Efficient separation system for protein production

Abstract

The utility model discloses an efficient separation system for protein production, which is characterized in that a storage separation barrel is fixed at the top end of a fixed support frame, a connecting support frame is welded at the top end of the storage separation barrel, a liquid separation annular barrel is fixed on the inner side of the connecting support frame, and a plurality of lifting fixing openings are formed in the side end of a centrifugal barrel at equal intervals; lower piezoelectric push rods are symmetrically installed at the side ends of the connecting supporting frame, a multi-opening lifting frame is fixed to the bottom ends of the two lower piezoelectric push rods, rising electric push rods are symmetrically installed at the top end of the centrifugal barrel, a closed sleeve is fixed to the top ends of the two rising electric push rods, and a transmission motor is installed on the inner side of the closed sleeve through a motor base. The discharging motor drives the linkage double-layer plate to push the separated materials to flow along the molecular sieve net, the molecular sieve net is used for screening the protein granularity, the two sets of separation components are used for purifying the protein, crude purification treatment and fine purification treatment of the protein are achieved, and the separation effect and efficiency of the protein are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of proteins, in particular to an efficient separation system for protein production. Background Technique

[0002] Proteins are important components that make up all cells and tissues of the human body. Proteins are the material basis of life, organic macromolecules, the basic organic substances that make up cells, and the main bearers of life activities. Protein production and separation equipment is an important part of the biotechnology and pharmaceutical industries, used to extract and purify proteins from raw materials.

[0003] However, when processing proteins currently, due to the single function of the separation equipment, it is impossible to separate different types of protein materials and proteins with different particle sizes in the same equipment during separation, resulting in the inability to finely separate proteins and affecting the separation efficiency and speed. Summary of the Utility Model

[0004] The utility model provides an efficient separation system for protein production, which can effectively solve the problem proposed in the above background technique that when processing proteins currently, due to the single function of the separation equipment, it is impossible to separate different types of protein materials and proteins with different particle sizes in the same equipment during separation, resulting in the inability to finely separate proteins and affecting the separation efficiency and speed.

[0005] To achieve the above purpose, the utility model provides the following technical solution: An efficient separation system for protein production, including a fixed support frame, and a processing component is arranged at the top of the fixed support frame;

[0006] The processing component includes a storage and separation barrel, a connection support frame, a liquid separation annular barrel, a centrifugal barrel, a lifting fixed port, a lower piezoelectric push rod, a multi-port lifting frame, an upper piezoelectric push rod, a closing sleeve, a driving motor, a centrifugal frame, an electromagnetic discharge plate, a discharging motor, a molecular sieve mesh, and a linkage double-layer plate;

[0007] A storage and separation barrel is fixed at the top end of the fixed support frame. A connection support frame is welded to the top end of the storage and separation barrel. A liquid separation annular barrel is fixed inside the connection support frame. A centrifugal barrel is fixed in the middle of the liquid separation annular barrel. A number of lifting and fixing ports are equidistantly arranged on the side end of the centrifugal barrel. Lower piezoelectric push rods are symmetrically installed on the side end of the connection support frame. A multi-port lifting frame is fixed at the bottom ends of the two lower piezoelectric push rods. Rising electric push rods are symmetrically installed at the top end of the centrifugal barrel. A closing sleeve is fixed at the top ends of the two rising electric push rods. A drive motor is installed inside the closing sleeve through a motor base. A centrifugal frame is clamped to the output shaft of the drive motor. An electromagnetic discharge plate is rotatably connected inside the multi-port lifting frame. A blanking motor is installed at the bottom end of the storage and separation barrel through a motor base. A molecular sieve mesh is fixed inside the storage and separation barrel. A linkage double-layer plate is clamped to the top end of the output shaft of the blanking motor.

[0008] According to the above technical solution, the multi-port lifting frame is slidably installed inside the lifting and fixing ports, and the multi-port lifting frame is slidably installed inside the storage and separation barrel.

[0009] According to the above technical solution, the bottom end of the centrifugal frame is sleeved with the top end of the electromagnetic discharge plate, and both the centrifugal frame and the electromagnetic discharge plate are rotatably installed inside the centrifugal barrel.

[0010] According to the above technical solution, the linkage double-layer plate is rotatably attached to the molecular sieve mesh, and the input ends of the lower piezoelectric push rod, the rising electric push rod, the drive motor, the electromagnetic discharge plate, and the blanking motor are all electrically connected to the output end of an external power supply.

[0011] According to the above technical solution, a separation component is provided at the top end of the fixed support frame;

[0012] The separation component includes a vacuum box, a heat drying plate, an injection pipe, a booster pump, an atomizing spray head, an external discharge pipe, a return pipe, a drying box, and a diversion fan;

[0013] A vacuum box is fixed on one side of the top end of the fixed support frame. A heat drying plate is fixed inside the vacuum box. An injection pipe penetrates and connects to the bottom end of the vacuum box. A booster pump is installed at the position corresponding to the injection pipe at the bottom end of the vacuum box through a motor base. An atomizing spray head is fixed at the top end of the injection pipe. A number of external discharge pipes penetrate and connect to one end of the vacuum box at equal intervals. A number of return pipes penetrate and connect to the top end of the vacuum box at equal intervals. A drying box is connected between the external discharge pipe and the return pipe. A diversion fan is embedded and installed at one end of the external discharge pipe.

[0014] According to the above technical solution, one end of the injection pipe penetrates and is installed at the bottom end of the storage and separation barrel, and the input ends of the heat drying plate, the booster pump, and the diversion fan are all electrically connected to the output end of an external power supply.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows: The structure of the present utility model is scientific and reasonable, and it is safe and convenient to use:

[0016] 1. A processing component is provided. The drive motor and the centrifuge frame drive the mixed liquid to rotate at high speed for centrifugation. The rising electric push rod drives the closing sleeve, the drive motor and the centrifuge frame to be embedded downward into the inner side of the electromagnetic discharge plate. Then, the lower piezoelectric push rod drives the multi-port lifting frame to move, and cooperates with the lifting fixing port and the liquid separation annular barrel to realize liquid discharge treatment. The drive motor drives the centrifuge frame and the electromagnetic discharge plate to push the separated material into the inner side of the storage separation barrel. By adjusting the position of the multi-port lifting frame, discharge treatment at different positions can be realized, and different protein materials are separated layer by layer. The feeding motor drives the linkage double-layer plate to push the separated material to flow along the molecular sieve mesh. The molecular sieve mesh is used to screen the protein particle size, and two separation components are used to purify the protein, realizing the rough purification treatment and fine purification treatment of the protein, and improving the separation effect and efficiency.

[0017] 2. A separation component is provided. The booster pump and the injection pipe extract the separation liquid in the storage separation barrel. The separation liquid is atomized and sprayed along the injection pipe and the atomizing spray head. The hot baking plate heats the inside of the vacuum box. By using vacuum sublimation and continuous hot baking treatment, the separation of protein and water is realized. By using vacuum drying, the situation where the protein is denatured by high temperature is avoided. The hot steam in the vacuum box is extracted through the outer discharge pipe and the diversion fan, and the hot steam flows back to the inner side of the vacuum box along the outer discharge pipe, the drying box and the return pipe, realizing circulating constant temperature heating. By using the air flow rotation and direct blowing treatment, the drying speed is increased and the drying efficiency is accelerated. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The drawings are used to provide a further understanding of the present utility model, and constitute a part of the specification. They are used together with the embodiments of the present utility model to explain the present utility model, and do not constitute a limitation to the present utility model.

[0019] In the drawings:

[0020] Figure 1 is the three-dimensional structure schematic diagram of the present utility model;

[0021] Figure 2 is the structure schematic diagram of the processing component of the present utility model;

[0022] Figure 3 is the installation structure schematic diagram of the centrifuge frame of the present utility model;

[0023] Figure 4 is the installation structure schematic diagram of the lower piezoelectric push rod of the present utility model;

[0024] Figure 5 is the structure schematic diagram of the separation component of the present utility model;

[0025] Reference numerals in the figure: 1. Fixed support frame;

[0026] 2. Processing component; 201. Storage separation barrel; 202. Connecting support frame; 203. Liquid separation annular barrel; 204. Centrifugal barrel; 205. Lifting fixed port; 206. Lower piezoelectric push rod; 207. Multi-port lifting frame; 208. Rising electric push rod; 209. Closing sleeve; 210. Transmission motor; 211. Centrifugal frame; 212. Electromagnetic discharge plate; 213. Discharging motor; 214. Molecular sieve mesh; 215. Linkage double-layer plate;

[0027] 3. Separation component; 301. Vacuum box; 302. Heat drying plate; 303. Injection pipe; 304. Booster pump; 305. Atomizing spray head; 306. Outer discharge pipe; 307. Return pipe; 308. Drying box; 309. Guide fan. Specific implementation mode

[0028] The preferred embodiments of the present utility model will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are only for the purpose of illustrating and explaining the present utility model, and are not used to limit the present utility model.

[0029] Embodiment: As Figures 1-5 shown, the present utility model provides a technical solution, an efficient separation system for protein production, including a fixed support frame 1, and a processing component 2 is arranged at the top of the fixed support frame 1;

[0030] The processing component 2 includes a storage separation barrel 201, a connecting support frame 202, a liquid separation annular barrel 203, a centrifugal barrel 204, a lifting fixed port 205, a lower piezoelectric push rod 206, a multi-port lifting frame 207, a rising electric push rod 208, a closing sleeve 209, a transmission motor 210, a centrifugal frame 211, an electromagnetic discharge plate 212, a discharging motor 213, a molecular sieve mesh 214 and a linkage double-layer plate 215;

[0031] At the top of the fixed support frame 1, a storage and separation barrel 201 is fixed. At the top of the storage and separation barrel 201, a connecting support frame 202 is welded. Inside the connecting support frame 202, a liquid separation annular barrel 203 is fixed. In the middle of the liquid separation annular barrel 203, a centrifugal barrel 204 is fixed. At equal intervals on the side of the centrifugal barrel 204, a number of lifting and fixing ports 205 are opened. On the side of the connecting support frame 202, piezoelectric push rods 206 are symmetrically installed. At the bottom of the two piezoelectric push rods 206, a multi-port lifting frame 207 is fixed. The multi-port lifting frame 207 is slidably installed inside the lifting and fixing port 205. The multi-port lifting frame 207 is slidably installed inside the storage and separation barrel 201, realizing sliding detachment and supporting engagement, ensuring the stable operation of separation and discharging. At the top of the centrifugal barrel 204, rising electric push rods 208 are symmetrically installed. At the top of the two rising electric push rods 208, a closing sleeve 209 is fixed. Inside the closing sleeve 209, a driving motor 210 is installed through a motor seat. The output shaft of the driving motor 210 is clamped with a centrifugal frame 211. Inside the multi-port lifting frame 207, an electromagnetic discharge plate 212 is rotatably connected. The bottom end of the centrifugal frame 211 is sleeved with the top end of the electromagnetic discharge plate 212. The centrifugal frame 211 and the electromagnetic discharge plate 212 are both rotatably installed inside the centrifugal barrel 204, realizing stable centrifugal discharging and can be adjusted according to the actual operation to improve the accuracy of equipment operation. At the bottom of the storage and separation barrel 201, a blanking motor 213 is installed through a motor seat. Inside the storage and separation barrel 201, a molecular sieve mesh 214 is fixed. The top end of the output shaft of the blanking motor 213 is clamped with a linkage double-layer plate 215. The linkage double-layer plate 215 is rotationally attached to the molecular sieve mesh 214, realizing separation processing and improving the stability and speed of separation. For the stable operation of the equipment, the input ends of the piezoelectric push rods 206, the rising electric push rods 208, the driving motor 210, the electromagnetic discharge plate 212 and the blanking motor 213 are all electrically connected to the output end of an external power supply.

[0032] At the top of the fixed support frame 1, a separation component 3 is provided;

[0033] The separation component 3 includes a vacuum box 301, a heat drying plate 302, an injection pipe 303, a booster pump 304, an atomizing spray head 305, an external discharge pipe 306, a return pipe 307, a drying box 308 and a diversion fan 309;

[0034] One side of the top end of the fixed support frame 1 is fixedly provided with a vacuum box 301. Inside the vacuum box 301, a hot drying plate 302 is fixedly installed. The bottom end of the vacuum box 301 is penetrated and connected with an injection pipe 303. One end of the injection pipe 303 is penetrated and installed at the bottom end of the storage and separation barrel 201 to achieve stable feeding and discharging. At the position corresponding to the injection pipe 303 at the bottom end of the vacuum box 301, a booster pump 304 is installed through a motor base. The top end of the injection pipe 303 is fixedly provided with an atomizing spray head 305. A number of outer discharge pipes 306 are penetrated and connected at equal intervals at one end of the vacuum box 301. A number of return pipes 307 are penetrated and connected at equal intervals at the top end of the vacuum box 301. A drying box 308 is connected between the outer discharge pipe 306 and the return pipe 307. One end of the outer discharge pipe 306 is embedded with a diversion fan 309. For the stable operation of the equipment, the input ends of the hot drying plate 302, the booster pump 304 and the diversion fan 309 are all electrically connected to the output end of an external power supply.

[0035] The working principle and usage process of the present utility model: When producing proteins, the staff places the processed semi-finished protein materials inside the centrifugal barrel 204. The driving motor 210 drives the centrifugal frame 211 to rotate at high speed along the centrifugal barrel 204, driving the mixed liquid to rotate at high speed inside the centrifugal barrel 204 to achieve centrifugal treatment. After centrifugation is completed, the mixed liquid is allowed to stand. Layers appear in the liquid. At this time, the rising electric push rod 208 drives the closing sleeve 209, the driving motor 210 and the centrifugal frame 211 to move downward, embedding the centrifugal frame 211 inside the electromagnetic discharging plate 212. Using the magnetic attraction combination of the electromagnetic discharging plate 212 and the centrifugal frame 211, and then the downward electric push rod 206 drives the multi-port lifting frame 207 to move downward along the lifting fixing port 205 to separate the centrifugal barrel 204 from the multi-port lifting frame 207. At this time, the water after centrifugal standing enters the inner side of the liquid separation annular barrel 203 along the lifting fixing port 205 to achieve liquid discharging treatment. After liquid discharging is completed, the downward electric push rod 206 drives the multi-port lifting frame 207 to move downward again, moving the multi-port lifting frame 207 to the discharging position. The driving motor 210 drives the centrifugal frame 211 and the electromagnetic discharging plate 212 to rotate and push the separated materials to flow out along the centrifugal barrel 204. When protein particles are centrifuged in a medium with a density gradient, particles with large mass and density settle faster than particles with small mass and density. And when each protein particle settles to the density gradient of the medium equal to its own density, it stops moving forward. Finally, various proteins are separated into different zones. The separated materials flow into the inner side of the storage and separation barrel 201 along the centrifugal barrel 204, the lifting fixing port 205 and the multi-port lifting frame 207. The separated materials fall onto the top end of the molecular sieve mesh 214 inside the storage and separation barrel 201. The feeding motor 213 drives the linkage double-layer plate 215 to push the separated materials to flow along the molecular sieve mesh 214, using the molecular sieve mesh 214 to screen the protein particle size, and using two sets of separation components to purify the proteins, improving the separation effect and efficiency.

[0036] The separation liquid in the storage separation barrel 201 is extracted by the booster pump 304 and the injection pipe 303. The separation liquid flows along the injection pipe 303 to the position of the atomizing spray head 305 and is subjected to atomizing spray treatment through the atomizing spray head 305. At this time, the inside of the vacuum chamber 301 is heated by the hot drying plate 302. By using vacuum sublimation and continuous hot drying treatment, the separation of protein and water is achieved. The hot steam in the vacuum chamber 301 is extracted by the exhaust pipe 306 and the diversion fan 309. The hot steam flows along the exhaust pipe 306 into the inner side of the drying chamber 308 and finally returns to the inner side of the vacuum chamber 301 through the return pipe 307 to achieve constant temperature heating treatment. Moreover, by using the air flow rotation and direct blowing treatment, the drying speed is increased and the drying efficiency is accelerated.

[0037] Finally, it should be noted that the above are only preferred examples of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An efficient separation system for protein production, comprising a fixed support frame (1), characterized in that: A processing component (2) is provided at the top of the fixed support frame (1); The processing component (2) includes a storage and separation barrel (201), a connection support frame (202), a liquid separation annular barrel (203), a centrifugal barrel (204), a lifting fixed port (205), a lower piezoelectric push rod (206), a multi-port lifting frame (207), an ascending electric push rod (208), a closing sleeve (209), a transmission motor (210), a centrifugal frame (211), an electromagnetic discharge plate (212), a blanking motor (213), a molecular sieve mesh (214), and a linkage double-layer plate (215); The storage and separation barrel (201) is fixed to the top of the fixed support frame (1). The connection support frame (202) is welded to the top of the storage and separation barrel (201). The liquid separation annular barrel (203) is fixed inside the connection support frame (202). The centrifugal barrel (204) is fixed in the middle of the liquid separation annular barrel (203). A number of lifting fixed ports (205) are equidistantly arranged on the side of the centrifugal barrel (204). The lower piezoelectric push rods (206) are symmetrically installed on the side of the connection support frame (202). The bottom ends of the two lower piezoelectric push rods (206) are fixed to the multi-port lifting frame (207). The ascending electric push rods (208) are symmetrically installed on the top of the centrifugal barrel (204). The top ends of the two ascending electric push rods (208) are fixed to the closing sleeve (209). The transmission motor (210) is installed inside the closing sleeve (209) through a motor base. The output shaft of the transmission motor (210) is clamped with the centrifugal frame (211). The electromagnetic discharge plate (212) is rotatably connected inside the multi-port lifting frame (207). The blanking motor (213) is installed at the bottom of the storage and separation barrel (201) through a motor base. The molecular sieve mesh (214) is fixed inside the storage and separation barrel (201). The top end of the output shaft of the blanking motor (213) is clamped with the linkage double-layer plate (215).

2. The high-efficiency separation system for protein production according to claim 1, wherein The multi-port lifting frame (207) is slidably installed inside the lifting fixed port (205), and the multi-port lifting frame (207) is slidably installed inside the storage and separation barrel (201).

3. The high-efficiency separation system for protein production according to claim 1, wherein The bottom end of the centrifugal frame (211) is sleeved with the top end of the electromagnetic discharge plate (212), and both the centrifugal frame (211) and the electromagnetic discharge plate (212) are rotatably installed inside the centrifugal barrel (204).

4. The high-efficiency separation system for protein production according to claim 1, characterized in that, The linkage double-layer plate (215) is rotatably attached to the molecular sieve mesh (214). The input ends of the lower piezoelectric push rod (206), the ascending electric push rod (208), the transmission motor (210), the electromagnetic discharge plate (212), and the blanking motor (213) are all electrically connected to the output end of an external power supply.

5. The highly efficient separation system for protein production according to claim 1, wherein A separation component (3) is provided at the top of the fixed support frame (1); The separation component (3) includes a vacuum box (301), a heat drying plate (302), an injection pipe (303), a booster pump (304), an atomizing spray head (305), an external discharge pipe (306), a reflux pipe (307), a drying box (308), and a diversion blower (309); One side of the top end of the fixed support frame (1) is fixedly provided with a vacuum box (301). A hot air drying plate (302) is fixedly arranged inside the vacuum box (301). The bottom end of the vacuum box (301) is penetrated and connected with an injection pipe (303). A booster pump (304) is installed through a motor base at a position corresponding to the injection pipe (303) at the bottom end of the vacuum box (301). The top end of the injection pipe (303) is fixedly provided with an atomizing spray head (305). A plurality of outer discharge pipes (306) are penetrated and connected at equal intervals at one end of the vacuum box (301). A plurality of reflux pipes (307) are penetrated and connected at equal intervals at the top end of the vacuum box (301). A drying box (308) is connected between the outer discharge pipes (306) and the reflux pipes (307). A diversion fan (309) is embedded and installed at one end of the outer discharge pipe (306).

6. The high-efficiency separation system for protein production according to claim 5, wherein, One end of the injection pipe (303) is penetrated and installed at the bottom end of the storage and separation barrel (201). The input ends of the hot air drying plate (302), the booster pump (304), and the diversion fan (309) are all electrically connected to the output end of an external power supply.

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