Mixing device for polypeptide production

Abstract

The utility model provides a mixing device for polypeptide production, which relates to the technical field of polypeptide production and comprises a main plate, a mixing barrel is fixed at the top end of the main plate, a top cover is arranged at the top end of the mixing barrel, a motor is arranged at the top end of the top cover, and the output end of the motor penetrates through the top cover and is provided with a stirring shaft. A plurality of stirring rods are fixed to the two ends of the outer wall of the stirring shaft, and scrapers are fixed to the opposite ends of the two stirring rods. Through operation of a water pump, a polypeptide solution at the bottom end in the mixing barrel flows out from the upper end of the inner wall of the mixing barrel through circulation of a backflow pipe, the solution at the bottom end of the mixing barrel flows back to the top end of the mixing barrel, the solution and the mixing barrel are comprehensively fused, and practicability is higher; and through operation of the first telescopic rod, the whole top cover is driven to transversely move, so that the top cover can be moved out of the position above the mixing barrel, and subsequent replacement and maintenance of the whole stirring shaft are facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide production, in particular to a mixing device for polypeptide production. Background Art

[0002] With the rapid development of the biopharmaceutical industry, polypeptides, as important bioactive molecules, are increasingly widely used in the fields of drug research and development, treatment, etc. For example, many polypeptide drugs can be used to regulate the physiological functions of the human body. Insulin, which is used to treat diabetes, is a typical polypeptide drug. In order to meet the large-scale and high-quality polypeptide production requirements, an efficient mixing device is needed to ensure the uniform mixing of various raw materials and reagents to guarantee the consistency and accuracy of the polypeptide synthesis or production process.

[0003] At present, in a mixing device for polypeptide production in the prior art, when stirring and mixing, there will be a phenomenon that the concentration at the bottom is high and the concentration at the top is low, resulting in poor mixing effect and poor practicability. In addition, in a mixing device for polypeptide production in the prior art, when replacing and repairing the stirring shaft, etc., it is usually moved out to the top of the mixing barrel for installation and disassembly. This installation and disassembly method is very inconvenient due to the height and obstruction of the mixing barrel, with large limitations and poor practicability. Summary of the Utility Model

[0004] The purpose of the utility model is to solve the problems in the prior art that when stirring and mixing, there will be a phenomenon that the concentration at the bottom is high and the concentration at the top is low, resulting in poor mixing effect, and when replacing and repairing the stirring shaft, etc., it is usually moved out to the top of the mixing barrel for installation and disassembly. This installation and disassembly method is very inconvenient due to the height and obstruction of the mixing barrel, with large limitations, and a mixing device for polypeptide production is proposed.

[0005] To achieve the above purpose, the utility model adopts the following technical scheme: A mixing device for polypeptide production, including a main board, a mixing barrel is fixed at the top end of the main board, a top cover is arranged at the top end of the mixing barrel, a motor is arranged at the top end of the top cover, the output end of the motor penetrates through the top cover and is installed with a stirring shaft, both ends of the outer wall of the stirring shaft are fixed with a plurality of stirring rods, scraping plates are fixed at the opposite ends of the two groups of stirring rods, and the opposite ends of the two scraping plates are attached to the inner wall of the mixing barrel. A support is fixed at the top end of the main board, a first telescopic rod is installed on the inner wall of the support, a moving block is fixed at the output end of the first telescopic rod, a second telescopic rod is installed at the bottom end of the moving block, and the output end of the second telescopic rod is fixed to the top cover.

[0006] Preferably, a water pump is installed on the outer wall of the mixing barrel. One end of the water pump away from the mixing barrel is fixed with a return pipe. The end of the return pipe away from the water pump is communicated with the mixing barrel. A support plate is fixed on the outer wall of the mixing barrel, and the return pipe is fixed to the mixing barrel through the support plate.

[0007] Preferably, a sealing sleeve is fixed to the bottom end of the top cover, and a sealing groove matching the sealing sleeve is formed at the top end of the mixing barrel.

[0008] Preferably, flanges are fixed to the outer walls of the opposite ends of the output end of the motor and the stirring shaft. The two flanges are fixed by bolts. Stabilizing blocks are fixed to both ends of the moving block, and stabilizing grooves matching the stabilizing blocks are formed at both ends of the inner wall of the bracket.

[0009] Preferably, a discharge pipe is fixed to the bottom end of the mixing barrel. The bottom end of the discharge pipe penetrates through the main board and is located below the main board. A control valve is installed on the outer wall of the discharge pipe below the main board.

[0010] Preferably, legs are fixed to the four corners of the bottom end of the main board, a fixing frame is fixed to the top end of the mixing barrel, and the motor is installed at one end of the fixing frame facing the mixing barrel.

[0011] Compared with the prior art, the advantages and positive effects of the present utility model are as follows;

[0012] In the present utility model, through the operation of the water pump, the polypeptide solution at the bottom end inside the mixing barrel flows out from the upper end of the inner wall of the mixing barrel through the circulation of the return pipe, so that the solution at the bottom end of the mixing barrel flows back to the top end of the mixing barrel, enabling comprehensive fusion and stronger practicability. In addition, through the operation of the second telescopic rod, the entire top cover can be driven to rise, and then through the operation of the first telescopic rod, the entire top cover can be driven to move horizontally, enabling it to move out above the mixing barrel, facilitating subsequent replacement and repair of the entire stirring shaft, and having stronger practicability. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 is a perspective view of a mixing device for polypeptide production proposed by the present utility model;

[0014] Figure 2 is a cross-sectional view of a mixing device for polypeptide production proposed by the present utility model;

[0015] Figure 3 is a schematic diagram of the internal structure of the mixing barrel of a mixing device for polypeptide production proposed by the present utility model;

[0016] Figure 4 is a schematic diagram of the internal structure of the bracket of a mixing device for polypeptide production proposed by the present utility model.

[0017] Legend: 1. Main board; 2. Mixing barrel; 3. Top cover; 4. Sealing sleeve; 5. Sealing groove; 6. Motor; 7. Stirring shaft; 8. Flange; 9. Bolt; 10. Stirring rod; 11. Scraper; 12. Discharge pipe; 13. Control valve; 14. Water pump; 15. Return pipe; 16. Support plate; 17. Bracket; 18. First telescopic rod; 19. Moving block; 20. Second telescopic rod; 21. Stabilizing block; 22. Stabilizing groove; 23. Leg; 24. Fixed frame. Detailed implementation mode

[0018] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, without conflict, the embodiments of the present application and the features in the embodiments can be combined with each other.

[0019] In the following description, many specific details are set forth in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the limitations of the specific embodiments disclosed in the following specification.

[0020] Embodiment 1, as Figures 1-4 shown, the present invention provides a mixing device for polypeptide production, including a main board 1, a mixing barrel 2 is fixed at the top of the main board 1, a top cover 3 is provided at the top of the mixing barrel 2, a motor 6 is provided at the top of the top cover 3, the output end of the motor 6 penetrates the top cover 3 and is provided with a stirring shaft 7, a plurality of stirring rods 10 are fixed at both ends of the outer wall of the stirring shaft 7, scraping plates 11 are fixed at the opposite ends of the two groups of stirring rods 10, and the opposite ends of the two scraping plates 11 are attached to the inner wall of the mixing barrel 2. A bracket 17 is fixed at the top of the main board 1, a first telescopic rod 18 is installed on the inner wall of the bracket 17, the output end of the first telescopic rod 18 is fixed with a moving block 19, a second telescopic rod 20 is installed at the bottom of the moving block 19, and the output end of the second telescopic rod 20 is fixed to the top cover 3.

[0021] The overall effect achieved by the entire Embodiment 1 is that through the operation of the motor 6, the stirring shaft 7 is driven to rotate, thereby driving the stirring rods 10 to rotate, and the solution in the mixing barrel 2 is stirred and mixed. When the stirring rods 10 rotate, the scraping plates 11 will be driven to rotate, and the solution adhering to the inner wall of the mixing barrel 2 will be automatically scraped off, which is more practical. Through the operation of the second telescopic rod 20, the entire top cover 3 can be driven to rise, and then through the operation of the first telescopic rod 18, the entire top cover 3 can be driven to move horizontally, so that it can be moved out above the mixing barrel 2, facilitating subsequent replacement and repair of the entire stirring shaft 7, which is more practical.

[0022] Embodiment 2, as Figures 1-4As shown, a water pump 14 is installed on the outer wall of the mixing barrel 2, and a return pipe 15 is fixed to the end of the water pump 14 away from the mixing barrel 2. The end of the return pipe 15 away from the water pump 14 is connected to the mixing barrel 2. A support plate 16 is fixed to the outer wall of the mixing barrel 2, and the return pipe 15 is fixed to the mixing barrel 2 through the support plate 16. A sealing sleeve 4 is fixed to the bottom end of the top cover 3, and a sealing groove 5 matching the sealing sleeve 4 is opened at the top of the mixing barrel 2. A flange 8 is fixed to the outer wall of the end opposite to the stirring shaft 7 of the output end of the motor 6. The two flanges 8 are connected. It is fixed by bolts 9, and stabilizing blocks 21 are fixed at both ends of the moving block 19. Stabilizing grooves 22 matching the stabilizing blocks 21 are provided at both ends of the inner wall of the bracket 17. A discharge pipe 12 is fixed to the bottom end of the mixing barrel 2. The bottom end of the discharge pipe 12 passes through the main board 1 and is arranged below the main board 1. A control valve 13 is installed on the outer wall of the discharge pipe 12 below the main board 1. Support legs 23 are fixed at the four corners of the bottom end of the main board 1. A fixing frame 24 is fixed to the top of the mixing barrel 2, and the motor 6 is installed at the end of the fixing frame 24 facing the mixing barrel 2.

[0023] The effect achieved by the entire embodiment 2 is that, through the operation of the water pump 14, the polypeptide solution at the bottom end of the mixing barrel 2 is circulated through the reflux pipe 15 and flows out from the upper end of the inner wall of the mixing barrel 2, so that the solution at the bottom end of the mixing barrel 2 flows back to the top of the mixing barrel 2, so that it is fully integrated, and the practicality is stronger. The arrangement of the flange 8 and the bolt 9 facilitates the installation and removal of the stirring shaft 7 as a whole, and facilitates the replacement of the new stirring shaft 7, the stirring rod 10 and the scraper 11, which is more practical. By opening the control valve 13, the mixed solution is discharged through the discharge pipe 12. By the arrangement of the sealing sleeve 4 and the sealing groove 5, when the top cover 3 is moved down and docked, a sealing effect is achieved.

[0024] Working principle: When the device is used, the solution is poured into the opening at the top of the mixing barrel 2, and the second telescopic rod 20 is moved downward to drive the top cover 3 to be clamped on the top of the mixing barrel 2. At this time, the operation of the motor 6 drives the stirring shaft 7 to rotate, thereby driving the stirring rod 10 to rotate, stirring and mixing the solution in the mixing barrel 2. When the stirring rod 10 rotates, it drives the scraper 11 to rotate, which automatically scrapes off the solution stuck on the inner wall of the mixing barrel 2. Through the operation of the water pump 14, the polypeptide solution at the bottom of the mixing barrel 2 is circulated through the reflux pipe 15 and is discharged from the mixing barrel 2. The upper end of the inner wall of the mixing barrel 2 flows out, causing the solution at the bottom of the mixing barrel 2 to flow back to the top of the mixing barrel 2, so that the solution is fully fused. After the fusion is completed, the control valve 13 is opened to discharge the mixed solution through the discharge pipe 12. When the stirring shaft 7, stirring rod 10 and scraper 11 need to be repaired or replaced, the operation of the second telescopic rod 20 can drive the top cover 3 to rise as a whole, and then the operation of the first telescopic rod 18 can drive the top cover 3 to move horizontally as a whole, so that it can be moved out from above the mixing barrel 2, which is convenient for the subsequent replacement and maintenance of the stirring shaft 7 as a whole.

[0025] The above are only the preferred embodiments of the present utility model, and are not intended to limit the present utility model in other forms. Any person skilled in the relevant art may use the technical content disclosed above to make changes or modifications into equivalent embodiments with equivalent changes and apply them to other fields. However, as long as they do not depart from the technical solution content of the present utility model, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present utility model still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A mixing device for polypeptide production, comprising a main board (1), characterized in that: At the top of the main board (1), a mixing barrel (2) is fixed. At the top of the mixing barrel (2), a top cover (3) is provided. At the top of the top cover (3), a motor (6) is provided. The output end of the motor (6) penetrates through the top cover (3) and is equipped with a stirring shaft (7). At both ends of the outer wall of the stirring shaft (7), a plurality of stirring rods (10) are fixed. At one end of the two groups of stirring rods (10) facing away from each other, a scraping plate (11) is fixed. At one end of the two scraping plates (11) facing away from each other, they are in contact with the inner wall of the mixing barrel (2). At the top of the main board (1), a bracket (17) is fixed. Inside the inner wall of the bracket (17), a first telescopic rod (18) is installed. The output end of the first telescopic rod (18) is fixed with a moving block (19). At the bottom end of the moving block (19), a second telescopic rod (20) is installed. The output end of the second telescopic rod (20) is fixed to the top cover (3).

2. The mixing device for polypeptide production according to claim 1, characterized in that: On the outer wall of the mixing barrel (2), a water pump (14) is installed. At one end of the water pump (14) away from the mixing barrel (2), a return pipe (15) is fixed. At one end of the return pipe (15) away from the water pump (14), it is communicated with the mixing barrel (2). On the outer wall of the mixing barrel (2), a support plate (16) is fixed. The return pipe (15) is fixed to the mixing barrel (2) through the support plate (16).

3. The mixing device for polypeptide production according to claim 1, characterized in that: At the bottom end of the top cover (3), a sealing sleeve (4) is fixed. At the top of the mixing barrel (2), a sealing groove (5) matching the sealing sleeve (4) is opened.

4. A mixing device for polypeptide production according to claim 1, characterized in that: On the outer walls of the opposite ends of the output end of the motor (6) and the stirring shaft (7), flanges (8) are fixed. The two flanges (8) are fixed by bolts (9). At both ends of the moving block (19), stabilizing blocks (21) are fixed. At both ends of the inner wall of the bracket (17), stabilizing grooves (22) matching the stabilizing blocks (21) are opened.

5. A mixing device for polypeptide production according to claim 1, wherein: At the bottom end of the mixing barrel (2), a discharge pipe (12) is fixed. The bottom end of the discharge pipe (12) penetrates through the main board (1) and is located below the main board (1). On the outer wall of the discharge pipe (12) below the main board (1), a control valve (13) is installed.

6. The mixing device for polypeptide production according to claim 1, characterized in that: At the four corners of the bottom end of the main board (1), legs (23) are fixed. At the top of the mixing barrel (2), a fixing frame (24) is fixed. The motor (6) is installed at one end of the fixing frame (24) facing the mixing barrel (2).

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