Preparation device for headspace gas standard bottle in penicillin bottle

Abstract

The utility model provides a preparation device for headspace gas standard bottles in penicillin bottles, which comprises a vacuumizing mechanism, an air supply mechanism and a sealing mechanism, the sealing mechanism comprises a carrying box, at least one penicillin bottle is placed in the carrying box, and the penicillin bottle is arranged in the carrying box. A pressing plate and a driving structure for driving the pressing plate to press downwards to seal the penicillin bottles are arranged at the positions, located at the upper ends of the penicillin bottles, in the carrying box, and hole sites corresponding to the penicillin bottles in number and matched with the penicillin bottles in position are formed in the pressing plate. Consistency can be guaranteed, and the method is used for comparison, sample reserving and the like.

Description

Technical Field

[0001] The utility model relates to the field of preparation of medical supplies, in particular to a preparation device for a headspace gas standard bottle in a vial. Background Art

[0002] In the pharmaceutical industry, vials are common drug packaging containers. To ensure the quality stability of drugs during production, storage, and transportation, it is necessary to strictly control the headspace gas content in vials. Therefore, the determination of the headspace gas content is an important indicator. To accurately measure the headspace gas content, an accurate headspace gas standard bottle needs to be made. However, the existing methods and devices for making headspace gas standard bottles have problems such as complex operation, low precision, and poor stability.

[0003] In the prior art, during the filling of vials, the stoppers of vials are manually added, which is not convenient for operation and cannot achieve batch capping. Summary of the Invention

[0004] To solve the problems of the above-mentioned prior art, the utility model provides a preparation device for a headspace gas standard bottle in a vial, which uses a capping press to seal instead of manual operation. The sealing performance inside the entire loading box is good, and batch preparation can be carried out in the same environment, which can ensure consistency and is used for comparison, sample retention, etc.

[0005] The technical solution adopted is as follows:

[0006] A preparation device for a headspace gas standard bottle in a vial includes a vacuum pumping mechanism, a gas supply mechanism, and a sealing mechanism. The sealing mechanism includes a loading box. At least one vial is placed inside the loading box. A pressing plate and a driving structure for driving the pressing plate to press down to seal the vial are provided above the vial inside the loading box. The pressing plate is provided with holes corresponding to the number of vials and in position cooperation.

[0007] Further, a sealing plug matching the mouth of the corresponding vial can be provided in the hole on the pressing plate. The hole can be a groove. The groove is provided on the side of the pressing plate that cooperates with the vial. A small hole is also provided at the corresponding position on the other side of the pressing plate.

[0008] Further, the loading box includes a base. At least one bottle position for placing vials is provided on the base. The bottle position is matched with the bottom diameter of the vial.

[0009] Further, the loading box further includes a glass cover covering the outside of the base and a detachable upper cover provided at the upper end of the glass cover. At least two sliding rods for the up and down movement of the pressing plate are further provided on the upper cover. One end of the sliding rod is provided on the upper cover, and the other end is provided on the base.

[0010] Further, a first air port corresponding to and connected with the vacuum pumping mechanism and a second air port corresponding to and connected with the air supply mechanism are provided on the upper cover.

[0011] Further, a first sealing ring is provided between the base and the glass cover; a second sealing ring is provided between the upper cover and the glass cover.

[0012] Further, three sliding rods are provided, and a corresponding number of guide bushings matching with the sliding rods are sleeved outside the sliding rods. The guide bushings are arranged at the connection holes where the pressing plate and the sliding rods are matched.

[0013] Further, the driving structure includes a driving motor arranged at the upper end of the upper cover and a lead screw fixed on the lead screw fixing seat. A nut slider matching with the lead screw is provided on the pressing plate.

[0014] Further, the upper ends of the sliding rods are arranged on the upper cover, and fixing rings are arranged at the lower ends.

[0015] Further, a gas sensor for detecting the gas concentration is arranged inside the carrier box, and a vacuum pressure gauge for detecting the internal pressure of the carrier box is further provided on the upper cover of the carrier box.

[0016] Compared with the prior art, the beneficial effects produced by the present utility model are as follows:

[0017] The present utility model provides a preparation device for a headspace gas standard bottle in a vial, which includes a carrier box. A vial is placed inside the carrier box. A pressing plate and a pressing plate driving mechanism are arranged above the vial in the carrier box. A hole position for installing a sealing plug corresponding to the vial is provided on the pressing plate. The pressing plate presses down to make the sealing plug plug into the vial to seal the vial. Sealing rings are provided both above and below the carrier box, and the overall sealing effect is good, making the gas purity of the produced standard bottle higher.

[0018] The present utility model adopts a vacuum pumping method to create a vacuum environment. After all the gas in the bottle is pumped away, the prepared standard gas is filled to form a standard bottle with this concentration. And it can be batch-prepared in the same environment, which can ensure consistency and is used for comparison, sample retention, etc. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic structural diagram of the carrier box of the present utility model;

[0020] Figure 2 It is a schematic diagram of the air supply mechanism of the present utility model;

[0021] Figure 3 It is a schematic diagram of the vacuum pumping mechanism of the present utility model;

[0022] Figure 4 It is a partially disassembled schematic diagram of the carrier box of the present utility model;

[0023] Figure 5 Schematic diagram of the pressing plate;

[0024] Figure 6 Schematic diagram of the bottom plate;

[0025] Figure 7 Cross-sectional view of the pressing plate;

[0026] Among them, the carrier box 1, the base 101, the glass cover 102, the upper cover 103, the vial 2, the pressing plate 3, the sliding rod 4, the driving structure 5, the driving motor 501, the vacuum pumping mechanism 6, the vacuum pump 601, the first air pipe 602, the first solenoid valve 603, the air supply mechanism 7, the calibration gas cylinder 701, the second air pipe 702, the pressure reducing valve 703, the first air port 8, the second air port 9, the first sealing ring 10, the second sealing ring 11, the guide bushing 12, the screw rod fixing seat 13, the screw rod 14, the nut slider 15, the magnetic coupling 16, the flange bearing 17, the fixing ring 18, the gas sensor 19, the vacuum pressure gauge 20, the hole position 21, the bottle position 22, the small hole 23. Detailed implementation manners

[0027] The following further describes the present utility model in conjunction with specific embodiments.

[0028] Refer to Figure 1-7 , a preparation device for a headspace gas standard bottle in a vial, including a vacuum pumping mechanism 6, an air supply mechanism 7 and a sealing mechanism. The sealing mechanism includes a carrier box 1, at least one vial 2 is placed in the carrier box, a pressing plate 3 and a driving structure 5 for driving the pressing plate to press down to seal the vial are arranged above the vial 2 inside the carrier box 1, and hole positions 21 corresponding to the number of vials 2 and with matching positions are arranged on the pressing plate 3.

[0029] Sealing plugs matching the bottle mouths of the corresponding vials are arranged in the hole positions 21 on the pressing plate 3, and the hole positions are matched with the diameters of the sealing plugs. The driving structure 5 drives the pressing plate to press down, so that the sealing plugs on the pressing plate are inserted into the bottle mouths of the vials to seal the vials.

[0030] The hole positions 21 are grooves matching the sealing plugs, and the grooves are arranged on one side of the pressing plate 3 for matching with the vials. As a preference, small holes 23 are further arranged at positions corresponding to the grooves on the other side of the pressing plate. The diameter of the small holes 23 is smaller than that of the grooves. The small holes 23 are arranged to facilitate the installation of the sealing plugs. When the sealing plugs are inserted into the grooves, the air between the sealing plugs and the grooves can be discharged through the small holes 23.

[0031] The carrier box 1 includes a base 101, a glass cover 102 covering the outside of the base, and a detachable upper cover 103 arranged at the upper end of the glass cover.

[0032] The base 101 is provided with at least one bottle position 22 for placing the vial 2. The bottle position is matched with the bottom diameter of the vial to play a certain role in fixing and positioning the vial 2. At least one vial 2 can be provided. In this embodiment, eight vials are provided. The base 101 is equidistantly provided with eight bottle positions 22 that can accommodate vials 2 with various different specifications of diameters. The holes in the pressing plate 3 are provided with sealing plugs. The sealing plugs correspond to the vials 2 one by one and can seal and fix the eight vials 2.

[0033] The upper cover 103 is further provided with at least two sliding rods 4 for the up and down movement of the pressing plate. Preferably, three sliding rods 4 are provided. The outer sleeves of the sliding rods 4 are provided with corresponding numbers of guide bushings 12 that cooperate with the sliding rods. The guide bushings 12 are arranged at the connection holes where the pressing plate 3 cooperates with the sliding rods 4. By providing three sliding rods 4 and at the same time providing guide bushings 12 on the pressing plate 3, it is more convenient for the pressing plate 3 to slide on the sliding rods 4.

[0034] As an embodiment, one end of the sliding rod 4 is arranged on the upper cover 103, and the other end is arranged on the base 101; as another embodiment, the upper end of the sliding rod 4 is arranged on the upper cover 103, and the lower end is provided with a fixing ring 18. The fixing ring 18 connects the three sliding rods 4 at the same time, playing a fixing role to prevent the sliding rods from shifting. At the same time, the vial 2 is arranged inside the fixing ring 18, which can prevent the vial 2 from tipping over.

[0035] The upper cover is provided with a first air port 8 corresponding to the connection of the vacuum pumping mechanism and a second air port 9 corresponding to the connection of the gas supply mechanism. The vacuum pumping mechanism 6 includes a vacuum pump 601, a first air pipe 602 connected to the first air port 8, and a first electromagnetic valve 603 arranged between the vacuum pump 601 and the first air pipe 602; the gas supply mechanism 7 includes a standard gas cylinder 701, a second air pipe 702 connected to the second air port 9, and a pressure reducing valve 703 arranged between the standard gas cylinder 701 and the second air pipe 702. The vacuum pumping mechanism 6 is used to pump vacuum in the load box, and then the gas supply mechanism 7 supplies gas into the load box 1.

[0036] A first sealing ring 10 is arranged between the base 101 and the glass cover 102; a second sealing ring 11 is arranged between the upper cover 103 and the glass cover 102. By providing the sealing rings, the overall sealing performance of the load box 1 is higher, and the gas purity in the produced standard bottle is purer.

[0037] The driving structure 5 includes a driving motor 501 arranged at the upper end of the upper cover and a lead screw 14 fixed on the lead screw fixing seat 13. The pressing plate 3 is provided with a nut slider 15 that cooperates with the lead screw.

[0038] A magnetic coupling 16 is provided between the driving motor and the lead screw. The upper half of the magnetic coupling 16 is connected to the motor shaft of the driving motor, and the lower half is connected to the lead screw. As a transmission component, the driving motor drives the lead screw to rotate. After the lead screw rotates, it drives the nut slider 15 to move up and down, thereby driving the pressing plate 3 to move up and down. A flange bearing 17 is also provided on the lead screw outside the lead screw fixing seat, making the up and down movement of the lead screw smoother and facilitating the sliding of the lead screw.

[0039] A gas sensor 19 for detecting the gas concentration is provided inside the carrier box 1. A vacuum pressure gauge 20 for detecting the internal pressure of the carrier box is also provided on the upper cover of the carrier box 1. The gas sensor 19 uses laser gas absorption technology to monitor the gas concentration in the glass cover in real time, and the vacuum pressure gauge monitors the pressure in the glass cover in real time.

[0040] The steps for preparing the headspace gas standard bottle in the vial are as follows:

[0041] (1) In the initial state, the vial is cleaned and dried to ensure no impurities and moisture. The pressure gauge is in the closed state, and the base and the glass cover are in a well-sealed installation state.

[0042] (2) When evacuating, lift the driving motor 501 by hand to remove the upper cover. Place the eight vials 2 to be filled in the eight mating holes on the base 101. Place the eight rubber stoppers in the grooves on the pressing plate, and then seal and install the upper cover on the glass cover 102 (the upper cover is detachably connected to the glass cover). At this time, turn on the vacuum pump 601 to evacuate the glass cover 102. At the same time, observe the reading of the vacuum pressure gauge 20. When the pressure value shows below 10 Pa, then close the first solenoid valve 603 and the vacuum pump 601 in sequence. At this time, the vacuum pumping step is completed.

[0043] (3) When filling with the standard gas, open the standard gas cylinder and observe the reading of the vacuum pressure gauge 20. At this time, the gas in the standard gas cylinder enters the glass cover 102 through the second air pipe 702. The glass cover 102 is broken into a vacuum at this time and the pressure continues to rise. When the value of the vacuum pressure gauge shows 0.1 MPa, then close the standard gas cylinder 701. At this time, the gas in the glass cover is the same concentration as that in the standard gas cylinder. At this time, the standard gas filling step is completed.

[0044] (4) When crimping and sealing the vial, the driving motor rotates to drive the magnetic coupling to rotate, thereby driving the lead screw to rotate. At this time, the lead screw rotates and drives the pressing plate connected by the lead screw nut to move downward. The sealing plugs on the pressing plate move downward and correspond to the vials one by one and are squeezed into the vials by the pressing plate. At this time, the gas in the vials is sealed by the rubber stoppers, completing the crimping and sealing of the vials. Or the sealing plugs can be semi-pressed into the vials to also complete the crimping and sealing operation of the vials.

[0045] When removing the vial, loosen the upper cover connecting screw and remove the upper cover, then the intact vial 2 encapsulated in the glass cover can be taken out.

[0046] During reset, by controlling the driving motor to rotate in the reverse direction, the pressure plate can be moved upward for reset, so as to perform the encapsulation operation on the vial next time.

[0047] (6)Perform a sealing test on the removed vial.

[0048] (7)After the sealing test is passed, mark information such as gas concentration and production date on the bottle body to complete the preparation of the standard vial for the headspace gas in the vial.

[0049] The above are only optional embodiments of the present utility model, and do not limit the patent scope of the present utility model accordingly. Any equivalent structural transformation made by using the content of the specification and drawings of the present utility model under the inventive concept of the present utility model, or direct / indirect application in other related technical fields shall be included in the patent protection scope of the present utility model.

Claims

1. An apparatus for preparing a standard bottle of headspace gas in a vial, comprising a vacuum pumping mechanism (6), a gas supply mechanism (7) and a sealing mechanism, characterized in that: The sealing mechanism includes a load box (1) in which at least one vial (2) is placed. Inside the load box (1), a pressing plate (3) and a driving structure (5) for driving the pressing plate to press down to seal the vial are provided above the vial (2). The pressing plate (3) is provided with holes (21) corresponding to the number of vials (2) and in position cooperation.

2. The preparation device of the headspace gas standard bottle in the vial, characterized in that: Sealing plugs that match the bottle mouths of the corresponding vials can be placed in the holes (21) on the pressing plate (3). The holes (21) can be grooves, and the grooves are provided on the side of the pressing plate (3) that cooperates with the vials. Small holes (23) are also provided at the corresponding positions of the other side of the pressing plate.

3. The preparation device of the headspace gas standard bottle in the vial, as claimed in claim 1, wherein: The load box (1) includes a base (101), and at least one bottle position (22) for placing the vial (2) is provided on the base (101). The bottle position matches the bottom diameter of the vial.

4. The preparation device of the headspace gas standard bottle in the vial according to claim 3, characterized in that: The load box (1) further includes a glass cover (102) covering the outside of the base and a detachable upper cover (103) provided at the upper end of the glass cover. At least two sliding rods (4) for the up and down movement of the pressing plate are also provided on the upper cover (103). One end of the sliding rod (4) is provided on the upper cover (103), and the other end is provided on the base (101).

5. The preparation device of the headspace gas standard bottle in the vial, characterized in that: A first air port (8) corresponding to the connection of the vacuum pumping mechanism and a second air port (9) corresponding to the connection of the air supply mechanism are provided on the upper cover.

6. The preparation device of the headspace gas standard bottle in the vial, characterized in that: A first sealing ring (10) is provided between the base (101) and the glass cover (102); a second sealing ring (11) is provided between the upper cover (103) and the glass cover (102).

7. The preparation device of the headspace gas standard bottle in the vial according to claim 4, characterized in that: There are three sliding rods (4), and a corresponding number of guide bushings (12) that cooperate with the sliding rods are sleeved outside the sliding rods (4). The guide bushings (12) are provided at the connection holes where the pressing plate (3) cooperates with the sliding rods (4).

8. The preparation device of the standard bottle for the headspace gas in the vial according to claim 1, characterized in that: The driving structure (5) includes a driving motor (501) provided at the upper end of the upper cover and a lead screw (14) fixed on a lead screw fixing seat (13). A nut slider (15) that cooperates with the lead screw is provided on the pressing plate (3).

9. The preparation device of the standard bottle for the headspace gas in the vial according to claim 4, characterized in that: The upper end of the sliding rod (4) is provided on the upper cover (103), and a fixed ring (18) is provided at the lower end.

10. The preparation device of the standard bottle for the headspace gas in the vial according to claim 1, characterized in that: A gas sensor (19) for detecting the gas concentration is provided inside the load box (1), and a vacuum pressure gauge (20) for detecting the internal pressure of the load box is also provided on the upper cover of the load box (1).

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