;

[0020] Figure 4 Perspective view of the crystallization mechanism in the present invention;

[0021] Figure 5 First perspective view of the bottom cover in the present invention;

[0022] Figure 6 Second perspective view of the bottom cover in the present invention;

[0023] Figure 7 Perspective view of the top cover in the present invention;

[0024] Figure 8 Combined perspective view of the top cover, stirring rod and scraping ring in the present invention;

[0025] Figure 9 Combined perspective view of the inner tank, heating tube, scraping ring and telescopic rod in the present invention.

[0026] In the figure: 1. Support mechanism; 2. Crystallization mechanism; 3. Controller; 11. First bracket; 12. Universal brake wheel; 13. Lead screw; 14. Anti-slip pad; 15. Support plate; 151. Arc-shaped hole; 152. First threaded post; 21. Crystallization tank; 211. Outer shell; 2111. Mounting block; 2112. Second threaded post; 2113. Connecting rod; 2114. First nut; 2115. Support shaft; 2116. Second nut; 212. Heating pipe; 213. Inner tank; 214. Top cover; 215. Bottom cover; 2151. Discharge pipe; 2152. First solenoid valve; 22. Telescopic rod; 221. Scraping ring; 23. Motor; 24. Stirring rod; 25. Second bracket; 26. Feed pipe; 261. Second solenoid valve; 27. Exhaust pipe; 271. Third solenoid valve; 28. Humidity sensor; 29. Temperature sensor. Detailed implementation manners

[0027] In order to enable those skilled in the art to better understand the solutions of this application, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are only a part of the embodiments of this application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of this application.

[0028] It should be noted that, without conflict, the embodiments in this application and the features in the embodiments can be combined with each other. The following will refer to the attached Figures 1 - 9 drawings and describe this application in detail in conjunction with the embodiments.

[0029] The embodiment discloses a pharmaceutical intermediate crystallization device, including a support mechanism 1. A crystallization mechanism 2 is arranged inside the support mechanism 1. The support mechanism 1 includes two first brackets 11 and a support plate 15. A support plate 15 is arranged above the first bracket 11. Two arc-shaped holes 151 are symmetrically arranged inside the support plate 15. The crystallization mechanism 2 includes a crystallization tank 21. The crystallization tank 21 includes an outer shell 211 and an inner tank 213. The inner tank 213 is arranged inside the outer shell 211. A heating pipe 212 is spirally wound outside the inner tank 213. Two support shafts 2115 are arranged on both sides of the outer shell 211. The support shafts 2115 penetrate through the inside of the arc-shaped holes 151 and are slidably connected with the arc-shaped holes 151. The upper and lower ends of the outer shell 211 and the inner tank 213 are respectively connected with a top cover 214 and a bottom cover 215.

[0030] Such as Figure 1 , Figure 2 and Figure 3As shown in the figure, two universal brake wheels 12 are connected below the first bracket 11, which is convenient for adjusting the position of the crystallization device and fixing it. A lead screw 13 is penetrated through the middle of the lower end of the first bracket 11. The lead screw 13 is threadedly connected to the first bracket 11. A non-slip pad 14 is connected below the lead screw 13, which can make the protective pad contact the ground by rotating the lead screw 13 to further fix the crystallization device. Both ends of the support plate 15 are connected with first threaded posts 152, which are convenient for connecting with the connecting rod 2113.

[0031] As Figure 1 and Figure 4 shown in the figure, mounting blocks 2111 are arranged on both sides of the outer shell 211. Both ends of the mounting block 2111 are connected with second threaded posts 2112. A connecting rod 2113 is connected between the second threaded posts 2112 and the first threaded posts 152 on the same side. First nuts 2114 are threadedly connected to the outer sides of the second threaded posts 2112 and the first threaded posts 152, which can fix the angle of the crystallization mechanism 2 when the crystallization mechanism 2 is in a vertical state, so that the crystallization mechanism 2 remains stable during use. The support shaft 2115 is slidably connected with the arc-shaped hole 151, which can provide support for the crystallization mechanism 2 and limit the position of the crystallization mechanism 2 when it rotates. A second nut 2116 is threadedly connected to the outer side of the support shaft 2115, which can tighten the second nut 2116 to fix the angle of the crystallization mechanism 2 after the angle adjustment of the crystallization mechanism 2 is completed, so as to facilitate the cleaning and maintenance of components such as the top cover 214, bottom cover 215, scraping ring 221, and stirring rod 24 in the crystallization mechanism 2.

[0032] As Figure 1 、 Figure 4 、 Figure 5 、 Figure 6 and Figure 9 shown in the figure, both ends of the heating pipe 212 penetrate into the interior of the outer shell 211, which is convenient for connection with the control. The heating pipe 212 is detachably connected to the inner shell. Both ends of the outer shell 211 and the inner shell are respectively detachably connected to the top cover 214 and the bottom cover 215, which is convenient for the installation and maintenance of the above components and their connecting components. A discharge pipe 2151 is arranged below the bottom cover 215. A first solenoid valve 2152 is arranged at one end of the discharge pipe 2151, which is convenient for discharging the crystallized liquid medicine intermediate from the crystallization tank 21.

[0033] As Figure 1 、 Figure 2 、 Figure 7 and Figure 8As shown, telescopic rods 22 are provided on both sides above the top cover 214. The telescopic ends of the two telescopic rods 22 penetrate into the interior of the top cover 214. The telescopic ends of the telescopic rods 22 are connected to scraping rings 221, facilitating the up and down movement of the scraping rings 221 driven by the telescopic movement of the telescopic rods 22 to scrape off the crystals of the pharmaceutical intermediate remaining on the inner wall of the inner tank 213. A motor 23 is provided in the middle of the top cover 214. The output end of the motor 23 is connected to a stirring rod 24. The upper end of the stirring rod 24 is rotatably connected to the top cover 214, facilitating the rotation of the stirring rod 24 driven by the motor 23 to uniformly heat the liquid medicine in the crystallization tank 21 and break up the crystals of the pharmaceutical intermediate after crystallization is completed, facilitating the discharge of the intermediate crystals.

[0034] As Figure 1 , Figure 2 and Figure 8 As shown, a second support 25 is connected to the outside of the motor 23. The two ends of the second support 25 are respectively connected to the two telescopic rods 22. The lower end of the second support 25 is connected to the top cover 214, which can provide stable support for the motor 23 and the telescopic rods 22, facilitating the installation and maintenance of the second support 25. A feed pipe 26 is provided on one side of the motor 23. A second solenoid valve 261 is provided at one end of the feed pipe 26, facilitating the injection of the liquid medicine to be crystallized into the crystallization tank 21. An exhaust pipe 27 is provided on one side of the feed pipe 26. A third solenoid valve 271 is provided at one end of the exhaust pipe 27, facilitating the discharge of the steam generated during the crystallization of the intermediate. A temperature sensor 29 is provided on one side of the exhaust pipe 27, facilitating the monitoring of the temperature in the crystallization tank 21. A humidity sensor 28 is provided on one side of the temperature sensor 29, facilitating the monitoring of the humidity in the crystallization tank 21, so that workers can judge the crystallization stage of the pharmaceutical intermediate according to the humidity situation in the crystallization tank 21.

[0035] As Figure 1 As shown, a controller 3 is provided on one side of one of the first supports 11. Both ends of the heating pipe 212 are connected to the controller 3 through wires. The temperature sensor 29 and the humidity sensor 28 are both connected to the controller 3 through data lines, facilitating the control of the operation of relevant components in the crystallization device and receiving the data transmitted back by the temperature sensor 29 and the humidity sensor 28.

[0036] Before using the pharmaceutical intermediate crystallization device disclosed in this embodiment, loosen the brake of the universal brake wheel 12, move the device to a suitable position, and then step on the brake of the universal brake wheel 12 to fix it. Rotate the two lead screws 13 in sequence to make the anti-slip pads 14 closely contact the ground to further fix the device. Connect the original humidity measuring instrument to the controller 3 to measure the humidity of the environment where the crystallization device is located. Connect the exhaust pipe 27 to the original pipeline. Use the controller 3 to open the third solenoid valve 271 and the second solenoid valve 261. Inject a sufficient amount of the solution to be crystallized into the inner tank 213 of the crystallization tank 21 through the feed pipe 26. Use the controller 3 to start the heating tube 212 and the motor 23, so that the heating tube 212 heats the inner tank 213 and the solution inside it, and the motor 23 drives the stirring rod 24 to rotate to stir the solution and make the solution evenly heated. When the solution reaches a certain temperature, the water in the solution evaporates into water vapor and is discharged from the exhaust pipe 27. After a period of time, the crystallization is completed. At this time, the value transmitted back by the humidity sensor 28 is close to the humidity value in the environment where the crystallization device is located. Use the controller 3 to turn off the heating tube 212 to stop heating, and let the crystallization tank 21 and the pharmaceutical intermediate inside it cool down. After a period of time, observe the temperature value inside the crystallization tank 21 transmitted back by the temperature sensor 29. When the temperature in the crystallization tank 21 drops to a certain level, use the controller 3 to open the first valve so that the intermediate crystal in the crystallization tank 21 is discharged through the discharge pipe 2151. During the discharging process, use the controller 3 to simultaneously control the two telescopic rods 22 to extend, driving the scraping ring 221 to move from the top cover 214 to the bottom cover 215 to scrape off the intermediate crystal remaining on the inner wall of the inner tank 213. After the intermediate crystal in the crystallization tank 21 is completely discharged, turn off the motor 23 to stop the stirring rod 24 from rotating.

[0037] Disconnect the feed pipe 26 and the exhaust pipe 27 from the original pipes. Unscrew a plurality of first nuts 2114 from the outside of the first threaded column 152 and the second threaded column 2112 in sequence, remove the connecting rod 2113 from the outside of the first threaded column 152 and the second threaded column 2112, and place it aside. Loosen the second nut 2116 outside the support shaft 2115 to release the fixation of the angle of the crystallization mechanism 2. Pull the crystallization mechanism 2 to one side to make the crystallization mechanism 2 tilt to one side. During the tilting process, the support shaft 2115 slides in the arc-shaped hole 151. After tilting to an angle convenient for removing the top cover 214, tighten the second nut 2116 outside the support shaft 2115 to fix the angle of the crystallization mechanism 2. Then remove the top cover 214 and the bottom cover 215, and clean the residual intermediate crystals on the stirring rod 24, the scraping ring 221 and the bottom cover 215. After cleaning, reset the top cover 214 and the bottom cover 215. Loosen the second nut 2116 outside the support shaft 2115 again, push the crystallization mechanism 2 back to the correct position in the opposite direction, tighten the second nut 2116, and restore the connection of the connecting rod 2113 and the first nut 2114 to the first threaded column 152 and the second threaded column 2112, and fix the crystallization mechanism 2 in a vertical state. Then repeat the above operations to perform the crystallization operation of the next batch of pharmaceutical intermediates.

[0038] Components such as the controller 3, the universal brake wheel 12, the lead screw 13, the anti-slip pad 14, the first threaded column 152, the second threaded column 2112, the first nut 2114, the second nut 2116, the heating pipe 212, the discharge pipe 2151, the first solenoid valve 2152, the telescopic rod 22, the motor 23, the stirring rod 24, the feed pipe 26, the second solenoid valve 261, the exhaust pipe 27, the third solenoid valve 271, the humidity sensor 28, the temperature sensor 29, etc. disclosed in the present utility model are all common standard components or components known to those skilled in the art. Their structures and principles can all be known by those skilled in the art through technical manuals or through conventional experimental methods.

[0039] The above is only a preferred embodiment of the present utility model, and it is not intended to limit the present utility model. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A crystallization device for a pharmaceutical intermediate, comprising a support mechanism, characterized in that, Inside the support mechanism, a crystallization mechanism is provided. The support mechanism includes two first brackets and a support plate. Above the first brackets, a support plate is provided. Inside the support plate, two arc-shaped holes are symmetrically arranged. The crystallization mechanism includes a crystallization tank. The crystallization tank includes an outer shell and an inner tank. Inside the outer shell, the inner tank is provided. A heating pipe is spirally wound around the outside of the inner tank. On both sides of the outer shell, two support shafts are provided. The support shafts penetrate through the inside of the arc-shaped holes and are slidably connected to the arc-shaped holes. The upper and lower ends of the outer shell and the inner tank are respectively connected to a top cover and a bottom cover.

2. The crystallization device for a pharmaceutical intermediate according to claim 1, characterized in that, Below the first brackets, two universal brake wheels are connected. In the middle of the lower end of the first brackets, a lead screw is penetrated. The lead screw is threadedly connected to the first brackets. Below the lead screw, an anti-slip pad is connected. At both ends of the support plate, first threaded posts are connected.

3. A crystallization device for a pharmaceutical intermediate according to claim 1, characterized in that, On both sides of the outer shell, mounting blocks are provided. At both ends of the mounting blocks, second threaded posts are connected. Between the second threaded posts and the first threaded posts on the same side, a connecting rod is connected. On the outer sides of the second threaded posts and the first threaded posts, first nuts are threadedly connected. The support shafts are slidably connected to the arc-shaped holes. On the outer sides of the support shafts, second nuts are threadedly connected.

4. A pharmaceutical intermediate crystallization device according to claim 2, characterized in that, Both ends of the heating pipe penetrate through the inside of the outer shell. The heating pipe is detachably connected to the inner shell. The two ends of the outer shell and the inner shell are respectively detachably connected to the top cover and the bottom cover. Below the bottom cover, a discharge pipe is provided. At one end of the discharge pipe, a first solenoid valve is provided.

5. A crystallization device for a pharmaceutical intermediate according to claim 1, characterized in that, Above the top cover, on both sides, telescopic rods are provided. The telescopic ends of the two telescopic rods penetrate through the inside of the top cover. The telescopic ends of the telescopic rods are connected to a scraping ring. In the middle of the top cover, a motor is provided. The output end of the motor is connected to a stirring rod. The upper end of the stirring rod is rotatably connected to the top cover.

6. The crystallization device for a pharmaceutical intermediate according to claim 5, characterized in that, On the outer side of the motor, a second bracket is connected. The two ends of the second bracket are respectively connected to the two telescopic rods. The lower end of the second bracket is connected to the top cover. On one side of the motor, a feed pipe is provided. At one end of the feed pipe, a second solenoid valve is provided. On one side of the feed pipe, an exhaust pipe is provided. At one end of the exhaust pipe, a third solenoid valve is provided. On one side of the exhaust pipe, a temperature sensor is provided. On one side of the temperature sensor, a humidity sensor is provided.

7. The crystallization device for a pharmaceutical intermediate according to claim 1, characterized in that, On one side of one of the first brackets, a controller is provided. Both ends of the heating pipe are connected to the controller through wires. The temperature sensor and the humidity sensor are both connected to the controller through data lines.

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